4.7 Article

The fungicide tebuconazole modulates the sodium current of human NaV1.5 channels expressed in HEK293 cells

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Medicine, Research & Experimental

The insecticide β-Cyfluthrin induces acute arrhythmic cardiotoxicity through interaction with NaV1.5 and ranolazine reverses the phenotype

Maria Vitoria da Silva et al.

Summary: This study investigated the acute toxicity of 3-Cyfluthrin on the heart and its cellular basis. The results showed that 3-Cyfluthrin caused significant cardiac alterations, including prolongation of the action potential repolarization and disruption of cardiomyocyte contraction and calcium dynamics. The antiarrhythmic drug Ranolazine was able to attenuate these alterations.

CLINICAL SCIENCE (2022)

Article Environmental Sciences

Combined lethal toxicity, biochemical responses, and gene expression variations induced by tebuconazole, bifenthrin and their mixture in zebrafish (Danio rerio)

Yanhua Wang et al.

Summary: The study revealed that the combination of triazole fungicides and pyrethroid insecticides induced synergistic acute toxicity in zebrafish, affecting their antioxidant system and gene expression. Therefore, the joint effects of pesticides at low concentrations should be prioritized in mixture risk management in aquatic ecosystems. More research is needed to identify the threshold concentrations of realistic pesticide mixtures where synergistic interactions occur.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2022)

Article Biochemistry & Molecular Biology

Cell glycosaminoglycans content modulates human voltage-gated proton channel (H(V)1) gating

Diego J. B. Orts et al.

Summary: Voltage-gated proton channels (H(V)1) play crucial roles in various physiological processes, while glycosaminoglycans can modulate membrane receptors and ion channels. Defective biosynthesis of chondroitin sulfate and heparan sulfate in CHO-745 cells leads to gating alterations in the H(V)1 channel, affecting the coupling between voltage- and Delta pH-sensing.

FEBS JOURNAL (2022)

Article Toxicology

The fungicide Tebuconazole induces electromechanical cardiotoxicity in murine heart and human cardiomyocytes derived from induced pluripotent stem cells

Artur Santos-Miranda et al.

Summary: This research examines the acute exposure to Tebuconazole and its impact on cardiomyocytes, finding that TEB affects the electromechanical properties of cardiac tissue and triggers ECG abnormalities.

TOXICOLOGY LETTERS (2022)

Article Biochemistry & Molecular Biology

Characterization in Potent Modulation on Voltage-Gated Na+ Current Exerted by Deltamethrin, a Pyrethroid Insecticide

Mao-Hsun Lin et al.

Summary: This study found that Deltamethrin (DLT) and related compounds can stimulate voltage-gated sodium current in pituitary tumor cells, potentially altering gating characteristics, frequency dependence, and voltage-dependent hysteresis behavior.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Review Entomology

Interaction of Insecticides and Fungicides in Bees

Antonia Schuhmann et al.

Summary: Honeybees and wild bees, as important pollinators, have been experiencing a significant decline in recent years. This review discusses the effects of different combinations of major insecticide and fungicide classes on honeybees and wild bees, highlighting the potential toxicity of certain combinations and the need for further research.

FRONTIERS IN INSECT SCIENCE (2022)

Article Environmental Sciences

Gestational exposure to tebuconazole affects the development of rat fetal Leydig cells

Feifei Ma et al.

Summary: Exposure to tebuconazole in utero causes the proliferation of fetal Leydig cells, possibly through effects on cell autophagy and proliferation mechanisms.

CHEMOSPHERE (2021)

Article Environmental Sciences

Repeated exposure to fungicide tebuconazole alters the degradation characteristics, soil microbial community and functional profiles*

Lingxi Han et al.

Summary: The study found that repeated applications of tebuconazole led to slow degradation in soil, reduction in soil microbial biomass and functional diversity, as well as decreased complexity in soil bacterial community networks. It also resulted in the accumulation of residues and long-term negative effects on soil ecology.

ENVIRONMENTAL POLLUTION (2021)

Article Biochemistry & Molecular Biology

Tebuconazole induced cytotoxic and genotoxic effects in HCT116 cells through ROS generation

Yosra Ben Othmene et al.

Summary: This study investigated the toxic effects of TEB in HCT116 cells, revealing that TEB caused cytotoxicity, induced oxidative stress and apoptosis.

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY (2021)

Article Cardiac & Cardiovascular Systems

Cardiac Late Sodium Channel Current Is a Molecular Target for the Sodium/Glucose Cotransporter 2 Inhibitor Empagliflozin

Koenraad Philippaert et al.

Summary: SGLT2 inhibitors have cardioprotective effects against heart failure by inhibiting the late component of the cardiac sodium channel current.

CIRCULATION (2021)

Article Environmental Sciences

Trends in Agricultural Triazole Fungicide Use in the United States, 1992-2016 and Possible Implications for Antifungal-Resistant Fungi in Human Disease Comment

Mitsuru Toda et al.

Summary: The use of triazole fungicides in the United States has increased significantly from 2006 to 2016, particularly in Midwest and Southeast states. This increase is correlated with the emergence of triazole-resistant infections caused by A. fumigatus. Chemical similarities between fungicides and antifungal drugs may contribute to the development of triazole resistance, emphasizing the need for enhanced monitoring and strategies to mitigate resistance.

ENVIRONMENTAL HEALTH PERSPECTIVES (2021)

Review Cell Biology

Cardiac Conduction Velocity, Remodeling and Arrhythmogenesis

Bo Han et al.

Summary: Cardiac electrophysiological disorders, especially arrhythmias, are a major cause of morbidity and mortality worldwide. Altered conduction velocity (CV) is a key substrate for arrhythmogenesis, and understanding methods and determinants of CV is crucial for preventing arrhythmias.
Article Environmental Sciences

Tebuconazole induces liver injury coupled with ROS-mediated hepatic metabolism disorder

Tingting Ku et al.

Summary: The study found that low doses of tebuconazole mainly accumulated in the liver of mice, causing histopathological damage. Tebuconazole significantly dysregulated metabolizing enzymes, efflux transporters, and fatty acid metabolism-related genes in the liver, leading to liver hypertrophy and steatosis. Furthermore, excessive induction of ROS and oxidative stress partly accounted for the metabolic abnormalities mediated by tebuconazole.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

Article Chemistry, Applied

US Food and Drug Administration regulatory pesticide residue monitoring of human foods: 2009-2017

Chia-Pei Liang et al.

Summary: Most human food samples were compliant with federal standards, but the violation rate was higher for imported samples and increased over time. Mismatches between US tolerances and international MRLs, especially in rice, can lead to violations. DDT, although still present in the environment, was found in a small percentage of samples with most below the limit of quantitation.

FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT (2021)

Article Food Science & Technology

Tebuconazole induced cardiotoxicity in male adult rat

Yosra Ben Othmene et al.

FOOD AND CHEMICAL TOXICOLOGY (2020)

Article Biochemistry & Molecular Biology

Oxidative stress, DNA damage and apoptosis induced by tebuconazole in the kidney of male Wistar rat

Yosra Ben Othmene et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2020)

Article Biochemistry & Molecular Biology

Molecular Dynamics Investigations of Binding Mechanism for Triazoles Inhibitors to CYP51

Na Shi et al.

FRONTIERS IN MOLECULAR BIOSCIENCES (2020)

Article Biochemistry & Molecular Biology

Tebuconazole induced oxidative stress and histopathological alterations in adult rat heart

Yosra Ben Othmene et al.

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY (2020)

Article Environmental Sciences

Endocrine disrupting effects of tebuconazole on different life stages of zebrafish (Danio rerio)

Shuying Li et al.

ENVIRONMENTAL POLLUTION (2019)

Article Plant Sciences

Toxic effects of the fungicide tebuconazole on the root system of fusarium-infected wheat plants

Ekaterina Shishatskaya et al.

PLANT PHYSIOLOGY AND BIOCHEMISTRY (2018)

Review Cardiac & Cardiovascular Systems

Disease Modifiers of Inherited SCN5A Channelopathy

Arie O. Verkerk et al.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2018)

Article Biophysics

Voltage-gated sodium channels as targets for pyrethroid insecticides

Linda M. Field et al.

EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS (2017)

Review Physiology

MURINE ELECTROPHYSIOLOGICAL MODELS OF CARDIAC ARRHYTHMOGENESIS

Christopher L. -H. Huang

PHYSIOLOGICAL REVIEWS (2017)

Article Environmental Sciences

Chiral bioaccumulation behavior of tebuconazole in the zebrafish (Danio rerio)

Na Liu et al.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2016)

Article Environmental Sciences

Pesticide pollution of multiple drinking water sources in the Mekong Delta, Vietnam: evidence from two provinces

N. D. G. Chau et al.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2015)

Article Plant Sciences

Mixtures of Pesticides in Tank, in Brazilian Farms

D. L. P. Gazziero

PLANTA DANINHA (2015)

Article Public, Environmental & Occupational Health

Pesticides in drinking water - the Brazilian monitoring program

Auria M. C. Barbosa et al.

FRONTIERS IN PUBLIC HEALTH (2015)

Review Physiology

Determinants of myocardial conduction velocity: implications for arrhythmogenesis

James H. King et al.

FRONTIERS IN PHYSIOLOGY (2013)

Article Food Science & Technology

Brazilian monitoring programs for pesticide residues in food - Results from 2001 to 2010

Andreia N. O. Jardim et al.

FOOD CONTROL (2012)

Review Neurosciences

Mechanisms of closed-state inactivation in voltage-gated ion channels

Robert Baehring et al.

JOURNAL OF PHYSIOLOGY-LONDON (2011)

Article Pharmacology & Pharmacy

Predicting drug-induced slowing of conduction and pro-arrhythmia: identifying the 'bad' sodium current blockers

Hua Rong Lu et al.

BRITISH JOURNAL OF PHARMACOLOGY (2010)

Review Cardiac & Cardiovascular Systems

Sodium Channel Molecular Conformations and Antiarrhythmic Drug Affinity

Michael F. Sheets et al.

TRENDS IN CARDIOVASCULAR MEDICINE (2010)

Article Andrology

Endocrine-disrupting properties in vivo of widely used azole fungicides

C. Taxvig et al.

INTERNATIONAL JOURNAL OF ANDROLOGY (2008)

Review Biochemistry & Molecular Biology

SCN5A channelopathies - An update on mutations and mechanisms

Thomas Zimmer et al.

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2008)

Article Multidisciplinary Sciences

Na channel inactivation from open and closed states

Clay M. Armstrong

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Review Physiology

Basic mechanisms of cardiac impulse propagation and associated arrhythmias

AG Kléber et al.

PHYSIOLOGICAL REVIEWS (2004)

Article Multidisciplinary Sciences

Slowed conduction and ventricular tachycardia after targeted disruption of the cardiac sodium channel gene Scn5a

GA Papadatos et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)