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Oxymatrine exhibits anti-neuroinflammatory effects on Aβ1-42-induced primary microglia cells by inhibiting NF-κB and MAPK signaling pathways
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Oxymatrine inhibits the migration of human colorectal carcinoma RKO cells via inhibition of PAI-1 and the TGF-β1/Smad signaling pathway
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The regulatory effect of oxymatrine on the TLR4/MyD88/NF-κB signaling pathway in lipopolysaccharide-induced MS1 cells
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Oxymatrine inhibits renal fibrosis of obstructive nephropathy by downregulating the TGF-1-Smad3 pathway
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Anti-hepatitis B virus effect of matrine-type alkaloid and involvement of p38 mitogen-activated protein kinase and tumor necrosis factor receptor-associated factor 6
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Evaluation of pharmacokinetics underlies the collaborated usage of lamivudine and oxymatrine in beagle dogs
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Oxymatrine ameliorates renal ischemia-reperfusion injury from oxidative stress through Nrf2/HO-1 pathway
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Oxymatrine suppresses proliferation and induces apoptosis of hemangioma cells through inhibition of HIF-1a signaling
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Oxymatrine inhibits the proliferation of prostate cancer cells in vitro and in vivo
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Oxymatrine attenuated hypoxic-ischemic brain damage in neonatal rats via improving antioxidant enzyme activities and inhibiting cell death
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CANCER CHEMOTHERAPY AND PHARMACOLOGY (2015)
Oxymatrine attenuates diabetes-associated cognitive deficits in rats
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ACTA PHARMACOLOGICA SINICA (2014)
Oxymatrine induces apoptosis in human cervical cancer cells through guanine nucleotide depletion
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CELL BIOCHEMISTRY AND BIOPHYSICS (2014)
Oxymatrine Extracted from Sophora flavescens Inhibited Cell Growth and Induced Apoptosis in Human Osteosarcoma MG-63 Cells In Vitro
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CELL BIOCHEMISTRY AND BIOPHYSICS (2014)
The protective effects of the combination of sodium ferulate and oxymatrine on ethanol-induced liver damage in mice
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ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2014)
Targeted delivery of the RGD-labeled biodegradable polymersomes loaded with the hydrophilic drug oxymatrine on cultured hepatic stellate cells and liver fibrosis in rats
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EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2014)
Cardioprotective effects of oxymatrine on isoproterenol-induced heart failure via regulation of DDAH/ADMA metabolism pathway in rats
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EUROPEAN JOURNAL OF PHARMACOLOGY (2014)
Oxymatrine prevents hypoxia- and monocrotaline-induced pulmonary hypertension in rats
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FREE RADICAL BIOLOGY AND MEDICINE (2014)
Hypoglycemic and hypolipidemic effects of oxymatrine in high-fat diet and streptozotocin-induced diabetic rats
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Oxymatrine Improves Intestinal Epithelial Barrier Function Involving NF-κB-Mediated Signaling Pathway in CCl4-Induced Cirrhotic Rats
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Oxymatrine induces mitochondria dependent apoptosis in human osteosarcoma MNNG/HOS cells through inhibition of PI3K/Akt pathway
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TUMOR BIOLOGY (2014)
Oxymatrine triggers apoptosis by regulating Bcl-2 family proteins and activating caspase-3/caspase-9 pathway in human leukemia HL-60 cells
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TUMOR BIOLOGY (2014)
Determination of Matrine and Oxymatrine in Sophora Flavescens by Nonaqueous Capillary Electrophoresis-Electrospray Ionization-Ion Trap-Mass Spectrometry
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ANALYTICAL LETTERS (2013)
Oxymatrine attenuates hepatic steatosis in non-alcoholic fatty liver disease rats fed with high fructose diet through inhibition of sterol regulatory element binding transcription factor 1(Srebf1) and activation of peroxisome proliferator activated receptor alpha (Ppar alpha)
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EUROPEAN JOURNAL OF PHARMACOLOGY (2013)
Combining Oxymatrine or Matrine with Lamivudine Increased Its Antireplication Effect against the Hepatitis B Virus In Vitro
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EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013)
Determination of oxymatrine and its active metabolite matrine in human plasma after administration of oxymatrine oral solution by high-performance liquid chromatography coupled with mass spectrometry
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FITOTERAPIA (2013)
Pharmacokinetic characterization of oxymatrine and matrine in rats after oral administration of radix Sophorae tonkinensis extract and oxymatrine by sensitive and robust UPLC-MS/MS method
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JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2013)
Oxymatrine protects against myocardial injury via inhibition of JAK2/STAT3 signaling in rat septic shock
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MOLECULAR MEDICINE REPORTS (2013)
Antiangiogenic effects of oxymatrine on pancreatic cancer by inhibition of the NF-κB-mediated VEGF signaling pathway
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ONCOLOGY REPORTS (2013)
Neuroprotective effects of oxymatrine against excitotoxicity partially through down-regulation of NR2B-containing NMDA receptors
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PHYTOMEDICINE (2013)
Effect of oxymatrine, the active component from Radix Sophorae flavescentis (Kushen), on ventricular remodeling in spontaneously hypertensive rats
Xiao Yan Huang et al.
PHYTOMEDICINE (2013)
Antinociceptive effects of oxymatrine from Sophora flavescens, through regulation of NR2B-containing NMDA receptor-ERK/CREB signaling in a mice model of neuropathic pain
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PHYTOMEDICINE (2013)
Oxymatrine Prevents NF-κB Nuclear Translocation And Ameliorates Acute Intestinal Inflammation
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Effects of Oxymatrine on the Neuropathic Pain Induced by Chronic Constriction Injury in Mice
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CNS NEUROSCIENCE & THERAPEUTICS (2012)
Oxymatrine Ameliorates L-Arginine-Induced Acute Pancreatitis in Rats
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INFLAMMATION (2012)
Oxymatrine inhibits collagen synthesis in keloid fibroblasts via inhibition of transforming growth factor-ß1/Smad signaling pathway
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INTERNATIONAL JOURNAL OF DERMATOLOGY (2012)
The protective role of oxymatrine on neuronal cell apoptosis in the hemorrhagic rat brain
Man Huang et al.
JOURNAL OF ETHNOPHARMACOLOGY (2012)
Oxymatrine liposome attenuates hepatic fibrosis via targeting hepatic stellate cells
Ning-Li Chai et al.
WORLD JOURNAL OF GASTROENTEROLOGY (2012)
Oxymatrine inhibits hepatitis B infection with an advantage of overcoming drug-resistance
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ANTIVIRAL RESEARCH (2011)
A Combination of a Microemulsion and a Phospholipid Complex for Topical Delivery of Oxymatrine
Fa-Hao Cao et al.
ARCHIVES OF PHARMACAL RESEARCH (2011)
The Neuroprotection of Oxymatrine in Cerebral Ischemia/Reperfusion Is Related to Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2)-Mediated Antioxidant Response: Role of Nrf2 and Hemeoxygenase-1 Expression
Min Li et al.
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2011)
Effects of oxymatrine on sympathoexcitatory reflex induced by myocardial ischemic signaling mediated by P2X3 receptors in rat SCG and DRG
Guilin Li et al.
BRAIN RESEARCH BULLETIN (2011)
EFFECT OF OXYMATRINE COMBINED WITH LOW DOSE 5-FU ON LYMPHATIC VESSEL AND MICROVASCULAR ENDOTHELIAL CELL GROWTH OF GASTRIC CANCER IN A SEVERE COMBINED IMMUNODEFICIENT MOUSE ORTHOTOPIC IMPLANTATION MODEL
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EUROPEAN JOURNAL OF INFLAMMATION (2011)
Oxymatrine reduces neuronal cell apoptosis by inhibiting Toll-like receptor 4/nuclear factor kappa-B-dependent inflammatory responses in traumatic rat brain injury
Xiao-Qiao Dong et al.
INFLAMMATION RESEARCH (2011)
Protective effect of oxymatrine on myocardial fibrosis induced by acute myocardial infarction in rats involved in TGF-1-Smads signal pathway
Xiang-Chun Shen et al.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH (2011)
Oxymatrine induces human pancreatic cancer PANC-1 cells apoptosis via regulating expression of Bcl-2 and IAP families, and releasing of cytochrome C
Qi Ling et al.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2011)
Oxymatrine diminishes the side population and inhibits the expression of β-catenin in MCF-7 breast cancer cells
Ying Zhang et al.
MEDICAL ONCOLOGY (2011)
Neuroprotection and underlying mechanisms of oxymatrine in cerebral ischemia of rats
Lili Cui et al.
NEUROLOGICAL RESEARCH (2011)
Oxymatrine, the Main Alkaloid Component of Sophora Roots, Protects Heart against Arrhythmias in Rats
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PLANTA MEDICA (2011)
The role of endogenous reactive oxygen species in oxymatrine-induced caspase-3-dependent apoptosis in human melanoma A375 cells
Yingfan Zhang et al.
ANTI-CANCER DRUGS (2010)
Toxic Effect and Biochemical Study of Chlorfluazuron, Oxymatrine, and Spinosad on Honey Bees (Apis mellifera)
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ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY (2010)
Oxymatrine-carbenoxolone sodium inclusion compound induces antinociception and increases the expression of GABAAα1 receptors in mice
Junjun Zhou et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2010)
Process optimization, characterization and evaluation in vivo of oxymatrine-phospholipid complex
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INTERNATIONAL JOURNAL OF PHARMACEUTICS (2010)
Solid-phase extraction of matrine and oxymatrine from Sophora Flavescens Ait using amino-imidazolium polymer
Wentao Bi et al.
JOURNAL OF SEPARATION SCIENCE (2010)
Antiarrhythmic Effects and Ionic Mechanisms of Oxymatrine from Sophora flavescens
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PHYTOTHERAPY RESEARCH (2010)
Effect of oxymatrine on the replication cycle of hepatitis B virus in vitro
Wen-Sheng Xu et al.
WORLD JOURNAL OF GASTROENTEROLOGY (2010)
Determination of oxymatrine and its metabolite matrine in rat blood and dermal microdialysates by high throughput liquid chromatography/tandem mass spectrometry
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JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2009)
Oxymatrine Downregulates TLR4, TLR2, MyD88, and NF-kappa B and Protects Rat Brains against Focal Ischemia
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Attenuation of bleomycin-induced lung fibrosis by oxymatrine is associated with regulation of fibroblast proliferation and collagen production in primary culture
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BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2008)
Oxymatrine Improves TNBS-induced Colitis in Rats by Inhibiting the Expression of NF-κB p65
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JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES (2008)
Determination of matrine and oxymatrine in Sophora Flavescens Ait. via high performance liquid chromatography
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Pharmacokinetic study of matrine, oxymatrine and oxysophocarpine in rat plasma after oral administration of Sophora flavescens Ait. extract by liquid chromatography tandem mass spectrometry
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JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2008)
Cardioprotective effects and underlying mechanisms of oxymatrine against ischemic myocardial injuries of rats
Sun Hong-li et al.
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Oxymatrine attenuates intestinal ischemia/reperfusion injury in rats
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SURGERY TODAY (2008)
Effect of Oxymatrine on the TGFbeta-Smad signaling pathway in rats with CCl4-induced hepatic fibrosis
Xiao-Ling Wu et al.
WORLD JOURNAL OF GASTROENTEROLOGY (2008)
Synergistic effect of oxymatrine and angiogenesis inhibitor NM-3 on modulating apoptosis in human gastric cancer cells
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WORLD JOURNAL OF GASTROENTEROLOGY (2007)
Quinolizidine alkaloids with anti-HBV activity from Sophora tonkinensis
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Growth factor-delivery systems for tissue engineering: a materials perspective
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Anti-apoptosis effects of oxymatrine protect the liver from warm ischemia reperfusion injury in rats
HC Jiang et al.
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Anti-inflammatory mechanism of oxymatrine in dextran sulfate sodium-induced colitis of rats
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WORLD JOURNAL OF GASTROENTEROLOGY (2005)
Attenuation of acute lung injury in mice by oxymatrine is associated with inhibition of phosphorylated p38 mitogen-activated protein kinase
GL Xu et al.
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