A MASP-like functions as PRR to regulate the mRNA expressions of inflammatory factors in the Pacific oyster Crassostrea gigas

Article Immunology

Lung epithelial cell-derived C3 protects against pneumonia-induced lung injury

Sanjaya K. Sahu et al.

Summary: The source of C3 affects pneumonia and cell survival. Liver-derived C3 protects the lung from injuries, while locally derived C3 and Factor B protect the lung mucosal barrier effectively.

SCIENCE IMMUNOLOGY (2023)

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Article Fisheries

The primitive complement system in molluscs

Jiejie Sun et al.

Summary: The complement system is an important immune defense mechanism in vertebrates, and research on its origin and evolution in invertebrates, particularly in molluscs, has been increasing. Complement components such as C3, C1qDCP, CTL, MASPL, and factor B have been identified in molluscs, suggesting the existence of a complement system in these organisms. The lectin pathway has been outlined, and the activation of C3 regulates immune effectors, mediates phagocytosis, and inhibits bacterial growth. This article provides a review of the complement system in molluscs, including its components, activation mechanisms, and functions in the immune response.

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY (2023)

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Article Fisheries

CgIL17-5 regulates the mRNA expressions of immune effectors through inducing the phosphorylation of CgMAPKs and the nuclear translocation of CgRel and CgAP-1 in the Pacific oyster Crassostrea gigas

Xiaoqian Lv et al.

Summary: The study found that CgIL17-5 is an important pro-inflammatory factor in oysters, promoting the activation of CgMAPKs and nuclear translocation of CgRel and CgAP-1, leading to increased mRNA expressions of cytokines and antibacterial peptides.

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY (2022)

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Article Biochemistry & Molecular Biology

CgHMGB1 functions as a broad-spectrum recognition molecule to induce the expressions of CgIL17-5 and Cgdefh2 via MAPK or NF-KB signaling pathway in Crassostrea gigas

Xiaoqian Lv et al.

Summary: The study investigates the role of CgHMGB1 in immune recognition and signaling pathways in oysters. CgHMGB1 functions as an immune recognition molecule, inducing the expression of immune effectors through MAPK and NF-KB pathways. This indicates its ability to recognize various PAMPs and bacteria.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Article Fisheries

CgCaspase-3 activates the translocation of CgGSDME in haemocytes of Pacific oyster Crassostrea gigas

Xiaopeng Li et al.

Summary: The study found that CgCaspase-3 can bind various pathogen associated molecular patterns and activate the translocation of CgGSDME in oyster haemocytes, thereby participating in the immune response against pathogen invasion.

FISH & SHELLFISH IMMUNOLOGY (2022)

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Article Fisheries

The truncated MyD88s negatively regulates TLR2 signal on expression of IL17-1 in oyster Crassostrea gigas

Siqi Fan et al.

Summary: Toll-like receptor signaling plays a crucial role in the immune response of Pacific oysters. In this study, a receptor called CgTLR2 was identified, which interacts with CgMyD88 proteins and is involved in the regulation of the inflammatory factor CgIL17-1.

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY (2022)

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Article Environmental Sciences

Roles of hemocyte subpopulations in silver nanoparticle transformation and toxicity in the oysters Crassostrea hongkongensis

Yali Luo et al.

Summary: This study investigated the different immune responses of oyster hemocyte subpopulations to silver nanoparticles (AgNPs). The results showed that AgNPs could rapidly enter the oyster hemocytes, causing different immune responses in different cell subtypes. The most affected cell subtype was granulocytes, followed by semigranulocytes, while agranulocytes were not affected. AgNPs also induced granule formation in semigranulocytes and increased the proportion of granulocytes. The dissolved Ag ions accumulated in lysosomes, leading to lysosomal dysfunction and impaired immunity system in oysters. This study provides insights into the immune responses of oyster hemocyte subpopulations to AgNPs and their ecotoxicological risks in aquatic systems.

ENVIRONMENTAL POLLUTION (2022)

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Article Medical Laboratory Technology

MASP-2 and MASP-3 inhibitors block complement activation, inflammation, and microvascular stasis in a murine model of vaso-occlusion in sickle cell disease

John D. Belcher et al.

Summary: This study found that both the lectin pathway (LP) and the alternative pathway (AP) play a role in promoting inflammation and vaso-occlusion in sickle cell disease (SCD). Inhibiting complement activation via LP or AP may inhibit inflammation and prevent vaso-occlusive crisis (VOC) in SCD patients.

TRANSLATIONAL RESEARCH (2022)

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Article Biochemistry & Molecular Biology

Expression and functional characterization of the CUB domain-containing protein from the triangle sail mussel (Hyriopsis cumingii) in response to pathogenic infection

Ying Huang et al.

Summary: A CUB domain-containing protein HcCDCP was cloned and characterized from freshwater pearl mussel. Tissue distribution analysis showed that HcCDCP was expressed in all tissues, with the highest expression in hepatopancreas.

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

A novel C-type lectin activates the complement cascade in the primitive oyster Crassostrea gigas

Jiejie Sun et al.

Summary: The study found an ancient lectin pathway in molluscs, which regulates the production of immune effectors, phagocytosis, and bacterial lysis through complement cascade activation.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

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Article Immunology

PDGFRβ Recognizes and Binds Bacteria to Activate Src/Stat Pathway in Oysters

Jiejie Sun et al.

Summary: The study identified a platelet-derived growth factor receptor (CgPDGFR beta) in Pacific oysters, which, upon binding bacteria, activates the Src/Stat signaling pathway to induce the expressions of various antimicrobial and immune factors.

JOURNAL OF IMMUNOLOGY (2021)

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Article Fisheries

A fibrinogen-related protein mediates the recognition of various bacteria and haemocyte phagocytosis in oyster Crassostrea gigas

Wenwen Yang et al.

Summary: CgFREP1, identified in oysters, serves as a pattern recognition receptor to recognize and agglutinate various bacteria, as well as mediate haemocytes phagocytosis towards Vibrio splendidus.

FISH & SHELLFISH IMMUNOLOGY (2021)

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Article Multidisciplinary Sciences