4.7 Article

PDK inhibition promotes glucose utilization, reduces hepatic lipid deposition, and improves oxidative stress in largemouth bass (Micropterus salmoides) by increasing pyruvate oxidative phosphorylation

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Nutrition & Dietetics

Resveratrol inclusion alleviated high-dietary-carbohydrate-induced glycogen deposition and immune response of largemouth bass, Micropterus salmoides

Yijun Liu et al.

Summary: This study found that the addition of resveratrol helps prevent excessive hepatic glycogen accumulation and impaired immune response.

BRITISH JOURNAL OF NUTRITION (2022)

Article Multidisciplinary Sciences

Dichloroacetate, a pyruvate dehydrogenase kinase inhibitor, ameliorates type 2 diabetes via reduced gluconeogenesis

Yuko Katayama et al.

Summary: This study investigated the antidiabetic effect of PDK inhibition using DCA and found that it can effectively lower blood glucose levels, suggesting its potential value in the treatment of diabetes.

HELIYON (2022)

Review Endocrinology & Metabolism

Insulin: The master regulator of glucose metabolism

Luke Norton et al.

Summary: Insulin plays a crucial role in regulating glucose, lipid, and protein metabolism by suppressing glucose production, promoting glucose uptake, inhibiting lipolysis, and inducing vasodilation.

METABOLISM-CLINICAL AND EXPERIMENTAL (2022)

Article Agriculture, Dairy & Animal Science

Inhibition of pyruvate dehydrogenase kinase improves carbohydrate utilization in Nile tilapia by regulating PDK2/4-PDHE1a axis and insulin sensitivity

Yuan Luo et al.

Summary: This study investigated the regulatory function of the PDK-PDHE1a axis in glucose metabolism in fish. The results showed that inhibiting PDK can enhance PDHE1a activity and improve glucose catabolism in fish.

ANIMAL NUTRITION (2022)

Review Biochemistry & Molecular Biology

Heart failure-emerging roles for the mitochondrial pyruvate carrier

Mariana Fernandez-Caggiano et al.

Summary: The mitochondrial pyruvate carrier (MPC) plays a crucial role in determining the fate of pyruvate in cells, with decreased expression contributing to lactate accumulation in the cytosol. Reduced MPC abundance has also been observed in failing hearts, suggesting a potential causal role in heart failure progression.

CELL DEATH AND DIFFERENTIATION (2021)

Article Biology

Dichloroacetate reverses sepsis-induced hepatic metabolic dysfunction

Rabina Mainali et al.

Summary: Metabolic reprogramming occurs in the immune system during sepsis, particularly in the liver, with changes in lipid metabolism, mitochondrial energy, and redox balance. Targeting mitochondrial energy metabolism can rebalance the transcriptional and metabolic manifestations of sepsis in the liver.
Review Cell Biology

The Metabolic Fates of Pyruvate in Normal and Neoplastic Cells

Edward V. Prochownik et al.

Summary: Pyruvate plays a central role in metabolism, influenced by various cell-intrinsic and extrinsic factors. It is at the crossroads of glycolysis and the tricarboxylic acid cycle, with its production and fate being regulated by factors such as cell type, redox state, nutrient levels, and vascular supply. Six pathways impact pyruvate content and utilization, including lactate dehydrogenase pathway, alanine pathway, pyruvate dehydrogenase complex pathway, pyruvate carboxylase reaction, malic enzyme pathway, and acetate biosynthetic pathway. The review explores the mechanisms controlling these pathways and how they work together to achieve optimal growth and metabolic harmony.
Article Fisheries

Different effects of two dietary levels of tea polyphenols on the lipid deposition, immunity and antioxidant capacity of juvenile GIFT tilapia (Oreochromis niloticus) fed a high-fat diet

Yu-Cheng Qian et al.

Summary: The study found that adding 50 mg/kg or 200 mg/kg of TP can improve the adverse effects of high-fat diets on tilapia, reducing hepatic lipid deposition and increasing fish survival rates.

AQUACULTURE (2021)

Article Cell Biology

The requirement for pyruvate dehydrogenase in leukemogenesis depends on cell lineage

Sojeong Jun et al.

Summary: Cancer cells have metabolic similarities with normal tissues, but differences may be due to reprogramming during transformation or maintenance of specific cell type metabolism. This study compared glucose metabolism in hematopoiesis and leukemia, finding that PDH deletion affects the development of T cell leukemia but not myeloid neoplasms, emphasizing the role of PDH in maintaining normal cell metabolism in leukemia.

CELL METABOLISM (2021)

Article Biochemistry & Molecular Biology

Metabolic responses of Chinese perch (Siniperca chuatsi) to different levels of dietary carbohydrate

Yanpeng Zhang et al.

Summary: The metabolic responses of Chinese perch to moderate and high dietary carbohydrate levels were investigated. The results showed that Chinese perch effectively utilized 17.5% dietary carbohydrates, converting some into glycogen while maintaining glucose homeostasis. However, the utilization of 27.5% dietary carbohydrates was limited, leading to negative metabolic effects such as increased liver lipid levels, decreased protein content, and liver damage.

FISH PHYSIOLOGY AND BIOCHEMISTRY (2021)

Article Cell Biology

Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier

Claire L. Bensard et al.

CELL METABOLISM (2020)

Article Biochemistry & Molecular Biology

Stimulation of glycolysis promotes cardiomyocyte proliferation after injury in adult zebrafish

Ryuichi Fukuda et al.

EMBO REPORTS (2020)

Article Biochemistry & Molecular Biology

Mitochondria in non-alcoholic fatty liver disease

Ines C. M. Simoes et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2018)

Article Biochemistry & Molecular Biology

A novel inhibitor of pyruvate dehydrogenase kinase stimulates myocardial carbohydrate oxidation in diet-induced obesity

Cheng-Yang Wu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

Article Endocrinology & Metabolism

Leptin Selectively Regulates Nutrients Metabolism in Nile Tilapia Fed on High Carbohydrate or High Fat Diet

Cai-Zhi Liu et al.

FRONTIERS IN ENDOCRINOLOGY (2018)

Article Multidisciplinary Sciences

The PDK1 Inhibitor Dichloroacetate Controls Cholesterol Homeostasis Through the ERK5/MEF2 Pathway

Abrar Ul Haq Khan et al.

SCIENTIFIC REPORTS (2017)

Article Biochemistry & Molecular Biology

Inflammation increases pyruvate dehydrogenase kinase 4 (PDK4) expression via the Jun N-Terminal Kinase (JNK) pathway in C2C12 cells

Hana Park et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

Article Multidisciplinary Sciences

HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity

Hiroaki Semba et al.

NATURE COMMUNICATIONS (2016)

Review Biochemistry & Molecular Biology

Regulation of glucose metabolism from a liver-centric perspective

Hye-Sook Han et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2016)

Review Biochemistry & Molecular Biology

Mitochondrial pyruvate transport: a historical perspective and future research directions

Kyle S. McCommis et al.

BIOCHEMICAL JOURNAL (2015)

Review Endocrinology & Metabolism

GLUT2, glucose sensing and glucose homeostasis

Bernard Thorens

DIABETOLOGIA (2015)

Review Cell Biology

Comprehensive review on lactate metabolism in human health

M. Adeva-Andany et al.

MITOCHONDRION (2014)

Review Nutrition & Dietetics

The pivotal role of pyruvate dehydrogenase kinases in metabolic flexibility

Shuai Zhang et al.

NUTRITION & METABOLISM (2014)

Review Biochemistry & Molecular Biology

Glucosensing and glucose homeostasis: From fish to mammals

Sergio Polakof et al.

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY (2011)

Review Medical Laboratory Technology

Non-alcoholic fatty liver disease

Briohny W. Smith et al.

CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES (2011)

Article Biochemistry & Molecular Biology

Nutritional regulation of hepatic glucose metabolism in fish

P. Enes et al.

FISH PHYSIOLOGY AND BIOCHEMISTRY (2009)

Article Cardiac & Cardiovascular Systems

Overexpression of pyruvate dehydrogenase kinase 4 in heart perturbs metabolism and exacerbates calcineurin-induced cardiomyopathy

Guixiang Zhao et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2008)

Review Oncology

Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer

E. D. Michelakis et al.

BRITISH JOURNAL OF CANCER (2008)

Review Fisheries

Expanding the utilization of sustainable plant products in aquafeeds:: a review

Delbert M. Gatlin et al.

AQUACULTURE RESEARCH (2007)

Review Fisheries

Carbohydrates in fish nutrition:: digestion and absorption in postlarval stages

Å Krogdahl et al.

AQUACULTURE NUTRITION (2005)