期刊
FEBS JOURNAL
卷 -, 期 -, 页码 -出版社
WILEY
DOI: 10.1111/febs.16913
关键词
central nervous system; lateral floor plate; neurons; patterning; progenitor domain; specification; spinal cord; V2 domain; zebrafish
The vertebrate nervous system consists of diverse neurons and synaptic connections. The spinal cord is an ideal model for studying neuronal diversity due to its simple network and conserved molecular processes. This review focuses on two different progenitor domains in the zebrafish spinal cord: the lateral floor plate (LFP) and the p2 progenitor domain. These domains generate different types of neurons and subtypes through specific signaling pathways and transcription factors.
The vertebrate nervous system is composed of a wide range of neurons and complex synaptic connections, raising the intriguing question of how neuronal diversity is generated. The spinal cord provides an excellent model for exploring the mechanisms governing neuronal diversity due to its simple neural network and the conserved molecular processes involved in neuron formation and specification during evolution. This review specifically examines two distinct progenitor domains present in the zebrafish ventral spinal cord: the lateral floor plate (LFP) and the p2 progenitor domain. The LFP is responsible for the production of GABAergic Kolmer-Agduhr neurons (KA & DPRIME;), glutamatergic V3 neurons, and intraspinal serotonergic neurons, while the p2 domain generates V2 precursors that subsequently differentiate into three unique subpopulations of V2 neurons, namely glutamatergic V2a, GABAergic V2b, and glycinergic V2s. Based on recent findings, we will examine the fundamental signaling pathways and transcription factors that play a key role in the specification of these diverse neurons and neuronal subtypes derived from the LFP and p2 progenitor domains.
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