An innate immune sensor wandering around-NOD1 promotes cell migration via non-canonical signaling

Article Biochemistry & Molecular Biology

NOD1 cooperates with HAX-1 to promote cell migration in a RIPK2-and NF-& kappa;B-independent manner

Lucy Hezinger et al.

Summary: The study found that the human NOD-like receptor protein NOD1 is involved in cell migration and chemotaxis in cervical cancer cells by regulating cofilin phosphorylation status. Additionally, HAX-1 was identified as a new interacting protein of NOD1, and both proteins act in the same signaling pathway.

FEBS JOURNAL (2023)

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Review Cell Biology

The principles of directed cell migration

Shuvasree SenGupta et al.

Summary: Cells are capable of sensing various signals and migrating towards or away from them, involving signal generation, sensing, transduction, and polarized force generation. Understanding the mechanisms underlying cell migration is crucial for understanding migration in vivo.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

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Review Biochemistry & Molecular Biology

Pattern recognition receptors in health and diseases

Danyang Li et al.

Summary: Pattern recognition receptors (PRRs) are a class of receptors that can directly recognize specific molecular structures on pathogens, apoptotic host cells, and damaged senescent cells, bridging nonspecific immunity and specific immunity. Through the recognition and binding of ligands, PRRs can produce immunoprotective effects against infections and tumors. Research on PRRs and their ligands has greatly enhanced understanding of the signaling pathways involved, providing insights for the treatment of immune-related diseases and tumors.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Review Immunology