An innate immune sensor wandering around-NOD1 promotes cell migration via non-canonical signaling

NOD1 is a cytosolic immune receptor well known for recognizing intracellular bacteria and inducing innate immune responses. Upon ligand binding, it usually forms a complex with the serine/threonine kinase RIPK2 to activate the transcription factor NF-?B. Next to its role in pathogen recognition, NOD1 has been associated with cancer progression. In this regard, Hezinger et al. investigated a non-canonical role of NOD1 in cell migration. They discovered that NOD1 is crucial for the migration and chemotaxis of HeLa cells and identified HAX-1 as a novel interaction partner.

Automated summary

NOD1 is an intracellular immune receptor that recognizes bacteria and activates immune responses. In addition to its role in pathogen recognition, NOD1 is also involved in cancer progression. Hezinger et al. discovered a non-canonical role of NOD1 in cell migration and identified HAX-1 as a novel interaction partner.