4.7 Article

Mice lacking intestinal Nr1i2 have normal intestinal homeostasis under steady-state conditions and are not hypersensitive to inflammation under lipopolysaccharide treatment

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Gastroenterology & Hepatology

The Pregnane X Receptor and Indole-3-Propionic Acid Shape the Intestinal Mesenchyme to Restrain Inflammation and Fibrosis

Kyle L. Flannigan et al.

Summary: The pregnane X receptor (PXR) plays an important role in regulating intestinal inflammation and fibrosis. Microbiota-derived indole-3-propionic acid (IPA) influences PXR signaling. Deletion of PXR exacerbates fibrosis, suggesting that microbiota metabolites may be a vital determinant in the progression of fibrotic complications in inflammatory bowel diseases (IBDs).

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2023)

Review Pharmacology & Pharmacy

Pregnane X Receptor and the Gut-Liver Axis: A Recent Update

Moumita Dutta et al.

Summary: This article summarizes recent research advancements on the pregnane X receptor (PXR), including novel PXR-target genes, modulating factors, and interactions with gut microbiome.

DRUG METABOLISM AND DISPOSITION (2022)

Review Cell Biology

Gut-liver axis: Pathophysiological concepts and clinical implications

Herbert Tilg et al.

Summary: Bidirectional crosstalk between the gut and liver plays a crucial role in regulating gastrointestinal health and disease. Nutrients, microbial antigens, metabolites, and bile acids regulate metabolism and immune responses in the gut and liver, which reciprocally shape the structure and function of the microbial community. Perturbation of this host-microbe interaction is observed in various liver diseases and is exacerbated by impaired intestinal barrier, contributing to hepatic inflammation and disease progression.

CELL METABOLISM (2022)

Article Food Science & Technology

Quercetin effectively improves LPS-induced intestinal inflammation, pyroptosis, and disruption of the barrier function through the TLR4/NF-κB/NLRP3 signaling pathway in vivo and in vitro

Hui-Xin Zhang et al.

Summary: The study found that quercetin can reduce inflammation caused by bacterial enteritis and pyroptosis through the TLR4/NF-κB/NLRP3 pathway.

FOOD & NUTRITION RESEARCH (2022)

Article Environmental Sciences

Effects of Dicyclohexyl Phthalate Exposure on PXR Activation and Lipid Homeostasis in Mice

Yipeng Sui et al.

Summary: The study found that DCHP activates PXR to induce hypercholesterolemia and ceramide production in mice, suggesting a potentially important role of PXR in the adverse effects of plastic-associated EDCs on cardiovascular health in humans. Testing PXR activation should be considered for risk assessment of phthalates and other EDCs.

ENVIRONMENTAL HEALTH PERSPECTIVES (2021)

Article Medicine, Research & Experimental

The atypical antipsychotic quetiapine induces hyperlipidemia by activating intestinal PXR signaling

Zhaojie Meng et al.

JCI INSIGHT (2019)

Review Infectious Diseases

Gut-origin sepsis in the critically ill patient: pathophysiology and treatment

Stelios F. Assimakopoulos et al.

INFECTION (2018)

Editorial Material Medicine, Research & Experimental

Intestinal hyperpermeability: a gateway to multi-organ failure?

Qiqi Zhou et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Article Pharmacology & Pharmacy

Involvement of Nuclear Factor κB, not Pregnane X Receptor, in Inflammation-Mediated Regulation of Hepatic Transporters

Walaa A. Abualsunun et al.

DRUG METABOLISM AND DISPOSITION (2017)

Article Biochemistry & Molecular Biology

INFRAFRONTIER-providing mutant mouse resources as research tools for the international scientific community

Terrence F. Meehan et al.

NUCLEIC ACIDS RESEARCH (2015)

Article Pharmacology & Pharmacy

Pregnane X Receptor Modulates the Inflammatory Response in Primary Cultures of Hepatocytes

Mengxi Sun et al.

DRUG METABOLISM AND DISPOSITION (2015)

Article Multidisciplinary Sciences

Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

Vanessa K. Ridaura et al.

SCIENCE (2013)

Review Pharmacology & Pharmacy

Xenobiotic, Bile Acid, and Cholesterol Transporters: Function and Regulation

Curtis D. Klaassen et al.

PHARMACOLOGICAL REVIEWS (2010)

Article Multidisciplinary Sciences

Protection from lethal Gram-negative bacterial sepsis by targeting Toll-like receptor 4

Thierry Roger et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Endocrinology & Metabolism

Metabolic endotoxemia initiates obesity and insulin resistance

Patrice D. Cani et al.

DIABETES (2007)

Article Gastroenterology & Hepatology

Pregnane X receptor activation ameliorates DSS-induced inflammatory bowel disease via inhibition of NF-κB target gene expression

Yatrik M. Shah et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2007)

Article Medicine, Research & Experimental

Mutual repression between steroid and xenobiotic receptor and NF-κB signaling pathways links xenobiotic metabolism and inflammation

Changcheng Zhou et al.

JOURNAL OF CLINICAL INVESTIGATION (2006)

Review Endocrinology & Metabolism

The nuclear pregnane X receptor: A key regulator of xenobiotic metabolism

SA Kliewer et al.

ENDOCRINE REVIEWS (2002)

Review Biochemistry & Molecular Biology

Rate-limiting steps in cytochrome P450 catalysis

FP Guengerich

BIOLOGICAL CHEMISTRY (2002)

Review Gastroenterology & Hepatology

Regulation of hepatic drug metabolism: Role of the nuclear receptors PXR and CAR

C Liddle et al.

SEMINARS IN LIVER DISEASE (2002)

Article Multidisciplinary Sciences

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

JL Staudinger et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)