期刊
FASEB JOURNAL
卷 37, 期 8, 页码 -出版社
WILEY
DOI: 10.1096/fj.202300354R
关键词
caloric restriction; db/db mouse model; diabetic kidney disease; diabetic neuropathy; intermittent fasting; low-carbohydrate diet; type 2 diabetes
Patients with type 2 diabetes often experience complications such as diabetic kidney disease and diabetic peripheral neuropathy, which lower their quality of life and increase mortality. This study examined the therapeutic efficacy of three dietary interventions in a type 2 diabetes mouse model. The interventions improved weight and glycemic status and alleviated diabetic kidney disease, but did not affect diabetic peripheral neuropathy.
Patients with type 2 diabetes often develop the microvascular complications of diabetic kidney disease (DKD) and diabetic peripheral neuropathy (DPN), which decrease quality of life and increase mortality. Unfortunately, treatment options for DKD and DPN are limited. Lifestyle interventions, such as changes to diet, have been proposed as non-pharmacological treatment options for preventing or improving DKD and DPN. However, there are no reported studies simultaneously evaluating the therapeutic efficacy of varying dietary interventions in a type 2 diabetes mouse model of both DKD and DPN. Therefore, we compared the efficacy of a 12-week regimen of three dietary interventions, low carbohydrate, caloric restriction, and alternate day fasting, for preventing complications in a db/db type 2 diabetes mouse model by performing metabolic, DKD, and DPN phenotyping. All three dietary interventions promoted weight loss, ameliorated glycemic status, and improved DKD, but did not impact percent fat mass and DPN. Multiple regression analysis identified a negative correlation between fat mass and motor nerve conduction velocity. Collectively, our data indicate that these three dietary interventions improved weight and glycemic status and alleviated DKD but not DPN. Moreover, diets that decrease fat mass may be a promising non-pharmacological approach to improve DPN in type 2 diabetes given the negative correlation between fat mass and motor nerve conduction velocity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据