☆ 4.4 Review

In-depth review of delivery carriers associated with vaccine adjuvants: current status and future perspectives

EXPERT REVIEW OF VACCINES (2023)

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Review Virology

Recent developments in SARS-CoV-2 vaccines: A systematic review of the current studies

Mona Sadeghalvad et al.

Summary: This study systematically reviews the construction and efficacy of COVID-19 vaccines globally, focusing on their effectiveness in healthy individuals and those with pre-existing diseases. The results show that almost all investigated vaccines are well tolerated and induce good immune responses. A longer interval between doses and the number of doses administered are crucial for optimal antibody response. Immunocompromised patients have lower immunogenicity to the vaccines. Adverse events of interest include thrombotic events, Bell's palsy, and myocarditis/pericarditis. The findings emphasize the potency and importance of COVID-19 vaccines in preventing the disease.

REVIEWS IN MEDICAL VIROLOGY (2023)

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Review Biochemical Research Methods

Virus-like particles against infectious disease and cancer: guidance for the nano-architect

Rory A. Hills et al.

Summary: This article introduces the important roles of VLPs in prevention and therapy for infectious diseases and cancer, as well as recent advances in rational construction of VLP assemblies and enhancing immune responses. Optimal spacing of antigens was identified through DNA origami and computational protein design. Chemical biology advances allowed simple and irreversible decoration of VLPs with protein or polysaccharide antigens. Mosaic VLPs co-displayed antigens to generate cross-reactive antibodies against different strains of viruses.

CURRENT OPINION IN BIOTECHNOLOGY (2022)

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Article Chemistry, Medicinal

The nano delivery systems and applications of mRNA

Mingyuan Li et al.

Summary: The current COVID-19 epidemic has accelerated the application of mRNA technology, highlighting challenges in overcoming mRNA instability in human physiological environments. Research has also shown that mRNA has potential applications beyond COVID-19 vaccines, such as in treating other diseases and genetic disorders.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)

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Review Immunology

The T cell immune response against SARS-CoV-2

Paul Moss

Summary: T cell immunity plays a central role in controlling SARS-CoV-2 infection, with early responses correlating with protection. T cell memory provides broad recognition of viral proteins, limiting the impact of viral variants and offering protection against severe disease. Current COVID-19 vaccines elicit robust T cell responses, contributing to the prevention of hospitalization or death. Therefore, the importance of T cell immunity may have been underestimated.

NATURE IMMUNOLOGY (2022)

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Article Chemistry, Multidisciplinary

Biodistribution and Non-linear Gene Expression of mRNA LNPs Affected by Delivery Route and Particle Size

Jiaxing Di et al.

Summary: This study reveals that biomolecules encapsulated in locally injected LNPs can reach other organs and tissues via systemic circulation. The biodistribution and pharmacokinetics of LNPs are influenced by particle size and injection route, and these factors affect gene expression levels. The liver exhibits the most prominent transgene expression.

PHARMACEUTICAL RESEARCH (2022)

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Article Cell Biology

An aluminum hydroxide:CpG adjuvant enhances protection elicited by a SARS-CoV-2 receptor binding domain vaccine in aged mice

Etsuro Nanishi et al.

Summary: The global deployment of vaccines for COVID-19 is urgently needed, especially in low- and middle-income countries. The study found that a specific adjuvant formulation significantly increased neutralizing antibody levels and protected aged mice from SARS-CoV-2. These findings support the further development of this adjuvanted vaccine as an effective and affordable option.

SCIENCE TRANSLATIONAL MEDICINE (2022)

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Review Pharmacology & Pharmacy

Delivery Strategies for mRNA Vaccines

Sivakumar Ramachandran et al.

Summary: This article summarizes the various delivery strategies explored for mRNA vaccines, including different carriers and formulation technologies, as well as the successful cases of COVID-19 vaccines. However, there is still a need to improve the storage stability of these vaccines for transportation to developing countries at low temperatures.

PHARMACEUTICAL MEDICINE (2022)

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Article Allergy

Development and preclinical evaluation of virus-like particle vaccine against COVID-19 infection

Ismail Cem Yilmaz et al.

Summary: The study demonstrates that VLP vaccines incorporating all four structural protein antigens of SARS-CoV-2 are immunogenic and can protect animals from developing COVID-19 infection.

ALLERGY (2022)

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Article Immunology

Covax-19/Spikogen® vaccine based on recombinant spike protein extracellular domain with Advax-CpG55.2 adjuvant provides single dose protection against SARS-CoV-2 infection in hamsters

Lei Li et al.

Summary: This study compares the immunogenicity and protective efficacy of several recombinant SARS-CoV-2 spike protein candidates expressed in insect cells. The soluble secreted spike protein extracellular domain (ECD) formulated with adjuvants elicited robust immune responses and showed good protective effects in animal experiments. There was a strong correlation between serum neutralizing antibody levels and lung protection. Based on these findings, the spike protein ECD formulated with Advax-CpG55.2 was selected for human clinical development.

VACCINE (2022)

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Review Biotechnology & Applied Microbiology

Biological Nanoparticles in Vaccine Development

Stephanie M. Curley et al.

Summary: Vaccines have been highly successful in improving public health, but there are still diseases without available vaccines. New technologies, such as nanoscale platforms, have the potential to enhance vaccine development. Biological nanoparticles, in particular, offer useful properties and can be a promising vaccine platform.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

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Article Chemistry, Medicinal

From Sharks to Yeasts: Squalene in the Development of Vaccine Adjuvants

Adelia Mendes et al.

Summary: Squalene is a natural compound widely used in vaccines and drug delivery emulsions. Its current main sources are fish liver oils and vegetable oils. However, the demand for squalene raises concerns about ecological impact, leading to a need for more sustainable production methods.

PHARMACEUTICALS (2022)

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Article Chemistry, Multidisciplinary

Virus-Like Particle-Templated Silica-Adjuvanted Nanovaccines with Enhanced Humoral and Cellular Immunity

Min Li et al.

Summary: A one-step strategy using VLPs as biotemplates to synthesize raspberry-like silica-adjuvanted VLP@Silica nano vaccines was developed to enhance balanced immunity and improve antigen-specific antibody and T-cell mediated immune responses.

ACS NANO (2022)

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Article Multidisciplinary Sciences

Manganese-coordinated mRNA vaccines with enhanced mRNA expression and immunogenicity induce robust immune responses against SARS-CoV-2 variants

Na Fan et al.

Summary: In this study, a novel mRNA delivery system was developed by introducing a STING agonist, manganese, to promote antigen-presenting cell maturation and mRNA expression. mRNA vaccines targeting the Delta and Omicron variants were prepared and both induced specific immune responses with strong neutralization ability and good safety.

SCIENCE ADVANCES (2022)

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Article Biotechnology & Applied Microbiology

Antigen-adjuvant interactions, stability, and immunogenicity profiles of a SARS-CoV-2 receptor-binding domain (RBD) antigen formulated with aluminum salt and CpG adjuvants

Sakshi Bajoria et al.

Summary: Low-cost, refrigerator-stable COVID-19 vaccines are important for global accessibility and vaccine coverage. This study found that aluminum-salt and CpG adjuvants decrease the stability of the RBD-J antigen, but enhance the immune response in mice, with the AH+CpG formulation being the most effective at inducing SARS-CoV-2 pseudovirus neutralizing antibodies.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2022)

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Article Immunology

Intramuscular Inoculation of AS02-Adjuvanted Respiratory Syncytial Virus (RSV) F Subunit Vaccine Shows Better Efficiency and Safety Than Subcutaneous Inoculation in BALB/c Mice

Lijun Bian et al.

Summary: This study compares the immune response and protective efficacy of RSV subunit vaccines administered via intramuscular injection and subcutaneous injection. The results show that intramuscular injection is more effective and requires less antigen dose, and the adjuvant plays a critical role in influencing the immune response and bias. Furthermore, intramuscular administration of the adjuvant is safer.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Immunology

Immune System Modulation by the Adjuvants Poly (I:C) and Montanide ISA 720

Rodolfo F. Marques et al.

Summary: This study describes the immune response induced by Poly(I:C) and Montanide ISA 720 in mice immunized with a recombinant protein vaccine against Plasmodium vivax. The results showed that mice vaccinated with the recombinant protein and Montanide ISA 720 exhibited a stronger humoral immune response with antibodies of higher affinity to the antigen. Additionally, Poly(I:C) caused more perturbations in the T cell transcriptome.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Engineering, Biomedical

Exosomes decorated with a recombinant SARS-CoV-2 receptor-binding domain as an inhalable COVID-19 vaccine

Zhenzhen Wang et al.

Summary: Researchers have developed an inhalable and room-temperature-stable virus-like particle COVID-19 vaccine that induces systemic and mucosal immune responses in small animals. The vaccine, consisting of a recombinant SARS-CoV-2 receptor-binding domain conjugated to lung-derived exosomes, enhanced the retention of the receptor-binding domain in the respiratory airway and lungs, and cleared SARS-CoV-2 pseudovirus in mice. In hamsters, the vaccine attenuated severe pneumonia and reduced inflammatory infiltrates after a challenge with live SARS-CoV-2.

NATURE BIOMEDICAL ENGINEERING (2022)

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Article Biochemistry & Molecular Biology

MF59 Promoted the Combination of CpG ODN1826 and MUC1-MBP Vaccine-Induced Antitumor Activity Involved in the Enhancement of DC Maturation by Prolonging the Local Retention Time of Antigen and Down-Regulating of IL-6/STAT3

Jing Jie et al.

Summary: This study evaluates the effects of MF59/CpG 1826 as a vaccine compound adjuvant on immune response, tumor suppression, and survival. The results demonstrate that MF59 enhances tumor growth inhibition and Th1-prone cellular immune response induced by CpG 1826/M-M vaccine. Furthermore, MF59 reduces individual differences in tumor growth and prolongs prophylactic and therapeutic mouse survival. The mechanism may involve the promotion of dendritic cell maturation by MF59.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Chemistry, Multidisciplinary

Smart combination of aluminum hydroxide and MF59 to induce strong cellular immune responses

Zhengjun Chen et al.

Summary: Researchers have developed a novel nano-vaccine delivery system, AlNEs, which combines aluminum hydroxide and MF59, and has shown the potential to enhance antigen-specific humoral and cellular immune responses, leading to the inhibition of tumor growth in a mouse model.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Multidisciplinary Sciences

Nanodelivery of nucleic acids

Barbara B. Mendes et al.

Summary: There is a growing need for a safe and effective method to deliver gene therapy materials, and nanomaterials offer an unprecedented opportunity to overcome these challenges. By utilizing their diverse physico-chemical properties, nanomaterials can be functionalized to selectively target specific biomolecules. The combination of gene therapies and nanoscale delivery systems has expanded the therapeutic and biomedical applications of nucleic acid therapeutics.

NATURE REVIEWS METHODS PRIMERS (2022)

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Review Virology

Monkeypox virus: a re-emergent threat to humans

Qizan Gong et al.

Summary: This review summarizes the features, transmission pathways, pathogenicity, laboratory diagnosis, and prevention and treatment strategies of human monkeypox. By understanding this information, it provides basic knowledge for the prevention and control of future outbreaks of monkeypox.

VIROLOGICA SINICA (2022)

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Article Immunology

Low dose recombinant full-length circumsporozoite protein-based Plasmodium falciparum vaccine is well-tolerated and highly immunogenic in phase 1 first-in-human clinical testing

Deanna J. Friedman-Klabanoff et al.

Summary: The new full-length rCSP vaccine combined with the GLA-LSQ adjuvant showed a good safety and immunogenicity profile in clinical trials, confirming the immunostimulatory capacity of GLA-LSQ and supporting further steps in clinical product development.

VACCINE (2021)

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Review Chemistry, Multidisciplinary

Natural and synthetic carbohydrate-based vaccine adjuvants and their mechanisms of action

Carlo Pifferi et al.

Summary: Modern subunit vaccines based on homogeneous antigens offer precise targeting and safety, but are less immunogenic and require adjuvants. Both natural and synthetic carbohydrate structures have been used as adjuvants in clinical trials, but naturally derived ones are difficult to obtain and unstable.

NATURE REVIEWS CHEMISTRY (2021)

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Article Immunology

The Use of Nanobiotechnology in Immunology and Vaccination

Reza Keikha et al.

Summary: Nanotechnology utilizes nanostructures with a size of 1 to 200 nanometers to produce new vaccines and drugs, delivering immunological compounds more effectively to target sites. The goal is to better respond to a wide range of infectious and non-infectious diseases.

VACCINES (2021)

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Article Immunology

Hepatitis B Vaccines

Jade Pattyn et al.

Summary: The coverage of hepatitis B vaccines is increasing, and the effective implementation of vaccination programs has significantly reduced the morbidity and mortality related to hepatitis B.

JOURNAL OF INFECTIOUS DISEASES (2021)

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Article Chemistry, Physical

Emulsification and emulsion stability: The role of the interfacial properties

Francesca Ravera et al.

Summary: This review highlights the effects of interfacial properties on the aging mechanisms of emulsions, including flocculation, coalescence, and Ostwald ripening, as well as the role of emulsifiers in the emulsification process. It also summarizes experimental approaches and the involvement of different surface-active species in emulsion production.

ADVANCES IN COLLOID AND INTERFACE SCIENCE (2021)

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Article Chemistry, Multidisciplinary

Rational design of adjuvants for subunit vaccines: The format of cationic adjuvants affects the induction of antigen-specific antibody responses

Giulia Anderluzzi et al.

Summary: Through the study of four different cationic delivery systems, it was found that they have different characteristics and effects. In vitro, particulate systems were better at promoting cell uptake and antigen processing, while emulsions were less effective. However, emulsions induced the highest antibody responses in vivo compared to other systems tested.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Medicine, General & Internal

Safety and immunogenicity of S-Trimer (SCB-2019), a protein subunit vaccine candidate for COVID-19 in healthy adults: a phase 1, randomised, double-blind, placebo-controlled trial

Peter Richmond et al.

Summary: A study in Australia evaluated the dose-finding and adjuvant justification of the SCB-2019 vaccine against SARS-CoV-2. The vaccine, which contains a stabilised trimeric form of the spike protein (S-Trimer) combined with AS03 or CpG/Alum adjuvants, elicited robust humoral and cellular immune responses in both younger and older adults.

LANCET (2021)

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Review Biotechnology & Applied Microbiology

Recent developments in mesoporous polydopamine-derived nanoplatforms for cancer theranostics

Menglu Zhu et al.

Summary: MPDA, a mesoporous polydopamine material, has simple preparation process, low cost, high specific surface area, and excellent biocompatibility, making it suitable for various nanodrug delivery systems. It shows great potential in a wide range of applications in anti-tumor therapy.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Review Virology

A brief review of influenza virus infection

Mostafa Javanian et al.

Summary: Influenza is an acute viral respiratory infection that affects all age groups and is associated with high mortality. Vaccination is the most effective method for prevention, but antiviral drugs are also available for treatment.

JOURNAL OF MEDICAL VIROLOGY (2021)

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Review Biotechnology & Applied Microbiology

Emerging concepts in the science of vaccine adjuvants

Bali Pulendran et al.

Summary: Adjuvants are vaccine components that enhance the immune response. Recent advances in understanding the molecular mechanisms and systems vaccinology have revitalized the science and development of novel adjuvants for use in vaccines against COVID-19 and future pandemics.

NATURE REVIEWS DRUG DISCOVERY (2021)

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Review Immunology

Cancer Vaccines, Adjuvants, and Delivery Systems

Samantha J. Paston et al.

Summary: Vaccination has had a significant impact in preventing infectious diseases, but the development of therapeutic cancer vaccines has been challenging.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Chemistry, Multidisciplinary

A Comprehensive Review of the Global Efforts on COVID-19 Vaccine Development

Yingzhu Li et al.

Summary: The report examines a significant number of vaccine candidates for the COVID-19 pandemic that emerged last year, discussing their technological advantages and disadvantages, the use of adjuvants and delivery systems, and providing insights into their future direction.

ACS CENTRAL SCIENCE (2021)

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Review Pharmacology & Pharmacy

An Overview of Nanocarrier-Based Adjuvants for Vaccine Delivery

Kailash C. Petkar et al.

Summary: The development of vaccines has evolved from live attenuated pathogen vaccines to killed whole organisms or inactivated toxins, with nanotechnology playing a significant role in developing efficient vaccine adjuvants and delivery systems. The key to vaccination lies in generating memory response and protection against infection, with the effective delivery of antigen being crucial for a robust immune response.

PHARMACEUTICS (2021)

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Review Chemistry, Multidisciplinary

Lipid Nanoparticles-From Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement

Rumiana Tenchov et al.

Summary: Lipid nanoparticles (LNPs) have become promising vehicles in the pharmaceutical industry for delivering various therapeutics, particularly highlighted in the COVID-19 mRNA vaccines. LNPs exhibit versatility and physical stability, allowing for targeted delivery of therapeutic drugs to specific locations within the body. Liposomes, an early version of LNPs, have already been widely applied in medical practice.

ACS NANO (2021)

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Review Microbiology

Bacterial Outer Membrane Vesicles: From Discovery to Applications

Mariana G. Sartorio et al.

Summary: Production of extracellular vesicles in bacteria, particularly outer membrane vesicles (OMVs) in gram-negative bacteria, is a well-documented but poorly understood process. Besides their roles in pathogenesis, cell-to-cell communication, and stress responses, OMVs also play important roles in immunomodulation and balancing the gut microbiota. The review discusses the various roles of OMVs and the current understanding of their biogenesis, as well as the expanding biotechnological applications of OMVs.

ANNUAL REVIEW OF MICROBIOLOGY, VOL 75, 2021 (2021)

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Article Immunology

Nanovaccine: an emerging strategy

Amrita Das et al.

Summary: Nanovaccines, as efficient vaccine delivery systems, show great potential in improving tissue targeting, antigen presentation, and targeted delivery, providing promising strategies to combat infectious diseases and cancer.

EXPERT REVIEW OF VACCINES (2021)

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Review Nanoscience & Nanotechnology

CpG-Based Nanovaccines for Cancer Immunotherapy

Wenqiang Chen et al.

Summary: Nanoparticles used as carriers and/or adjuvants in tumor vaccines have shown significant therapeutic effects in cancer treatment. CpG ODN, a commonly used immune stimulant, can activate humoral and cellular immunity through Toll-like receptor 9 for cancer prevention or treatment.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Article Biochemistry & Molecular Biology

Design and application of nanoparticles as vaccine adjuvants against human corona virus infection

Lichun Mao et al.

Summary: The article discusses the potential of nanoparticles as vaccine adjuvants, indicating their unique properties and application prospects in combating viruses, and proposes design points for the coronavirus to accelerate the development and clinical application of personalized vaccines and adjuvants.

JOURNAL OF INORGANIC BIOCHEMISTRY (2021)

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Review Chemistry, Physical

Liposomes as biomembrane models: Biophysical techniques for drug-membrane interaction studies

Stephanie Andrade et al.

Summary: Understanding how drugs interact with biological membranes is crucial for the pharmaceutical industry. In vitro lipid-based membrane models provide a simple alternative to study these interactions. Different lipid models and biophysical methodologies using liposomes are discussed for investigating drug-membrane interactions.

JOURNAL OF MOLECULAR LIQUIDS (2021)

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Review Biotechnology & Applied Microbiology

mRNA vaccines for infectious diseases: principles, delivery and clinical translation

Namit Chaudhary et al.

Summary: mRNA vaccines have been established as a rapid, effective, and safe approach for protecting individuals from infectious diseases, especially during the COVID-19 pandemic. Further research is needed to optimize mRNA vaccine design, delivery, and applications for a range of infectious diseases.

NATURE REVIEWS DRUG DISCOVERY (2021)

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Article Cell Biology

A recombinant spike protein subunit vaccine confers protective immunity against SARS-CoV-2 infection and transmission in hamsters

Yangtao Wu et al.

Summary: This study developed a protein subunit vaccine consisting of spike ectodomain protein and a nitrogen bisphosphonate-modified zinc-aluminum hybrid adjuvant, which showed higher neutralizing antibody titers in animal models and induced T cell responses. The vaccine provided protection against SARS-CoV-2 challenge and reduced virus transmission among vaccinated and unvaccinated animals.

SCIENCE TRANSLATIONAL MEDICINE (2021)

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Review Virology

Human Papilloma Virus Vaccination

Kendal Rosalik et al.

Summary: HPV is the most common sexually transmitted infection worldwide, leading to various diseases, and vaccines are effective in preventing HPV-related diseases. There is a need for better global distribution and acceptance of vaccines to combat HPV.

VIRUSES-BASEL (2021)

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Review Immunology

The Use of Iron Oxide Nanoparticles to Reprogram Macrophage Responses and the Immunological Tumor Microenvironment

Vladimir Mulens-Arias et al.

Summary: The synthesis and functionalization of iron oxide nanoparticles have sparked interest in studying them as theranostic agents, particularly in the field of cancer immunotherapy. Understanding the effects of IONPs on the immune system is crucial, as they may impact immune cell responses through various mechanisms. Furthermore, harnessing the properties of IONPs could lead to the development of innovative therapies for cancer treatment.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Oncology

STING agonist loaded lipid nanoparticles overcome anti-PD-1 resistance in melanoma lung metastasis via NK cell activation

Takashi Nakamura et al.

Summary: STING-LNP treatment can overcome PD-1 resistance by activating NK cells, resulting in an increase in PD-L1 expression on cancer cells and ultimately producing a synergistic antitumor effect.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

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Review Biochemistry & Molecular Biology

Toll-like Receptors and the Control of Immunity

Katherine A. Fitzgerald et al.

CELL (2020)

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Article Multidisciplinary Sciences

Synthetic mycobacterial molecular patterns partially complete Freund's adjuvant

Jean-Yves Dube et al.

SCIENTIFIC REPORTS (2020)

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Review Immunology

Recent Progress on the Versatility of Virus-Like Particles

Ciying Qian et al.

VACCINES (2020)

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Article Immunology

3M-052, a synthetic TLR-7/8 agonist, induces durable HIV-1 envelope-specific plasma cells and humoral immunity in nonhuman primates

Sudhir Pai Kasturi et al.

SCIENCE IMMUNOLOGY (2020)

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Article Chemistry, Multidisciplinary

Biomineralized Bacterial Outer Membrane Vesicles Potentiate Safe and Efficient Tumor Microenvironment Reprogramming for Anticancer Therapy

Shuang Qing et al.

ADVANCED MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Particulate Alum via Pickering Emulsion for an Enhanced COVID-19 Vaccine Adjuvant

Sha Peng et al.

ADVANCED MATERIALS (2020)

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Article Engineering, Biomedical

Lymph node-targeted immune-activation mediated by imiquimod-loaded mesoporous polydopamine based-nanocarriers

Lu Wang et al.

BIOMATERIALS (2020)

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Editorial Material Biochemistry & Molecular Biology

Why and How Vaccines Work

Akiko Iwasaki et al.

CELL (2020)

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News Item Multidisciplinary Sciences

THE HIDDEN HISTORY OF ANCIENT PLAGUES

Laura Spinney

NATURE (2020)

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Article Multidisciplinary Sciences

ChAdOx1 nCoV-19 vaccine prevents SARS-CoV-2 pneumonia in rhesus macaques

Neeltje van Doremalen et al.

NATURE (2020)

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Editorial Material Biotechnology & Applied Microbiology

Whither COVID-19 vaccines?

Galit Alter et al.

NATURE BIOTECHNOLOGY (2020)

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Review Immunology

Poly-ICLC, a multi-functional immune modulator for treating cancer

Hussein Sultan et al.

SEMINARS IN IMMUNOLOGY (2020)

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Review Immunology

Vaccine adjuvants: Understanding the structure and mechanism of adjuvanticity

Shuting Shi et al.

VACCINE (2019)

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Article Chemistry, Multidisciplinary

Engineering Magnetosomes for High-Performance Cancer Vaccination

Feng Li et al.

ACS CENTRAL SCIENCE (2019)

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Editorial Material Chemistry, Multidisciplinary

A Magnetic Nanovaccine Enhances Cancer Immunotherapy

Yugang Guo et al.

ACS CENTRAL SCIENCE (2019)

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Article Immunology

The TLR4 agonist adjuvant SLA-SE promotes functional mucosal antibodies against a parenterally delivered ETEC vaccine

Hong Liang et al.

NPJ VACCINES (2019)

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Review Chemistry, Multidisciplinary

Pickering emulsions: Preparation processes, key parameters governing their properties and potential for pharmaceutical applications

Claire Albert et al.

JOURNAL OF CONTROLLED RELEASE (2019)

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Review Chemistry, Multidisciplinary

Liposomes used as a vaccine adjuvant-delivery system: From basics to clinical immunization

Ning Wang et al.

JOURNAL OF CONTROLLED RELEASE (2019)

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Article Immunology

Ebola Virus Disease Epidemiology, Clinical Features, Management, and Prevention

Emanuele Nicastri et al.

INFECTIOUS DISEASE CLINICS OF NORTH AMERICA (2019)

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Review Pharmacology & Pharmacy

Nanoparticulate Carriers Used as Vaccine Adjuvant Delivery Systems

Ning Wang et al.

CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS (2019)

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Review Immunology

Flagellin as a vaccine adjuvant

Baofeng Cui et al.

EXPERT REVIEW OF VACCINES (2018)

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Article Immunology

Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses

Chenguang Wang et al.

IMMUNITY (2018)

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Article Immunology

Matrix-M™ adjuvant enhances immunogenicity of both protein- and modified vaccinia virus Ankara-based influenza vaccines in mice

Sofia E. Magnusson et al.

IMMUNOLOGIC RESEARCH (2018)

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Article Nanoscience & Nanotechnology

Polyethyleneimine modification of aluminum hydroxide nanoparticle enhances antigen transportation and cross-presentation of dendritic cells

Heng Dong et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2018)

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Article Chemistry, Physical

Exploiting the pliability and lateral mobility of Pickering emulsion for enhanced vaccination

Yufei Xia et al.

NATURE MATERIALS (2018)

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Review Biotechnology & Applied Microbiology

mRNA vaccines - a new era in vaccinology

Norbert Pardi et al.

NATURE REVIEWS DRUG DISCOVERY (2018)

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Review Immunology

Correlates of adjuvanticity: A review on adjuvants in licensed vaccines

Giuseppe Del Giudice et al.

SEMINARS IN IMMUNOLOGY (2018)

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Review Biotechnology & Applied Microbiology

Nanoemulsions in drug delivery: formulation to medical application

Hossam H. Tayeb et al.

NANOMEDICINE (2018)

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Review Geriatrics & Gerontology

Recombinant Zoster Vaccine (Shingrix®): A Review in Herpes Zoster

Yahiya Y. Syed

DRUGS & AGING (2018)

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Review Immunology

Adjuvant system AS01: helping to overcome the challenges of modern vaccines

Arnaud M. Didierlaurent et al.

EXPERT REVIEW OF VACCINES (2017)

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Review Biotechnology & Applied Microbiology

From discovery to licensure, the Adjuvant System story

Nathalie Garcon et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2017)

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Review Virology

Targeting Pattern Recognition Receptors (PRR) for Vaccine Adjuvantation: From Synthetic PRR Agonists to the Potential of Defective Interfering Particles of Viruses

Andri Vasou et al.

VIRUSES-BASEL (2017)

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Article Immunology

Cellular and molecular synergy in AS01-adjuvanted vaccines results in an early IFNγ response promoting vaccine immunogenicity

Margherita Coccia et al.

NPJ VACCINES (2017)

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Review Pharmacology & Pharmacy

Nanocarriers for cancer-targeted drug delivery

Preeti Kumari et al.

JOURNAL OF DRUG TARGETING (2016)

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Review Biotechnology & Applied Microbiology

Safety and tolerability evaluation of the use of Montanide ISA (TM) 51 as vaccine adjuvant: A systematic review

Eva van Doorn et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2016)

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Article Immunology

The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons

Elizabeth. C. Carroll et al.

IMMUNITY (2016)

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Review Medicine, Research & Experimental

Beyond antigens and adjuvants: formulating future vaccines

Tyson J. Moyer et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

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Article Chemistry, Multidisciplinary

Adsorption of a synthetic TLR7/8 ligand to aluminum oxyhydroxide for enhanced vaccine adjuvant activity: A formulation approach

Christopher B. Fox et al.

JOURNAL OF CONTROLLED RELEASE (2016)

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Review Cell Biology

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

Marina Colombo et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 30 (2014)

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Review Immunology

An overview of adjuvant formulations and delivery

Alexis Garcia et al.

APMIS (2014)

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Article Chemistry, Multidisciplinary

Aluminum hydroxide nanoparticles show a stronger vaccine adjuvant activity than traditional aluminum hydroxide microparticles

Xinran Li et al.

JOURNAL OF CONTROLLED RELEASE (2014)

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Article Biotechnology & Applied Microbiology

A Cationic Nanoemulsion for the Delivery of Next-generation RNA Vaccines

Luis A. Brito et al.

MOLECULAR THERAPY (2014)

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Article Multidisciplinary Sciences

GLA-AF, an Emulsion-Free Vaccine Adjuvant for Pandemic Influenza

Christopher H. Clegg et al.

PLOS ONE (2014)

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Review Immunology

Adjuvants for vaccines to drugs of abuse and addiction

Carl R. Alving et al.

VACCINE (2014)

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Article Immunology

A novel liposomal adjuvant system, CAF01, promotes long-lived Mycobacterium tuberculosis-specific T-cell responses in human

Jaap T. van Dissel et al.

VACCINE (2014)

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Article Endocrinology & Metabolism

Age-Associated Changes in Immune Function: Impact of Vitamin E Intervention and the Underlying Mechanisms

Dayong Wu et al.

ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS (2014)

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Review Chemistry, Medicinal

Modern Subunit Vaccines: Development, Components, and Research Opportunities

Peter Michael Moyle et al.

CHEMMEDCHEM (2013)

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Review Immunology

The history of MF59 (R) adjuvant: a phoenix that arose from the ashes

Derek T. O'Hagan et al.

EXPERT REVIEW OF VACCINES (2013)

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Review Chemistry, Multidisciplinary

Progress in microRNA delivery

Yu Zhang et al.

JOURNAL OF CONTROLLED RELEASE (2013)

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Review Biochemistry & Molecular Biology

Key roles of adjuvants in modern vaccines

Steven G. Reed et al.

NATURE MEDICINE (2013)

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Review Chemistry, Multidisciplinary

NLRP3 Inflammasome Activation Induced by Engineered Nanomaterials

Bingbing Sun et al.

SMALL (2013)

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Article Chemistry, Multidisciplinary

Mesoporous Silica Nanoparticles Act as a Self-Adjuvant for Ovalbumin Model Antigen in Mice

Donna Mahony et al.

SMALL (2013)

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Review Nanoscience & Nanotechnology

Liposome: classification, preparation, and applications

Abolfazl Akbarzadeh et al.

NANOSCALE RESEARCH LETTERS (2013)

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Review Immunology

Applications of nanotechnology for immunology

Douglas M. Smith et al.

NATURE REVIEWS IMMUNOLOGY (2013)

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Review Biochemistry & Molecular Biology

Exosomes: Current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials

Alexander V. Vlassov et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2012)

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Review Immunology

Liposomes containing lipid A: an effective, safe, generic adjuvant system for synthetic vaccines

Carl R. Alving et al.

EXPERT REVIEW OF VACCINES (2012)

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Review Immunology

Development and evaluation of AS03, an Adjuvant System containing α-tocopherol and squalene in an oil-in-water emulsion

Nathalie Garcon et al.

EXPERT REVIEW OF VACCINES (2012)

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Article Immunology

GLA-SE, a Synthetic Toll-like Receptor 4 Agonist, Enhances T-Cell Responses to Influenza Vaccine in Older Adults

Hayedeh Behzad et al.

JOURNAL OF INFECTIOUS DISEASES (2012)

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Review Microbiology

ISCOMATRIX: a novel adjuvant for use in prophylactic and therapeutic vaccines against infectious diseases

Adriana Baz Morelli et al.

JOURNAL OF MEDICAL MICROBIOLOGY (2012)

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Article Chemistry, Medicinal

AF03, an alternative squalene emulsion-based vaccine adjuvant prepared by a phase inversion temperature method

Marie-Francoise Klucker et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2012)

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Article Immunology

The mechanism of action of MF59 - An innately attractive adjuvant formulation

D. T. O'Hagan et al.

VACCINE (2012)

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Review Cell Biology

Human immunodeficiency virus-1 vaccine design: where do we go now?

Danushka K. Wijesundara et al.

IMMUNOLOGY AND CELL BIOLOGY (2011)

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Article Virology

Innate and adaptive immune responses to viral infection and vaccination

Taiki Aoshi et al.

CURRENT OPINION IN VIROLOGY (2011)

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Article Virology

PIKA provides an adjuvant effect to induce strong mucosal and systemic humoral immunity against SARS-CoV

Wei-wei Gai et al.

VIROLOGICA SINICA (2011)

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Article Engineering, Biomedical

Signalling pathways involved in the activation of dendritic cells by layered double hydroxide nanoparticles

Ang Li et al.

BIOMATERIALS (2010)

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Article Immunology

AS04, an Aluminum Salt- and TLR4 Agonist-Based Adjuvant System, Induces a Transient Localized Innate Immune Response Leading to Enhanced Adaptive Immunity

Arnaud M. Didierlaurent et al.

JOURNAL OF IMMUNOLOGY (2009)

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Article Immunology

IC31®, a Two-Component Novel Adjuvant Mixed with a Conjugate Vaccine Enhances Protective Immunity against Pneumococcal Disease in Neonatal Mice

T. A. Olafsdottir et al.

SCANDINAVIAN JOURNAL OF IMMUNOLOGY (2009)

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Article Immunology

Epaxal®: a virosomal vaccine to prevent hepatitis A infection

Patrick A. Bovier

EXPERT REVIEW OF VACCINES (2008)

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Review Immunology

Relationship between physical and chemical properties of aluminum-containing adjuvants and immunopotentiation

Stanley L. Hem et al.

EXPERT REVIEW OF VACCINES (2007)

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Review Immunology

GlaxoSmithKline Adjuvant systems in vaccines: concepts, achievements and perspectives

Nathalie Garcon et al.

EXPERT REVIEW OF VACCINES (2007)

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Review Microbiology

The perfect mix: recent progress in adjuvant research

Bruno Guy

NATURE REVIEWS MICROBIOLOGY (2007)

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Letter Immunology

Imject® Alum is not aluminum hydroxide adjuvant or aluminum phosphate adjuvant

Stanley L. Hem et al.

VACCINE (2007)

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Article Immunology

Cytokine GM-CSF genetic adjuvant facilitates prophylactic DNA vaccine against pseudorabies virus through enhanced immune responses

HA Yoon et al.

MICROBIOLOGY AND IMMUNOLOGY (2006)

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Review Pharmacology & Pharmacy

Immunity in response to particulate antigen-delivery systems

T Storni et al.

ADVANCED DRUG DELIVERY REVIEWS (2005)

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Review Oncology

IL-12: a promising adjuvant for cancer vaccination

JEA Portielje et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2003)

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Article Immunology

Inflexal®V a trivalent virosome subunit influenza vaccine:: production

R Mischler et al.

VACCINE (2002)

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Review Biochemistry & Molecular Biology

Adenovirus and adeno-associated virus vectors

CM Lai et al.

DNA AND CELL BIOLOGY (2002)

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Article Biochemical Research Methods

Surface phosphophilicity of aluminum-containing adjuvants probed by their efficiency for catalyzing the P-O bond cleavage with chromogenic and fluorogenic substrates

QJ Zhao et al.

ANALYTICAL BIOCHEMISTRY (2001)

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