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Article
Materials Science, Multidisciplinary
Huilong Luo et al.
Summary: Wrapping bacterial cells with an adhesive drug-loadable nanocoating allows for the encoding of bacterial colonization and therapeutic modality. Encoded bacteria can colonize a wide range of biointerfaces and carry various cargoes for multimodal therapy. In vivo studies demonstrate that orally ingested encoded bacteria exhibit significantly improved intestinal colonization and synergistically enhanced treatment efficacy. This work reveals a versatile platform for advanced microbial therapy through the encoding of bacterial colonization and modality with a single-cell coating.
Article
Chemistry, Multidisciplinary
Martina Ussia et al.
Summary: This study reports a new biodegradable magnetically actuated zinc/cystine-based microrobots for in situ treatment of prostate cancer cells. The microrobots are fabricated through metal-ion-mediated self-assembly of cystine encapsulating superparamagnetic Fe3O4 nanoparticles, allowing precise manipulation by a rotating magnetic field. Inside the cells, the enzymatic reducing environment promotes the disassembly of the cystine structure and disrupts non-covalent interactions with metal ions, enabling site-specific delivery of zinc ions for tumor cell killing via a Trojan horse effect.
Review
Engineering, Biomedical
Haiyang Su et al.
Summary: Janus particles possess distinct domains and can integrate different properties, allowing them to perform multiple functions simultaneously. Integrating Janus structure with micro/nanorobots holds promise for biomedical applications.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Rodolfo Mundaca-Uribe et al.
Summary: Type 2 diabetes mellitus (T2DM) is characterized by high blood glucose levels due to insulin resistance, and metformin is the most commonly prescribed oral drug for lowering blood glucose levels in T2DM patients. However, its absorption and bioavailability are poor. This study introduces magnesium-based microstirrers to a metformin-containing pill matrix to enhance the glucose-lowering effect of metformin.
Article
Chemistry, Multidisciplinary
Lishan Zhang et al.
Summary: A self-driving yeast micro/nanorobot (Cur@ CaY-robot) is designed via dual biomineralization and acid catalysis, which demonstrates efficient motion in gastric acid and can penetrate the thick gastric mucus for improved drug accumulation in the stomach wall tissue. Additionally, the released Ca2+ cations from the robot synergistically repair the gastric motility of gastritis mice. The biocompatible and biodegradable nature of these yeast micro/nanorobots, along with their good drug loading capacity, make them promising for active drug delivery and precise therapy.
Article
Chemistry, Multidisciplinary
Zhi-Hao Wang et al.
Summary: Self-thermophoretic nanoparticles (CTPB) have been developed to enhance intestinal mucus penetration and reduce pathogenic bacteria interception, resulting in improved drug delivery efficiency for colorectal cancer therapy.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Ying Feng et al.
Summary: This review provides an overview of chemically driven micro/nanorobots, including their material properties, preparation, driving forms, and mechanisms. It summarizes the current research status of these robots in various biomedical applications and analyzes the possible safety issues. Finally, challenges and future directions of chemically driven micro/nanorobots are presented.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Multidisciplinary Sciences
Zhongmin Geng et al.
Summary: This study presents a cytocompatible approach of biointerface mineralization to generate an ultraresistant and self-removable coating on bacterial surface, addressing the challenges faced by bacteria during the manufacturing process. The mineral coating provides bacteria with resistance against oxygen exposure, ultraviolet irradiation, and ethanol. Upon oral ingestion, the coating actively neutralizes gastric acid and releases encapsulated bacteria through a rapid double-decomposition reaction. Furthermore, the generated calcium ions trigger bile acid micellar aggregation, enabling dual exemptions from gastric acid and bile acid insults for uncompromised bacterial viability. Supported by therapeutic efficacy in colitis mice, biointerface mineralization offers a versatile platform for developing next-generation living oral biotherapeutics.
Article
Multidisciplinary Sciences
Baozhen Zhang et al.
Summary: A twin-bioengine yeast micro/nanorobot (TBY-robot) with self-propelling and self-adaptive capabilities has been developed for targeted gastrointestinal inflammation therapy. The TBY-robot uses an enzyme-macrophage switching mechanism to autonomously navigate to inflamed sites. It successfully overcomes barriers in the gastrointestinal tract and enhances drug accumulation at the diseased site, demonstrating its potential for precision treatment of inflammatory diseases.
Review
Chemistry, Multidisciplinary
Yun Wang et al.
Summary: Untethered miniature robots have shown great potential for targeted delivery and therapy inside the gastrointestinal tract. They can be controlled externally and utilize the local environment for therapeutic purposes. Compared to conventional surgical tools, these robots offer minimally invasive diagnosis and treatment, multifunctionality, and easy access to narrow lumens. The active motion of microrobots also improves drug penetration and retention in tissues. This review discusses the advances in miniature robots for minimally invasive targeted delivery and therapy, including the imaging modalities used for tracking, and highlights the challenges and future research directions in this field.
Article
Chemistry, Multidisciplinary
Kun Liu et al.
Summary: A mini-tablet system based on self-propelled micromotors was successfully developed for oral colon administration of insulin. The system achieved controlled release of insulin through the degradation of esterified starch coating. The released micromotors, with autonomous movement, significantly enhanced colonic uptake and absorption of insulin, leading to long-term blood glucose control. This system not only expands the biomedical applications of self-propelled micromotors but also provides an appealing strategy for oral administration of biomacromolecular drugs.
Review
Materials Science, Multidisciplinary
Mengyue Li et al.
Summary: Micro/nanorobots, characterized by their sizes between 1 nm and 1 mm, have the ability to convert external energy sources into mechanical energy. In recent years, they have made significant progress in different research fields, particularly in biomedicine. The small size and flexibility of micro/nanorobots enable them to achieve efficient movement and operation in microscale spaces. Their potential applications in minimally invasive surgery, targeted therapy, detection, and sensing have attracted extensive interest. This article reviews the research achievements and progress of micro/nanorobots in biomedicine from the perspectives of different propulsion methods and discusses the challenges they face in clinical applications.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Review
Chemistry, Multidisciplinary
Wei Liu et al.
Summary: Untethered mobile micro-/nanomotors (MNMs) are seen as the next-generation disease treatment tools. However, the complexity of the biological environment and the particularity of disease microenvironment hinder their advances. This review comprehensively addresses the design, imaging, and disease treatment of biomedical MNMs, highlighting intelligent MNMs with biomimetic functionality and chemotactic capability, emphasizing the applicability of different imaging techniques, and focusing on various proof-of-concept studies for the treatment of major diseases. The challenges and limitations of current biomedical MNMs are discussed, inspiring future research towards clinical translation.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Shuhao Zhang et al.
Summary: Oral administration is a convenient way to treat gastrointestinal diseases with good patient compliance, but the nonspecific distribution of drugs can lead to serious side effects. To overcome this, oral drug delivery systems (ODDS) have been developed, but they are limited by physiological barriers in the gastrointestinal tract. Micro/nanomotors (MNMs) have shown potential in targeted drug delivery, and this review comprehensively discusses their applications in overcoming physiological barriers in ODDS for gastrointestinal diseases. This review provides inspiration and direction for MNMs in the therapy of gastrointestinal diseases and advances the clinical application of MNMs in oral drug delivery.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Nanoscience & Nanotechnology
Runzan Zhang et al.
Summary: Microbiota-based tumor immunotherapy has become a hotspot in cancer research. However, using microorganisms alone for antitumor therapy was unsatisfactory. In this study, gold nanoparticles and platinum nanoparticles were synthesized based on yeast microcapsules to activate the immune response for antitumor treatment in synergy with chemodynamic therapy and photothermal therapy. The results showed that this immunological nanomaterial significantly improved the tumor microenvironments, effectively inhibiting or even eradicating primary tumors and improving the overall survival of mice. Therefore, yeast microcapsule-based immunomodulatory nanoparticles could be an effective cancer treatment modality.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Chemistry, Multidisciplinary
Yan Zhou et al.
Summary: Stimuli-responsive functional micro-/nanorobots (srFM/Ns) are intelligent, efficient, and promising microrobots that react to external stimuli and perform designated tasks. They have significant roles in targeted therapy, biological detection, tissue engineering, and other fields. However, there are few reviews focusing on them, hence the necessity of providing an overview of their current development to inspire further advancements in this field.
Review
Chemistry, Multidisciplinary
Fangyu Zhang et al.
Summary: This review focuses on the integration of microorganisms and artificial components to create biohybrid microrobots, with a specific emphasis on microalgae-based systems. The distinct propulsion and phototaxis behaviors of microalgae, as well as methods for functionalizing their surface, are discussed. Various applications of these biohybrid microrobots in biomedical and environmental fields are presented, highlighting their advantages and challenges.
ADVANCED MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Xue Dong et al.
Summary: This review summarizes recent developments in engineered living materials for treating various diseases and discusses future perspectives and challenges, providing considerations for further advances in biomedical applications.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Applied
Ya Wu et al.
Summary: Oral drug delivery is the preferred route for long-term medication. The yeast-based beta-glucan system is a promising platform for oral administration, protecting the drug in the harsh gastrointestinal environment and achieving targeted therapeutic effects by recognizing immune cells. This review covers the structure and function of yeast-based beta-glucan, preparation methods of carriers, applications in different diseases, and introduces current challenges and future perspectives.
CARBOHYDRATE POLYMERS
(2023)
Review
Microbiology
Ana S. Luis et al.
Summary: The colon mucus layer consists of an inner layer that prevents bacterial penetration and an outer layer that allows microbiota colonization. MUC2, a heavily glycosylated protein, is a major component of the mucus. Goblet cells in the intestine are responsible for glycosylation and mucus production. Some microbiota members encode proteins that interact with and modify mucin glycans. This review examines the interaction between commensal microbes and intestinal mucus and discusses its impact on health and disease.
CELL HOST & MICROBE
(2023)
Article
Engineering, Biomedical
Rodolfo Mundaca-Uribe et al.
Summary: Robotic pills leverage the advantages of oral pharmaceutical formulations and microrobotic systems, allowing for the realization of sophisticated multifunctional closed-loop systems.
NATURE BIOMEDICAL ENGINEERING
(2023)
Review
Immunology
Anna Jessica Duarte Silva et al.
Summary: In recent decades, technological advances have allowed for the manipulation of RNA and its application in vaccine development. Yeasts have emerged as a new approach for delivering protein antigens and have shown efficacy through preclinical and clinical trials. Yeast-based delivery systems have the ability to modulate immune responses, carry nucleic acids, and target specific cells, making them a promising strategy for RNA-based vaccines.
Review
Medicine, Research & Experimental
Yingshu Guo et al.
Summary: Micro/nanomotors are tiny containers that can move in liquid media and carry cargo. They have great potential for biosensing and disease treatment applications, but their small size makes it challenging to overcome random Brownian forces when moving on targets. Additionally, addressing the issues of expensive materials, short lifetimes, poor biocompatibility, complex preparation methods, and potential adverse effects is crucial for practical applications. This review discusses the working principles of micro/nanomotors, explores key materials for driving them, and considers their applications in biosensing, cancer treatment, gynecological diseases, and assisted fertilization.
Review
Automation & Control Systems
Tiancong Zhao et al.
Summary: Nanomotors with active motion have attracted widespread attention. Researchers have developed various nanomotors with different architectures and propulsion mechanisms, and explored the application prospects of nanomotors in multiple fields. However, the current nanomotors are still far from achieving precise control of sophisticated motions. With advancements in nanofabrication techniques, modulating the nanoparticle structure has become a welcomed approach to tuning the nanomotors' motion.
ADVANCED INTELLIGENT SYSTEMS
(2023)
Review
Chemistry, Physical
De Gong et al.
Summary: Microorganisms have become a new source for fabricating intricate micro/nano structures via bottom-up approaches. These biotemplates, produced by nature, exhibit unique structural and material features accumulated over thousands of years. Compared to other micro/nanofabrication techniques, microorganism-based fabrication is considerably superior and cost-effective for fabricating complex and heterogeneous structures. This review consolidates the recent advances in biologically driven micro/nanofabrication, assembly, and actuation based on microorganisms, covering detailed development, ordered assembly, controlled actuation properties, and typical engineering applications. The developing perspectives and challenges of microorganism-based micro/nanofabrication are also discussed to inspire further research and promote the field's development.
Article
Chemistry, Multidisciplinary
Yong Wang et al.
Summary: This study introduces a novel approach using MNRs as maneuverable immunoassay probes to achieve automated and efficient ELISA analysis, significantly reducing assay time and minimizing manpower input.
Review
Chemistry, Multidisciplinary
Jinhua Li et al.
Summary: This review provides a comprehensive overview of the applications of ultrasound in driving micro- and nanorobots, including theory, design, fabrication methods, propulsion mechanisms, and hybrid motion with other driving methods. It highlights the potential applications of ultrasound-powered micro/nanorobots in various fields and offers a future outlook on the development of ultrasound-driven micro/nanorobots.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Wufa Fan et al.
Summary: The study introduces a novel polymeric micelle that can penetrate mucus layer and be absorbed by villi, efficiently delivering anticancer drugs to tumors with improved therapeutic efficacy.
ADVANCED MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Fernando Soto et al.
Summary: In the past 15 years, the field of microrobotics has experienced explosive growth, and smart materials have played a crucial role. The future efforts in microrobotics will focus on propulsion and biocompatibility, cooperation between individual units and human operators, and intelligence.
Review
Chemistry, Analytical
Conghui Liu et al.
Summary: This article reviews the characteristics and progress of light-responsive Janus micro-/nanomotors in biomedicine and focuses on their applications in biosensing, bioimaging, and theranostic. The remaining challenges in practical application are summarized, and potential solutions are proposed.
Review
Gastroenterology & Hepatology
Jacqueline N. Chu et al.
Summary: Gastrointestinal-based drug delivery is preferred for its convenience and improved patient adherence, but absorption of drugs is limited by unique characteristics of the gastrointestinal tract, particularly for biologics. Overcoming challenges and considering unique features of each gastrointestinal compartment are essential for successful drug formulation. Emerging technologies aim to address remaining obstacles in gastrointestinal-based drug delivery.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2022)
Review
Engineering, Biomedical
Dong Liu et al.
Summary: The article discusses the potential applications of untethered microrobots in medical treatment, particularly focusing on the advantages of active drug delivery systems compared to traditional passive systems. It introduces an integrated 5D radar chart analysis model and addresses the various factors that need to be considered before clinical application of microrobots.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Multidisciplinary Sciences
Wei Chen et al.
Summary: Oral drug administration remains the preferred route for patients and health care providers, but delivering macromolecules through this route is challenging. In this study, a delivery system combining physical and nonphysical drug delivery enhancement modes was developed and tested in a large animal model. Inspired by a thorny-headed intestinal worm, a dynamic omnidirectional mucoadhesive microneedle system was created, which showed prolonged fixation on the gastric mucosa. The incorporation of sodium N-[8-(2-hydroxybenzoyl)amino] caprylate along with semaglutide demonstrated enhanced absorption in swine, and a targeted capsule system was developed to deploy intact microneedle-containing systems, enabling drug delivery in a privileged region of the gastrointestinal tract.
Review
Chemistry, Multidisciplinary
Jie Wang et al.
Summary: Cancer is a difficult-to-treat disease due to its high mortality rate and lack of effective diagnostic and treatment tools. Recent advancements in micro-/nanorobot technology provide opportunities for the development of cancer theragnostic platforms, which can enable precise drug delivery and improved permeation.
ADVANCED MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Yifu Tan et al.
Summary: Yeast has been widely studied and used as a drug carrier for the treatment of diseases. This article summarizes the latest research on yeast carriers, including the gastrointestinal absorption mechanism and different packaging forms for drug molecules and nanoparticles. The advantages and development of yeast-based vaccine carriers in veterinary and aquaculture applications are also discussed, along with the current challenges and future directions for yeast carriers.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Engineering, Biomedical
Hyunsik Choi et al.
Summary: This study developed a bioinspired enzyme-powered biopolymer micromotor that converts urea to ammonia to facilitate its penetration into the stomach tissue layer. The successful fabrication of micromotors was confirmed and they showed enhanced penetration and prolonged retention in the stomach. Furthermore, the micromotors did not cause any toxicity in the GI tract.
BIOACTIVE MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Xingxing Feng et al.
Summary: This study designed a macrophages-targeting oral drug delivery system for ulcerative colitis, using berberine and Epigallocatechin Gallate encapsulated in yeast microcapsules. The system effectively transported the drugs to inflammation sites and exerted anti-inflammatory effects through the interaction with macrophage receptors. It provided a new targeting strategy for UC treatment.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Multidisciplinary Sciences
Fangyu Zhang et al.
Summary: Acidophilic microalgae biomotors can maintain swimming behavior in harsh acidic environments, making them suitable for gastrointestinal delivery applications. They can also be loaded with various cargo and their precise localization in the gastrointestinal tract can be controlled by tuning the cargo's surface properties.
Article
Multidisciplinary Sciences
Jeremiah Bernier-Latmani et al.
Summary: The specialized structure of small intestinal villus tip blood vessels is maintained by ADAMTS18(+) telocytes, which regulate the level and location of VEGFA signaling to ensure the presence of endothelial fenestrae for nutrient absorption, while avoiding excessive leakiness and destabilization of villus tip epithelial structures.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Zhi-Hao Wang et al.
Summary: This study presents a biological chemotaxis-guided self-thermophoretic nanoplatform that improves the efficacy of oral drug delivery systems for colorectal cancer treatment. The nanoplatform achieves precise intestinal positioning and autonomous mucus penetration by introducing platinum-sprayed mesoporous silica and camouflaging with Staphylococcus aureus membrane. The nanoplatform significantly enhances the oral bioavailability of cisplatin and exhibits a high tumor inhibition rate in CRC-bearing mice.
Review
Pharmacology & Pharmacy
Feng Wu et al.
Summary: The use of living bacteria as therapeutic agents or drug carriers has shown great potential in treating various diseases. However, the fragility of cells and inadequate therapeutic responses are challenges in achieving effective treatment. Surface decoration of bacteria has emerged as a strategy to enhance their resistance to environmental stressors and endow them with additional characteristics. This review systematically introduces the advancements in surface modification technologies for bacteria, with a focus on single-cell surface decoration strategies. The review highlights the applications of surface-decorated bacteria in improving the bioavailability and efficacy of therapeutic agents, as well as targeted drug delivery. The promises and challenges of using surface-decorated bacteria in cancer therapy, intestinal disease treatment, bioimaging, and diagnosis are discussed, with implications for future clinical translation.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Chemistry, Physical
Fangyu Zhang et al.
Summary: Biohybrid microrobots consisting of nanoparticle-modified microalgae are constructed for active drug delivery in the lungs. In an acute bacterial pneumonia model, the microrobots effectively reduce bacterial burden and lessen animal mortality.
Article
Chemistry, Multidisciplinary
Yingui Cao et al.
Summary: This study developed mesoporous manganese oxide-based nanomotors driven by hydrogen peroxide/ultrasound to improve the penetration of oral nanomedicines into colon tumors and activate anti-tumor immunity. The nanomotors demonstrated enhanced locomotory activities and tumor-targeting capacities, and the excess hydrogen peroxide in the tumor microenvironment could be decomposed into oxygen and hydroxyl radicals, leading to effective treatment of colon cancer through chemodynamic therapy and sonodynamic therapy.
Article
Robotics
Fangyu Zhang et al.
Summary: This study reports on an efficient algae-based micromotor platform that takes advantage of the fast and long-lasting swimming behavior of natural microalgae in the intestinal fluid to extend their retention in the gastrointestinal tract. In vivo experiments in mice showed that the algae motors significantly improved the distribution and retention of drugs in the gastrointestinal tract compared to traditional micromotors.
Review
Chemistry, Multidisciplinary
Tianyi Liu et al.
Summary: Inspired by natural mobile microorganisms, researchers have developed micro/nanomotors (MNMs) that can autonomously move and have made tremendous progress in various biomedical applications. However, controversy and challenges still exist in propulsion mechanisms and motion manipulation of MNMs. Recently, diverse MNMs with different propulsion strategies, morphologies, sizes, porosities, and chemical structures have been fabricated and utilized for various purposes.
CHEMICAL SOCIETY REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Changyong Gao et al.
Summary: Self-propelled micro- and nanomotors have great potential in biomedical applications, but challenges such as overcoming biological barriers and in vivo navigation still need to be addressed. With continued attention and innovation, it is believed that they will improve targeted drug delivery efficiency in the future.
ADVANCED MATERIALS
(2021)
Review
Pharmacology & Pharmacy
Yonghyun Lee et al.
Summary: The gastrointestinal tract plays a crucial role in both local and systemic diseases, influenced by factors like the mucosal immune system, intestinal barrier, and gut microbiota. Selective drug delivery for oral vaccines, immune tolerance, and inflammatory diseases faces challenges due to the physiological and biological barriers of the GIT. Advances in oral nanomedicine offer potential solutions for overcoming these barriers and effectively targeting treatments to the GIT.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Engineering, Biomedical
Hyunsik Choi et al.
Summary: Self-propelling micro- and nano-motors are a multifunctional platform for smart healthcare applications, including biosensing, bioimaging, and targeted drug delivery. They can be powered and guided by chemical substances or external stimuli, showing promise for in vivo applications and future clinical use. Despite some limitations, MNMs have the potential to revolutionize diagnostic and therapeutic approaches in healthcare.
Review
Chemistry, Inorganic & Nuclear
Neeharika Senthilkumar et al.
Summary: Magnetic nanoparticles with unique physicochemical properties are widely used for in vivo applications, but ensuring compliance with safety regulations remains a challenge.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Chemistry, Multidisciplinary
Jun Liu et al.
Summary: A double-layer coating strategy using tannic acid and enteric L100 was reported to encapsulate probiotics for improved delivery in the gastrointestinal tract. The encapsulated Escherichia coli demonstrated enhanced survival and proliferation capabilities, leading to superior efficacy against colitis. This spatiotemporal delivery method shows promise in enhancing the therapeutic efficacy of bacteria-based therapy for GI tract-related diseases.
Article
Chemistry, Multidisciplinary
Yang Wu et al.
Summary: The study uses nanomotors loaded with drugs to combat gastric cancer caused by Helicobacter pylori infection, successfully achieving rapid neutralization of gastric acid and drug release in animal models to achieve good therapeutic effects.
Article
Food Science & Technology
Chen Tan et al.
Summary: Yeast cells are considered emerging bioinspired delivery carriers with great potential in encapsulating hydrophobic and hydrophilic compounds, protection against environmental stresses, controlled release, biocompatibility, and biodegradability. The latest research developments from 2015 to 2021 have focused on intact and pretreated yeast cells, as well as their integration with other systems such as polymeric hydrogels and nano-in micro systems. Promising results have shown the potential of yeast cells in encapsulating, protecting, and controlled releasing food-related bioactives, suggesting a bright future in functional food industries.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Huaijuan Zhou et al.
Summary: Magnetic micro/nanorobots can be manipulated and guided in different fluid environments using magnetic fields, offering advantages such as remote control, reconfigurability, and fuel-free operation. They have diverse applications in targeted drug delivery, biofilm disruption, and environmental remediation.
Article
Multidisciplinary Sciences
Danni Zhong et al.
Summary: The innovative strategy of oral drug delivery using a formulation based on Spirulina platensis loaded with curcumin shows promise for treating intestinal diseases. The formulation not only improves drug bioavailability but also demonstrates excellent antitumor and anti-inflammatory efficacy.
Article
Chemistry, Multidisciplinary
Rodolfo Mundaca-Uribe et al.
Summary: A new microstirring pill technology has been developed to enhance the bioavailability of orally administered drugs. The embedded microstirrers allow for faster disintegration and dissolution of the drug, leading to improved release profiles of the medication. In vitro and in vivo studies demonstrate the potential for increased drug absorption and bioavailability with this technology.
Article
Multidisciplinary Sciences
Sisi Lin et al.
Summary: The oral delivery of camouflaged probiotics can induce mucosal immune responses, regulate the gut microbiota, maintain gut homeostasis, and provide defense against external threats. Studies show that this approach effectively prevents intestinal barrier breakdown, bacterial translocation, and systemic inflammation.
Article
Robotics
Ben Wang et al.
Summary: The study introduces a soft and resilient magnetic cell microrobot with high biocompatibility for navigation inside the human body. It demonstrates efficient delivery of soft microrobots through the integrated platform called endoscopy-assisted magnetic actuation with dual imaging system (EMADIS), allowing access to tiny regions deep within the body that are commonly inaccessible by traditional endoscopes and medical robots.
Article
Chemistry, Multidisciplinary
Hyun Sun Choi et al.
Summary: The esophagus is a highly dynamic environment where targeting drug delivery can be compromised due to turbulent processes. Magnetically guidable drug vehicles using bioengineered mussel adhesive protein (MAP) were proposed to achieve localized delivery of therapeutic drugs to target sites. The fabricated microfluidic MAP@IO MPs were successfully targeted and retained in the esophagus, showing effective drug release and anticancer activity with excellent biocompatibility. This approach provides an intelligent modular strategy for targeted therapeutic delivery in tubular organs like the esophagus.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Xiaoxuan Zhang et al.
Summary: The novel magneto-responsive microneedle robots are designed for efficient oral delivery of versatile macromolecules. With polarized magnetic substrate, the microneedle tips can target the small intestinal wall, insert into the tissue, and release encapsulated actives under specific magnetic fields, demonstrating practical values in oral delivery of insulin and blood glucose regulation.
ADVANCED MATERIALS
(2021)
Article
Gastroenterology & Hepatology
Wei-Ting Kuo et al.
Summary: The study found that ZO-1 expression was reduced in biopsy specimens from patients with inflammatory bowel disease. Despite mildly increased intestinal permeability, ZO-1(KO.IEC) mice were healthy and did not develop spontaneous disease. However, these mice were hypersensitive to mucosal insults and displayed defective repair.
Article
Multidisciplinary Sciences
Rita Manco et al.
Summary: Combining single-cell RNA sequencing with spatial information allows for the reconstruction of spatially-resolved tissue cell atlases, which is challenging for rare cell types. The ClumpSeq approach presented in this study enables the establishment of spatial atlases for all epithelial cell types in the small intestine, revealing immune-modulatory gene expression in villus tip goblet and tuft cells as well as heterogeneous migration patterns of enteroendocrine cells.
NATURE COMMUNICATIONS
(2021)
Review
Chemistry, Multidisciplinary
Yi Zhang et al.
Summary: The article discusses the advantages and potential of photodynamic therapy and sonodynamic therapy in the treatment of deep-seated tumors, as well as imaging-guided precise SDT and recent clinical trials. It also summarizes the strategies for designing sonosensitizers based on tumor environment and structure modifications, as well as the approach of SDT combination therapy.
CHEMICAL SOCIETY REVIEWS
(2021)
Review
Chemistry, Multidisciplinary
Matilde Duran-Lobato et al.
ADVANCED MATERIALS
(2020)
Review
Chemistry, Multidisciplinary
Marina Fernandez-Medina et al.
ADVANCED FUNCTIONAL MATERIALS
(2020)
Review
Oncology
Li-Qiang Zhou et al.
Article
Environmental Sciences
Susaimanickam Anto et al.
Review
Chemistry, Multidisciplinary
Juanfeng Ou et al.
Review
Nanoscience & Nanotechnology
Tyler D. Brown et al.
NATURE REVIEWS MATERIALS
(2020)
Review
Engineering, Biomedical
Vibhuti Agrahari et al.
Review
Genetics & Heredity
Swastik Sen et al.
FUNGAL GENETICS AND BIOLOGY
(2020)
Review
Chemistry, Multidisciplinary
Xuejing Cui et al.
Review
Gastroenterology & Hepatology
Rui Cai et al.
Article
Multidisciplinary Sciences
Xinyue Wang et al.
Article
Robotics
Songsong Tang et al.
Article
Engineering, Biomedical
Rodolfo Mundaca-Uribe et al.
ADVANCED HEALTHCARE MATERIALS
(2020)
Review
Cell Biology
Tetsuhisa Otani et al.
TRENDS IN CELL BIOLOGY
(2020)
Review
Multidisciplinary Sciences
Dekai Zhou et al.
Review
Multidisciplinary Sciences
Christine K. Schmidt et al.
NATURE COMMUNICATIONS
(2020)
Review
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Zhiguang Wu et al.
CHEMICAL SOCIETY REVIEWS
(2020)
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Jihong Min et al.
ADVANCED THERAPEUTICS
(2020)
Review
Materials Science, Biomaterials
Xiankang Hu et al.
BIOMATERIALS SCIENCE
(2020)
Review
Gastroenterology & Hepatology
Arthur J. Kastl et al.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2020)
Article
Chemistry, Multidisciplinary
Xiaoli Wei et al.
Review
Immunology
Andrea Dillon et al.
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Robotics
Zhiguang Wu et al.
Article
Chemistry, Multidisciplinary
Emil Karshalev et al.
Article
Multidisciplinary Sciences
Zhenping Cao et al.
NATURE COMMUNICATIONS
(2019)
Article
Robotics
Hui Xie et al.
Review
Engineering, Biomedical
T. L. Carlson et al.
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 20
(2018)
Review
Pharmacology & Pharmacy
Xabier Murgia et al.
ADVANCED DRUG DELIVERY REVIEWS
(2018)
Article
Chemistry, Multidisciplinary
Ming Luo et al.
ADVANCED FUNCTIONAL MATERIALS
(2018)
Article
Pharmacology & Pharmacy
Rahul Mittal et al.
EXPERT OPINION ON DRUG DELIVERY
(2018)
Review
Microbiology
Eric C. Martens et al.
NATURE REVIEWS MICROBIOLOGY
(2018)
Review
Chemistry, Multidisciplinary
Chuanrui Chen et al.
Review
Chemistry, Multidisciplinary
Berta Esteban-Fernandez de Avila et al.
ACCOUNTS OF CHEMICAL RESEARCH
(2018)
Article
Chemistry, Multidisciplinary
Emil Karshalev et al.
Article
Chemistry, Multidisciplinary
Oncay Yasa et al.
ADVANCED MATERIALS
(2018)
Review
Pharmacology & Pharmacy
A. Bak et al.
ADVANCED DRUG DELIVERY REVIEWS
(2018)
Review
Pharmacology & Pharmacy
Jonas Reinholz et al.
Article
Chemistry, Multidisciplinary
Berta Esteban-Fernandez de Avila et al.
ADVANCED FUNCTIONAL MATERIALS
(2018)
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