☆ 4.6 Review

Design of experiment (DoE) as a quality by design (QbD) tool to optimise formulations of lipid nanoparticles for nose-to-brain drug delivery

EXPERT OPINION ON DRUG DELIVERY (2023)

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Article Pharmacology & Pharmacy

Brain-targeted delivery of Valsartan using solid lipid nanoparticles labeled with Rhodamine B; a promising technique for mitigating the negative effects of stroke

Shereen A. A. Sabry et al.

Summary: The research aims to utilize solid lipid nanoparticles (SLNs) to transport valsartan across the blood-brain barrier (BBB) and mitigate the adverse effects of stroke. The optimized SLN formula showed sustained drug release, reducing the dose frequency and improving patient compliance. This method holds promise for delivering valsartan to the brain and alleviating the negative consequences of stroke.

DRUG DELIVERY (2023)

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Article Chemistry, Multidisciplinary

Design of experiments in the optimization of nanoparticle-based drug delivery systems

Riccardo Rampado et al.

Summary: Design of experiment (DoE) is a powerful statistical technique that aims to optimize output variables by varying multiple factors simultaneously, using the minimum number of experimental runs. Although DoE has great potential for innovation and process optimization, it is not widely applied in nanomedicine and is often not well understood.

JOURNAL OF CONTROLLED RELEASE (2023)

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Review Pharmacology & Pharmacy

Solid Lipid Nanoparticles vs. Nanostructured Lipid Carriers: A Comparative Review

Claudia Viegas et al.

Summary: Solid-lipid nanoparticles and nanostructured lipid carriers are delivery systems that enhance drug solubility, permeability, and bioavailability. The use of liquid and solid lipids in nanostructured lipid carriers allows for higher drug loading, improved drug release properties, and increased stability. This review discusses the production methods, characterization, and performance of solid lipid nanoparticles and nanostructured lipid carriers, and also addresses the toxicity concerns.

PHARMACEUTICS (2023)

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Article Chemistry, Medicinal

Lyophilized Nasal Inserts of Atomoxetine HCl Solid Lipid Nanoparticles for Brain Targeting as a Treatment of Attention-Deficit/Hyperactivity Disorder (ADHD): A Pharmacokinetics Study on Rats

Mahmoud H. Teaima et al.

Summary: The study investigated the use of lyophilized nasal inserts of nanosized atomoxetine HCl solid lipid nanoparticles (ATM-SLNs) to directly deliver atomoxetine to the brain. A full factorial design was used to optimize the formulation of the ATM-SLNs, and Design Expert software was used to select the optimal formulations. The two optimum formulations were then evaluated for their physicochemical properties and compared to atomoxetine oral solution and intraperitoneal injection.

PHARMACEUTICALS (2023)

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Review Chemistry, Physical

Nose-to-Brain Targeting via Nanoemulsion: Significance and Evidence

Shashi Kiran Misra et al.

Summary: Non-invasive and patient-friendly nose-to-brain pathway is the best route for brain delivery of therapeutics, bypassing the blood-brain barrier. The olfactory and trigeminal pathways provide a direct route for the entry of therapeutics into the brain, facilitating better biodistribution and bypassing BBB issues.

COLLOIDS AND INTERFACES (2023)

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Article Pharmacology & Pharmacy

Development of Atomoxetine-Loaded NLC In Situ Gel for Nose-to-Brain Delivery: Optimization, In Vitro, and Preclinical Evaluation

Dibyalochan Mohanty et al.

Summary: This study investigates the brain-targeted efficiency of atomoxetine-loaded nanostructured lipid carrier-loaded thermosensitive in situ gel after intranasal administration. The optimized AXT-NLC formulation showed excellent properties and high encapsulation efficiency. The AXT-NLC in situ gel displayed sustained release and improved brain delivery through the intranasal route.

PHARMACEUTICS (2023)

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Article Pharmacology & Pharmacy

Cod liver oil nano-structured lipid carriers (Cod-NLCs) as a promising platform for nose to brain delivery: Preparation, in vitro optimization, ex vivo cytotoxicity & in vivo biodistribution utilizing radioiodinated zopiclone

Esraa Taha et al.

Summary: Nano-structured lipid carriers were prepared for targeted drug delivery of zopiclone to the brain via the nasal route. The optimized lipid carriers exhibited high encapsulation efficiency, small particle size, and low polydispersity index. In vivo studies in mice confirmed the superiority of nasal administration in delivering zopiclone to the brain. Therefore, nano-structured lipid carriers hold great potential as an effective tool for insomnia treatment.

INTERNATIONAL JOURNAL OF PHARMACEUTICS-X (2023)

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Article Pharmacology & Pharmacy

Intranasal delivery of chitosan decorated nanostructured lipid carriers of Buspirone for brain targeting: Formulation development, optimization and In-Vivo preclinical evaluation

K. M. Noorulla et al.

Summary: The study aimed to design and optimize Buspirone-loaded nano structured lipid carriers coated with Chitosan for nose to brain delivery. The optimized formulation exhibited acceptable performance with higher bioavailability and targeting efficiency.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2022)

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Article Pharmacology & Pharmacy

Thermoresponsive in situ gel of curcumin loaded solid lipid nanoparticle: Design, optimization and in vitro characterization

Mukta Agrawal et al.

Summary: Curcumin has been shown to have antioxidant, anti-inflammatory, amyloid inhibition, and neuroprotective properties, but its poor solubility, lipophilicity, rapid metabolism, and short half-life limit its efficacy in treating AD. This study developed curcumin-loaded solid lipid nanoparticles (CSL) to improve the physicochemical properties and achieved prolonged release. However, the loading reduced the antioxidant potency of curcumin.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2022)

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Review Pharmacology & Pharmacy

Solid lipid nanoparticles and nanostructured lipid carriers: a review of the methods of manufacture and routes of administration

Jafar Akbari et al.

Summary: The bioavailability of drugs depends on factors like solubility and administration route. Lipid nanoparticles are being used in pharmaceutical science due to their importance in green chemistry. They can act as carriers for both lipophilic and hydrophilic drugs. Solid lipid nanoparticles and nanostructured lipid carriers are attractive delivery systems because of their ease of manufacture, biocompatibility, biodegradability, and scalability.

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY (2022)

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Article Pharmacology & Pharmacy

Thymoquinone-Enriched Naringenin-Loaded Nanostructured Lipid Carrier for Brain Delivery via Nasal Route: In Vitro Prospect and In Vivo Therapeutic Efficacy for the Treatment of Depression

Farheen Fatima Qizilbash et al.

Summary: In this study, a thymoquinone-enriched naringenin-loaded nanostructured lipid carrier was developed for nasal delivery in the treatment of depression. The optimized carrier exhibited excellent drug release and permeation properties, leading to improved therapeutic effect compared to traditional suspension and marketed formulation.

PHARMACEUTICS (2022)

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Review Pharmacology & Pharmacy

Lipid nanoparticles strategies to modify pharmacokinetics of central nervous system targeting drugs: Crossing or circumventing the blood- brain barrier (BBB) to manage neurological disorders

A. C. Correia et al.

Summary: The success of central nervous system therapies is limited by the challenge of drugs crossing the blood-brain barrier. This review discusses the use of lipid nanoparticles to modify the pharmacokinetics of drugs used in neurological disorders, with a focus on improving drug delivery to the brain.

ADVANCED DRUG DELIVERY REVIEWS (2022)

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Article Geriatrics & Gerontology

QbD-based rivastigmine tartrate-loaded solid lipid nanoparticles for enhanced intranasal delivery to the brain for Alzheimer's therapeutics

Deepshi Arora et al.

Summary: This study developed solid lipid nanoparticles loaded with rivastigmine tartrate for intranasal delivery and evaluated its efficiency. The results showed the potential of this nanoparticle system for the treatment of Alzheimer's disease.

FRONTIERS IN AGING NEUROSCIENCE (2022)

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Article Pharmacology & Pharmacy

Formulation of intranasal surface engineered nanostructured lipid carriers of rotigotine: Full factorial design optimization, in vitro characterization, and pharmacokinetic evaluation

Ameeduzzafar Zafar et al.

Summary: The objective of this research was to develop, optimize, and evaluate rotigotine-loaded chitosan coated nanostructured lipid carriers for nose-to-brain delivery. The optimized formulation showed small particle size, high encapsulation efficiency, sustained drug release, and improved brain targeting potential. The results suggest that this formulation could be a promising strategy for targeting rotigotine to the brain via intranasal administration.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

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Article Pharmacology & Pharmacy

Nose to brain delivery of donepezil through surface modified NLCs: Formulation development, optimization, and brain targeting study

Mohd Yasir et al.

Summary: The study aimed to develop DPZ-loaded nanostructured lipid carriers coated with chitosan for brain targeting via intranasal route, showing promising results for the treatment of Alzheimer's disease.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2022)

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Editorial Material Chemistry, Medicinal

Editorial-Current Insights on Lipid-Based Nanosystems

Ana Catarina Silva et al.

PHARMACEUTICALS (2022)

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Proceedings Paper Materials Science, Multidisciplinary

Design, Development and Optimization of Solid Lipid Nanoparticles of Rizatriptan for Intranasal delivery: Invitro & Invivo assessment

Vasudha Bakshi et al.

Summary: Solid lipid nanoparticles have emerged as a promising technology in nanomedicine, offering a range of potential applications in drug delivery. The incorporation of drugs into nanocarriers allows for targeted drug delivery to the brain and improved drug absorption.

MATERIALS TODAY-PROCEEDINGS (2022)

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Review Engineering, Biomedical

Lipid Nanoparticles for Drug Delivery

Letao Xu et al.

Summary: This article provides an overview of lipid nanoparticles, including their different types, preparation methods, and applications in drug delivery. It also summarizes the challenges and potential future studies for lipid nanoparticles to achieve wider clinical and pharmaceutical applications.

ADVANCED NANOBIOMED RESEARCH (2022)

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Article Chemistry, Medicinal

Development and Characterization of n-Propyl Gallate Encapsulated Solid Lipid Nanoparticles-Loaded Hydrogel for Intranasal Delivery

Fakhara Sabir et al.

Summary: The study successfully developed solid lipid nanoparticles loaded with n-propyl gallate in a hydrogel formulation using Transcutol-P as a permeation enhancer. The optimized PG-SLNs-loaded HG showed lower burst effect, sustained release profile, improved antioxidant activity, and enhanced permeation compared to SLNs. The combination of SLNs and HG has the potential to improve nasal absorption of antioxidants due to enhanced stability and mucoadhesive properties.

PHARMACEUTICALS (2021)

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Article Pharmacology & Pharmacy

Buspirone loaded solid lipid nanoparticles for amplification of nose to brain efficacy: Formulation development, optimization by Box-Behnken design, in-vitro characterization and in-vivo biological evaluation

Mohd Yasir et al.

Summary: The study explored the use of solid lipid nanoparticles (SLNs) loaded with Buspirone (BUS) for nose to brain delivery, showing improved brain targeting efficiency compared to conventional methods. Results indicated that SLNs could serve as a potential drug delivery system for brain targeting via intranasal route.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2021)

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Review Pharmacology & Pharmacy

Intranasal delivery of nanostructured lipid carriers, solid lipid nanoparticles and nanoemulsions: A current overview of in vivo studies

Claudia Pina Costa et al.

Summary: The management of CNS disorders is challenging due to the need for drugs to cross the BBB and reach the brain. Using the intranasal route combined with lipid-based nanocarriers has shown promising results in targeting drugs to the brain. Although the exact mechanism remains unclear, these systems are more effective than other routes and are expected to be approved by regulatory authorities in the future.

ACTA PHARMACEUTICA SINICA B (2021)

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Review Pharmacology & Pharmacy

Machine learning directed drug formulation development

Pauric Bannigan et al.

Summary: Machine learning has made significant advances in the healthcare and pharmaceutical sectors, especially in drug formulation development. Traditional approaches to drug formulation development are time-consuming and limited, while machine learning can help accelerate drug formulation development, improve the bioavailability and targeted delivery of new drugs.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Article Pharmacology & Pharmacy

Intranasal delivery of Naloxone-loaded solid lipid nanoparticles as a promising simple and non-invasive approach for the management of opioid overdose

Nazeer Hasan et al.

Summary: The study developed naloxone-loaded solid-lipid nanoparticles for intranasal administration, addressing the limitations of oral administration and achieving improved therapeutic effects; the optimized formulation showed efficient drug release and uptake by nasal membrane; in vitro and in vivo experiments demonstrated the effectiveness and safety of the nanoscale formulation in treating opioid overdose.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Article Pharmacology & Pharmacy

Clozapine loaded nanostructured lipid carriers engineered for brain targeting via nose-to-brain delivery: Optimization and in vivo pharmacokinetic studies

Hetal P. Patel et al.

Summary: Tailored clozapine-loaded nanostructured lipid carriers (NLCs) designed in this study significantly improved the therapeutic concentration of clozapine in brain tissue, bypassed hepatic first-pass metabolism, and overcame the blood-brain barrier, showing a 6.15-fold increase in relative bioavailability, potentially benefiting schizophrenia treatment.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2021)

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Article Pharmacology & Pharmacy

Sesame Oil-Based Nanostructured Lipid Carriers of Nicergoline, Intranasal Delivery System for Brain Targeting of Synergistic Cerebrovascular Protection

Mohammed A. S. Abourehab et al.

Summary: Sesame oil-based NIC-NLC was successfully formulated and optimized for intranasal delivery, showing promising synergy in neuroprotection. The optimized formula exhibited excellent bioavailability and brain targeting efficiency, indicating its potential for treating dementia.

PHARMACEUTICS (2021)

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Review Pharmacology & Pharmacy

The importance of pre-formulation studies and of 3D-printed nasal casts in the success of a pharmaceutical product intended for nose-to-brain delivery

Laura Deruyver et al.

Summary: This review discusses three hot topics in drug delivery: pre-formulation of new products for nose-to-brain delivery, development of nasal casts for studying efficacy of potential systems, and use of 3D printing technology. These topics are interconnected and should be considered as a whole for effective drug delivery strategies.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Article Biophysics

Systematically designed chitosan-coated solid lipid nanoparticles of ferulic acid for effective management of Alzheimer's disease: A preclinical evidence

Sumant Saini et al.

Summary: The study aimed to improve the therapeutic efficacy of ferulic acid (FA) in Alzheimer's disease (AD) by developing chitosan-coated solid lipid nanoparticles (SLNs) using quality by design (QbD) approach. The optimized SLNs showed promising outcomes in terms of improved mucoadhesion and permeation, extended drug release, enhanced patient compliance potential, safety, and effectiveness in preclinical studies.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

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Article Nanoscience & Nanotechnology

Improving Drug Delivery for Alzheimer's Disease Through Nose-to-Brain Delivery Using Nanoemulsions, Nanostructured Lipid Carriers (NLC) and in situ Hydrogels

Sara Cunha et al.

Summary: Treatment for Alzheimer's disease focuses on slowing symptom progression and enhancing quality of life. Nasal delivery offers a potential alternative route to directly deliver drugs to the brain, but clearance mechanisms in the nasal cavity hinder drug delivery efficiency. Formulations of lipid-based nanosystems show promise in optimizing nose-to-brain drug delivery, minimizing side effects, and maximizing therapeutic benefits.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Article Pharmacology & Pharmacy

Quality by design (QbD) optimization of diazepam-loaded nanostructured lipid carriers (NLC) for nose-to-brain delivery: Toxicological effect of surface charge on human neuronal cells

C. P. Costa et al.

Summary: Optimized diazepam-loaded NLC formulation with negative surface charge showed smaller particle size, higher encapsulation efficiency, and better biocompatibility for targeting the brain compared to the formulation with positive surface charge. The sustained drug release effect was observed in both formulations, with the negative surface charge formulation exhibiting greater cytotoxicity than the positive surface charge formulation.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Article Pharmacology & Pharmacy

Design, optimization and pharmacokinetic evaluation of Piribedil loaded solid lipid nanoparticles dispersed in nasal in situ gelling system for effective management of Parkinson's disease

Chandra Teja Uppuluri et al.

Summary: In this study, solid lipid nanoparticles (PBD-SLNs) were developed as a drug delivery system for the anti-Parkinson's drug, Piribedil (PBD), to improve its absorption efficiency and stability. By optimizing the particle size and morphology, the PBD-SLNs showed significantly increased drug uptake and stability. Loading the SLNs into thermoresponsive Methyl Cellulose in situ gel (PBD-SLN-ISG) led to improved drug delivery to the brain in rats, resulting in a four-fold increase in the area under the curve (AUC) and a 2.3-fold decrease in maximum plasma concentration (C-max) compared to plain intranasal suspension of PBD.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Article Pharmacology & Pharmacy

Nose to brain delivery of Rotigotine loaded solid lipid nanoparticles: Quality by design based optimization and characterization

Jagruti B. Prajapati et al.

Summary: In this study, Rotigotine-loaded Solid Lipid Nanoparticles (RTG-SLNs) were optimized using a Quality by Design approach to improve oral bioavailability. The optimized RTG-SLNs demonstrated desired particle size, entrapment efficiency, polydispersivity index, and in-vitro drug release rate. Permeability studies and cellular uptake analysis confirmed the permeability and non-toxicity of RTG-SLNs.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2021)

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Review Food Science & Technology

Recent Applications of Mixture Designs in Beverages, Foods, and Pharmaceutical Health: A Systematic Review and Meta-Analysis

Diego Galvan et al.

Summary: This review highlights the widespread application of mixture designs in the food, beverage, and pharmaceutical health fields, with Brazil being the country with the most works using MDs and America and Asia showing equal prevalence in applications. Data analysis by SOM reveals the prevalence of MDs in functional/nutraceutical product development in America and health science in Asia.

FOODS (2021)

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Article Pharmacology & Pharmacy

Development of Carbamazepine Nanostructured Lipid Carrier Loaded Thermosensitive Gel for Intranasal Delivery

Sanjeevani Shekhar Deshkar et al.

Summary: The study aimed to develop and evaluate a nanostructured lipid carrier (NLC) based in-situ gel for nasal delivery of carbamazepine (CBZ), showing improved anticonvulsant activity. The optimized CBZ NLC formulation had 20% drug loading, particle size of 132.8 nm, entrapment efficiency of 89.73%, and drug diffusion of 55.95%.

ADVANCED PHARMACEUTICAL BULLETIN (2021)

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Article Pharmacology & Pharmacy

Formulation development of lipid nanoparticles: Improved lipid screening and development of tacrolimus loaded nanostructured lipid carriers (NLC)

Andelka B. Kovacevic et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

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Article Chemistry, Medicinal

Coated Lipidic Nanoparticles as a New Strategy for Enhancing Nose -to -Brain Delivery of a Hydrophilic Drug Molecule

Lamis H. Salem et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2020)

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Review Nanoscience & Nanotechnology

Using the quality by design (QbD) approach to optimize formulations of lipid nanoparticles and nanoemulsions: A review

Sara Cunha et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2020)

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Article Pharmacology & Pharmacy

Double Optimization of Rivastigmine-Loaded Nanostructured Lipid Carriers (NLC) for Nose-to-Brain Delivery Using the Quality by Design (QbD) Approach: Formulation Variables and Instrumental Parameters

Sara Cunha et al.

PHARMACEUTICS (2020)

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Article Chemistry, Multidisciplinary

Can machine learning predict drug nanocrystals?

Yuan He et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Pharmacology & Pharmacy

Nose-to-brain delivery of sumatriptan-loaded nanostructured lipid carriers: preparation, optimization, characterization and pharmacokinetic evaluation

Moein Masjedi et al.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2020)

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Pessaries containing nanostructured lipid carriers (NLC) for prolonged vaginal delivery of progesterone

A. Correia et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2020)

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Nose-to-brain delivery of lipid-based nanosystems for epileptic seizures and anxiety crisis

C. Costa et al.

JOURNAL OF CONTROLLED RELEASE (2019)

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Review Pharmacology & Pharmacy

Nanoemulsions for Nose-to-Brain Drug Delivery

Maria Cristina Bonferoni et al.

PHARMACEUTICS (2019)

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Article Chemistry, Medicinal

y Optimization of Nanostructured Lipid Carriers of Lurasidone Hydrochloride Using Box-Behnken Design for Brain Targeting: In Vitro and In Vivo Studies

Imrana Jazuli et al.

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Design of Experiments in Pharmaceutical Development

Abhishek S. Dhoot et al.

PHARMACEUTICAL CHEMISTRY JOURNAL (2019)

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Statistical Design of Experiments for Screening and Optimization

Robert Lee

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Nanostructured lipid carriers for improved oral delivery and prolonged antihyperlipidemic effect of simvastatin

Heba A. Fathi et al.

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Review Pharmacology & Pharmacy

Formulations based on solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for cutaneous use: A review

A. Garces et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2018)

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Review Pharmacology & Pharmacy

Lipid nanoparticles for intranasal administration: application to nose-to-brain delivery

Luigi Battaglia et al.

EXPERT OPINION ON DRUG DELIVERY (2018)

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Review Chemistry, Multidisciplinary

Nose-to-brain drug delivery: An update on clinical challenges and progress towards approval of anti-Alzheimer drugs

Mukta Agrawal et al.

JOURNAL OF CONTROLLED RELEASE (2018)

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Review Pharmacology & Pharmacy

Impact of Particle Size and Polydispersity Index on the Clinical Applications of Lipidic Nanocarrier Systems

M. Danaei et al.

PHARMACEUTICS (2018)

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Review Pharmacology & Pharmacy

Surface-Modified Nanocarriers for Nose-to-Brain Delivery: From Bioadhesion to Targeting

Fabio Sonvico et al.

PHARMACEUTICS (2018)

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Review Pharmacology & Pharmacy

Quality by design (QbD) approaches in current pharmaceutical set-up

Vijay Mishra et al.

EXPERT OPINION ON DRUG DELIVERY (2018)

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Article Chemistry, Multidisciplinary

Evidence of nose-to-brain delivery of nanoemulsions: cargoes but not vehicles

Ejaj Ahmad et al.

NANOSCALE (2017)

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Review Pharmacology & Pharmacy

Intranasal Lipid Nanoparticles for the Treatment of Neurodegenerative Diseases

S. Cunha et al.

CURRENT PHARMACEUTICAL DESIGN (2017)

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Review Chemistry, Multidisciplinary

Lipid nanoparticles: Different preparation techniques, characterization, hurdles, and strategies for the production of solid lipid nanoparticles and nanostructured lipid carriers for oral drug delivery

Poovi Ganesan et al.

SUSTAINABLE CHEMISTRY AND PHARMACY (2017)

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Review Chemistry, Medicinal

Design of experiments (DoE) in pharmaceutical development

Stavros N. Politis et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2017)

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Review Pharmacology & Pharmacy

PEGylation as a strategy for improving nanoparticle-based drug and gene delivery

Jung Soo Suk et al.

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Article Pharmacology & Pharmacy

Quality by design case study 1: Design of 5-fluorouracil loaded lipid nanoparticles by the W/O/W double emulsion - Solvent evaporation method

Gulin Amasya et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2016)

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Pharmaceutical product development: A quality by design approach

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INTERNATIONAL JOURNAL OF PHARMACEUTICAL INVESTIGATION (2016)

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Understanding Pharmaceutical Quality by Design

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AAPS JOURNAL (2014)

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Effect of surface charge on the brain delivery of nanostructured lipid carriers in situ gels via the nasal route

Yasmine M. Gabal et al.

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Experimental design and multiple response optimization. Using the desirability function in analytical methods development

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A quality by design approach using artificial intelligence techniques to control the critical quality attributes of ramipril tablets manufactured by wet granulation

Buket Aksu et al.

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Solid lipid nanoparticles Production, characterization and applications

Wolfgang Mehnert et al.

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Solid lipid nanoparticles (SLN) - based hydrogels as potential carriers for oral transmucosal delivery of Risperidone: Preparation and characterization studies

A. C. Silva et al.

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Risperidone Release from Solid Lipid Nanoparticles (SLN): Validated HPLC Method and Modelling Kinetic Profile

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Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues

Samuel K. Lai et al.

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Samuel K. Lai et al.

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Box-Behnken design: An alternative for the optimization of analytical methods

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Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus

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Mixture and mixture process variable experiments for pharmaceutical applications

CM Anderson-Cook et al.

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Optimisation of a flow injection system with electrochemical detection using the desirability function - Application to the determination of hydroquinone in cosmetics

ME Rueda et al.

ANALYTICA CHIMICA ACTA (2003)

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An example of application of a mixture design with constraints to a pharmaceutical formulation

S Cafaggi et al.

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JOURNAL OF CHEMOMETRICS (2002)

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Solid lipid nanoparticles (SLN) for controlled drug delivery -: a review of the state of the art

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