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Synthetic engineered bacteria for cancer therapy

EXPERT OPINION ON DRUG DELIVERY (2023)

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Article Oncology

Association of Machine Learning-Based Assessment of Tumor-Infiltrating Lymphocytes on Standard Histologic Images With Outcomes of Immunotherapy in Patients With NSCLC

Mehrdad Rakaee et al.

Summary: This study developed a machine-learning-based approach to evaluate the association between tumor-infiltrating lymphocytes (TILs) and immune checkpoint inhibitor (ICI) therapy in lung cancer patients. The results showed that high levels of TILs were associated with ICI treatment response and could be used for patient selection and precision therapy guidance.

JAMA ONCOLOGY (2023)

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Article Oncology

Intraventricular B7-H3 CAR T Cells for Diffuse Intrinsic Pontine Glioma: Preliminary First-in-Human Bioactivity and Safety

Nicholas A. Vitanza et al.

Summary: This study reports the first administration of repeatedly dosed intracranial B7-H3 CAR T cells for patients with DIPG, indicating tolerability, detection of CAR T cells in the CSF, elevation of CSF cytokines supporting locoregional immune activation, and the feasibility of serial mass spectrometry from both serum and CSF.

CANCER DISCOVERY (2023)

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Article Multidisciplinary Sciences

Programming the lifestyles of engineered bacteria for cancer therapy

Shengwei Fu et al.

Summary: Programming intratumoral bacterial lifestyle transitions allows precise control of multiple key steps throughout the bacteria-mediated cancer therapy process and therapeutic efficacy can be greatly improved by controlling the localization and dosage of therapeutic agents via optimizing the illumination scheme.

NATIONAL SCIENCE REVIEW (2023)

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Article Chemistry, Multidisciplinary

Dressing Bacteria With a Hybrid Immunoactive Nanosurface to Elicit Dual Anticancer and Antiviral Immunity

Ying Liu et al.

Summary: This article reports a method of treating cancer and protecting susceptible patients from lethal infections (such as COVID-19) by dressing bacteria with a hybrid immunoactive nanosurface. The dressed bacteria release immunoactivators to stimulate immune cells, promoting immune responses against tumors and viruses.

ADVANCED MATERIALS (2023)

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Article Cell & Tissue Engineering

Targeting of low ALK antigen density neuroblastoma using AND logic- gate engineered CAR-T cells

Emma Halliwell et al.

Summary: The authors generated and screened a single-chain variable fragment library to obtain a panel of new anti-ALK CAR T-cell constructs, and one of the novel CAR T-cell constructs showed specific cytotoxicity against neuroblastoma cells expressing low levels of ALK. They also demonstrated the strategy of amplifying ALK CAR T cells by introducing signal 2 from anti-B7H3 or GD2 chimeric co-stimulatory receptors, which successfully avoided on-target off-tumor toxicity. These data provide further proof of concept for ALK as a neuroblastoma CAR T-cell target.

CYTOTHERAPY (2023)

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Article Chemistry, Multidisciplinary

Engineered Bacteria for Enhanced Radiotherapy against Breast Carcinoma

Pei Pan et al.

Summary: In this study, an integrated nanosystem composed of engineered bacteria and nanoparticles was developed for sensitizing radiotherapy. The system could target tumor sites and release a radiosensitizer, enhancing the effectiveness of radiotherapy.

ACS NANO (2022)

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Article Chemistry, Multidisciplinary

Direct Synthesis of Photosensitizable Bacterial Cellulose as Engineered Living Material for Skin Wound Repair

Xingang Liu et al.

Summary: Living materials based on bacterial cellulose have great potential as natural wound dressings. This study explores a direct synthetic method using microbial metabolism to fabricate photosensitizer-grafted bacterial cellulose, which exhibits excellent fluorescence and light-triggered bactericidal activity for skin wound repair.

ADVANCED MATERIALS (2022)

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Article Oncology

Cancer statistics, 2022

Rebecca L. Siegel et al.

Summary: Each year, the American Cancer Society compiles data on cancer occurrence and outcomes in the United States. The latest data shows that breast and prostate cancer progress has stagnated, while lung cancer has shown improvements in survival rates. Lung cancer incidence for advanced disease has declined while localized-stage rates have increased, resulting in higher survival rates. Mortality patterns align with incidence trends, with lung cancer deaths declining rapidly, breast cancer deaths slowing, and prostate cancer deaths stabilizing.

CA-A CANCER JOURNAL FOR CLINICIANS (2022)

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Article Chemistry, Multidisciplinary

Nanoengineered Bifidobacterium bifidum with Optical Activity for Photothermal Cancer Immunotheranostics

Sheethal Reghu et al.

Summary: This study demonstrates the nanoengineering of bacteria to encapsulate dye molecules and create functional bacteria with fluorescence and anticancer properties. The functional bacteria showed excellent tumor targeting and immune responses in a mouse tumor model, making them a promising strategy for cancer immunotherapy.

NANO LETTERS (2022)

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Article Chemistry, Multidisciplinary

Microbiotic nanomedicine for tumor-specific chemotherapy-synergized innate/adaptive antitumor immunity

Wencheng Wu et al.

Summary: This study reports a novel microbiotic nanomedicine LOD/TPZ@Lips-LA, which combines lactate oxidase (LOD) and prodrug tirapazamine (TPZ) loaded liposomes anchored on lactobacillus (LA) surface for chemotherapy-synergized antitumor immunity. The nanomedicine induces tumor cell apoptosis through in situ ROS generation and TPZ activation based on LA metabolism, resulting in strong immunogenic cell death (ICD). By regulating biomarker expression, it promotes anti-tumorigenic M1 polarization of innate tumor-associated macrophages and infiltration of adaptive cytotoxic CD8+ T cells, synergistically enhancing the tumor inhibition effects.

NANO TODAY (2022)

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Review Oncology

Radiotherapy as a tool to elicit clinically actionable signalling pathways in cancer

Giulia Petroni et al.

Summary: Targeted anticancer agents have been successful in inhibiting specific molecular alterations in cancer cells, while radiotherapy activates cytotoxic pathways and protective mechanisms that can enhance the efficacy of these agents. By promoting non-oncogene dependence on targetable signaling pathways, radiotherapy has the potential to benefit a greater number of patients who may not respond to targeted therapies alone.

NATURE REVIEWS CLINICAL ONCOLOGY (2022)

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Article Chemistry, Multidisciplinary

Bacterially Synthesized Tellurium Nanorods for Elimination of Advanced Malignant Tumor by Photothermal Immunotherapy

Yuzhu Yao et al.

Summary: Probiotic Escherichia coli Nissle 1917 is used as a bioreactor to synthesize tellurium nanorods, creating a biohybrid therapeutic platform for eliminating advanced malignant tumors through photothermal immunotherapy. The bacteria-synthesized nanorods show superior photothermal properties and can effectively suppress tumor metastasis and recurrence, with minimal acute side effects in healthy mice.

SMALL (2022)

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Review Oncology

Hallmarks of Cancer: New Dimensions

Douglas Hanahan

Summary: The concept of the hallmarks of cancer is a tool for simplifying the complexity of cancer phenotypes and genotypes into basic principles. This article proposes phenotypic plasticity and disrupted differentiation as distinct hallmark capabilities, and discusses nonmutational epigenetic reprogramming and polymorphic microbiomes as enabling characteristics. Additionally, the importance of senescent cells in the tumor microenvironment is highlighted. The integrative concept of the hallmarks of cancer helps in understanding the mechanisms of cancer development and applying that knowledge to cancer medicine.

CANCER DISCOVERY (2022)

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Article Biotechnology & Applied Microbiology

Bacteria-engineered porous sponge for hemostasis and vascularization

Jie Bian et al.

Summary: The study introduces a new hemostatic sponge, OBNC-DFO, which promotes rapid clotting and vascularization. The results indicate that OBNC-DFO has superior pro-coagulation and vascularization effects, promoting skin regeneration and functional recovery.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Article Chemistry, Multidisciplinary

Polydopamine Nanoparticle-Mediated Dopaminergic Immunoregulation in Colitis

Juanjuan Li et al.

Summary: The study explores the use of the dopaminergic system to suppress hyperactive immune responses and synthesizes a polydopamine nanoparticular immunosuppressant. It shows that the immunosuppressant can regulate T cell balance and be combined with gut microbiota modulation to treat inflammation effectively.

ADVANCED SCIENCE (2022)

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Article Engineering, Biomedical

Systemic immune responses to irradiated tumours via the transport of antigens to the tumour periphery by injected flagellate bacteria

Wenguang Wang et al.

Summary: Flagellated bacteria coated with antigen-adsorbing polymer nanoparticles and injected into tumours in mice after radiotherapy elicit systemic antitumour effects by transporting antigens to the tumour's periphery. This finding highlights the potential of leveraging bacteria to enhance dendritic cell activation and improve in situ cancer vaccination strategies.

NATURE BIOMEDICAL ENGINEERING (2022)

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Review Oncology

Chemotherapy: a double-edged sword in cancer treatment

Nafiseh Behranvand et al.

Summary: Chemotherapy is a well-known and effective treatment for cancers, but its efficiency in eradicating all cancer cells falls short of expectations. Research suggests that alterations in the tumor microenvironment's physiological conditions may contribute to this. Using mild anti-inflammatory drugs during chemotherapy could potentially lead to more successful clinical outcomes.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2022)

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Article Nanoscience & Nanotechnology

Smart Magnetotactic Bacteria Enable the Inhibition of Neuroblastoma under an Alternating Magnetic Field

Changyou Chen et al.

Summary: Magnetotactic bacteria are microorganisms that can synthesize magnetic nanoparticles called magnetosomes. The intact cells of Magnetospirillum magneticum AMB-1 show promising potential as a natural material for cancer therapy using magnetic hyperthermia. In both in vitro and in vivo experiments, the intact cells demonstrate superior heating capability compared to magnetosome chains or individual magnetosomes. They also exhibit better dispersal and decreased cellular viability when incubated with tumor cells under an alternating magnetic field. In vivo experiments with mice further confirmed the excellent antitumor activity of intact AMB-1 cells compared to other treatment groups.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Nanoscience & Nanotechnology

Bacteria-Mediated Intracellular Click Reaction for Drug Enrichment and Selective Apoptosis of Drug-Resistant Tumor Cells

Zhiqiang Gao et al.

Summary: This study reports the enrichment of therapeutic drugs in tumor cells through intracellular click reaction with functionalized bacteria. Functionalized biocarriers, constructed by combining positively charged oligo(phenylene-vinylene)-alkyne with E. coli, can retain and enrich drug molecules inside drug-resistant tumor cells, providing a solution to overcome drug efflux and selectively induce apoptosis.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Chemistry, Multidisciplinary

Intravenous Delivery of Living Listeria monocytogenes Elicits Gasdmermin-Dependent Tumor Pyroptosis and Motivates Anti-Tumor Immune Response

Yao Liu et al.

Summary: In this study, an immunotherapy system based on red blood cell membrane encapsulated Listeria monacytagenes (Lmo@RBC) was developed to address the limitations of Lmo as a cancer vaccine. Lmo@RBC showed low systemic inflammatory response and enhanced accumulation in tumors, resulting in a strong and durable anti-tumor immune response with excellent therapeutic effects.

ACS NANO (2022)

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Article Chemistry, Multidisciplinary

An Engineered Bacteria-Hybrid Microrobot with the Magnetothermal Bioswitch for Remotely Collective Perception and Imaging-Guided Cancer Treatment

Haotian Chen et al.

Summary: This study presents a biohybrid microrobot that integrates magnetic, thermal, and hypoxia sensitivities for targeted cancer treatment. The microrobot demonstrates good thermal sensitivity and active targeting ability under a magnetic field, and efficiently triggers cancer cell apoptosis through magnetothermal ablation and NDH-2-induced ROS damage.

ACS NANO (2022)

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Article Chemistry, Multidisciplinary

Physiologically Inspired Mucin Coated Escherichia coli Nissle 1917 Enhances Biotherapy by Regulating the Pathological Microenvironment to Improve Intestinal Colonization

Xinyuan Yang et al.

Summary: Coating probiotics with tannic acid and mucin can enhance their survival and colonization in the gastrointestinal tract, leading to potential applications in disease prevention and treatment.

ACS NANO (2022)

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Article Chemistry, Multidisciplinary

Cell-Mediated Biointerfacial Phenolic Assembly for Probiotic Nano Encapsulation

Franco Centurion et al.

Summary: The concept of a cell-mediated catalytic process for forming protective nano-shells on probiotic cells is demonstrated. This method leverages the cell environment to induce the oxidation of phenolic compounds and assemble them into nano-coatings around the cell surfaces. The coated probiotic cells show improved gastric tolerance, enhanced adhesion, and high antioxidant activity.

ADVANCED FUNCTIONAL MATERIALS (2022)

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Article Chemistry, Multidisciplinary

Decorating Bacteria with Triple Immune Nanoactivators Generates Tumor-Resident Living Immunotherapeutics

Juanjuan Li et al.

Summary: This study reports a method of decorating bacteria with triple immune nanoactivators to develop tumor-resident living immunotherapeutics. The decorated bacteria show targeted tumor retention and release of drugs, achieving potent antitumor effects. This work provides a versatile platform for cancer immunotherapy.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

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Article Biochemistry & Molecular Biology

Drug-loaded nanoparticles conjugated with genetically engineered bacteria for cancer therapy

Yan Du et al.

Summary: In this study, genetically engineered bacteria and drug-loaded nanoparticles were combined to enhance the therapeutic efficacy of high-intensity focused ultrasound (HIFU) tumor ablation therapy. The results showed that conjugating cationic lipid nanoparticles loaded with paclitaxel and perfluorohexane with genetically modified Escherichia coil enhanced the treatment efficacy.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2022)

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Article Engineering, Environmental

An oral ?Super probiotics? with versatile self-assembly adventitia for enhanced intestinal colonization by autonomous regulating the pathological microenvironment

Jiali Yang et al.

Summary: Transplanting beneficial bacteria to the gut microbiome is a promising strategy for disease prevention and treatment. However, oral probiotic delivery faces challenges from the physiological and pathological microenvironments. In this study, a Super Gut Microorganism (SGM) was designed with a self-assembling coating that enhanced intestinal colonization and autonomously modulated the pathological microenvironment, improving probiotic survival. Additionally, the coating facilitated strong intestinal mucosal adhesion, particularly in disease conditions. SGM significantly improved the prevention and treatment of colitis in vivo.

CHEMICAL ENGINEERING JOURNAL (2022)

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Article Chemistry, Physical

Near-infrared carbon nanodots for effective identification and inactivation of Gram-positive bacteria

Wen-Bo Zhao et al.

Summary: The article introduces a carbon nanodot derived from perilla that can accurately identify and kill specific bacteria, with near-infrared absorption and emission properties; its hydrophobic chain surface enables selective staining of Gram-positive bacteria. In in vivo experiments, it has shown good antibacterial properties and can effectively eliminate inflammation caused by bacterial infections.

NANO RESEARCH (2022)

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Article Multidisciplinary Sciences

A programmable encapsulation system improves delivery of therapeutic bacteria in mice

Tetsuhiro Harimoto et al.

Summary: This study developed a genetically encoded microbial encapsulation system with tunable and dynamic expression of surface capsular polysaccharides to enhance systemic delivery. The system allowed bacteria to temporarily evade immune attack and be effectively cleared in vivo. The results showed that this strategy increased the maximum tolerated dose of bacteria and improved anti-tumor efficacy.

CURRENT SCIENCE (2022)

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Review Oncology

Preparing for CAR T cell therapy: patient selection, bridging therapies and lymphodepletion

Leila Amini et al.

Summary: Chimeric antigen receptor (CAR) T cell therapy is an effective treatment for certain hematological cancers. Successful CAR-T cell infusion requires timely preparation and consideration of various factors. This review provides a summary of the considerations in preparing patients for CAR-T cell therapy and highlights current limitations and future research areas.

NATURE REVIEWS CLINICAL ONCOLOGY (2022)

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Review Biotechnology & Applied Microbiology

Engineering the next generation of cell-based therapeutics

Caleb J. Bashor et al.

Summary: The widespread clinical translation and commercialization of cell-based therapies are hindered by challenges related to cell source, product quality, and manufacturing processes. However, biological engineering approaches such as genome editing, synthetic biology, and the use of biomaterials are gradually addressing these issues.

NATURE REVIEWS DRUG DISCOVERY (2022)

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Article Cell Biology

Listeria delivers tetanus toxoid protein to pancreatic tumors and induces cancer cell death in mice

Benson Chellakkan Selvanesan et al.

Summary: This study introduces a microbial-based immunotherapeutic treatment that utilizes attenuated Listeria monocytogenes to deliver an immunogenic protein into pancreatic ductal adenocarcinoma (PDAC) tumor cells. By reactivating TT-specific memory T cells, this treatment effectively kills infected tumor cells and reduces tumor burden. Additionally, low doses of gemcitabine enhance the immune effects, promoting an immune response against the cold tumors.

SCIENCE TRANSLATIONAL MEDICINE (2022)

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Article Multidisciplinary Sciences

Ultrasound-controllable engineered bacteria for cancer immunotherapy

Mohamad H. Abedi et al.

Summary: Synthetic biology has enabled the design of strategies for bacteria-based cancer immunotherapy. This study developed ultrasound-activatable therapeutic bacteria that express anti-CTLA-4 and anti-PD-L1 nanobodies, successfully suppressing tumor growth in a clinically relevant cancer model.

NATURE COMMUNICATIONS (2022)

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Article Multidisciplinary Sciences

A single-cell nanocoating of probiotics for enhanced amelioration of antibiotic-associated diarrhea

Jiezhou Pan et al.

Summary: The authors developed a polyphenol-based nanoarmor coating that protects probiotics from antibiotics and enhances their effectiveness against antibiotic-mediated diarrhea. The nanoarmor absorbs antibiotic molecules and allows the bacteria to colonize in the gastrointestinal tract, reducing diarrhea and inflammation caused by antibiotics.

NATURE COMMUNICATIONS (2022)

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Article Oncology

Next-Generation CAR T-cell Therapies

Regina M. Young et al.

Summary: CD19 and BCMA-directed CAR T cells have shown remarkable efficacy in treating certain hematologic malignancies, but there are still unmet treatment needs. Next-generation CAR T cells will incorporate gene engineering and synthetic biology to improve functionality and persistence, and reduce treatment-related toxicities. Combining autologous CAR T cells with allogeneic cell treatment strategies targeting the tumor microenvironment will expand the impact of CAR T-cell therapies.

CANCER DISCOVERY (2022)

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Article Biotechnology & Applied Microbiology

Bacteria-driven hypoxia targeting delivery of chemotherapeutic drug proving outcome of breast cancer

Susu Xiao et al.

Summary: Local hypoxia is a common feature of solid tumors. In this study, a biocompatible bacteria/nanoparticles biohybrid platform was developed to target breast tumors. The results showed that the biohybrid was able to effectively colonize hypoxic tumors, increasing drug accumulation and reducing toxic side-effects.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Article Chemistry, Multidisciplinary

Living Bacteria-Based Immuno-Photodynamic Therapy: Metabolic Labeling of Clostridium butyricum for Eradicating Malignant Melanoma

Leilei Shi et al.

Summary: Metabolic engineering labeled anaerobic oncolytic bacteria can effectively ablate melanoma by modifying the bacterial metabolic substrate and photosensitizer, enabling engineered bacteria to proliferate in the tumor and stimulate immune environment, eliminate the hypoxic region, and then exert a photodynamic effect in the oxygen-rich region to completely remove melanoma.

ADVANCED SCIENCE (2022)

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Article Chemistry, Multidisciplinary

Bacteria-Elicited Specific Thrombosis Utilizing Acid-Induced Cytolysin A Expression to Enable Potent Tumor Therapy

Wenjun Qin et al.

Summary: A therapeutic platform is developed using attenuated Escherichia coli to target solid tumors. By disrupting blood vessels and inducing thrombosis in tumor tissues, this strategy effectively inhibits tumor growth and metastasis in a mouse model.

ADVANCED SCIENCE (2022)

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Article Chemistry, Multidisciplinary

Hierarchy-Assembled Dual Probiotics System Ameliorates Cholestatic Drug-Induced Liver Injury via Gut-Liver Axis Modulation

Qi-Wen Chen et al.

Summary: Cholestatic drug-induced liver injury (DILI), a severe clinical syndrome, can be effectively prevented by living materials consisting of dual probiotics that modulate the gut-liver axis. The constructed materials release probiotic Lactobacillus rhamnosus GG in the intestines, which inhibits hepatic bile acid synthesis and promotes bile acid excretion. Additionally, the materials absorb excessive bile acids and decrease their total amount in the enterohepatic circulation.

ADVANCED SCIENCE (2022)

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Article Multidisciplinary Sciences

Photocatalyst-mineralized biofilms as living bio-abiotic interfaces for single enzyme to whole-cell photocatalytic applications

Xinyu Wang et al.

Summary: There is a growing trend of combining living cells with inorganic semiconductors to create a stable and biocompatible bio-abiotic interface for solar-to-chemical conversions. The use of living mineralized biofilms as a bio-abiotic interface has shown efficient photoelectrical responses and the ability to be regenerated, demonstrating the potential for sustainable photocatalytic applications.

SCIENCE ADVANCES (2022)

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Article Engineering, Biomedical

Antigen-bearing outer membrane vesicles as tumour vaccines produced in situ by ingested genetically engineered bacteria

Yale Yue et al.

Summary: Outer membrane vesicles (OMVs) produced in the intestine by ingested genetically engineered bacteria, which are fused with tumour antigens, can serve as effective oral tumour vaccines in mice. These OMVs can stimulate dendritic cell maturation, inhibit tumour growth, and generate long-term antitumour immunity.

NATURE BIOMEDICAL ENGINEERING (2022)

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Article Chemistry, Multidisciplinary

Biohybrid bacterial microswimmers with metal-organic framework exoskeletons enable cytoprotection and active drug delivery in a harsh environment

Y. Li et al.

Summary: By using metal-organic framework exoskeletons to protect bacterial microswimmers from enzyme degradation, a versatile system capable of drug delivery and improved therapeutic efficacy has been developed. This multifunctional biohybrid microswimmer design shows potential for targeted disease treatment and active drug delivery in harsh environments.

MATERIALS TODAY CHEMISTRY (2022)

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Article Nanoscience & Nanotechnology

Acid-Directed Electrostatic Self-Assembly Generates Charge-Reversible Bacteria for Enhanced Tumor Targeting and Low Tissue Trapping

Jing Feng et al.

Summary: The study reports a simple and efficient method for self-assembling lipid onto bacteria used in cancer therapy, reducing their minimum effective dose and toxicity to normal organs while enhancing their tumor specificity and effectiveness. Multiple visualization techniques demonstrate the circulation of bacteria in the blood and normal organs.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Chemistry, Multidisciplinary

Pleiotropic Immunomodulatory Functions of Radioactive Inactivated Bacterial Vectors for Enhanced Cancer Radio-immunotherapy

Pei Pei et al.

Summary: In this study, an inactivated bacteria vector labeled with I-125/I-131 was constructed to deliver radioiodine to tumor cells and tumor-associated macrophages, achieving effective internal radioisotope therapy of the primary tumor. Furthermore, it was found that local radioisotope therapy could stimulate robust systemic antitumor immune responses through the activation of innate and adaptive immune pathways. Combined with systemic checkpoint blockade therapy, it effectively suppressed in situ colon cancer and protected against tumor rechallenge.

ACS NANO (2022)

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Article Engineering, Biomedical

Dual drugs decorated bacteria irradiate deep hypoxic tumor and arouse strong immune responses

Wenfei Chen et al.

Summary: This study demonstrates the successful use of engineered Salmonella bacteria with modified surface to achieve targeted photothermal therapy and magnified immunotherapy in tumor tissues. The synergistic strategy stimulates the immune system from multiple dimensions, leading to effective prevention and inhibition of tumor growth.

BIOMATERIALS (2022)

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Review Multidisciplinary Sciences

The future of engineered immune cell therapies

Darrell J. Irvine et al.

Summary: Immune cell therapy is a promising approach to treating diseases, especially cancer, by engineering immune cells to recognize and respond to specific conditions. This therapy has already been approved for clinical use and continues to be developed and tested in various applications.

SCIENCE (2022)

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Review Multidisciplinary Sciences

Engineering bacteria as interactive cancer therapies

Candice R. Gurbatri et al.

Summary: With the use of synthetic biology tools, researchers are repurposing bacteria as tumor-specific delivery systems, which can modulate the tumor microenvironment and enhance therapeutic efficacy and safety through their immunogenicity and local payload production.

SCIENCE (2022)

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Article Oncology

CD19/CD20 Bispecific Chimeric Antigen Receptor (CAR) in Naïve/Memory T Cells for the Treatment of Relapsed or Refractory Non-Hodgkin Lymphoma

Sarah M. Larson et al.

Cancer Discovery (2022)

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Article Multidisciplinary Sciences

Mucoadhesive probiotic backpacks with ROS nanoscavengers enhance the bacteriotherapy for inflammatory bowel diseases

Jun Liu et al.

Summary: Inflammatory bowel diseases (IBDs) are associated with elevated levels of reactive oxygen species (ROS) and dysregulated gut microbiota. In this study, researchers developed ROS-scavenging nanoparticles (HPN) to effectively scavenge ROS. They targeted the colon tissue by conjugating HPN to modified probiotic Escherichia coli Nissle 1917 (EcN). To enhance the efficacy of bacteriotherapy, the EcN cells were encapsulated with a poly-norepinephrine (NE) layer for protection against environmental assaults and prolonged retention in the intestine. The HPN-NE-EcN treatment showed enhanced efficacy in colitis models and increased abundance and diversity of gut microbiota.

SCIENCE ADVANCES (2022)

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Article Chemistry, Multidisciplinary

Multimodal oncolytic bacteria by coating with tumor cell derived nanoshells

Rui Liu et al.

Summary: This study describes the development of carcinoma cell-mimetic bacteria (CCMB), which are bacteria coated with tumor cell-derived nanoshells, to enhance their tumor-targeting and therapeutic capabilities. The CCMB exhibit low inflammatory reaction, prolonged survival in the body, tumor-specific localization, and dual modality of antigen-specific immunotherapy and microbial therapy.

NANO TODAY (2022)

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Article Multidisciplinary Sciences

Programmable probiotics modulate inflammation and gut microbiota for inflammatory bowel disease treatment after effective oral delivery

Jun Zhou et al.

Summary: In this study, genetically engineered probiotics with self-producing functional proteins and biofilm self-coating were developed for the safe and efficient treatment of inflammatory bowel disease (IBD) in mice. The engineered probiotics effectively reduced inflammation, repaired epithelial barriers, and regulated intestinal microbial communities. This study lays a foundation for the development of living therapeutic proteins using probiotics to treat intestinal-related diseases.

NATURE COMMUNICATIONS (2022)

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Article Multidisciplinary Sciences

Spatiotemporal control of engineered bacteria to express interferon-γ by focused ultrasound for tumor immunotherapy

Yuhao Chen et al.

Summary: The authors designed an ultrasound-responsive bacterium to release the immune regulatory molecule IFN-γ at the tumor site, promoting anti-tumor immune responses. This approach solves the challenge of controlling gene expression in the tumor site and provides a new strategy for bacteria-mediated tumor immunotherapy.

NATURE COMMUNICATIONS (2022)

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Article Multidisciplinary Sciences

Magnetically steerable bacterial microrobots moving in 3D biological matrices for stimuli-responsive cargo delivery

Mukrime Birgul Akolpoglu et al.

Summary: Bacterial biohybrids controlled by magnetic fields can efficiently deliver drugs to specific regions in 3D biological matrices, demonstrating potential for minimally invasive medicine.

SCIENCE ADVANCES (2022)

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Article Chemistry, Multidisciplinary

Non-Native Amino Acid Click Chemistry-Based Technology for Site-Specific Polysaccharide Conjugation to a Bacterial Protein Serving as Both Carrier and Vaccine Antigen

Neeraj Kapoor et al.

Summary: Surface-expressed bacterial polysaccharides are important vaccine antigens that require conjugation with carrier proteins for efficient antigen presentation and strong immune response. Current carrier proteins have limitations in pediatric immunization. Recent research proposes a new method using cell-free protein synthesis to generate pathogen-specific carrier proteins for the development of multivalent subunit vaccines, which showed promising results in protecting against bacterial pathogens.

ACS OMEGA (2022)

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Article Nanoscience & Nanotechnology

Enhanced Stability and Function of Probiotic Streptococcus thermophilus with Self-Encapsulation by Increasing the Biosynthesis of Hyaluronan

Dong-Xu Ma et al.

Summary: This study demonstrates that the encapsulation of a probiotic strain with endogenously produced hyaluronan improves its oral bioavailability and enhances its effects in the gastrointestinal tract. The engineered probiotic strain showed increased survival and colonization time in the gut, and promoted the production of goblet cells, mucus, and microorganisms related to short-chain fatty acid biosynthesis, leading to the enhancement of the intestinal barrier.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Nanoscience & Nanotechnology

Upconversion Optogenetic Engineered Bacteria System for Time-Resolved Imaging Diagnosis and Light-Controlled Cancer Therapy

Yingying Zhang et al.

Summary: In this paper, a light control engineered bacteria system based on UCNP-mediated TRI was constructed for colorectal cancer theranostic and therapy, which could achieve accurate tumor diagnosis and light-controlled cancer therapy.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Review Immunology

CAR NK cell therapy in hematologic malignancies and solid tumors; obstacles and strategies to overcome the challenges

Ayda Baghery Saghchy Khorasani et al.

Summary: CAR NK cells have attracted attention as a viable alternative to CAR T cells due to their MHC-independency, shorter life expectancy, potential for off-the-shelf immune product creation, and potent antitumor properties. This article provides an updated review of the differences between CAR T and CAR NK cells, current enhancements in CAR NK design, sources for collecting NK cells, and strategies for transducing CARs to NK cells.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

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Article Chemistry, Multidisciplinary

Tumor inhibition via magneto-mechanical oscillation by magnetotactic bacteria under a swing MF

Pingping Wang et al.

Summary: In this study, we developed a technique for cell modulation and tumor suppression using magnetotactic bacteria (MTB) and a swing magnetic field. Modified MTB bacteria bound to tumor cell surfaces could induce sustained magnetomechanical oscillation and inhibit tumor growth by activating Ca2+ influx in vitro and in vivo.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Biochemistry & Molecular Biology

Post-infusion CAR TReg cells identify patients resistant to CD19-CAR therapy

Zinaida Good et al.

Summary: Single-cell proteomic profiling of circulating CAR T cells in patients treated with CD19-CAR reveals that CD4(+)Helios(+) CAR T cells on day 7 after infusion are associated with progressive disease and less severe neurotoxicity.

NATURE MEDICINE (2022)

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Article Biochemistry & Molecular Biology

Distinct cellular dynamics associated with response to CAR-T therapy for refractory B cell lymphoma

Nicholas J. Haradhvala et al.

Summary: This study reveals the role of CAR-T regulatory cells in treatment relapse and the different molecular phenotypes of CAR-T cells with different designs.

NATURE MEDICINE (2022)

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Article Multidisciplinary Sciences

Bacteria loaded with glucose polymer and photosensitive ICG silicon-nanoparticles for glioblastoma photothermal immunotherapy

Rong Sun et al.

Summary: The authors have developed a bacteria-based drug delivery system for the treatment of glioblastoma. This system bypasses the blood-brain barrier and uses photothermal therapy and immune responses to destroy bacteria-infected glioblastoma cells and prolong the survival of mice. The residual bacteria can also be effectively eliminated from the body.

NATURE COMMUNICATIONS (2022)

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Article Multidisciplinary Sciences

Enhancing Gasdermin-induced tumor pyroptosis through preventing ESCRT-dependent cell membrane repair augments antitumor immune response

Zhaoting Li et al.

Summary: Blocking cell membrane repair and sustained release of pro-inflammatory substances can enhance tumor cell pyroptosis and boost the anti-tumor immune response.

NATURE COMMUNICATIONS (2022)

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Article Chemistry, Multidisciplinary

In Situ Bioorthogonal Conjugation of Delivered Bacteria with Gut Inhabitants for Enhancing Probiotics Colonization

Wen -Fang Song et al.

Summary: This study developed a bioorthogonal-mediated bacterial delivery strategy to enhance the colonization of probiotics by modulating bacterial adhesion between probiotics and gut inhabitants, thereby improving the clinical treatment efficacy of oral bacterial therapy.

ACS CENTRAL SCIENCE (2022)

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Review Oncology

Tumor Infiltrating Lymphocyte (TIL) Therapy for Solid Tumor Treatment: Progressions and Challenges

Yueshui Zhao et al.

Summary: Cell-based immunotherapy, especially tumor-infiltrating lymphocytes (TILs) therapy, has emerged as a powerful strategy in solid cancer treatment. This review summarizes the current strategies and challenges in TIL generation, and discusses the clinical trials where TIL therapy is used independently or in combination with other therapies for solid tumor treatment. The limitations, future potential, and directions of TIL therapy for solid tumors are also discussed.

CANCERS (2022)

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Review Oncology

Natural killer cells in antitumour adoptive cell immunotherapy

Tamara J. Laskowski et al.

Summary: This review provides an overview of NK cell-based immunotherapies, discussing strategies to increase NK cell cytotoxicity and persistence and highlighting the current challenges and future opportunities for the design of next-generation NK cell therapies.

NATURE REVIEWS CANCER (2022)

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Article Materials Science, Biomaterials

Metal-phenolic networks as tuneable spore coat mimetics

Pris Wasuwanich et al.

Summary: The application of self-assembled metal-phenolic network (MPN) cellular coatings protects Bacillus subtilis from lyophilization stresses and provides a more comprehensive understanding of the role of each component in MPNs.

JOURNAL OF MATERIALS CHEMISTRY B (2022)

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Article Chemistry, Multidisciplinary

Magneto-optical hyperthermia agents based on probiotic bacteria loaded with magnetic and gold nanoparticles

Victor Garces et al.

Summary: In this study, probiotic bacteria were used as carriers of metallic nanoparticles for the development of oral agents for hyperthermia cancer therapy. Two synthetic strategies were employed to produce different therapeutic agents. The results suggest that the heterobimetallic AuNP/MNP-bacteria systems could be used as novel oral agents for cancer treatment using magnetic hyperthermia and photothermal therapy, particularly for gastric diseases.

NANOSCALE (2022)

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Article Chemistry, Multidisciplinary

A Self-Driven Bioreactor Based on Bacterium-Metal-Organic Framework Biohybrids for Boosting Chemotherapy via Lactate Catabolism

Jia-Wei Wang et al.

Summary: In this study, a self-driven bioreactor called SO@MDH was constructed to sensitize chemotherapy through active targeting, lactate degradation, rapid drug release, and inhibition of multidrug resistance. The research demonstrated high tumor specificity and promising therapeutic prospects, indicating the potential of SO@MDH in cancer therapy.

ACS NANO (2021)

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Review Oncology

The role of hypoxia in the tumor microenvironment and development of cancer stem cell: a novel approach to developing treatment

Asieh Emami Nejad et al.

Summary: Tumor hypoxia, caused by rapid tumor growth and abnormal blood vessel formation, can activate angiogenesis, increase tumor survival, suppress immunity, and requires management through mechanisms such as altering gene expression. The potential use of cancer stem cells in tumor treatment has been highlighted.

CANCER CELL INTERNATIONAL (2021)

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Article Engineering, Environmental

Engineered NIR light-responsive bacteria as anti-tumor agent for targeted and precise cancer therapy

Huizhuo Pan et al.

Summary: Using near-infrared light-responsive bacteria as antitumor agents can efficiently inhibit tumor growth and achieve precise tumor ablation, thus improving the controllability of treatment.

CHEMICAL ENGINEERING JOURNAL (2021)

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Review Oncology

Outlook for New CAR-Based Therapies with a Focus on CAR NK Cells: What Lies Beyond CAR-Engineered T Cells in the Race against Cancer

May Daher et al.

Summary: CAR engineering has transformed the field of cellular therapy for cancer treatment by redirecting the specificity of immune effector cells. The use of natural killer (NK) cells as platforms for CAR engineering has emerged as a safe and effective alternative to traditional CAR-T cells. Expanding this strategy beyond T lymphocytes may lead to safer and more effective off-the-shelf cellular therapy products to combat cancer.

CANCER DISCOVERY (2021)

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Article Multidisciplinary Sciences

Biosynthesis of gold nanoparticles using marine microbe (Vibrio alginolyticus) and its anticancer and antioxidant analysis

Rajeshkumar Shunmugam et al.

Summary: The study utilized marine bacteria for the biosynthesis of gold nanoparticles, characterized by various spectroscopic analysis methods, showing antioxidant and anti-cancer effects, particularly with significant inhibitory effects on colon cancer cells.

JOURNAL OF KING SAUD UNIVERSITY SCIENCE (2021)

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Article Agricultural Engineering

Metabolic integration of azide functionalized glycan on Escherichia coli cell surface for specific covalent immobilization onto magnetic nanoparticles with click chemistry

Xiao-Man Fan et al.

Summary: A method for specific immobilization of whole-cell was developed through a click reaction between alkyne and azide groups, showing significantly higher activity, operational stability, and reusability compared to free cells.

BIORESOURCE TECHNOLOGY (2021)

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Article Multidisciplinary Sciences

Metabolic modulation of tumours with engineered bacteria for immunotherapy

Fernando P. Canale et al.

Summary: Engineered bacteria were developed to convert ammonia to l-arginine in tumors, increasing intratumoral l-arginine concentrations, T cell infiltration, and synergistic effects with PD-L1 blocking antibodies in tumor clearance. These results indicate that microbial therapies can enhance immunotherapy efficacy by modulating the tumor microenvironment.

NATURE (2021)

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Article Biochemistry & Molecular Biology

Neurocognitive and hypokinetic movement disorder with features of parkinsonism after BCMA-targeting CAR-T cell therapy

Oliver Van Oekelen et al.

Summary: The study presents a case of a multiple myeloma patient who developed parkinsonism symptoms after receiving BCMA-targeted CAR-T cell therapy, highlighting the importance of close neurological monitoring for patients on such therapies.

NATURE MEDICINE (2021)

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Article Biochemistry & Molecular Biology

TCR-engineered T cells targeting E7 for patients with metastatic HPV-associated epithelial cancers

Nisha B. Nagarsheth et al.

Summary: In a first-in-human phase 1 trial, T cells targeting HPV-16 E7 showed promising results in treating metastatic epithelial cancers, with objective clinical responses observed in 6 out of 12 patients. This suggests that genetically engineered T cell therapy may be effective in treating common carcinomas, but further studies are needed to understand the resistance mechanisms in advanced epithelial cancer.

NATURE MEDICINE (2021)

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Article Immunology

Bacterial-Based Cancer Therapy (BBCT): Recent Advances, Current Challenges, and Future Prospects for Cancer Immunotherapy

Kajal H. Gupta et al.

Summary: Cancer currently ranks as the sixth leading cause of death globally, with immunotherapy showing significant advancements in combating cancer. The use of bacteria and bacterial products as cancer therapy has promising potential to address ongoing challenges in cancer treatment.

VACCINES (2021)

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Article Chemistry, Multidisciplinary

Photoelectric Bacteria Enhance the In Situ Production of Tetrodotoxin for Antitumor Therapy

Xia-Nan Wang et al.

Summary: The study introduced an optically controlled material-assisted microbial system that enhances the synthesis of antitumor drugs at tumor sites by biosynthesizing gold nanoparticles on bacterial surface. This system has the potential to provide a promising antitumor therapy strategy with improved drug synthesis efficiency in situ.

NANO LETTERS (2021)

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Article Chemistry, Multidisciplinary

Polarization of Tumor-Associated Macrophages by Nanoparticle-Loaded Escherichia coli Combined with Immunogenic Cell Death for Cancer Immunotherapy

Baicheng Wei et al.

Summary: A new cancer treatment strategy has been developed, where tumor-associated macrophage polarization therapy combined with ICD induced by low-dose chemotherapy drugs can significantly enhance the efficacy of immunotherapy.

NANO LETTERS (2021)

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Review Biotechnology & Applied Microbiology

Navigating CAR-T cells through the solid-tumour microenvironment

Andrew J. Hou et al.

Summary: CAR-T cells have limited efficacy in treating solid tumors, but various engineering strategies can overcome the obstacles posed by the tumor microenvironment, producing next-generation T cells with enhanced specificity and sustained effector function.

NATURE REVIEWS DRUG DISCOVERY (2021)

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Review Oncology

CAR-T cell therapy: current limitations and potential strategies

Robert C. Sterner et al.

Summary: CAR-T cell therapy has shown remarkable clinical responses in certain subsets of leukemia or lymphoma, but faces challenges in solid tumors and hematological malignancies. Innovative strategies and approaches are necessary to overcome these challenges and improve the efficacy of CAR-T cells.

BLOOD CANCER JOURNAL (2021)

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Article Multidisciplinary Sciences

Mucosal immunity-mediated modulation of the gut microbiome by oral delivery of probiotics into Peyer's patches

Sisi Lin et al.

Summary: The oral delivery of camouflaged probiotics can induce mucosal immune responses, regulate the gut microbiota, maintain gut homeostasis, and provide defense against external threats. Studies show that this approach effectively prevents intestinal barrier breakdown, bacterial translocation, and systemic inflammation.

SCIENCE ADVANCES (2021)

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Article Biochemistry & Molecular Biology

Tumor-infiltrating lymphocyte treatment for anti-PD-1-resistant metastatic lung cancer: a phase 1 trial

Benjamin C. Creelan et al.

Summary: Adoptive cell therapy using tumor-infiltrating lymphocytes (TILs) in combination with nivolumab showed potential safety and clinical activity in patients with advanced non-small cell lung cancer, indicating a promising new treatment strategy for metastatic lung cancer.

NATURE MEDICINE (2021)

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Article Chemistry, Multidisciplinary

Bacteria-Mediated Tumor Therapy via Photothermally-Programmed Cytolysin A Expression

Longyu Wang et al.

Summary: By utilizing bacteria to express therapeutic protein and constructing a thermally-activated biohybrid with gold nanoparticles on the bacterial surface, a photothermal therapy targeting tumors is achieved. This treatment modality results in tumor cell destruction through NIR laser-induced heat production. Both in vitro and in vivo experiments confirm the effectiveness of this therapy in inhibiting tumor cell proliferation.

SMALL (2021)

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Article Chemistry, Multidisciplinary

Bright Bacterium for Hypoxia-Tolerant Photodynamic Therapy Against Orthotopic Colon Tumors by an Interventional Method

Daoming Zhu et al.

Summary: This study developed a novel bacteria-based AIEgen hybrid system that can facilitate hypoxia-tolerant PDT treatment of orthotopic colon tumors through an interventional method, significantly impairing tumor growth and overcoming PDT defects.

ADVANCED SCIENCE (2021)

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Article Materials Science, Biomaterials

Interventional nuclear medicine: click chemistry as an in vivo targeting strategy for imaging microspheres and bacteria

M. M. Welling et al.

Summary: The study successfully demonstrated in vivo imaging and targeting of functionalized microspheres and bacteria using a copper-free click chemistry strategy. Results showed increased accumulation of imaging agents at target sites, indicating the efficacy of this conjugation approach in achieving targeted delivery.

BIOMATERIALS SCIENCE (2021)

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Article Chemistry, Multidisciplinary

Efficient and selective DNA modification on bacterial membranes

Qian Tian et al.

Summary: Researchers have developed a simple, fast, and highly efficient system to engineer bacterial membranes with designer DNA molecules using lipid-DNA conjugates, showing great potential for the broad usage of DNA nanotechnology in bacterial membrane analysis, functionalization, and therapy.

CHEMICAL SCIENCE (2021)

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Article Chemistry, Multidisciplinary

Visualization and In Situ Ablation of Intracellular Bacterial Pathogens through Metabolic Labeling

Fang Hu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Article Chemistry, Multidisciplinary

In Situ Photocatalyzed Oxygen Generation with Photosynthetic Bacteria to Enable Robust Immunogenic Photodynamic Therapy in Triple-Negative Breast Cancer

Lanlan Liu et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Metabolic Labeling of Peptidoglycan with NIR-II Dye Enables In Vivo Imaging of Gut Microbiota

Wei Wang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Article Cell Biology

Engineered probiotics for local tumor delivery of checkpoint blockade nanobodies

Candice R. Gurbatri et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

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Review Biotechnology & Applied Microbiology

Toward an Optimized Process for Clinical Manufacturing of CAR-Treg Cell Therapy

Enrico Fritsche et al.

TRENDS IN BIOTECHNOLOGY (2020)

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Article Chemistry, Multidisciplinary

DNA Nanostructures for Targeted Antimicrobial Delivery

Ioanna Mela et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Review Biochemistry & Molecular Biology

The Emerging Landscape of Immune Cell Therapies

Evan W. Weber et al.

CELL (2020)

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Article Multidisciplinary Sciences

Decorating bacteria with self-assembled synthetic receptors

Naama Lahav-Mankovski et al.

NATURE COMMUNICATIONS (2020)

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Article Multidisciplinary Sciences

Immunotherapy with engineered bacteria by targeting the STING pathway for anti-tumor immunity

Daniel S. Leventhal et al.

NATURE COMMUNICATIONS (2020)

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Article Engineering, Biomedical

Biomineralization of Bacteria by a Metal-Organic Framework for Therapeutic Delivery

Yan Shuangqian et al.

ADVANCED HEALTHCARE MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Inhibition of Tumor Progression through the Coupling of Bacterial Respiration with Tumor Metabolism

Qi-Wen Chen et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Article Multidisciplinary Sciences

Bioinspired oral delivery of gut microbiota by self-coating with biofilms

Xinyue Wang et al.

SCIENCE ADVANCES (2020)

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Article Biochemical Research Methods

Engineering E. coli for Magnetic Control and the Spatial Localization of Functions

Mary Aubry et al.

ACS SYNTHETIC BIOLOGY (2020)

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Article Chemistry, Multidisciplinary

An RGB-emitting molecular cocktail for the detection of bacterial fingerprints

Sheng Hong et al.

CHEMICAL SCIENCE (2020)

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Review Immunology

T-reg cell-based therapies: challenges and perspectives

Caroline Raffin et al.

NATURE REVIEWS IMMUNOLOGY (2020)

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Article Engineering, Biomedical

Nanophotosensitizer-engineered Salmonella bacteria with hypoxia targeting and photothermal-assisted mutual bioaccumulation for solid tumor therapy

Fuming Chen et al.

BIOMATERIALS (2019)

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Review Oncology

Therapeutic bacteria to combat cancer; current advances, challenges, and opportunities

Mansour Sedighi et al.

CANCER MEDICINE (2019)

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Article Biochemistry & Molecular Biology

Programmable bacteria induce durable tumor regression and systemic antitumor immunity

Sreyan Chowdhury et al.

NATURE MEDICINE (2019)

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Article Multidisciplinary Sciences

Design and fabrication of flexible DNA polymer cocoons to encapsulate live cells

Tao Gao et al.

NATURE COMMUNICATIONS (2019)

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Article Biochemical Research Methods

Intestinal probiotics E. coli Nissle 1917 as a targeted vehicle for delivery of p53 and Tum-5 to solid tumors for cancer therapy

Lian He et al.

JOURNAL OF BIOLOGICAL ENGINEERING (2019)

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Article Multidisciplinary Sciences

Camouflaging bacteria by wrapping with cell membranes

Zhenping Cao et al.

NATURE COMMUNICATIONS (2019)

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Article Chemistry, Multidisciplinary

Bio-Orthogonal Bacterial Reactor for Remission of Heavy Metal Poisoning and ROS Elimination

Pei Pan et al.

ADVANCED SCIENCE (2019)

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Review Biochemistry & Molecular Biology

Bacteria-cancer interactions: bacteria-based cancer therapy

Mai Thi-Quynh Duong et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2019)

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Article Cell Biology

An engineered E-coli Nissle improves hyperammonemia and survival in mice and shows dose-dependent exposure in healthy humans

Caroline B. Kurtz et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

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Article Chemistry, Multidisciplinary

Nanoscale Bacteria-Enabled Autonomous Drug Delivery System (NanoBEADS) Enhances Intratumoral Transport of Nanomedicine

SeungBeum Suh et al.

ADVANCED SCIENCE (2019)

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Article Chemistry, Multidisciplinary

Engineered Bacterial Bioreactor for Tumor Therapy via Fenton-Like Reaction with Localized H2O2 Generation

Jin-Xuan Fan et al.

ADVANCED MATERIALS (2019)

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Article Biochemistry & Molecular Biology

CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy

Terry J. Fry et al.

NATURE MEDICINE (2018)

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Article Chemistry, Multidisciplinary

Bacteria-Driven Hypoxia Targeting for Combined Biotherapy and Photothermal Therapy

Wenfei Chen et al.

ACS NANO (2018)

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Article Biochemical Research Methods

Bacteria-Carried Iron Oxide Nanoparticles for Treatment of Anemia

Victor Garces et al.

BIOCONJUGATE CHEMISTRY (2018)

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Article Biotechnology & Applied Microbiology

Endostatin gene therapy delivered by attenuated Salmonella typhimurium in murine tumor models

Kang Liang et al.

CANCER GENE THERAPY (2018)

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Article Biochemistry & Molecular Biology

Potent antitumor efficacy of anti-GD2 CAR T cells in H3-K27M+ diffuse midline gliomas

Christopher W. Mount et al.

NATURE MEDICINE (2018)

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Review Microbiology

Engineering bacteria for diagnostic and therapeutic applications

David T. Riglar et al.

NATURE REVIEWS MICROBIOLOGY (2018)

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Article Engineering, Biomedical

Engineered commensal microbes for diet-mediated colorectal-cancer chemoprevention

Chun Loong Ho et al.

NATURE BIOMEDICAL ENGINEERING (2018)

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Article Hematology

EBV/LMP-specific T cells maintain remissions of T- and B-cell EBV lymphomas after allogeneic bone marrow transplantation

Lauren P. McLaughlin et al.

BLOOD (2018)

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Review Oncology

Tumour-targeting bacteria engineered to fight cancer

Shibin Zhou et al.

NATURE REVIEWS CANCER (2018)

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Article Robotics

Soft erythrocyte-based bacterial microswimmers for cargo delivery

Yunus Alapan et al.

SCIENCE ROBOTICS (2018)

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Article Oncology

Off-the-Shelf Virus-Specific T Cells to Treat BK Virus, Human Herpesvirus 6, Cytomegalovirus, Epstein-Barr Virus, and Adenovirus Infections After Allogeneic Hematopoietic Stem-Cell Transplantation

Ifigeneia Tzannou et al.

JOURNAL OF CLINICAL ONCOLOGY (2017)

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Review Medicine, General & Internal

Recent Developments in Radiotherapy

Deborah E. Citrin

NEW ENGLAND JOURNAL OF MEDICINE (2017)

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Article Cell Biology

Two-step enhanced cancer immunotherapy with engineered Salmonella typhimurium secreting heterologous flagellin

Jin Hai Zheng et al.

SCIENCE TRANSLATIONAL MEDICINE (2017)

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Article Oncology

Escherichia coli Nissle 1917 engineered to express Tum-5 can restrain murine melanoma growth

Lian He et al.

ONCOTARGET (2017)

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Article Oncology

32-Phosphorus selectively delivered by listeria to pancreatic cancer demonstrates a strong therapeutic effect

Dinesh Chandra et al.

ONCOTARGET (2017)

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Article Microbiology

Illuminating vital surface molecules of symbionts in health and disease

Jason E. Hudak et al.

NATURE MICROBIOLOGY (2017)

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Article Biotechnology & Applied Microbiology

Tumour-targeting bacteria-based cancer therapies for increased specificity and improved outcome

Sebastian Felgner et al.

MICROBIAL BIOTECHNOLOGY (2017)

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Article Chemistry, Multidisciplinary

Microemulsion-Based Soft Bacteria-Driven Microswimmers for Active Cargo Delivery

Ajay Vikram Singh et al.

ACS NANO (2017)

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Article Oncology

The Role of the Microbiome in Cancer Development and Therapy

Aadra P. Bhatt et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2017)

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Article Nanoscience & Nanotechnology

Cholesterol-Assisted Bacterial Cell Surface Engineering for Photodynamic Inactivation of Gram-Positive and Gram-Negative Bacteria

Hao-Ran Jia et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

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Article Oncology

Obstacles Posed by the Tumor Microenvironment to T cell Activity: A Case for Synergistic Therapies

Kristin G. Anderson et al.

CANCER CELL (2017)

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Article Oncology

Bifidobacteria Expressing Tumstatin Protein for Antitumor Therapy in Tumor-Bearing Mice

C. Wei et al.

TECHNOLOGY IN CANCER RESEARCH & TREATMENT (2016)

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Article Chemistry, Multidisciplinary

Layer-by-Layer Encapsulation of Probiotics for Delivery to the Microbiome

Aaron C. Anselmo et al.

ADVANCED MATERIALS (2016)

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Article Multidisciplinary Sciences

Synchronized cycles of bacterial lysis for in vivo delivery

M. Omar Din et al.

NATURE (2016)

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Article Medicine, Research & Experimental

RGD Peptide Cell-Surface Display Enhances the Targeting and Therapeutic Efficacy of Attenuated Salmonella-mediated Cancer Therapy

Seung-Hwan Park et al.

THERANOSTICS (2016)

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Article Chemistry, Multidisciplinary

Engineering Nanoparticle-Coated Bacteria as Oral DNA Vaccines for Cancer Immunotherapy

Qinglian Hu et al.

NANO LETTERS (2015)

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Article Biochemistry & Molecular Biology

In vivo imaging and tracking of host-microbiota interactions via metabolic labeling of gut anaerobic bacteria

Naama Geva-Zatorsky et al.

NATURE MEDICINE (2015)

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Review Oncology

Opportunities and challenges of radiotherapy for treating cancer

Doerthe Schaue et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2015)

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Article Oncology

Vasculature Disruption Enhances Bacterial Targeting of Autochthonous Tumors

Jeremy J. Drees et al.

JOURNAL OF CANCER (2015)

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Review Oncology

Metronomics: towards personalized chemotherapy?

Nicolas Andre et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2014)

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Article Hematology

Salmonella engineered to express CD20-targeting antibodies and a drug-converting enzyme can eradicate human lymphomas

Paul E. Massa et al.

BLOOD (2013)

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Article Biotechnology & Applied Microbiology

Bifidobacterium infantis-mediated HSV-TK/GCV suicide gene therapy induces both extrinsic and intrinsic apoptosis in a rat model of bladder cancer

X. Yin et al.

CANCER GENE THERAPY (2013)

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Review Chemistry, Multidisciplinary

Click Chemistry for Drug Development and Diverse Chemical-Biology Applications

Prakasam Thirumurugan et al.

CHEMICAL REVIEWS (2013)

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Article Chemistry, Multidisciplinary

Click-Mediated Labeling of Bacterial Membranes through Metabolic Modification of the Lipopolysaccharide Inner Core

Audrey Dumont et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)

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Article Oncology

Lactobacillus brevis CD2 lozenges reduce radiation- and chemotherapy-induced mucositis in patients with head and neck cancer: A randomized double-blind placebo-controlled study

Atul Sharma et al.

EUROPEAN JOURNAL OF CANCER (2012)

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Article Oncology

Targeting tumor vasculature with novel Listeria-based vaccines directed against CD105

Laurence M. Wood et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2011)

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Review Biochemical Research Methods

Tumor-seeking Salmonella amino acid auxotrophs

Robert M. Hoffman

CURRENT OPINION IN BIOTECHNOLOGY (2011)

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Review Chemistry, Multidisciplinary

Directed Self-Assembly of Nanoparticles

Marek Grzelczak et al.

ACS NANO (2010)

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Article Biotechnology & Applied Microbiology

Inhibition of Tumor Growth and Metastasis by a Combination of Escherichia coli-mediated Cytolytic Therapy and Radiotherapy

Sheng-Nan Jiang et al.

MOLECULAR THERAPY (2010)

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Review Oncology

Engineering the perfect (bacterial) cancer therapy

Neil S. Forbes

NATURE REVIEWS CANCER (2010)

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Article Nutrition & Dietetics

Use of Probiotics in the Management of Chemotherapy-Induced Diarrhea: A Case Study

Samia Abd El-Atti et al.

JOURNAL OF PARENTERAL AND ENTERAL NUTRITION (2009)

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Review Chemistry, Physical

Self-assembly: from crystals to cells

Bartosz A. Grzybowski et al.

SOFT MATTER (2009)

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Review Multidisciplinary Sciences

Assembling materials with DNA as the guide

Faisal A. Aldaye et al.

SCIENCE (2008)

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Article Oncology

Lactobacillus supplementation for diarrhoea related to chemotherapy of colorectal cancer:: a randomised study

P. Osterlund et al.

BRITISH JOURNAL OF CANCER (2007)

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Article Oncology

Repeated cycles of Clostridium-directed enzyme prodrug therapy result in sustained antitumour effects in vivo

J. Theys et al.

BRITISH JOURNAL OF CANCER (2006)

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Article Oncology

Timeline - Chemotherapy and the war on cancer

BA Chabner et al.

NATURE REVIEWS CANCER (2005)

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Article Multidisciplinary Sciences

Overcoming the hypoxic barrier to radiation therapy with anaerobic bacteria

C Bettegowda et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

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Article Biochemistry & Molecular Biology

The hypoxic core: a possible answer to the cancer paradox

M Guppy

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)

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Article Biotechnology & Applied Microbiology

Tumor-targeted Salmonella expressing cytosine deaminase as an anticancer agent

I King et al.

HUMAN GENE THERAPY (2002)

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Article Multidisciplinary Sciences

Combination bacteriolytic therapy for the treatment of experimental tumors

LH Dang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

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Review Biochemical Research Methods

Status of methods for assessing bacterial cell surface charge properties based on zeta potential measurements

WW Wilson et al.

JOURNAL OF MICROBIOLOGICAL METHODS (2001)

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Article Oncology

Antitumour effects of genetically engineered Salmonella in combination with radiation

J Platt et al.

EUROPEAN JOURNAL OF CANCER (2000)

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Article Immunology

Biodistribution and genetic stability of the novel antitumor agent VNP20009, a genetically modified strain of Salmonella typhimurium

C Clairmont et al.

JOURNAL OF INFECTIOUS DISEASES (2000)

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