The behavioral, pathological and therapeutic features of the triple transgenic Alzheimer's disease (3 x Tg-AD) mouse model strain

As a classic animal model of Alzheimer's disease (AD), the 3 x Tg-AD mouse not only recapitulates most of anatomical hallmarks observed in AD pathology but also displays cognitive alterations in memory and learning tasks. The 3 x Tg-AD can better show the two characteristics of AD, amyloid beta (A beta) and neurofibrillary tangles (NFT). Therefore, 3 x Tg-AD strain is widely used in AD pathogenesis research and new drug development of AD. In this paper, the construction methods, pathological changes, and treatment characteristics of 3 x Tg-AD mouse models commonly used in AD research are summarized and commented, hoping to provide reference for researchers to choose and establish experimental patterns.

Automated summary

This paper summarizes and comments on the construction methods, pathological changes, and treatment characteristics of commonly used 3 x Tg-AD mouse models in AD research, hoping to provide reference for researchers to choose and establish experimental patterns.