Rhein attenuates cerebral ischemia-reperfusion injury via inhibition of ferroptosis through NRF2/SLC7A11/GPX4 pathway

Article Biochemistry & Molecular Biology

Mitochondrial oxidative stress mediated Fe-induced ferroptosis via the NRF2-ARE pathway

Guang-Hui Chen et al.

Summary: This study provides direct evidence linking mitochondrial oxidative stress and ferroptosis through the NRF2-ARE pathway.

FREE RADICAL BIOLOGY AND MEDICINE (2022)

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Article Cell Biology

Effect of autophagy on ferroptosis in foam cells via Nrf2

Qi Peng et al.

Summary: In the progression of atherosclerotic plaque, the death of foam cells accelerates plaque development. While Nrf2 has been considered a major regulator of antioxidants, recent studies have shown that insufficient autophagy can deactivate Nrf2-mediated defense, leading to ferroptosis.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2022)

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Article Biochemistry & Molecular Biology

PRMT4 promotes ferroptosis to aggravate doxorubicin-induced cardiomyopathy via inhibition of the Nrf2/GPX4 pathway

Yilong Wang et al.

Summary: PRMT4 promotes ferroptosis in DOX-induced cardiomyocyte ferroptosis by interacting with Nrf2 and inhibiting its nuclear translocation, which subsequently suppresses the transcription of GPX4. Activation of Nrf2 or administration of Fer-1 abolishes the detrimental role of PRMT4 in DOX-induced cardiomyocyte ferroptosis.

CELL DEATH AND DIFFERENTIATION (2022)

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Article Plant Sciences

Rehmannioside A improves cognitive impairment and alleviates ferroptosis via activating PI3K/AKT/Nrf2 and SLC7A11/GPX4 signaling pathway after ischemia

Chen Fu et al.

Summary: This study aims to investigate the effect of Rehmannioside A on cognitive impairment after ischemia in rats and SH-SY5Y cells, and further evaluate the anti-oxidative and anti-ferroptosis mechanisms.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Cell Biology

STAT6 inhibits ferroptosis and alleviates acute lung injury via regulating P53/SLC7A11 pathway

Youjing Yang et al.

Summary: This study identified STAT6 as a critical regulator of epithelial ferroptosis during acute lung injury (ALI). STAT6 negatively regulates ferroptosis by competitively binding with CBP, inhibiting P53 acetylation and restoring SLC7A11 expression. Overexpression of STAT6 attenuated ALI-induced lung injury. STAT6 may be a potential therapeutic target for the treatment of ALI.

CELL DEATH & DISEASE (2022)

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Review Cell Biology

Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy

Pranavi Koppula et al.

Summary: The overexpression of SLC7A11 promotes tumor growth while causing significant metabolic reprogramming costs for cancer cells. Cancer cells with high expression of SLC7A11 exhibit glucose- and glutamine-dependency, presenting potential metabolic vulnerabilities for therapeutic targeting.

PROTEIN & CELL (2021)

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Review Cell Biology

Ferroptosis: molecular mechanisms and health implications

Daolin Tang et al.

Summary: Cell death can be executed through different subroutines, such as ferroptosis which is an iron-dependent form of non-apoptotic cell death. Ferroptosis can occur through two major pathways, driven by redox imbalance and abnormal expression of redox-active enzymes. The process is precisely regulated at multiple levels, with the transcription factor NFE2L2 playing a central role in anti-ferroptotic defense.

CELL RESEARCH (2021)

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Review Cell Biology

Ferroptosis: mechanisms, biology and role in disease

Xuejun Jiang et al.

Summary: Ferroptosis, as a form of regulated cell death driven by iron-dependent phospholipid peroxidation, has seen significant growth in research in recent years. Studies have focused on molecular mechanisms, regulation, and functions of ferroptosis, linking this cell death modality to various pathologies and proposing its roles in normal physiology and potential therapeutic targeting.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

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Article Clinical Neurology

Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019

Valery L. Feigin et al.

Summary: Regularly updated data on stroke including incidence, prevalence, mortality, disability, risk factors, and trends are crucial for evidence-based care planning. The Global Burden of Diseases Study provides comprehensive measurement of these metrics. From 1990 to 2019, while age-standardized rates improved, the number of strokes and deaths increased. Low-income countries had the highest stroke-related mortality and DALY rates, with high body-mass index being the fastest-growing risk factor.

LANCET NEUROLOGY (2021)

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Review Pharmacology & Pharmacy

A research update on the therapeutic potential of rhein and its derivatives

Li Cheng et al.

Summary: Rhein, a component of Rheum, has shown excellent clinical efficacy in treating various diseases. Recent studies summarized its pharmacological activities, association with different diseases, and highlighted its use in nanotechnology for future reference and exploration.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

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Review Cell Biology

Classical Active Ingredients and Extracts of Chinese Herbal Medicines: Pharmacokinetics, Pharmacodynamics, and Molecular Mechanisms for Ischemic Stroke

Ting Zhu et al.

Summary: Stroke is a major cause of death and disability globally, with ischemic stroke being the primary type. There is currently a lack of comprehensive and effective drugs for the treatment of ischemic stroke in clinical practice, but traditional Chinese medicine has unique advantages in this area. Research on the effects of TCM in treating ischemic stroke focuses on antioxidative stress, antiapoptotic, anti-inflammatory, and other effects.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Article Biochemistry & Molecular Biology

Kaempferol Ameliorates Oxygen-Glucose Deprivation/Reoxygenation-Induced Neuronal Ferroptosis by Activating Nrf2/SLC7A11/GPX4 Axis

Yuan Yuan et al.

Summary: The study demonstrated that oxygen-glucose deprivation/reperfusion induces ferroptosis in neurons, and kaempferol protects neurons from ferroptosis by activating the Nrf2/SLC7A11/GPX4 signaling pathway, reducing lipid peroxidation accumulation.

BIOMOLECULES (2021)

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Review Cell Biology

Ferroptosis: past, present and future

Jie Li et al.

CELL DEATH & DISEASE (2020)

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Article Biochemistry & Molecular Biology

Lipid peroxidation and ferroptosis: The role of GSH and GPx4

Fulvio Ursini et al.

FREE RADICAL BIOLOGY AND MEDICINE (2020)

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Review Neurosciences

Adiponectin peptide alleviates oxidative stress and NLRP3 inflammasome activation after cerebral ischemia-reperfusion injury by regulating AMPK/GSK-3β

Haixiao Liu et al.

EXPERIMENTAL NEUROLOGY (2020)

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Article Biochemistry & Molecular Biology

Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers

Mariluz Soula et al.

NATURE CHEMICAL BIOLOGY (2020)

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Article Clinical Neurology

Global, regional, and national burden of stroke, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016

Catherine Owens Johnson et al.

LANCET NEUROLOGY (2019)

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Review Biochemical Research Methods

GPX4 at the Crossroads of Lipid Homeostasis and Ferroptosis

Giovanni C. Forcina et al.

PROTEOMICS (2019)

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Article Biochemistry & Molecular Biology

Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke

Ishraq Alim et al.

CELL (2019)

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Article Clinical Neurology

Safety and efficacy of Edaravone Dexborneol versus edaravone for patients with acute ischaemic stroke: a phase II, multicentre, randomised, double-blind, multiple-dose, active-controlled clinical trial

Jie Xu et al.

STROKE AND VASCULAR NEUROLOGY (2019)

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Article Immunology

Rhein protects against barrier disruption and inhibits inflammation in intestinal epithelial cells

Shen Zhuang et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2019)

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Article Plant Sciences

Neuroprotective effect of glycosides in Buyang Huanwu Decoction on pyroptosis following cerebral ischemia-reperfusion injury in rats

Yan She et al.

JOURNAL OF ETHNOPHARMACOLOGY (2019)

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Article Multidisciplinary Sciences

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

Kirill Bersuker et al.

NATURE (2019)

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Article Biochemistry & Molecular Biology

Electroacupuncture ameliorates neuronal injury by Pink1/Parkin-mediated mitophagy clearance in cerebral ischemia-reperfusion

Huanyuan Wang et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2019)

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Article Medicine, Research & Experimental

Rhein ameliorates lipopolysaccharide-induced intestinal barrier injury via modulation of Nrf2 and MAPKs

Shen Zhuang et al.

LIFE SCIENCES (2019)

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Review Cell Biology

Free Radical Damage in Ischemia-Reperfusion Injury: An Obstacle in Acute Ischemic Stroke after Revascularization Therapy

Ming-Shuo Sun et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)

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Article Multidisciplinary Sciences

Anti-influenza A virus activity of rhein through regulating oxidative stress, TLR4, Akt, MAPK, and NF-κB signal pathways

Qian-Wen Wang et al.

PLOS ONE (2018)

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Review Biochemistry & Molecular Biology

Diverse roles of mitochondria in ischemic stroke

Jenq-Lin Yang et al.

REDOX BIOLOGY (2018)

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Article Oncology

Rhein exhibits antitumorigenic effects by interfering with the interaction between prolyl isomerase Pin 1 and c-Jun

Jin Hyoung Cho et al.

ONCOLOGY REPORTS (2017)

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Article Chemistry, Medicinal

Rhein attenuates inflammation through inhibition of NF-.B and NALP3 inflammasome in vivo and in vitro

Hui Ge et al.

DRUG DESIGN DEVELOPMENT AND THERAPY (2017)

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Article Physiology

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Theodore Kalogeris et al.

COMPREHENSIVE PHYSIOLOGY (2017)

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Review Biochemistry & Molecular Biology

Ferroptosis: process and function

Y. Xie et al.

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Article Chemistry, Medicinal

Anti-fibrotic and Anti-tumorigenic Effects of Rhein, a Natural Anthraquinone Derivative, in Mammalian Stellate and Carcinoma Cells

Siu Wai Tsang et al.

PHYTOTHERAPY RESEARCH (2015)

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Article Biochemistry & Molecular Biology

Rhein exerts pro- and anti-inflammatory actions by targeting IKKβ inhibition in LPS-activated macrophages

Yuan Gao et al.

FREE RADICAL BIOLOGY AND MEDICINE (2014)

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Article Cell Biology

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

Jose Pedro Friedmann Angeli et al.

NATURE CELL BIOLOGY (2014)

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Review Medicine, General & Internal

Ischemia-Reperfusion Damage

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EURASIAN JOURNAL OF MEDICINE (2013)

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Article Biochemistry & Molecular Biology

Essential role of caspase-8 in p53/p73-dependent apoptosis induced by etoposide in head and neck carcinoma cells

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MOLECULAR CANCER (2011)

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Article Neurosciences

Lipoxin A4 analogue protects brain and reduces inflammation in a rat model of focal cerebral ischemia reperfusion

Xi-Hong Ye et al.

BRAIN RESEARCH (2010)

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Article Pharmacology & Pharmacy

Intranasal Deferoxamine Provides Increased Brain Exposure and Significant Protection in Rat Ischemic Stroke

Leah R. Hanson et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2009)

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Article Pediatrics

Effects of deferoxamine, a chelator of free iron, on Na+, K+-ATPase activity of cortical brain cell membrane during early reperfusion after hypoxia-ischemia in newborn lambs

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PEDIATRIC RESEARCH (2000)

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Rhein attenuates cerebral ischemia-reperfusion injury via inhibition of ferroptosis through NRF2/SLC7A11/GPX4 pathway

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