The role of regulated necrosis in inflammation and ocular surface diseases

In recent decades, numerous types of regulated cell death have been identified, including pyroptosis, ferroptosis and necroptosis. Regulated necrosis is characterized by a series of amplified inflammatory responses that result in cell death. Therefore, it has been suggested to play an essential role in the pathogenesis of ocular surface diseases. The cell morphological features and molecular mechanisms of regulated necrosis are discussed in this review. Furthermore, it summarizes the role of ocular surface diseases, such as dry eye, keratitis, and cornea alkali burn, as potential disease prevention and treatment targets.

Automated summary

In recent decades, various forms of regulated cell death, including pyroptosis, ferroptosis, and necroptosis, have been discovered. Regulated necrosis is characterized by amplified inflammatory responses that lead to cell death, making it a crucial factor in the pathogenesis of ocular surface diseases. This review discusses the cellular morphological features and molecular mechanisms of regulated necrosis, as well as highlights the potential role of ocular surface diseases such as dry eye, keratitis, and cornea alkali burn as targets for prevention and treatment.