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Interleukin-6 in retinal diseases: From pathogenesis to therapy

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EXPERIMENTAL EYE RESEARCH
卷 233, 期 -, 页码 -

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ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exer.2023.109556

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Interleukin-6; Retinal diseases; Targeted-IL-6 treatment; Precision medicine

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This article comprehensively reviews the biological functions of interleukin-6 (IL-6) and its mechanisms in the pathogenesis of various retinal diseases. It also summarizes the potential application of drugs targeting IL-6 and its receptor in the treatment of retinal diseases, providing new ideas for their treatment.
Interleukin-6 (IL-6) is a pleiotropic cytokine that participates in immunomodulation, inflammation, increases vascular permeability, hematopoiesis, and stimulates cell proliferation, among other biological processes. It exerts effects primarily through the classic and trans-signaling pathways. Many studies have demonstrated that IL-6 plays a critical role in the development of retinal diseases including diabetic retinopathy, uveitis, age-related macular degeneration, glaucoma, retinal vein occlusion, central serous chorioretinopathy and proliferative vitreoretinopathy. Thus, the progressive development of drugs targeting IL-6 and IL-6 receptor may play a role in the treatment of multiple retinal diseases. In this article, we comprehensively review the IL-6's biological functions of and its mechanisms in the pathogenesis of various retinal diseases. Furthermore, we summarize the drugs targeting IL-6 and its receptor and prospect their potential application in retinal diseases, hoping to provide new ideas for the treatment of retinal diseases.

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