A cross-sectional cohort study on the skin microbiota in patients with different acne durations

Acne is a chronic disease that often persists for years. Skin microbial communities play an essential role in the development of acne. However, limited information is available about the dynamic patterns of skin microbiota in acne. This study aimed to characterize microbial community changes in skin pores and surfaces of acne patients with varying disease time. In this study, a total of 70 skin samples from 22 subjects were collected and sequenced using 16S rRNA amplicon sequencing. Although microbial compositions in skin pores were similar over time, significant differences in microbial structure were observed on the skin surface, with the dominance of Cutibacterium in the first 3 years and replacement by Staphylococcus in 4-6 years. Lactobacillus and Acinetobacter were more abundant in the normal group and continuingly decreased with disease time on the skin surface. Microbial networks further revealed substantial increases in microbial interactions in the 4-6 years group in both skin surfaces and pores. These results demonstrate that the skin microbiota alters with the disease duration and may provide a potential guide in redirecting skin microbiota towards healthy states.

Automated summary

This study found that the skin microbiota of acne patients is closely related to the duration of the disease. Cutibacterium dominated the skin surface in the first three years of acne, but was gradually replaced by Staphylococcus. Lactobacillus and Acinetobacter were more abundant on normal skin and decreased with increasing disease duration on the skin surface. Moreover, there was a significant increase in microbial interactions in both the skin surface and pores in the 4-6 years group.