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Article
Microbiology
Katja Spiess et al.
Summary: This study describes the design of a large-scale RT-qPCR platform and a flexible small-scale RT-qPCR platform to detect SARS-CoV-2 variants, supporting the control of SARS-CoV-2 in Denmark.
MICROBIOLOGY SPECTRUM
(2023)
Article
Multidisciplinary Sciences
Thomas D. Hughes et al.
Summary: This study aimed to determine the impact of SARS-CoV-2 variants on respiratory features, mortality, and vaccination status. A retrospective review of medical records was conducted to identify the effects of vaccination status on survival and respiratory features. The study found increased odds of death among unvaccinated individuals and those who were fully or partially vaccinated during multiple waves of the pandemic. Vaccination status was associated with a decreased frequency of respiratory features and improved survival. Recent SARS-CoV-2 variants showed a reduction in lower respiratory tract features and an increase in upper respiratory tract features.
SCIENTIFIC REPORTS
(2023)
Article
Infectious Diseases
Lamprini Veneti et al.
Summary: A study found that the Omicron variant of COVID-19 has a 73% reduced risk of hospitalization compared to the Delta variant. Omicron cases who had received two doses of the vaccine 7-179 days before diagnosis had a lower risk compared to Delta (66% vs 93%), while those who received three doses had a similar risk reduction (86% vs 88%).
Article
Infectious Diseases
Lamprini Veneti et al.
Summary: There was no difference in the risk of hospitalization between Delta variant cases and Alpha variant cases in Norway. Partially vaccinated and fully vaccinated cases had a lower risk of hospitalization compared to unvaccinated cases.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Letter
Medicine, General & Internal
Ana Cecilia Ulloa et al.
Summary: This study compares hospitalizations and deaths associated with SARS-CoV-2 Omicron variant to those of matched patients infected with the Delta variant.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Medicine, General & Internal
Nicole Wolter et al.
Summary: According to data analysis from South Africa, individuals infected with the omicron variant have a lower likelihood of hospitalization compared to those infected with non-omicron variants. Furthermore, individuals infected with the omicron variant have a lower odds of severe disease compared to individuals infected with the earlier delta variant.
Article
Multidisciplinary Sciences
Kenrie P. Y. Hui et al.
Summary: SARS-CoV-2 variants pose a threat to global public health. The Omicron variant replicates faster in bronchi but less efficiently in the lung parenchyma compared to other variants. All variants of concern have similar cellular tropism.
Letter
Medicine, General & Internal
Shirley Collie et al.
Summary: Preliminary data from a test-negative study design in South Africa showed that two doses of the BNT162b2 vaccine had an efficacy of 50 to 70% against hospitalization caused by the omicron variant in Gauteng province.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Infectious Diseases
Paula B. Blomquist et al.
Summary: When SARS-CoV-2 Omicron emerged, the failure of the S gene target provided a way to differentiate it from the dominant Delta variant. In England, where S gene target surveillance was already in place, this led to quick identification of potential Omicron cases and real-time monitoring of its growth. The use of S gene target surveillance played a crucial role in public health measures, including case identification and incident management, and we provide practical insights on its application.
Article
Infectious Diseases
Katherine A. Twohig et al.
Summary: A study in England found that patients with COVID-19 infected with the delta variant were more likely to be admitted to hospital or attend emergency care compared to those infected with the alpha variant. This suggests that outbreaks of the delta variant in unvaccinated populations may pose a greater burden on healthcare services.
LANCET INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
Cristina Menni et al.
Summary: This study investigated the differences in symptom prevalence, risk of hospital admission, and symptom duration between omicron and delta variants of the SARS-CoV-2 virus. The study found that loss of smell was less common in omicron infections, sore throat was more common, and the rate of hospital admission was lower.
Article
Medicine, General & Internal
Tommy Nyberg et al.
Summary: The Omicron variant shows lower severity compared to Delta, especially in terms of hospital admission and death, with significant variations by age. Unvaccinated cases experience a larger reduction in intrinsic severity, while vaccinated cases experience reduced vaccine effectiveness. Booster vaccination with mRNA vaccines provides over 70% protection against hospitalization and death in breakthrough Omicron infections.
Article
Infectious Diseases
Peter Bager et al.
Summary: This study aimed to estimate the risk of hospitalization after infection with the SARS-CoV-2 omicron variant compared with the delta variant in Denmark. The results showed that vaccination was associated with a lower risk of hospitalization, and Omicron infection was associated with a lower risk of hospitalization compared to Delta infection.
LANCET INFECTIOUS DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Olha Puhach et al.
Summary: The infectious viral load of SARS-CoV-2 Omicron BA.1 is lower than that of Delta in breakthrough infections of vaccinated individuals. Vaccines may lower transmission risk and have a public health benefit.
Letter
Pediatrics
Lindsey Wang et al.
Summary: This cohort study evaluates the incidence rates and clinical outcomes of SARS-CoV-2 infection caused by the Omicron and Delta variants in children younger than 5 years in the United States.
Article
Multidisciplinary Sciences
Yonatan Woodbridge et al.
Summary: This study demonstrates that recent vaccination reduces Omicron viral load, but its effect wanes rapidly. In contrast, recovered COVID-19 individuals show a significantly slower waning rate. Therefore, a reassessment of future booster campaigns is needed.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Joseph A. Lewnard et al.
Summary: Comparison of outcomes of SARS-CoV-2 Delta and Omicron infections reveals reduced severity of Omicron infections, especially in unvaccinated individuals. There is no differential risk of severe outcomes between subvariants BA.1 and BA.2. Continual assessment of clinical outcomes associated with SARS-CoV-2 variants is crucial for medical interventions and healthcare resource management.
Article
Pediatrics
Robert Whittaker et al.
Summary: This study compared the risk of hospitalization for acute COVID-19 and MIS-C among children and adolescents in Norway infected with different variants of COVID-19. The findings suggest that the risk of hospitalization for acute COVID-19 was lower in the Delta and Omicron waves compared to the Alpha wave. Additionally, the risk of MIS-C was lower for Omicron compared to both Alpha and Delta.
Article
Health Care Sciences & Services
Shaun R. Seaman et al.
Summary: When comparing the risk of a post-infection binary outcome between two variants of an infectious pathogen, it is crucial to adjust for the calendar time of infection. This study demonstrates that if the time from infection to positive test is correlated with the outcome, the risk ratio adjusted for positive test time can vary significantly from the risk ratio adjusted for infection time.
STATISTICAL METHODS IN MEDICAL RESEARCH
(2022)
Article
Infectious Diseases
Florence Halford et al.
LANCET INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Julia Stowe et al.
Summary: This study estimated the vaccine effectiveness (VE) against hospitalization with the Omicron and Delta variants using PCR testing linked to hospital records, and showed that VE estimates increase with the use of specific hospitalization definitions.
NATURE COMMUNICATIONS
(2022)
Letter
Infectious Diseases
Peter Bager et al.
LANCET INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Lamprini Veneti et al.
Summary: This study in Norway found that the B.1.1.7 and B.1.351 variants of concern were associated with an increased risk of hospitalisation and admission to ICU compared to non-VOC. The findings underscore the importance of prevention, vaccination, and hospital surge capacity planning in combating the spread of these variants.
Letter
Medicine, General & Internal
Aziz Sheikh et al.
Article
Infectious Diseases
Peter Bager et al.
Summary: The study conducted in Denmark found that individuals infected with the B.1.1.7 lineage of SARS-CoV-2 had a higher risk of hospitalisation for COVID-19 compared to those with other lineages. While the overall number of hospitalisations decreased during the study period, the proportion of individuals infected with B.1.1.7 significantly increased. The findings suggest implications for hospital preparedness and understanding the impact of the epidemic in areas with the dominant presence of B.1.1.7.
LANCET INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Tommy Nyberg et al.
Summary: The study evaluated the relationship between Covid-19 diagnosis and the B.1.1.7 variant of concern, finding a higher risk of hospital admission for individuals infected with the B.1.1.7 variant compared to wild-type SARS-CoV-2. This increased risk of severity may be specific to adults older than 30 years.
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Article
Multidisciplinary Sciences
Gareth J. Griffith et al.
NATURE COMMUNICATIONS
(2020)
