☆ 4.6 Review

European Association of Urology Guidelines on Upper Urinary Tract Urothelial Carcinoma: 2023 Update

EUROPEAN UROLOGY (2023)

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Article Oncology

Evidence or Prejudice? Critical Re-Analysis of Randomized Controlled Trials Comparing Overall Survival After Cisplatin Versus Carboplatin-Based Regimens in Advanced Urothelial Carcinoma

Anke Richters et al.

Summary: Guidelines have recommended cisplatin for the treatment of advanced urothelial carcinoma since 2008, but a secondary analysis of individual patient data did not show an overall survival benefit compared to carboplatin. Considering the lower toxicity and larger patient eligibility for carboplatin, a reevaluation of guideline recommendations is warranted.

CLINICAL GENITOURINARY CANCER (2022)

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Review Oncology

Chemotherapy is superior to checkpoint inhibitors after radical surgery for urothelial carcinoma: a systematic review and network meta-analysis of oncologic and toxicity outcomes

Ekaterina Laukhtina et al.

Summary: The objective of this study was to compare the oncologic and toxicity outcomes of adjuvant immunotherapy with immune checkpoint inhibitors (ICIs) and adjuvant chemotherapy for UC patients. The analysis showed that adjuvant chemotherapy had better results in both bladder UC and UTUC compared to ICIs, and the risk of adverse events with ICIs was comparable to that of observation/placebo.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2022)

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Article Gastroenterology & Hepatology

Evaluation of Urinalysis-Based Screening for Urothelial Carcinoma in Patients With Lynch Syndrome

Hanumant Chouhan et al.

Summary: Urinalysis-based screening for urothelial cancers in patients with Lynch syndrome did not detect any carcinomas, leading to false-positive results and the need for more effective screening approaches.

DISEASES OF THE COLON & RECTUM (2022)

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Article Urology & Nephrology

Durability of Response to Primary Chemoablation of Low-Grade Upper Tract Urothelial Carcinoma Using UGN-101, a Mitomycin-Containing Reverse Thermal Gel: OLYMPUS Trial Final Report

Surena F. Matin et al.

Summary: The study aimed to evaluate the long-term safety and durability of UGN-101 as a primary chemoablative treatment for low-grade upper tract urothelial carcinoma. The results showed that UGN-101 has a clinically meaningful durability of response, providing a kidney-sparing therapeutic alternative for patients with low-grade disease.

JOURNAL OF UROLOGY (2022)

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Review Urology & Nephrology

Immunohistochemical Screening of Upper Tract Urothelial Carcinomas for Lynch Syndrome Diagnostics: A Systematic Review

Maria Rasmussen et al.

Summary: After reviewing 12 studies, it was found that universal screening for MMR protein loss in UTUC may lead to Lynch syndrome diagnoses in 4.7% of patients, highlighting the importance of follow-up investigations for genetic testing.

UROLOGY (2022)

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Article Oncology

A feasibility study of preoperative pembrolizumab before radical nephroureterectomy in patients with high-risk, upper tract urothelial carcinoma: PURE-02

Andrea Necchi et al.

Summary: The study found that single-agent neoadjuvant pembrolizumab did not appear to be a promising treatment strategy for patients with biomarker-unselected, high-risk localized UTUC.

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (2022)

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Article Oncology

Does neoadjuvant chemotherapy have therapeutic benefit for node-positive upper tract urothelial carcinoma? Results of a multi-center cohort study

Keisuke Shigeta et al.

Summary: This study compared the clinical outcomes of neoadjuvant chemotherapy (NAC) followed by radical nephroureterectomy (RNU) and upfront RNU followed by adjuvant chemotherapy (AC) in lymph node-positive upper tract urothelial carcinoma (UTUC) patients. The results showed that NAC followed by RNU had significant advantages in disease recurrence and cancer-specific survival.

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (2022)

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Article Oncology

Benefit of lymph node dissection in cN plus patients in the treatment of upper tract urothelial carcinoma: Analysis of NCDB registry

Austin J. Piontkowski et al.

Summary: This study found that performing lymph node dissection (LND) in addition to radical nephroureterectomy (RNU) does not have a significant impact on overall survival (OS) in upper tract urothelial carcinoma (UTUC) patients with clinically positive nodes.

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (2022)

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Article Oncology

Oncologic Surveillance After Radical Nephroureterectomy for High-risk Upper Tract Urothelial Carcinoma

Alberto Martini et al.

Summary: The appropriate surveillance protocol after radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC) is still poorly addressed.

EUROPEAN UROLOGY ONCOLOGY (2022)

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Review Urology & Nephrology

Neoadjuvant and Adjuvant Chemotherapy for Upper Tract Urothelial Carcinoma: A 2020 Systematic Review and Meta-analysis, and Future Perspectives on Systemic Therapy

Jeffrey J. Leow et al.

Summary: Recent studies indicate that perioperative chemotherapy can prolong survival for patients with upper tract urothelial cancer, with stronger evidence supporting adjuvant chemotherapy over neoadjuvant chemotherapy.

EUROPEAN UROLOGY (2021)

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Article Oncology

Cancer Statistics, 2021

Rebecca L. Siegel et al.

Summary: Every year, the American Cancer Society projects the numbers of new cancer cases and deaths in the United States, with the latest data showing a significant decline in lung cancer mortality, while prostate cancer mortality has plateaued and breast and colorectal cancer mortality have slowed. Improvements in treatment have accelerated progress against lung cancer, leading to a record drop in overall cancer mortality.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Oncology

Additive Effects of Arsenic and Aristolochic Acid in Chemical Carcinogenesis of Upper Urinary Tract Urothelium

Chung-Hsin Chen et al.

Summary: This study found that exposure to both aristolochic acids (AA) and arsenic in Taiwan acts additively to increase the risk of developing upper tract urothelial carcinoma (UTUC). The presence of AA exposure showed an additive effect on the UTUC risk along with arsenic exposure.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2021)

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Review Biochemistry & Molecular Biology

Lynch Syndrome: Its Impact on Urothelial Carcinoma

Andrea Katharina Lindner et al.

Summary: Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer (HNPCC), is a familial cancer syndrome with increased risk for urothelial cancer (UC) due to mismatch repair (MMR) gene mutations and microsatellite instability.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Urology & Nephrology

Does Ureteral Stenting Increase the Risk of Metachronous Upper Tract Urothelial Carcinoma in Patients with Bladder Tumors? A Systematic Review and Meta-analysis

Petros Sountoulides et al.

Summary: Ureteral stenting in bladder cancer patients may increase the risk of metachronous upper tract urothelial carcinoma compared to no stents, but no significant difference was found compared to nephrostomy. In cases of hydronephrosis, drainage with either nephrostomy or stent is recommended.

JOURNAL OF UROLOGY (2021)

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Article Urology & Nephrology

Higher than expected and significantly increasing incidence of upper tract urothelial carcinoma. A population based study

Bjarte Almas et al.

Summary: The incidence of UTUC was higher than expected and increasing, with patient age at diagnosis increasing as well. The cancer-specific survival rate has improved over the years.

WORLD JOURNAL OF UROLOGY (2021)

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Article Medicine, General & Internal

Enfortumab Vedotin in Previously Treated Advanced Urothelial Carcinoma

Thomas Powles et al.

Summary: Enfortumab vedotin significantly prolonged survival compared with standard chemotherapy in patients with advanced urothelial carcinoma who had previously received platinum-based treatment and a PD-1 or PD-L1 inhibitor, as well as showing better progression-free survival outcomes.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Multidisciplinary Sciences

Tumor distribution affects bladder recurrence but not survival outcome of multifocal upper tract urothelial carcinoma treated with radical nephroureterectomy

Zai-Lin Sheu et al.

Summary: For patients with multifocal UTUC, tumor distribution does not impact cancer-specific outcomes, but synchronous lesions are associated with a higher rate of bladder recurrence.

SCIENTIFIC REPORTS (2021)

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Review Medicine, General & Internal

Survival differences of patients with ureteral versus pelvicalyceal tumours: a systematic review and meta-analysis

Krystian Kaczmarek et al.

Summary: Ureteral involvement in upper tract urothelial carcinoma is identified as an adverse prognostic factor, leading to worse cancer-specific survival and overall survival.

ARCHIVES OF MEDICAL SCIENCE (2021)

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Review Urology & Nephrology

Contemporary patterns of presentation, diagnostics and management of upper tract urothelial cancer in 101 centres: the Clinical Research Office of the Endourological Society Global upper tract urothelial carcinoma registry

Joyce Baard et al.

Summary: A multicentre registry was launched to assess patterns of presentation, diagnostics, and treatment in patients with upper tract urothelial carcinoma (UTUC). Data from 2380 patients over a 5-year period were collected, showing that most patients presented with symptoms, with macroscopic hematuria being the main symptom. Computed tomography (CT) was the most common imaging modality used, and ureteroscopy (URS) was part of the diagnostic process for nearly half of the patients, with a significant portion receiving endoscopic treatment. Overall, the data aligns with known epidemiologic characteristics of UTUC, highlighting the preference for CT imaging and the increasing use of diagnostic URS, though a substantial number of treatment decisions were made without complete endoscopic information.

CURRENT OPINION IN UROLOGY (2021)

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Article Oncology

TROPHY-U-01: A Phase II Open-Label Study of Sacituzumab Govitecan in Patients With Metastatic Urothelial Carcinoma Progressing After Platinum-Based Chemotherapy and Checkpoint Inhibitors

Scott T. Tagawa et al.

Summary: Patients with metastatic urothelial carcinoma who have progressed on platinum-based combination chemotherapy and checkpoint inhibitors have limited treatment options with low objective response rates. Sacituzumab govitecan, a TROP-2-targeted antibody-drug conjugate, has shown promising activity in this patient population, with notable efficacy compared to historical controls.

JOURNAL OF CLINICAL ONCOLOGY (2021)

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Review Andrology

Update on systemic treatment of upper tract urothelial carcinoma: a narrative review of the literature

Kilian M. Gust et al.

Summary: Urothelial cancer, commonly found in the urinary bladder and upper urinary tract, faces challenges in diagnosis, clinical staging, and recurrence post-surgery. The expanding therapeutic options, including novel targeted therapies and biomarker research, are reshaping the treatment landscape for UC. However, systemic treatment of UTUC presents specific challenges, such as loss of renal function after RNU affecting chemotherapy eligibility.

TRANSLATIONAL ANDROLOGY AND UROLOGY (2021)

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Editorial Material Urology & Nephrology

The Impact of Upper Tract Urothelial Carcinoma Diagnostic Modality on Intravesical Recurrence after Radical Nephroureterectomy: A Single Institution Series and Updated Meta-Analysis

[Anonymous]

JOURNAL OF UROLOGY (2021)

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Article Oncology

Molecular classification and diagnostics of upper urinary tract urothelial carcinoma

Yoichi Fujii et al.

Summary: Through an integrated genetic study involving 199 UTUC samples, the landscape of genetic alterations in UTUC was delineated, enabling genetic/molecular classification. UTUC is classified into five subtypes based on the mutational status of TP53, MDM2, RAS, and FGFR3, with discrete profiles of gene expression, tumor location/histology, and clinical outcome. Sequencing of urine sediment-derived DNA has high diagnostic value for UTUC with 82.2% sensitivity and 100% specificity, providing a solid basis for better diagnosis and management of UTUC.

CANCER CELL (2021)

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Article Oncology

Pembrolizumab alone or combined with chemotherapy versus chemotherapy as first-line therapy for advanced urothelial carcinoma (KEYNOTE-361): a randomised, open-label, phase 3 trial

Thomas Powles et al.

Summary: The study examined the outcomes of using pembrolizumab alone or combined with chemotherapy as first-line treatment for advanced urothelial carcinoma, and found that the addition of pembrolizumab to platinum-based chemotherapy did not significantly improve efficacy. Safety was assessed and the study concluded that this combination treatment should not be widely adopted for this type of cancer.

LANCET ONCOLOGY (2021)

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Article Medicine, General & Internal

Adjuvant Nivolumab versus Placebo in Muscle-Invasive Urothelial Carcinoma

D. F. Bajorin et al.

Summary: In a trial involving patients with high-risk muscle-invasive urothelial carcinoma who had undergone radical surgery, adjuvant nivolumab showed longer disease-free survival compared to placebo, especially among patients with a PD-L1 expression level of 1% or more, despite an increase in treatment-related adverse events.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Oncology

Incidence and Survival Rates of Contemporary Patients with Invasive Upper Tract Urothelial Carcinoma

Claudia Colla Ruvolo et al.

Summary: Based on data from the SEER database, the incidence of UTUC decreased in the USA from 2004 to 2016, but the incidence of metastatic UTUC increased. The majority of nonmetastatic UTUC cases were at the T1N0M0 stage, while in metastatic UTUC, chemotherapy and radical nephroureterectomy can lower overall mortality rates.

EUROPEAN UROLOGY ONCOLOGY (2021)

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Review Urology & Nephrology

Diagnostic performance of multidetector computed tomographic (MDCTU) in upper tract urothelial carcinoma (UTUC): a systematic review and meta-analysis

Florian Janisch et al.

WORLD JOURNAL OF UROLOGY (2020)

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Review Urology & Nephrology

Prognostic Value of Variant Histology in Upper Tract Urothelial Carcinoma Treated with Nephroureterectomy: A Systematic Review and Meta-Analysis

Keiichiro Mori et al.

JOURNAL OF UROLOGY (2020)

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Article Oncology

Urothelial Carcinoma of the Renal Pelvis and Ureter: Does Location Make a Difference?

Aye A. Lwin et al.

CLINICAL GENITOURINARY CANCER (2020)

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Article Oncology

Development and Validation of a Model for Predicting Intravesical Recurrence in Organ-confined Upper Urinary Tract Urothelial Carcinoma Patients after Radical Nephroureterectomy: a Retrospective Study in One Center with Long-term Follow-up

Xuanyu Zhang et al.

PATHOLOGY & ONCOLOGY RESEARCH (2020)

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Review Urology & Nephrology

Differential Effect of Sex on Outcomes after Radical Surgery for Upper Tract and Bladder Urothelial Carcinoma: A Systematic Review and Meta-Analysis

Keiichiro Mori et al.

JOURNAL OF UROLOGY (2020)

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Article Medicine, General & Internal

Adjuvant chemotherapy in upper tract urothelial carcinoma (the POUT trial): a phase 3, open-label, randomised controlled trial

Alison Birtle et al.

LANCET (2020)

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Article Urology & Nephrology

Importance of long-term follow-up after endoscopic management for upper tract urothelial carcinoma and factors leading to surgical management

Anand Mohapatra et al.

INTERNATIONAL UROLOGY AND NEPHROLOGY (2020)

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Article Oncology

Maintenance avelumab + best supportive care (BSC) versus BSC alone after platinum-based first-line (1L) chemotherapy in advanced urothelial carcinoma (UC): JAVELIN Bladder 100 phase III interim analysis.

Thomas Powles et al.

JOURNAL OF CLINICAL ONCOLOGY (2020)

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Article Medicine, General & Internal

Atezolizumab with or without chemotherapy in metastatic urothelial cancer (IMvigor130): a multicentre, randomised, placebo-controlled phase 3 trial

Matthew D. Galsky et al.

LANCET (2020)

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Article Oncology

Development and external validation of a preoperative nomogram for predicting pathological locally advanced disease of clinically localized upper urinary tract carcinoma

Takashi Yoshida et al.

CANCER MEDICINE (2020)

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Article Pathology

Universal Mismatch Repair Protein Screening in Upper Tract Urothelial Carcinoma A Validation Study With Comparison to Colorectal and Endometrial Adenocarcinoma

Matthew George Gayhart et al.

AMERICAN JOURNAL OF CLINICAL PATHOLOGY (2020)

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Review Oncology

Diagnostic accuracy of ureteroscopic biopsy in predicting stage and grade at final pathology in upper tract urothelial carcinoma: Systematic review and meta-analysis

Jose Daniel Subiela et al.

EJSO (2020)

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Article Oncology

Long-Term Outcomes in KEYNOTE-052: Phase II Study Investigating First-Line Pembrolizumab in Cisplatin-Ineligible Patients With Locally Advanced or Metastatic Urothelial Cancer

Jacqueline Vuky et al.

JOURNAL OF CLINICAL ONCOLOGY (2020)

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Article Oncology

The Performance of Tumor Size as Risk Stratification Parameter in Upper Tract Urothelial Carcinoma (UTUC)

Beat Foerster et al.

CLINICAL GENITOURINARY CANCER (2020)

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Article Oncology

Intraoperative prophylactic intravesical chemotherapy to reduce bladder recurrence following radical nephroureterectomy

Yuval Freifeld et al.

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (2020)

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Article Oncology

Durvalumab alone and durvalumab plus tremelimumab versus chemotherapy in previously untreated patients with unresectable, locally advanced or metastatic urothelial carcinoma (DANUBE): a randomised, open-label, multicentre, phase 3 trial

Thomas Powles et al.

LANCET ONCOLOGY (2020)

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Article Medicine, General & Internal

Avelumab Maintenance Therapy for Advanced or Metastatic Urothelial Carcinoma

Thomas Powles et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Oncology

Docetaxel with or without Ramucirumab after Platinum-Based Chemotherapy and Checkpoint Inhibitors in Advanced Urothelial Carcinoma: A Pre-Specified Subgroup Analysis from the Phase 3 RANGE Trial

Alexandra Drakaki et al.

BLADDER CANCER (2020)

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Article Oncology

Diagnostic Value of 18F-fluorodeoxyglucose Positron Emission Tomography with Computed Tomography for Lymph Node Staging in Patients with Upper Tract Urothelial Carcinoma

Charlotte S. Voskuilen et al.

EUROPEAN UROLOGY ONCOLOGY (2020)

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Article Oncology

Efficacy of Surgery in the Primary Tumor Site for Metastatic Urothelial Cancer: Analysis of an International, Multicenter, Multidisciplinary Database

Marco Moschini et al.

EUROPEAN UROLOGY ONCOLOGY (2020)

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Article Oncology

Survival Effect of Nephroureterectomy in Metastatic Upper Urinary Tract Urothelial Carcinoma

Sebastiano Nazzani et al.

CLINICAL GENITOURINARY CANCER (2019)

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Review Oncology

Endocavitary treatment for upper tract urothelial carcinoma: A meta-analysis of the current literature

Beat Foerster et al.

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (2019)

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Article Medicine, General & Internal

Erdafitinib in Locally Advanced or Metastatic Urothelial Carcinoma

Y. Loriot et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

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The role of adjuvant radiotherapy after surgery for upper and lower urinary tract urothelial carcinoma: A systematic review

Takehiro Iwata et al.

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (2019)

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Single Versus Maintenance Intravesical Chemotherapy for the Prevention of Bladder Recurrence after Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma: A Randomized Clinical Trial

Ahmed M. Harraz et al.

CLINICAL GENITOURINARY CANCER (2019)

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Prognostic Value of Lymphovascular Invasion in Upper Urinary Tract Urothelial Carcinoma after Radical Nephroureterectomy: A Systematic Review and Meta-Analysis

Wen Liu et al.

DISEASE MARKERS (2019)

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A Model for the Prediction of Survival in Patients With Upper Tract Urothelial Carcinoma After Surgery

Guang-lin Zhang et al.

DOSE-RESPONSE (2019)

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Clonal Relatedness and Mutational Differences between Upper Tract and Bladder Urothelial Carcinoma

Francois Audenet et al.

CLINICAL CANCER RESEARCH (2019)

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Rates of lymph node invasion and their impact on cancer specific mortality in upper urinary tract urothelial carcinoma

Sebastiano Nazzani et al.

EJSO (2019)

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Potential Benefit of Lymph Node Dissection During Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma: A Systematic Review by the European Association of Urology Guidelines Panel on Non-muscle-invasive Bladder Cancer

Jose Luis Dominguez-Escrig et al.

EUROPEAN UROLOGY FOCUS (2019)

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Review Urology & Nephrology

Oncological Outcomes of Laparoscopic Nephroureterectomy Versus Open Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma: An European Association of Urology Guidelines Systematic Review

Benoit Peyronnet et al.

EUROPEAN UROLOGY FOCUS (2019)

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Article Oncology

Robotic-Assisted Surgery for Upper Tract Urothelial Carcinoma: A Comparative Survival Analysis

Matthew B. Clements et al.

ANNALS OF SURGICAL ONCOLOGY (2018)

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Article Urology & Nephrology

Impact of Primary Tumor Location on Survival from the European Organization for the Research and Treatment of Cancer Advanced Urothelial Cancer Studies

Marco Moschini et al.

JOURNAL OF UROLOGY (2018)

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Article Oncology

Avelumab in metastatic urothelial carcinoma after platinum failure (JAVELIN Solid Tumor): pooled results from two expansion cohorts of an open-label, phase 1 trial

Manish R. Patel et al.

LANCET ONCOLOGY (2018)

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Article Oncology

Molecular subtype classification of urothelial carcinoma in Lynch syndrome

Christina Therkildsen et al.

MOLECULAR ONCOLOGY (2018)

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Article Oncology

Impact of surgical waiting time on survival in patients with upper tract urothelial carcinoma: A national cancer database study

Leilei Xia et al.

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (2018)

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Article Pathology

Universal Lynch Syndrome Screening Should be Performed in All Upper Tract Urothelial Carcinomas

Jennifer Y. Ju et al.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2018)

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Review Urology & Nephrology

Impact of ureteroscopy before radical nephroureterectomy for upper tract urothelial carcinomas on oncological outcomes: a meta-analysis

Run-Qi Guo et al.

BJU INTERNATIONAL (2018)

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Article Urology & Nephrology

Update of the ICUD-SIU consultation on upper tract urothelial carcinoma 2016: treatment of low-risk upper tract urothelial carcinoma

Rao S. Mandalapu et al.

WORLD JOURNAL OF UROLOGY (2017)

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Article Urology & Nephrology

Epidemiology, diagnosis, preoperative evaluation and prognostic assessment of upper-tract urothelial carcinoma (UTUC)

Francesco Soria et al.

WORLD JOURNAL OF UROLOGY (2017)

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Association between demographic factors and prognosis in urothelial carcinoma of the upper urinary tract: a systematic review and meta-analysis

Hyung Suk Kim et al.

ONCOTARGET (2017)

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Letter Urology & Nephrology

Efficacy of Systemic Chemotherapy Plus Radical Nephroureterectomy for Metastatic Upper Tract Urothelial Carcinoma

Thomas Seisen et al.

EUROPEAN UROLOGY (2017)

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Review Urology & Nephrology

Prognostic Performance and Reproducibility of the 1973 and 2004/2016 World Health Organization Grading Classification Systems in Non-muscle-invasive Bladder Cancer: A European Association of Urology Non-muscle Invasive Bladder Cancer Guidelines Panel Systematic Review

Viktor Soukup et al.

EUROPEAN UROLOGY (2017)

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Avelumab, an Anti-Programmed Death-Ligand 1 Antibody, In Patients With Refractory Metastatic Urothelial Carcinoma: Results From a Multicenter, Phase Ib Study

Andrea B. Apolo et al.

JOURNAL OF CLINICAL ONCOLOGY (2017)

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Article Urology & Nephrology

Stenting Prior to Cystectomy is an Independent Risk Factor for Upper Urinary Tract Recurrence

Bernhard Kiss et al.

JOURNAL OF UROLOGY (2017)

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The Conditional Survival with Time of Intravesical Recurrence of Upper Tract Urothelial Carcinoma

Keisuke Shigeta et al.

JOURNAL OF UROLOGY (2017)

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Postoperative Nomogram for Relapse-Free Survival in Patients with High Grade Upper Tract Urothelial Carcinoma

Laura-Maria Krabbe et al.

JOURNAL OF UROLOGY (2017)

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Article Medicine, General & Internal

Atezolizumab as first-line treatment in cisplatin-ineligible patients with locally advanced and metastatic urothelial carcinoma: a single-arm, multicentre, phase 2 trial

Arjun V. Balar et al.

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Article Oncology

Nivolumab in metastatic urothelial carcinoma after platinum therapy (CheckMate 275): a multicentre, single-arm, phase 2 trial

Padmanee Sharma et al.

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Article Medicine, General & Internal

Pembrolizumab as Second-Line Therapy for Advanced Urothelial Carcinoma

J. Bellmunt et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

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External validation of the pathological nodal staging score in upper tract urothelial carcinoma: A population-based study

Evanguelos Xylinas et al.

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (2017)

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Article Oncology

Variant histology as a significant predictor of survival after radical nephroureterectomy in patients with upper urinary tract urothelial carcinoma

Jung Kwon Kim et al.

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (2017)

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Article Urology & Nephrology

Diagnostic accuracy of upper tract urothelial carcinoma: how samples are collected matters

Camilla Malm et al.

SCANDINAVIAN JOURNAL OF UROLOGY (2017)

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Article Oncology

Efficacy and Safety of Durvalumab in Locally Advanced or Metastatic Urothelial Carcinoma Updated Results From a Phase 1/2 Open-label Study

Thomas Powles et al.

JAMA ONCOLOGY (2017)

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Article Oncology

Alcohol consumption and risk of upper-tract urothelial cancer

Masayoshi Zaitsu et al.

CANCER EPIDEMIOLOGY (2017)

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Article Oncology

Association between lymph node yield and survival among patients undergoing radical nephroureterectomy for urothelial carcinoma of the upper tract

Piotr Zareba et al.

CANCER (2017)

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Review Urology & Nephrology

Lynch syndrome in upper tract urothelial carcinoma: significance, screening, and surveillance

Benjamin Pradere et al.

CURRENT OPINION IN UROLOGY (2017)

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Review Urology & Nephrology

Early repeated ureteroscopy within 6-8 weeks after a primary endoscopic treatment in patients with upper tract urothelial cell carcinoma: preliminary findings

Luca Villa et al.

WORLD JOURNAL OF UROLOGY (2016)

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Review Urology & Nephrology

Oncologic Outcomes of Kidney-sparing Surgery Versus Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma: A Systematic Review by the EAU Non-muscle Invasive Bladder Cancer Guidelines Panel

Thomas Seisen et al.

EUROPEAN UROLOGY (2016)

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Article Urology & Nephrology

Survival Comparison Between Endoscopic and Surgical Management for Patients With Upper Tract Urothelial Cancer: A Matched Propensity Score Analysis Using Surveillance, Epidemiology and End Results-Medicare Data

Goutham Vemana et al.

UROLOGY (2016)

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Review Urology & Nephrology

A Systematic Review and Meta-analysis of Clinicopathologic Factors Linked to Intravesical Recurrence After Radical Nephroureterectomy to Treat Upper Tract Urothelial Carcinoma

Thomas Seisen et al.

EUROPEAN UROLOGY (2015)

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Article Urology & Nephrology

Oncologic Outcomes Following Robot-Assisted Laparoscopic Nephroureterectomy with Bladder Cuff Excision for Upper Tract Urothelial Carcinoma

Ahmed A. Aboumohamed et al.

JOURNAL OF UROLOGY (2015)

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Article Urology & Nephrology

Postoperative nomogram to predict cancer-specific survival after radical nephroureterectomy in patients with localised and/or locally advanced upper tract urothelial carcinoma without metastasis

Thomas Seisen et al.

BJU INTERNATIONAL (2014)

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Article Urology & Nephrology

Impact of smoking status and cumulative exposure on intravesical recurrence of upper tract urothelial carcinoma after radical nephroureterectomy

Evanguelos Xylinas et al.

BJU INTERNATIONAL (2014)

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Article Urology & Nephrology

Predictors of survival in patients with disease recurrence after radical nephroureterectomy

Luis A. Kluth et al.

BJU INTERNATIONAL (2014)

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Article Urology & Nephrology

Impact of Distal Ureter Management on Oncologic Outcomes Following Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma

Evanguelos Xylinas et al.

EUROPEAN UROLOGY (2014)

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Review Urology & Nephrology

Effect of Smoking on Outcomes of Urothelial Carcinoma: A Systematic Review of the Literature

Joseph J. Crivelli et al.

EUROPEAN UROLOGY (2014)

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Article Urology & Nephrology

Prediction of Intravesical Recurrence After Radical Nephroureterectomy: Development of a Clinical Decision-making Tool

Evanguelos Xylinas et al.

EUROPEAN UROLOGY (2014)

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Article Oncology

Comparative analysis of comorbidity and performance indices for prediction of oncological outcomes in patients with upper tract urothelial carcinoma who were treated with radical nephroureterectomy

Atiqullah Aziz et al.

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (2014)

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Article Urology & Nephrology

Long-term follow-up of patients with tumours of the renal pelvis and ureter: How often is a bladder tumour diagnosed after five tumour-free years?

Sten Holmang et al.

SCANDINAVIAN JOURNAL OF UROLOGY (2014)

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Review Environmental Sciences

Aristolochic acid nephropathy: Harbinger of a global iatrogenic disease

Arthur P. Grollman

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS (2013)

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Article Urology & Nephrology

Impact of Smoking on Oncologic Outcomes of Upper Tract Urothelial Carcinoma After Radical Nephroureterectomy

Michael Rink et al.

EUROPEAN UROLOGY (2013)

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Article Oncology

Prospective Randomized Phase II Trial of a Single Early Intravesical Instillation of Pirarubicin (THP) in the Prevention of Bladder Recurrence After Nephroureterectomy for Upper Urinary Tract Urothelial Carcinoma: The THP Monotherapy Study Group Trial

Akihiro Ito et al.

JOURNAL OF CLINICAL ONCOLOGY (2013)

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Article Urology & Nephrology

Prophylactic Intravesical Chemotherapy to Prevent Bladder Tumors after Nephroureterectomy for Primary Upper Urinary Tract Urothelial Carcinomas: A Systematic Review and Meta-Analysis

Dong Fang et al.

UROLOGIA INTERNATIONALIS (2013)

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Article Oncology

Low biopsy volume in ureteroscopy does not affect tumor biopsy grading in upper tract urothelial carcinoma

Claudia P. Rojas et al.

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (2013)

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Article Oncology

Multi-institutional validation of the ability of preoperative hydronephrosis to predict advanced pathologic tumor stage in upper-tract urothelial carcinoma

Jamie C. Messer et al.

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (2013)

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Article Urology & Nephrology

Upper urinary tract urothelial cell carcinoma: location as a predictive factor for concomitant bladder carcinoma

Marco Cosentino et al.

WORLD JOURNAL OF UROLOGY (2013)

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Article Radiology, Nuclear Medicine & Medical Imaging

Comparative Effectiveness of Imaging Modalities for the Diagnosis of Upper and Lower Urinary Tract Malignancy: A Critically Appraised Topic

Seyed Amirhossein Razavi et al.

ACADEMIC RADIOLOGY (2012)

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Article Oncology

Influence of Positive Surgical Margin Status After Radical Nephroureterectomy on Upper Urinary Tract Urothelial Carcinoma Survival

Pierre Colin et al.

ANNALS OF SURGICAL ONCOLOGY (2012)

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Article Urology & Nephrology

Comparison of oncological outcomes after segmental ureterectomy or radical nephroureterectomy in urothelial carcinomas of the upper urinary tract: results from a large French multicentre study

Pierre Colin et al.

BJU INTERNATIONAL (2012)

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Article Urology & Nephrology

A proportion of hereditary upper urinary tract urothelial carcinomas are misclassified as sporadic according to a multi-institutional database analysis: proposal of patient-specific risk identification tool

Francois Audenet et al.

BJU INTERNATIONAL (2012)

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Review Urology & Nephrology

Laparoscopic Versus Open Nephroureterectomy for the Treatment of Upper Urinary Tract Urothelial Carcinoma: A Systematic Review and Cumulative Analysis of Comparative Studies

Shaobin Ni et al.

EUROPEAN UROLOGY (2012)

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Article Urology & Nephrology

Oncological outcomes after radical nephroureterectomy for upper tract urothelial carcinoma: Comparison over the three decades

Mehrad Adibi et al.

INTERNATIONAL JOURNAL OF UROLOGY (2012)

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Article Oncology

Randomized Phase II/III Trial Assessing Gemcitabine/Carboplatin and Methotrexate/Carboplatin/Vinblastine in Patients With Advanced Urothelial Cancer Who Are Unfit for Cisplatin-Based Chemotherapy: EORTC Study 30986

Maria De Santis et al.

JOURNAL OF CLINICAL ONCOLOGY (2012)

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Article Urology & Nephrology

High-Grade Ureteroscopic Biopsy Is Associated with Advanced Pathology of Upper-Tract Urothelial Carcinoma Tumors at Definitive Surgical Resection

Thomas Clements et al.

JOURNAL OF ENDOUROLOGY (2012)

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Review Urology & Nephrology

CT urography for hematuria

Nigel C. Cowan

NATURE REVIEWS UROLOGY (2012)

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Article Oncology

Impact of the expression of Aurora-A, p53, and MIB-1 on the prognosis of urothelial carcinomas of the upper urinary tract

Sylvia Scarpini et al.

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (2012)

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Article Urology & Nephrology

Oncological outcomes after laparoscopic and open radical nephroureterectomy: results from an international cohort

Thomas J. Walton et al.

BJU INTERNATIONAL (2011)

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Article Urology & Nephrology

Racial differences in the outcome of patients with urothelial carcinoma of the upper urinary tract: an international study

Kazumasa Matsumoto et al.

BJU INTERNATIONAL (2011)

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Review Oncology

Small cell carcinoma of the upper urinary tract (UUT-SCC): Report of a rare entity and systematic review of the literature

Adil Ouzzane et al.

CANCER TREATMENT REVIEWS (2011)

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Article Urology & Nephrology

Prevention of Bladder Tumours after Nephroureterectomy for Primary Upper Urinary Tract Urothelial Carcinoma: A Prospective, Multicentre, Randomised Clinical Trial of a Single Postoperative Intravesical Dose of Mitomycin C (the ODMIT-C Trial)

Tim O'Brien et al.

EUROPEAN UROLOGY (2011)

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Article Urology & Nephrology

Prognostic factors for upper urinary tract urothelial carcinomas: stage, grade, and smoking status

Adnan Simsir et al.

INTERNATIONAL UROLOGY AND NEPHROLOGY (2011)

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Article Urology & Nephrology

Gender differences in radical nephroureterectomy for upper tract urothelial carcinoma

Shahrokh F. Shariat et al.

WORLD JOURNAL OF UROLOGY (2011)

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Article Urology & Nephrology

A delay in radical nephroureterectomy can lead to upstaging

Matthias Waldert et al.

BJU INTERNATIONAL (2010)

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Article Radiology, Nuclear Medicine & Medical Imaging

MR urography versus retrograde pyelography/ureteroscopy for the exclusion of upper urinary tract malignancy

K. S. Lee et al.

CLINICAL RADIOLOGY (2010)

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Article Urology & Nephrology

Changes in Renal Function Following Nephroureterectomy May Affect the Use of Perioperative Chemotherapy

Matthew G. Kaag et al.

EUROPEAN UROLOGY (2010)

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Article Urology & Nephrology

Comparison Between Laparoscopic and Open Radical Nephroureterectomy in a Contemporary Group of Patients: Are Recurrence and Disease-Specific Survival Associated with Surgical Technique?

Ricardo L. Favaretto et al.

EUROPEAN UROLOGY (2010)

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Article Urology & Nephrology

Template-based lymphadenectomy in urothelial carcinoma of the upper urinary tract: Impact on patient survival

Tsunenori Kondo et al.

INTERNATIONAL JOURNAL OF UROLOGY (2010)

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Article Urology & Nephrology

Impact of Diagnostic Ureteroscopy on Intravesical Recurrence and Survival in Patients With Urothelial Carcinoma of the Upper Urinary Tract

Shuhei Ishikawa et al.

JOURNAL OF UROLOGY (2010)

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Article Urology & Nephrology

Segmental Ureterectomy Can Safely be Performed in Patients With Transitional Cell Carcinoma of the Ureter

Claudio Jeldres et al.

JOURNAL OF UROLOGY (2010)

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Article Urology & Nephrology

Preoperative Hydronephrosis, Ureteroscopic Biopsy Grade and Urinary Cytology Can Improve Prediction of Advanced Upper Tract Urothelial Carcinoma

James C. Brien et al.

JOURNAL OF UROLOGY (2010)

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Article Urology & Nephrology

Gadolinium Enhanced Magnetic Resonance Urography for Upper Urinary Tract Malignancy

Naoki Takahashi et al.

JOURNAL OF UROLOGY (2010)

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Review Urology & Nephrology

Environmental factors involved in carcinogenesis of urothelial cell carcinomas of the upper urinary tract

Pierre Colin et al.

BJU INTERNATIONAL (2009)

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Article Oncology

Carcinoma of the Upper Urinary Tract Predictors of Survival and Competing Causes of Mortality

Brant A. Inman et al.

CANCER (2009)

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Article Oncology

Outcomes of Radical Nephroureterectomy: A Series From the Upper Tract Urothelial Carcinoma Collaboration

Vitally Margulis et al.

CANCER (2009)

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Review Urology & Nephrology

Oncological risk of laparoscopic surgery in urothelial carcinomas

Morgan Roupret et al.

WORLD JOURNAL OF UROLOGY (2009)

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Article Oncology

Screening for urinary tract cancer with urine cytology in Lynch syndrome and familial colorectal cancer

T. Myrhoj et al.

FAMILIAL CANCER (2008)

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Article Urology & Nephrology

Multidetector computed tomography urography for diagnosing upper urinary tract urothelial tumour

Nigel C. Cowan et al.

BJU INTERNATIONAL (2007)

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Article Urology & Nephrology

Upper urinary tract transitional cell carcinoma:: Recurrence rate after percutaneous endoscopic resection

Morgan Roupret et al.

EUROPEAN UROLOGY (2007)

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Article Pathology

High-grade urothelial carcinoma of the renal pelvis: clinicopathologic study of 108 cases with emphasis on unusual morphologic variants

D Perez-Montiel et al.

MODERN PATHOLOGY (2006)

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Article Urology & Nephrology

Bilateral metachronous ureteral and renal pelvic carcinomas: Incidence, clinical presentation, histopathology, treatment and outcome

S Holmang et al.

JOURNAL OF UROLOGY (2006)

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Review Public, Environmental & Occupational Health

Aristolochic acid and 'Chinese herbs nephropathy' - A review of the evidence to date

JP Cosyns

DRUG SAFETY (2003)

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Article Urology & Nephrology

Proposal for changes in cystoscopic follow-up of patients with low-grade pTa gladder tumor

O Oge et al.

EUROPEAN UROLOGY (2000)

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