More is better? Hypertonic saline dose and response for cystic fibrosis: efficacy, tolerability and implications for clinical practice

Article Critical Care Medicine

Discontinuation versus continuation of hypertonic saline or dornase alfa in modulator treated people with cystic fibrosis (SIMPLIFY): results from two parallel, multicentre, open-label, randomised, controlled, non-inferiority trials

Nicole Mayer-Hamblett et al.

Summary: The SIMPLIFY study aimed to assess the effects of discontinuing nebulised hypertonic saline or dornase alfa in people using CFTR modulator therapy. The study found that discontinuing these treatments for 6 weeks did not result in clinically meaningful differences in pulmonary function compared to continuing treatment in individuals with relatively well-preserved lung function.

LANCET RESPIRATORY MEDICINE (2023)

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Article Respiratory System

Saline at lower tonicity in cystic fibrosis (SALTI-CF) trial comparing 0.9% versus 3% versus 6% nebulised saline

Tiffany J. Dwyer et al.

Summary: This study evaluated the relative effectiveness and tolerability of different concentrations of saline nebulised twice daily in cystic fibrosis patients. The results showed that 3% saline significantly improved lung function and delayed pulmonary exacerbations, while 6% saline had similar benefits and also improved quality of life. However, the positive impacts of 6% saline on time to intravenous antibiotics for exacerbations and quality of life were not maintained.

EUROPEAN RESPIRATORY JOURNAL (2023)

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Article Critical Care Medicine

The effect of inhaled hypertonic saline on lung structure in children aged 3-6 years with cystic fibrosis (SHIP-CT): a multicentre, randomised, double-blind, controlled trial

Harm A. W. M. Tiddens et al.

Summary: A multicentre study demonstrated that inhaled hypertonic saline had a positive effect on structural lung changes in children aged 3-6 years with cystic fibrosis compared to isotonic saline.

LANCET RESPIRATORY MEDICINE (2022)

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Article Respiratory System