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Article
Polymer Science
Federico Karp et al.
Summary: Polymer controlled release systems are being extensively researched for their potential as new therapeutic options. These systems aim to control active principle levels, optimize drug doses, reduce secondary effects, and improve patient acceptance. This study focuses on designing delivery systems for tilmicosin and clarithromycin using synthetic and natural polymers to enhance encapsulation efficiencies and release rates. The results demonstrate varying encapsulation efficiencies and release rates depending on the type of antibiotic and synthesis factors. Incorporating microparticles into beads showed potential for biocomposite systems, but only resulted in diminished release rate for tilmicosin. Overall, these investigated systems offer interesting prospects for new therapeutic options in animal and human health.
IRANIAN POLYMER JOURNAL
(2023)
Review
Pharmacology & Pharmacy
Murtaza Haider Syed et al.
Summary: Polymers, especially biopolymers, are increasingly being used as a more environmentally friendly alternative to petroleum-based polymers due to their low carbon footprint and easy degradation. Drug delivery systems, especially nanofibers, hold great promise in the field of medicine and are the focus of researchers for improved therapies and tailor-made treatments. This review discusses the importance of naturally abundant biopolymers in recent medical applications, particularly their role in drug delivery systems, and provides a crucial comparison of the advantages and disadvantages of major drug delivery systems.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Yuanwen Jiang et al.
Summary: Smart bandages based on multimodal wearable devices have the potential to monitor and intervene in the healing process of chronic wounds. However, the integration of sensors and stimulators in current smart bandage technologies is limited. In this study, a flexible bioelectronic system with wireless power, closed-loop sensing and stimulation circuits, and skin-interfacing hydrogel electrodes with switchable adhesion was developed to address these challenges. The wound care system showed improved healing and tissue regeneration in preclinical wound models.
NATURE BIOTECHNOLOGY
(2023)
Article
Polymer Science
Ping Yu et al.
Summary: This article introduces a new technique called coaxial mechano-electrospinning, which utilizes the drawing force from a moving substrate and electric static force to achieve precise positioning and high deposition accuracy of core-shell fibers. Through a series of experiments, optimal process parameters were determined and a pressure sensor based on the core-shell fibers was developed.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2023)
Article
Engineering, Biomedical
Jiangyu Cai et al.
Summary: In this study, innovative nano-micro fibrous woven scaffolds with tendon-like structure and high-strength mechanical properties were fabricated for the treatment of large-size tendon injury. These scaffolds showed improved cell adhesion, elongation, proliferation, and maintained tenocyte phenotype. In vivo experiments demonstrated that the scaffold facilitated Achilles tendon regeneration with improved structure and biomechanical properties.
Review
Pharmacology & Pharmacy
Luca Eva Uhljar et al.
Summary: Electrospinning is a widely used technology for producing ultra-thin fibers. The morphology and physicochemical properties of the fibers depend on various factors. In the biomedical field, electrospun nanofibers have diverse applications, including medication delivery systems and tissue engineering scaffolds. The regulation of nanotechnology-made medical devices is still not properly defined. This review provides an overview of electrospinning and discusses developments in the field of electrospun medical devices, along with the relevant regulatory framework.
Review
Engineering, Biomedical
Behzad Shiroud Heidari et al.
Summary: Tendon and ligament injuries affect millions of people annually. Biopolymers play a significant role in TL tissue repair. Many different types of biopolymers have been studied in TL regeneration, but most have not been used clinically.
BIOACTIVE MATERIALS
(2023)
Review
Endocrinology & Metabolism
Ravindra V. Badhe et al.
Summary: In tissue engineering, the fate of organ/tissue regeneration depends on 3D architecture, cells used, and stimulus provided. 3D bio-printing has advanced the development of precise 3D structures using industrial software. The selection of bio-ink is crucial for the printing process, especially for bone and cartilage tissues. This review discusses different biomaterials used to develop bio-inks and their compatibility with cells, with a focus on applications in orthopedics and orthodontics.
Review
Engineering, Chemical
Gustavo Larsen et al.
Summary: This article provides a focused and brief review on needleless electrohydrodynamic (EHD) methods for producing submicron fibers and particles. It discusses the advantages of these methods over conventional EHD methods, particularly in terms of production scale. Key patent and journal literature are summarized to assist materials processing engineers in equipment design selection.
CHEMICAL ENGINEERING COMMUNICATIONS
(2023)
Review
Engineering, Chemical
Muhammad Omer Aijaz et al.
Summary: Membrane distillation (MD) is a highly promising technology for seawater desalination and wastewater treatment due to its unique advantages. Electrospinning provides a simple method for fabricating hydrophobic nanofibrous membranes for the MD process. These membranes offer various advantages such as small diameter, high surface area, high hydrophobicity, and high gas permeability.
Meeting Abstract
Endocrinology & Metabolism
Gozde Cay et al.
Article
Polymer Science
Ye Qi et al.
Summary: The study reports on a simple, quick, and cost-effective method to produce nanofiber-constructed yarns (NYs) using a combination of electrospinning, hand winding, and stretching post-treatment. The NYs demonstrated improved surface hydrophilicity and wettability with increasing silk fibroin (SF) content. Cells were able to sense and respond to the nanofibrous morphology and orientation of the NYs and SF promoted cell growth and proliferation. This research provides a simple and feasible method for fabricating PCL/SF NYs and NY-based biotextiles with great potential for tissue engineering and regenerative medicine applications.
EUROPEAN POLYMER JOURNAL
(2023)
Review
Food Science & Technology
Yue Wang et al.
Summary: Electrospinning natural biopolymers has gained great attention due to their versatile properties and potential applications in the food industry. These biopolymers, such as proteins and polysaccharides, are abundant, biocompatible, and degradable, making them suitable for use in food areas. However, challenges still exist in spinning natural biopolymers, such as the difficulty in spinning globular structure and the poor water vapor barrier properties. This review provides a comprehensive overview of the basic knowledge of natural biopolymers and their fiber fabrication methods, as well as the functional characteristics of micro/nanofibers. The emerging applications in food-related areas are also highlighted to promote the development of electrospinning fibers in the food industry.
FOOD AND BIOPROCESS TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Niloofar Dehghani et al.
Summary: In this study, a nanofiber wound dressing composed of chitosan/silk fibroin/N-doped carbon quantum dots/alpha-tricalcium phosphate was synthesized and characterized. The results showed that the nanofiber exhibited excellent biocompatibility and antimicrobial properties, promoting wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Xiaojie Xing et al.
Summary: Natural polymers derived from animals and plants have been widely used in biomedical applications due to their similarities with biomacromolecules in the human body. Chitosan, an alkaline polysaccharide, has attracted much attention in tissue regeneration and drug delivery. By combining chitosan with silk fibroin, the mechanical properties and degradation behavior drawbacks of chitosan can be overcome. Additionally, other natural and synthetic biopolymers have also been incorporated to improve the performance of chitosan/silk fibroin composites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Mduduzi N. Sithole et al.
Summary: This research utilized a 3D-printed biomaterial scaffold to enhance bone tissue regeneration. The scaffold exhibited essential biomineral trace elements and supported cell adhesion and proliferation. The protein-embedded scaffolds showed higher bone formation potential compared to the control group. It provides a potential platform for functional regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Nabilah Zulkefli et al.
Summary: Wounds caused by diabetes and obesity are a significant problem in healthcare. Unhealthy lifestyles and habits exacerbate the condition. Flavonoids have been shown to promote wound healing due to their anti-inflammatory, angiogenesis, re-epithelialization, and antioxidant effects. This review compiles existing evidence on the use of flavonoids as safe wound-healing agents, discusses current limitations, and provides future perspectives.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Polymer Science
Gayathri Chakrapani et al.
Summary: For centuries, nanofibers have been fabricated by converting polymeric materials into nanofibers with tunable properties and have shown great potential in various biomedical applications. In recent years, advances in nanotechnology have enabled the formation of electrospun nanofibers with customizable geometries and release properties. These nanofibers exhibit unique structural characteristics, such as a large surface-to-volume ratio and interconnected pores, which make them suitable for a wide range of healthcare, energy, and environmental applications. This review focuses on the recent advances in electrospun nanofibers for biomedical applications, including therapeutic delivery, tissue engineering, wound healing, and cancer research.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Chemistry, Physical
Samuel Varner et al.
Summary: Implicit solvent models are commonly used to study soft materials and biophysical systems by simplifying solvent degrees of freedom into effective interaction potentials. In electrolyte and polyelectrolyte solutions, the solvent degrees of freedom are coarse-grained into an effective dielectric constant, which incorporates the entropic contributions into the temperature dependence of the dielectric constant. Properly considering the electrostatic entropy is crucial for differentiating between enthalpically and entropically driven free energy changes. In this study, we investigate the entropic origin of electrostatic interactions in a dipolar solvent and provide a clearer physical understanding of the solvent dielectric response. We calculate the potential of mean force (PMF) between oppositely charged ions in a dipolar solvent using molecular dynamics and dipolar self-consistent field theory, and find that the PMF is primarily governed by the entropy gain from dipole release, resulting from reduced orientational polarization of the solvent. We also observe a nonmonotonic temperature dependence of the relative contribution of entropy to the free energy change. Our findings are expected to be applicable to a wide range of problems involving ionic interactions in polar solvents.
JOURNAL OF PHYSICAL CHEMISTRY B
(2023)
Review
Polymer Science
Meera Moydeen Abdul Hameed et al.
Summary: This review focuses on the controlled release mechanism in different electrospinning methods and the selectivity of hydrophilic, water-soluble polymers as drug carriers. The drug delivery mechanism mainly depends on the method of drug loading, polymeric interactions, and the nature of polymer swelling, erosion, or degradation.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2023)
Review
Polymer Science
Pratikshkumar R. Patel et al.
Summary: This review article focuses on the versatility, current status, and future efforts of electrospun nanofibers for various biomedical applications. It discusses the properties and background of nanofibers, as well as the different electrospinning methods and their mechanism. It also covers the factors affecting the properties of nanofibers and their applications in tissue engineering, drug delivery, biosensors, skin cancer treatment, and magnetic nanofibers.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2023)
Review
Materials Science, Multidisciplinary
Jaeyu Lee et al.
Summary: Electrospinning has attracted attention for its ability to create nonwoven nanofiber webs with high surface area and porosity. However, traditional needle and syringe-based systems have limited productivity. This article examines the latest developments in nonconventional electrospinning methods, such as needleless and syringeless electrospinning, which have the potential to meet industrial-scale manufacturing requirements and produce nanofibers that are difficult to spin using traditional techniques.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2023)
Review
Nanoscience & Nanotechnology
Satyanarayan Pattnaik et al.
Summary: Nanofibers, especially electrospun nanofibers, have been widely explored for drug delivery and addressing the poor aqueous solubility of drug molecules. This review provides an overview of key factors influencing the electrospinning process and characteristics of nanofibers, as well as various methodologies and types of nanofibers used for poorly soluble drugs.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2023)
Review
Polymer Science
Mohammad Javad Javid-Naderi et al.
Summary: Damage or loss of bone tissue is a major issue affecting human well-being, and tissue engineering is used to recover and regenerate bone fractures and damage. Polymer biomaterials are the most commonly required materials for synthetic bone scaffolds due to their suitable mechanical properties and degradation rates. Synthetic polymers offer advantages in bone replacement because they can be designed and changed easily, and their biocompatibility has been widely accepted in tissue engineering. This article updates on materials and application usage of scaffolds in bone tissue engineering for hard tissue regeneration.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2023)
Review
Chemistry, Physical
Maria Pia Ferraz
Summary: This review summarizes the various materials used for bone defect replacement or repair in dentistry and oral and maxillofacial surgeries. Factors such as tissue viability, size, shape, and defect volume influence the choice of material. Autologous bone is the gold standard for bone grafting but has limitations. Alternatives include allografts, xenografts, and synthetic materials. Calcium-phosphate-based ceramics, especially hydroxyapatite, are commonly used due to their similarity to natural bone. This review aims to provide a comprehensive analysis of grafting materials in dentistry and discusses their properties, advantages, and challenges.
Article
Chemistry, Multidisciplinary
Qiuyu Wang et al.
Summary: This study presents a novel electrospinning fiber-collecting device that can collect nanofiber scaffolds with a radially oriented structure. These scaffolds exhibit enhanced mechanical properties, decreased hydrophobicity, and promote cell proliferation, making them suitable for advanced applications such as wound dressings and tissue-engineered scaffolds.
Article
Materials Science, Biomaterials
Saba Fooladi et al.
Summary: A variety of bio-and nanomaterials have been used in cardiovascular tissue engineering, but challenges still exist regarding their biocompatibility and risk factors. Natural polysaccharide-and protein-based structures have been explored in this field, offering advantages in terms of biocompatibility and environmental aspects. Bacterial cellulose (BC) shows promise as a candidate for cardiovascular TE, but challenges such as absence of antimicrobial factors and low production yield still need to be addressed.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Review
Materials Science, Multidisciplinary
Antonios Keirouz et al.
Summary: Electrospinning has advanced rapidly, leading to the invention of new technologies and apparatuses. The revamping of conventional electrospinning focuses on achieving scalability, developing 3D nanofibrous macrostructures, and formulating novel fiber configurations. This review introduces a diverse group of electrospinning techniques and compares them based on apparatus type and output, assessing their advantages and limitations. Future developments of advanced electrospinning technologies are outlined with a focus on upscaling, translational research, sustainable manufacturing, and prospective solutions to current shortcomings.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Chemistry, Multidisciplinary
Gargi Ghosh et al.
Summary: Research on transient wearable electronics is gaining interest due to their ability to seamlessly conform to human tissues and disappear when disposed. However, the challenge lies in finding materials that are both biodegradable and stretchable. This study addresses these challenges by developing a biodegradable nanofiber-reinforced water-borne polyurethane with stretchability, toughness, and partial biodegradability. The research demonstrates the potential of these materials for use in transient wearable electronics.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Juhi Chauhan et al.
Summary: The development of new nutraceutical formulations with a broader range of probiotics, prebiotics, and synbiotics is needed to enhance the activity and functioning of gut microbiota. These techniques depend on the type of food and the application of biotic components, probiotics, and synbiotics, as well as the encapsulation method. Co-encapsulation is required to improve the oral transfer, viability, efficacy, and stability of synbiotics delivery within the intestine. The review highlights the utilization of diverse prebiotic polymers in synbiotic formulations, along with microbial biofilms, for enhancing gut microbiota activity and improving overall health.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Kui Zhang et al.
Summary: This paper reviews the progress in the application of polyvinyl alcohol/chitosan composite hydrogels in various medical fields, the different cross-linking agents and cross-linking methods, and the research progress in the optimization of composite hydrogels for their subsequent wide range of biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Nanoscience & Nanotechnology
Baljinder Singh et al.
Summary: An effective method for accelerating wound healing is through a smart delivery platform that releases drugs based on the different stages of healing. Electrospun nanofibers have gained attention due to their simple manufacturing process, unique structure, and biological functions similar to the extracellular matrix. In this study, a core-shell nanofiber platform loaded with two drugs was investigated, with the shell releasing the drug into an aqueous solution and the core generating localized heat for programmable drug release. This versatile platform can provide controlled and safe drug delivery to wound sites and potentially be used for treating other topical diseases.
ACS APPLIED BIO MATERIALS
(2023)
Review
Engineering, Multidisciplinary
Rikako Hama et al.
Summary: Inducing tissue regeneration in various skin defects has become an important clinical issue. Current methods such as cell sheets and growth factor-containing scaffolds have limitations in restoring normal skin tissue structure and function. Researchers have been exploring material design strategies, including mimicking the extracellular matrix (ECM) and its three-dimensional network structure, for more effective skin tissue regeneration.
Review
Materials Science, Biomaterials
Qilong Zhao et al.
Summary: Through bottom-up biomanufacturing technologies, engineering cell fibers can recreate the ordered organization of fiber bundles and mimic tissue functions, providing important applications in areas such as drug testing, cell therapy, and tissue engineering.
Editorial Material
Multidisciplinary Sciences
Wenliang Song et al.
Article
Chemistry, Multidisciplinary
Wanying Wei et al.
Summary: In this study, we investigated the impact of molecular interactions and solvent evaporation kinetics on the formation of porous structures in electrospun nanofibers. Using polyacrylonitrile (PAN) and polystyrene (PS) as model polymers, the coaxial electrospinning technique was employed to control the injection of water and ethylene glycol (EG) as nonsolvents into the polymer jets. The results revealed the crucial role of intermolecular interactions and the size and polarity of nonsolvent molecules in governing phase separation and porous structure formation. Moreover, the solvent evaporation kinetics were found to significantly affect the phase separation and the formation of distinct porous structures.
Review
Ophthalmology
Raziyeh Ghorbani et al.
Summary: This article introduces the interest of ophthalmology researchers in factors affecting the development/exacerbation of ocular diseases, focusing on the importance of extracellular matrix (ECM) changes and their role in various eye disorders. Currently, there is limited research in this area, so a better understanding of this process can help discover plausible strategies to prevent or treat eye disorders.
SEMINARS IN OPHTHALMOLOGY
(2023)
Article
Crystallography
Huifeng Shao et al.
Summary: Due to limitations in traditional bone repair techniques, 3D printing technology has emerged as a research focus in bone tissue engineering. In this study, high-precision magnesium-containing silicate (CSi-Mg) scaffolds were developed using three-dimensional printing technology. The influence of pore size on scaffold strength and the mechanical properties of the scaffold's sidewalls were systematically analyzed. The CSi-Mg scaffold exhibited high elasticity modulus, compressive strength, bioactivity, and biodegradability, making it a promising solution for challenging bone defect cases.
Article
Chemistry, Multidisciplinary
Marwan Y. Rezk et al.
Summary: Pumpkin seed oil was combined with polyvinyl alcohol (PVA) and chitosan (CS) to develop novel electrospun nanofibers. The pumpkin-loaded nanofibers exhibited significant antibacterial activity and promoted wound healing. These results suggest that pumpkin-loaded nanofibers have potential applications in wound healing.
Article
Chemistry, Physical
Qiang Wei et al.
Summary: Stem cells can be regulated through nanotopographies like nanofibers, which have aligned electrospun fibers that match the distribution and strength of the electric field. A collector was designed to produce nanofibrous membranes with defined alignment and pore size. The study shows that randomly oriented nanofibers with small pores promote self-renewal and differentiation of stem cells, while aligned mesh membranes with medium pores decrease cell proliferation and stemness.
COLLOID AND INTERFACE SCIENCE COMMUNICATIONS
(2023)
Review
Medicine, Research & Experimental
Huihui Zhang et al.
Summary: 3D bioprinting technology can replicate native tissue and organ microenvironments by precisely placing cells in bioinks. However, finding the ideal bioink is a challenge. Organ-derived decellularized ECM (dECM) bioink has optimal biomimetic properties but is non-printable due to poor mechanical properties. Recent studies have focused on improving the printability of dECM bioinks. This review highlights the methods used to produce these bioinks, strategies to improve printability, and advancements in tissue regeneration. Challenges and potential applications are also discussed.
Article
Materials Science, Multidisciplinary
Seok Hyeon Hwang et al.
Summary: An adaptive electrospinning system based on reinforcement learning was developed to produce uniform-thickness nanofiber filters. By measuring the transmitted light through the nanofiber filter and using a pre-trained reinforcement learning algorithm, the system detected and alleviated the non-uniformity of the filter thickness. The method significantly reduced the thickness non-uniformity of the nanofiber filters.
ADVANCED FIBER MATERIALS
(2023)
Review
Materials Science, Multidisciplinary
Jialing Song et al.
Summary: This review outlines the progress of research on electrospinning nanofibers with different morphologies and functional characteristics in environmental sensors over the past decade. Electrospun nanofibers possess advantages such as porous structure and high specific surface area, and introducing functional nanomaterials can improve the performance of sensors.
ADVANCED FIBER MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Yue Zhao et al.
Summary: Tissue engineering offers a promising approach for treating organ or tissue loss, with supramolecular adhesive hydrogels showing great potential due to their unique properties. This review comprehensively summarizes the design principles and applications of adhesive hydrogels, highlighting their efficacy in various tissue repair processes.
Article
Biochemistry & Molecular Biology
Seyedeh Sara Ashraf et al.
Summary: This study aimed to fabricate and characterize a nanofiber skin substitute with enhanced mechanical properties and cellular compatibility. The scaffold consisted of collagen, sodium alginate, and exopolysaccharides produced by Rhodotorula mucilaginosa sp. GUMS16. The cross-linked nanofibers were characterized and tested for cell viability and proliferation. The results showed that the incorporation of GUMS16-produced exopolysaccharides increased cell viability and proliferation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Biochemistry & Molecular Biology
Katarina Valachova et al.
Summary: This review paper provides a comprehensive overview of the electrospinning of hyaluronic acid and chitosan for wound dressing applications. It summarizes the methods of preparation and challenges faced in the electrospinning process, as well as strategies to overcome these difficulties. The review also explains the biological roles and mechanisms of hyaluronic acid and chitosan in wound healing, highlighting the advantages of nanofibers and their potential for drug delivery.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Mengxia Lin et al.
Summary: The development of antibacterial wound dressings that co-deliver two antibiotics, ciprofloxacin and tetracycline hydrochloride, in a coaxial nanofiber matrix shows great potential due to their strong antibacterial activity and biocompatibility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Sharda Gupta et al.
Summary: Novel magnesium-doped non-mulberry silk fibroin nanofibers were successfully fabricated using electrospinning technique, showing enhanced skin barrier function and potential for wound healing applications. The incorporation of magnesium nanoparticles in the nanofibers released Mg2+ ions at the wound site, promoting skin barrier repair and blood coagulation. The magnesium-doped nanofibrous film exhibited improved mechanical properties, satisfactory blood clotting ability, and good in vitro degradability, demonstrating its potential as a skin substitute film.
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Michael T. Brennan et al.
Summary: This clinical trial demonstrated that the use of Rivelin(R)-CLO patches for the treatment of OLP showed significant efficacy in improving ulcer area, symptom severity, disease activity, pain, and quality of life compared to placebo, with a favorable safety profile.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Kaleemullah Kalwar et al.
Summary: Electrospun cellulose acetate nanofibers were synthesized and decorated with Au@AgNPs to construct effective wound dressing material. The Au@AgNPs/cellulose exhibited excellent antimicrobial activity and showed promising results in wound healing experiment.
KOREAN JOURNAL OF CHEMICAL ENGINEERING
(2022)
Review
Materials Science, Multidisciplinary
Daniel P. Ura et al.
Summary: This article discusses the impact of electrical polarity on the properties of electrospun fibers, including changes in molecular structure and surface chemistry. Additionally, methods for investigating the effects of electrical polarity are presented.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2022)
Review
Materials Science, Textiles
Seyed Abdolkarim Hosseini Ravandi et al.
Summary: This paper provides a review of the latest developed electrospinning methods for high production rate of nanofibers, including multi-jet, needleless, bubble, centrifuge, and electro-centrifuge systems. It also investigates the jet formation in centrifugal spinning and electro-centrifuge systems through experimental and numerical analysis.
TEXTILE RESEARCH JOURNAL
(2022)
Article
Cell & Tissue Engineering
Busra Baskapan et al.
Summary: Current treatment options for renal diseases are insufficient, prompting the exploration of tissue engineering as a new approach. This study investigates the incorporation of laminin into polycaprolactone electrospun scaffolds, demonstrating the importance of hybrid scaffolds for kidney tissue engineering.
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2022)
Article
Food Science & Technology
Nicole Angel et al.
Summary: This review discusses the basic principles and variations of electrospinning, and explores electrospun fibers made from polysaccharides in detail. Methods to improve the electrospinnability of polysaccharides are also introduced. Electrospun fibers can be tailored for specific functions through optimization of the electrospinning process and spinning dope. Increasing fiber production rate and improving electrospinnability of polysaccharides are crucial for scaling up the electrospinning process. Biopolymer fibers show high potential in the field of biomedical applications due to their biodegradability and compatibility properties.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2022)
Review
Nanoscience & Nanotechnology
Deng-Guang Yu et al.
Summary: This review discusses the history and trends of the combination of electrospinning technology and sustained drug release (SDR), introducing 15 strategies for providing SDR profiles through multi-chamber core-shell nanostructures. Electrospun multi-chamber nanostructures are considered to be helpful in promoting the development of sustained drug release formulations.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2022)
Article
Polymer Science
Antonella Patti et al.
Summary: This study provides an overview of the use of biopolymers in textile processes to reduce the environmental impact of the industry. Biopolymers can be used in yarn production, textile finishing, imparting functional properties to textiles, replacing pollutive printing methods, and treating dye-contaminated water. Current projects by well-known companies on developing new materials for the textile market are also presented.
Article
Polymer Science
Denisa-Maria Radulescu et al.
Summary: In recent years, the development and characterization of biomaterials for regenerative medicine and controlled release have posed significant challenges. Hydrogels are considered optimal applications in the biomedical field, particularly in tissue engineering. However, their delicate nature and low mechanical strength limit their use. Therefore, developing stronger and more stable hydrogels with increased biocompatibility is essential. Natural and synthetic polymers both have limitations, but the development of hydrogels based on mixtures of these materials can optimize their properties. Incorporating different nanoparticles can improve stability and yield various biological effects. Essential oils and drug molecules can facilitate desired biological effects and even produce a synergistic effect. The main purpose of this study is to identify the key properties required to develop sustainable polymeric scaffolds for tissue engineering without adverse environmental effects.
Article
Biotechnology & Applied Microbiology
Chuanliang Liu et al.
Summary: A chitosan electrospun nanofibrous material containing Cur@beta-CD/AgNPs nanoparticles showed dual antibacterial and tissue repair properties. In vivo experiments demonstrated that it promoted wound closure and improved collagen distribution compared to commercial dressings.
Article
Biotechnology & Applied Microbiology
Jia Xin Yap et al.
Summary: This review summarizes the modifications and applications of natural biopolymeric culture scaffold using different crosslinkers. It also provides an overview of the recent progress in natural biopolymeric culture scaffold, including their properties, synthesis, modification, and application.
Review
Pharmacology & Pharmacy
Catarina S. Miranda et al.
Summary: This review introduces electrospinning and wet-spinning as two efficient techniques for producing polymeric fibrous constructs, discussing various fiber architectures and the influence of processing parameters. It also explores the biomedical applications of these fiber structures in detail.
Article
Nanoscience & Nanotechnology
Vianni Chopra et al.
Summary: By developing a scaffold that mimics the micro-/nano-bone structure, the differentiation of mesenchymal stem cells to osteogenic lineage can be accelerated without the need for exogenous osteogenic supplements. Additionally, the scaffold enhances angiogenesis and exhibits anti-biofilm activity.
ACS APPLIED NANO MATERIALS
(2022)
Article
Engineering, Biomedical
Zhengchao Yuan et al.
Summary: This study developed VEGF-binding aligned electrospun PCL/Gel scaffolds by incorporating BP sequence and demonstrated their potential in promoting ligament regeneration. The functionalized scaffolds accumulated VEGF, enhanced tubular formation of HUVECs and wound healing in vitro, and facilitated the regeneration of matured collagen in patellar ligament in vivo.
ACTA BIOMATERIALIA
(2022)
Article
Chemistry, Applied
Hsien-Tsung Lu et al.
Summary: In this study, chitosan electrospun nanofiber membranes were modified with fucoidan and CuS nanoparticles, enhancing acid resistance and reducing swelling rate. The composite material exhibited durable Fenton-like catalytic activity and was effective in killing bacteria through photothermal and photocatalytic effects. Additionally, the release of fucoidan and copper ions promoted the activity of osteoblast cells and capillary tube formation of endothelial cells.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Anna Liguori et al.
Summary: This study presents a composite hydrogel-electrospun nanofiber scaffold for the local therapy and post-surgical treatment of solid soft tumors. The scaffold showed modulate architecture and controlled release kinetics for two pharmaceutics. In vitro analyses confirmed the non-toxicity of the scaffold and demonstrated its role in tissue repair. Furthermore, in silico analysis supported the negative prognostic role of IL-10 in solid tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Deniz Atila et al.
Summary: This study optimized the electrospinning process of core/shell poly(methyl methacrylate)/silk fibroin fibers to mimic the extracellular matrix and induce tissue regeneration. By adjusting the morphology and chemical properties of the fibers, the water contact angle and porosity of the mats could be altered. The core/shell fibers exhibited intermediate mechanical properties, porous structure, and fine morphology. These fibers promoted the attachment and proliferation of dental pulp stem cells.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Review
Biochemistry & Molecular Biology
Sofia M. Costa et al.
Summary: Photodynamic therapy (PDT) has emerged as a promising treatment approach for various diseases. Using photosensitizers, light, and molecular oxygen, reactive oxygen species are produced to destroy cancer cells and inactivate pathogens. Electrospun polymeric nanofibers offer excellent characteristics for drug delivery, including high drug loading, porosity, flexibility, biocompatibility, and biodegradability.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Chemistry, Physical
Claudia Matschegewski et al.
Summary: This study evaluates the physicochemical and biological properties of nanofiber nonwovens for cardiac implants. It finds that hydrophobic nonwovens are insufficient for rapid cell colonization, but can be improved by plasma treatment. The results highlight the potential of plasma-activated electrospun polymer scaffolds for advanced cardiac implants.
Article
Polymer Science
Wei Ma et al.
Summary: In this study, two types of organic-inorganic composite scaffolds were prepared using modified chitosan and polyvinyl alcohol. The scaffolds displayed interconnected pore and surface nanofiber structures, high porosity, outstanding swelling properties, and controllable degradation rate. The mechanical properties of the scaffolds were significantly improved compared to traditional chitosan scaffolds. Cell experiments confirmed the excellent biocompatibility of the composite scaffolds.
Review
Chemistry, Multidisciplinary
Ayodele Temidayo Odularu
Summary: This study reviews an easy and simple approach process of producing electrospun nanofibres and explores its application in delivering anticancer drugs. Successful production of nanofibres was confirmed through characterization, and the advantages of electrospun nanofibres were utilized to overcome challenges in anticancer chemotherapy.
JOURNAL OF CHEMISTRY
(2022)
Review
Physics, Applied
Adel Mohammed Al-Dhahebi et al.
Summary: This article provides a detailed discussion of the lessons learned from three decades of research, innovation, and design in electrospinning technology. It critically addresses the historical developments, engineering design, and future opportunities of electrospun nanofibers. The article also comprehensively analyzes the transition gaps, potential applications, and academia-industry comparison of electrospinning technology and its products.
APPLIED PHYSICS REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Tao Li et al.
Summary: Electrospun nanofiber materials, particularly those based on gelatin, have shown promise as advanced dressings for wound healing and skin regeneration. They possess high porosity, excellent barrier performance against pathogens, and a mimicry of extracellular matrix fibrils. Various crosslinking approaches and innovative electrospinning strategies have been used to enhance their mechanical properties. Additionally, bioactive components and therapeutic agents can be incorporated to impart multiple functions to these nanofiber dressings. This review provides a comprehensive overview of gelatin-based nanofiber dressings and their applications in wound healing and skin regeneration.
Article
Chemistry, Multidisciplinary
Jia-Yi Yin et al.
Summary: PVDF membranes with good morphology and high crystallinity were prepared using different solvents and electrospinning parameters. The piezoelectric properties of the membranes can be regulated by controlling the solvent dipole moment and process parameters. This study reports, for the first time, the influence of solvent dipole moment on the piezoelectric properties of electrospun materials.
Article
Chemistry, Multidisciplinary
Homa Maleki et al.
Summary: Poly(lactic acid) (PLA) is a biodegradable material with favorable characteristics, making it a promising biopolymer for biomedical applications. Electrospun PLA nanofibers, with features such as similarity to the extracellular matrix, large specific surface area, and tunable mechanical properties, have shown great potential in the medical field.
APPLIED SCIENCES-BASEL
(2022)
Article
Food Science & Technology
Vahid Mosayebi et al.
Summary: Fast-dissolving antioxidant nanofibers based on Spirulina protein concentrate (SPC) and gelatin were successfully produced using needleless electrospinning technique. These nanofibers showed improved antioxidant activity and rapid dissolution in aqueous medium, making them potentially useful for nutraceutical delivery in food and packaging applications under high humidity.
Article
Engineering, Biomedical
Jiao Liu et al.
Summary: This study presents an integrated electrospinning system for fabricating nanofibrous textiles with excellent properties, which is of great significance in the field of tissue engineering and regenerative medicine.
MATERIALS TODAY BIO
(2022)
Article
Materials Science, Multidisciplinary
Rajalakshmi Ekambaram et al.
Summary: Research on nano-structured bio-materials, particularly a nanofibrous drug delivery system incorporating zinc oxide and docetaxel, has shown promising results in inhibiting the growth of cancer cells. The experiments demonstrated a strong correlation and apoptotic activity within the cells.
Article
Chemistry, Applied
Martina Gruppuso et al.
Summary: Polysaccharide electrospun wound dressings combine extracellular matrix-like structure with biomimicry, but face rapid dissolution in aqueous environments. This study investigated different crosslinking methods and found carbonyldiimidazole to be the best compromise for water resistance and degradability.
CARBOHYDRATE POLYMERS
(2022)
Article
Polymer Science
Hanie Abdolbaghian et al.
Summary: This research investigated the fabrication and characterization of core-shell hydrogel nanofibrous mats using a novel gas-assisted coaxial electrospinning technique. The results showed that the extra gas blowing system significantly increased the production of nanofibers. The core-shell structure was constructed by preparing separate core and shell solutions, and the electrospun mats exhibited potential applications as antibacterial dressings in biomedical fields.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Fatemeh Ajalloueian et al.
Summary: Loading antibiotics into nanofibers is a promising approach for drug delivery, providing stable antibacterial properties and prolonged drug release. This study successfully demonstrated the effectiveness of loading Amoxicillin into Pullulan nanofibers in terms of antibacterial properties and storage time.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Polymer Science
Abhinav Srivastava et al.
Summary: Based on the review of 115 literature items, the article presents biopolymers as renewable polymer materials for sustainable development. The types of biopolymers and their applications are discussed, along with issues of biocompatibility, sustainable chemistry principles, market trends, and future application directions.
Article
Polymer Science
Shahla Khalili et al.
Summary: A coaxial nanofibrous scaffold of poly (epsilon-caprolactone) and gelatin/cellulose acetate encapsulating anti-inflammatory and antibacterial drugs was developed for skin tissue regeneration. The crosslinked scaffold showed improved mechanical properties and slower drug release compared to the uncrosslinked scaffold. The scaffold exhibited significant antibacterial activity. This study suggests that the coaxial nanofibrous scaffold is a promising candidate for simultaneous tissue regeneration and controlled drug release.
Article
Polymer Science
Siripanyo Promnil et al.
Summary: Silk fibroin (SF) was used to improve cell adhesion and degradability of poly(lactic acid) (PLA) based scaffolds. By studying solution viscosity and SF content, a PLA/SF scaffold with both biological and mechanical properties was fabricated. The addition of SF improved the in vitro degradability and hydrophilicity of PLA based scaffolds, showing potential for meniscus tissue regeneration.
Article
Materials Science, Multidisciplinary
R. Rynkevic et al.
Summary: Additive manufacturing and 3D printing technologies enable personalized treatments using custom-made prosthetics, implants, and other medical devices. This study focused on characterizing novel biodegradable PCL implants for pelvic organ prolapse repair, produced using melt electrospinning technology. The research examined sterilization, degradation, mechanical behavior, and geometric variation of the implants, and compared them to the properties of vaginal tissues and a reference mesh. The results showed that the 3D printed PCL meshes closely matched the biomechanical properties of vaginal tissues and had more stable mesh pores compared to the reference mesh. Further studies will focus on improving the implant design and conducting in vitro experiments on cell adhesion and growth response.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Mónica Liliana Mejía Suaza et al.
Review
Pharmacology & Pharmacy
Amritha G. Nambiar et al.
Summary: Amorphous solid dispersions effectively improve the solubility and oral bioavailability of poorly water-soluble drugs. This review discusses recent advancements in utilizing amorphous solid dispersions to enhance dissolution and bioavailability, as well as the challenges faced in terms of stability and scale-up. The role of process analytical technology (PAT) and computational modeling techniques in supporting continuous manufacturing is highlighted.
Review
Polymer Science
Anahita Rohani Shirvan et al.
Summary: In the past decade, there has been significant growth in the use of fibre-based products and structures for biomedical applications. This review provides an overview of wet spinning, the effects of process parameters, and novel wet spinning-based manufacturing techniques. The potential applications of wet-spun fibrous structures in various medical fields are also discussed.
EUROPEAN POLYMER JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Sakshi Priya et al.
Summary: Nanofibers are fibrous nanocarriers that can be synthesized from various materials, including natural polymers. Natural polysaccharides-based nanofibers have gained attention in pharmaceutical and biomedical applications due to their biocompatibility, biodegradability, non-toxicity, and economic advantages. However, there is a lack of research on the scale-up and advanced therapeutic delivery of nanofibers.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Pharmacology & Pharmacy
Siew Mei Tan et al.
Summary: Electrospinning is a versatile technique for generating fibrous structures with potential applications in tissue engineering, wound dressings, and controlled drug delivery. However, there are limited pharmaceutical products manufactured using this technique, possibly due to the inherent instability of solid dispersion and the gap between lab-scale and industrial-scale production.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Zhaoxue Deng et al.
Summary: This study fabricated monolayer and multilayer structured nanofiber membranes for drug-controlled release of acetylsalicylic acid (ASA) using the one-step electrospinning technique. The monolayer PLGA-SF nanofiber membrane with a mass ratio of 2:1 showed improved hydrophilicity and mechanical properties compared to other nanofiber membranes. Additionally, the multilayer structured nanofiber membrane exhibited sustained release of ASA and good biocompatibility.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Review
Polymer Science
Renatha Jiffrin et al.
Summary: Electrospinning is a promising method for creating nanofiber membranes that can release drugs over time. These nanofiber composites have a large surface area to volume ratio, which aids in cell binding, drug loading, and mass transfer processes.
Article
Elham Vojoudi et al.
Pharmaceutical Nanotechnology
(2022)
Article
Sheersha Pramanik et al.
Engineered Regeneration
(2022)
Review
Materials Science, Multidisciplinary
Dingding Zong et al.
Summary: Electrospun nanofiber materials have been widely used in various fields due to their large specific surface area, small pore size, high porosity, good channel connectivity, and ease of functional modification. In recent years, researchers have made significant progress in constructing three-dimensional fiber materials through the 3D reconstruction of electrospun fiber membranes and direct electrospinning of fiber sponges. These advancements have led to the exploration of various applications in fields such as sound absorption, warmth retention, thermal insulation, air filtration, adsorption/separation, and tissue engineering. These research works have provided new ideas and methods for the fabrication of 3D fiber materials.
ADVANCED FIBER MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Arif Nadaf et al.
Summary: Electrospinning is a versatile technique for generating ultrathin fibers, and this review provides a comprehensive overview of electrospinning and non-electrospinning processes, their setup, fabrication process, components, and applications. The review covers the characteristics of nanofibers, materials required for their production, and the diverse applications they have in various fields. It also discusses the challenges and future prospects of nanofiber development.
Review
Materials Science, Biomaterials
Jaison Jeevanandam et al.
Summary: Biopolymer nanofibers have potential biomedical applications, but their instability and toxicity in biological fluids need to be addressed.
BIOMATERIALS SCIENCE
(2022)
Review
Pharmacology & Pharmacy
Varuna Naga Venkata Arjun Uppuluri et al.
Summary: Tissue engineering is a novel regenerative approach that promises the regeneration of damaged tissues. Hydrogel scaffolds play an important role in skin tissue regeneration as 3D cross-linked scaffolds.
ADVANCED PHARMACEUTICAL BULLETIN
(2022)
Review
Nanoscience & Nanotechnology
Md Ishak Khan et al.
Summary: Nanotechnology in cancer treatment has great potential, and the nanostructured drug delivery system can achieve high-efficiency drug delivery to specific cancer sites. Lipid-based NDDS is currently considered the most advanced and effective application field, while polymer-based and inorganic NDDS also have significant potential. However, challenges remain in the practical application of NDDS, such as dosage, stability, and biocompatibility of materials.
ACS APPLIED BIO MATERIALS
(2022)
Review
Polymer Science
Jianghong Huang et al.
Summary: Nanocomposite hydrogels, with their ability to mimic natural cartilage structure and exhibit nano-bio effects in response to external stimuli, show great potential as scaffold materials for cartilage tissue engineering. This review article summarizes the recent advances in nanocomposite hydrogels for artificial cartilage, including their preparation methods and application scope, while also highlighting the challenges faced in using hydrogel nanocomposites for cartilage repair.
Review
Nanoscience & Nanotechnology
Jiwang Chen et al.
Summary: This article introduces the characteristics and applications of membranes with asymmetric wettability, highlighting their better transport performance and separation efficiency compared to traditional membranes.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Applied
Tuhua Zhong et al.
Summary: Chitin was propionylated to improve its solubility in green solvents, and nanofibers with good mechanical strength, thermal stability, and hydrophobicity were successfully manufactured. The CP/PEO nanofiber mats showed potential for application in fluid filtration to separate fibrous pollutants such as carbon nanofibers and carbon nanotubes from water.
CARBOHYDRATE POLYMERS
(2021)
Article
Polymer Science
Sena Su et al.
Summary: New composite materials based on poly(epsilon-caprolactone)/polyethylene oxide loaded with hyaluronic acid (HA) and keratin (KR) were produced using emulsion and coaxial electrospinning methods. The fibers demonstrated distinct morphological and chemical characteristics, and showed potential for wound healing applications through in vitro studies, as the HA and KR incorporated into the fiber structure increased cell viability and proliferation synergistically.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Materials Science, Textiles
Mahsa Janmohammadi et al.
Summary: Skin tissue engineering is evolving with the use of electrospun scaffolds based on polycaprolactone (PCL) and hyaluronic acid (HA) containing L-ascorbic acid (AA). The combination of PCL and HA in the scaffolds enhance hydrophilicity and degradation rate, while promoting cell attachment, viability, and proliferation. The nanofibrous scaffold could potentially be applied for skin tissue engineering with improved outcomes.
FIBERS AND POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Maryam Zarei et al.
Summary: The conductive electrospun nanofiber scaffold containing polypyrrole was fabricated to accelerate tissue healing, with polypyrrole dispersed perfectly in the fibers and enhancing their conductivity up to 164.274 x 10(-3) s/m. The nanofibers with 10% polypyrrole showed better cell adhesion, growth, and proliferation properties, making them suitable for various tissue applications and particularly appropriate for body parts with electrical signals such as cardiovascular, heart muscles, or nerves.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Materials Science, Biomaterials
Haoyuan Lei et al.
Summary: Customization of porous scaffolds with different micro-topological structures can be achieved by adjusting 3D printing parameters. The structure of the scaffolds significantly impacts cell adhesion and proliferation, with regularly arranged pores and pore sizes suitable for cells playing a crucial role in regulating cell behavior.
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Nahideh Asadi et al.
Summary: A bilayer wound dressing with multifunctional properties was designed in this study, showing enhanced wound healing performance, including antibacterial, free radical scavenging, and biocompatibility properties. Through a full thickness wound model study, it was found that this scaffold had a faster wound closure rate, effective collagen deposition, quick re-epithelialization, and regulation of transforming growth factor-β1 (TGF-β1) and tumor necrosis factor-alpha (TNF-α).
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Chih-Hao Chen et al.
Summary: The study prepared core-sheath nanofibers with different structures for tendon tissue engineering, and demonstrated that the combined effects of aligned fibers and PRP could enhance cell proliferation rates and gene expression in tenocytes. Additionally, dynamic cell culture in a bioreactor with cyclic tension stimulation could accelerate tendon maturation in vitro, leading to improved cell proliferation rates and maintenance of tenogenic phenotype compared to static culture.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Clinical Neurology
Ahad Sabab et al.
Summary: Chitosan-based haemostats have been shown to be effective and safe for managing bleeding in neurosurgical settings, although clinical data in brain usage is lacking. Research indicates chitosan's safety and superior efficacy compared to commercial haemostats commonly used in neurosurgery, as well as its safety in peripheral tissue applications. Further studies are needed for clinical use of chitosan-based haemostats within the central nervous system.
JOURNAL OF CLINICAL NEUROSCIENCE
(2021)
Article
Chemistry, Applied
Jiage Ma et al.
Summary: In this study, gum arabic-based nanofibers combined with pullulan were prepared and characterized for the first time, serving as wall material for Lactobacillus encapsulation. The addition of gum arabic led to nanofibers with smaller diameter and better thermal stability. The hybrid nanofibers showed improved probiotic survivability compared to freeze-drying, providing a new approach for probiotic protection.
FOOD HYDROCOLLOIDS
(2021)
Review
Chemistry, Multidisciplinary
Ruonan Dong et al.
Summary: Wound management is a major challenge globally, and smart wound dressings offer potential solutions for promoting wound healing. By employing built-in sensors and smart materials, smart wound dressings can interact with wounds, sense and respond to changes in wound conditions or environment.
Review
Engineering, Biomedical
A. Hernandez-Rangel et al.
Summary: The development of functional wound dressings with bioactive properties has greatly improved wound care. Electrospun nanofibers mimicking the natural structure of skin ECM show high potential in promoting skin healing. Collagen-based wound dressings, either pure or blended with other materials, have been extensively researched for skin tissue engineering applications.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Review
Pharmacology & Pharmacy
Mohammed S. Alqahtani et al.
Summary: Oral route is the most common and preferred way of drug administration, due to its non-invasiveness and convenience. Factors affecting oral drug absorption include solubility, mucosal permeability, and stability in the gastrointestinal tract. Various pharmaceutical technologies like nanocarriers and micelles have been explored to improve oral drug absorption.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Safaa Omer et al.
Summary: In recent years, the electrospinning process has been extensively studied for its potential applications in various fields, particularly pharmaceutical and biomedical purposes. Companies have been working to develop electrospinning equipment, technological solutions, and electrospun materials for large-scale production to meet industry requirements. Various approaches have been explored to scale-up production, with needleless and centrifugal methods gaining the most attention and applications.
Article
Pharmacology & Pharmacy
Anam Razzaq et al.
Summary: This study prepared gelatin/polyvinyl alcohol nanofibers loaded with the antibiotic cephradine for the treatment of diabetic wound infections. The drug-loaded nanofibers exhibited superior thermal stability and sustained drug release, as well as stronger antibacterial activity both in vitro and in vivo. They were also found to be safer and more effective for promoting diabetic chronic wound healing, indicating their potential as valuable dressing materials for diabetic patients.
Review
Cell & Tissue Engineering
Xin Su et al.
Summary: Regenerative medicine was born out of the need for organ and tissue replacement due to shortages, with 3D printed bone tissue engineering scaffolds combined with stem cells offering a solution to large tissue defects and promoting regeneration.
REGENERATIVE THERAPY
(2021)
Article
Chemistry, Applied
Fuxin Xue et al.
Summary: The water resistance of electrospun hyaluronic acid (HA) nanofibers was improved by crosslinking with the periodate oxidation - adipic acid dihydrazide (ADH) strategy, allowing for potential applications in biomedical fields such as wound healing, adhesion prevention, and tissue engineering.
CARBOHYDRATE POLYMERS
(2021)
Article
Materials Science, Paper & Wood
Zhen Yuan et al.
Summary: Antibacterial and moisturizing dressings were fabricated using cellulose/konjac glucomannan/Ag nanoparticle composites, with properties easily manipulated by adjusting composition ratios. The CK7-Ag3 aerogel showed excellent antibacterial activity and biocompatibility, enabling complete wound recovery within just 14 days.
Review
Chemistry, Multidisciplinary
Baljinder Singh et al.
Summary: Nanofibers are widely used in on-demand drug delivery systems for customized drug release, with their distinguishing features and properties allowing for effective drug-loading capabilities and controllable release. Different types of nanofibers are classified based on their drug-release mechanisms, structure, and content, with additional consideration for the impact of polymer choice and environmental conditions on release characteristics.
Article
Gail Dutton
Genetic Engineering & Biotechnology News
(2021)
Article
Materials Science, Multidisciplinary
Mohammed A. Al-Baadani et al.
Summary: Co-electrospinning of PCL and Gel can produce composite membranes with good biocompatibility and controlled drug release ability. By adjusting the ratio of PCL to Gel, the drug release rate and total release period can be effectively controlled.
MATERIALS & DESIGN
(2021)
Review
Engineering, Biomedical
Neelima Anup et al.
Summary: Electrospun technology is a valuable method for fabricating functional polymeric nanofibers with unique morphological properties for drug delivery applications. These nanofibers are biocompatible, adhesive, sterile, and efficient in delivering various cargoes. The review discusses the capabilities of electrospun nanofibers in delivering different therapeutics and the challenges associated with administering them through various routes.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Nanoscience & Nanotechnology
Di Zhang et al.
Summary: Pelvic organ prolapse (POP) is a common disease affecting women, with weakening of pelvic ligaments playing a key role. Core-shell nanofibers can improve biocompatibility and enhance cellular activity, showing potential for pelvic ligament tissue engineering.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Andrea Luraghi et al.
Summary: Drug delivery devices are promising in maximizing therapeutic effects and minimizing undesired side effects. Electrospun nanofibers have unique features like biocompatibility and flexibility, making them efficient in delivering active principles for a wide range of drugs. The technique of electrospinning allows for easy tuning and endless combinations, potentially leading to personalized medicine.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Chemistry, Multidisciplinary
Nurul Huda Kamsani et al.
Summary: Electrospinning technique is a versatile method for producing continuous nanofibers, which has become cost-effective and drawn keen interests in the biomedical field. Smart electrospun pH-responsive nanofibers have various applications in emerging biomedical developments such as cancer drug targeting, wound healing, and vaginal drug delivery.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Article
Polymer Science
Oana Maria Ionescu et al.
Summary: The study incorporated natural active components such as propolis and Calendula officinalis into hyaluronic acid/poly(ethylene)oxide-based electrospun nanofiber membranes to design innovative wound-dressing biomaterials. The nanofiber membranes showed best antioxidant activity, cytocompatibility, and antimicrobial properties, making them suitable for clinical use as wound dressings.
Review
Polymer Science
M. Sai Bhargava Reddy et al.
Summary: Tissue engineering and regenerative medicine aim to restore or replace damaged tissues and organs using information and technology from various fields. Careful selection of scaffold materials and development of components are essential to achieve this goal.
Review
Biochemistry & Molecular Biology
Elbadawy A. Kamoun et al.
Summary: This study extensively discussed the modern perspectives of synthesized/developed electrospun nanofibrous hydrogel membranes based on popular carbohydrate polymers blend PVA, which have been widely used in versatile biomedical applications, particularly wound dressings, and compared them in detail with traditional fabricated membranes based films. The clinically relevant advantages of electrospun nanofibrous membranes were highlighted in terms of their biocompatibility, easy fabrication, and functionalization for different biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Pharmacology & Pharmacy
Mengning He et al.
Summary: Orally drug delivery films have attracted extensive interest due to their faster rate of drug absorption, higher bioavailability, and better patient compliance, especially for children and elders with swallowing difficulties. Recent advances in designing and developing novel oral films have focused on delivering proteins and peptides effectively. This review aims to summarize these newly developed oral films, discussing their formulation strategies, manufacturing methods, advantages, and limitations.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Pharmacology & Pharmacy
Saeed El-Ashram et al.
Summary: This passage summarizes the important factors affecting wound healing and the potential role of natural products in wound treatment. By studying these factors, it can help in the development of therapeutics that promote wound healing.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Chemistry, Applied
Kajal Ghosal et al.
Summary: Triaxial electrospinning is a widely studied process for forming nanofibers, particularly in drug delivery systems. It enables the formation of complex nanostructures, resolves limited drug solubility issues, and controls drug release kinetics. This method has great potential in developing sophisticated nanomaterials for specific drug delivery applications.
REACTIVE & FUNCTIONAL POLYMERS
(2021)
Article
Engineering, Biomedical
Shaohua Wu et al.
Summary: In this study, novel nanofiber yarns were developed by combining nanostructure with biodegradability and strong mechanical properties through a hot drawing process using poly(L-lactic acid) (PLLA). The thermally drawn PLLA nanofiber yarns showed superior fibrous structure, enhanced crystallinity, and excellent mechanical performances, and promoted the adhesion, alignment, proliferation, and differentiation of human adipose derived mesenchymal stem cells compared to untreated PLLA nanofiber yarns. The nanofiber yarns were further processed into various tissue scaffolds with adjustable properties, demonstrating their potential for advanced biotextiles in surgical implant applications.
Review
Polymer Science
Fatirah Fadil et al.
Summary: Electrospinning technology, previously seen as a scientific interdisciplinary research approach, is now being increasingly used in various fields as a practice-based interdisciplinary approach. While electrospun nanofiber materials have shown remarkable interest in applications across different industries, challenges in manufacturing and commercialization still limit their widespread adoption. Recent developments highlight the potential growth for commercially applied products based on electrospun nanofibers.
Review
Cell & Tissue Engineering
Shanshan Han et al.
Summary: This review summarizes recent developments in 3D electrospun nanofiber-based scaffolds (ENF-S) for tissue engineering, discussing three types of 3D scaffolds fabricated using different approaches and their applications in tissue regeneration. New functions and properties of these 3D ENF-S, as well as current challenges and future directions, are presented.
STEM CELLS INTERNATIONAL
(2021)
Review
Chemistry, Multidisciplinary
Ewin Tanzli et al.
Summary: In the field of biotechnology, cultivating mammalian cells on electrospun nanofiber mats has been shown to promote cell growth, adhesion, and proliferation. By using different surface morphologies and polymer blends, the nanofiber mats can achieve the required combination of mechanical and biological properties, making them highly suitable for tissue engineering and other biotechnological applications.
APPLIED SCIENCES-BASEL
(2021)
Article
Materials Science, Multidisciplinary
Xuan Ji et al.
Summary: The study fabricated Janus-structured nanofibers for wound healing, loaded with RCSPs and Ag-NPs, which showed low cytotoxicity and antibacterial activity while accelerating wound healing. The Janus nanofibers are promising wound dressing for skin tissue engineering.
MATERIALS & DESIGN
(2021)
Review
Materials Science, Multidisciplinary
Ya Li et al.
Summary: Electrospinning, a low-cost and straightforward method, has attracted great attention for its functional nanofibrous materials that can be widely used in various fields. This paper comprehensively reviews the latest advances in developing this unique technique and provides a future vision for challenges and perspectives in the field.
ADVANCED MATERIALS TECHNOLOGIES
(2021)
Review
Pharmacology & Pharmacy
Sibusiso Alven et al.
Summary: Nanofibrous scaffolds loaded with silver nanoparticles show promising biological and mechanical outcomes in wound healing, with good antibacterial and bioactive properties.
Proceedings Paper
Engineering, Biomedical
Ubaid Ullah et al.
Summary: The study demonstrates a fluoride sensor using PS-CRDS technology for rapid, portable, and accurate detection of fluoride in drinking water. The sensor, constructed with fiber Bragg gratings, uses SPADNS-zirconyl acid complex reagent to enhance absorption of fluoride, with a detection limit below 2 ppm.
OPTICAL FIBERS AND SENSORS FOR MEDICAL DIAGNOSTICS, TREATMENT AND ENVIRONMENTAL APPLICATIONS XXI
(2021)
Proceedings Paper
Materials Science, Multidisciplinary
Diana Faris et al.
Summary: The rheological properties of the polymer solution have an impact on the characteristics of nanofibers, with an increase in PVA concentrations leading to improvements in diameter, alignment, and Tg of the nanofibers.
MATERIALS TODAY-PROCEEDINGS
(2021)
Review
Chemistry, Multidisciplinary
Anabela Moreira et al.
Summary: This review explores the potential of electrohydrodynamic (EHD) techniques in developing peptide and protein delivery systems, discussing the principles of various EHD methods and encapsulation of biological molecules using these approaches, as well as exploring the possibilities of localized delivery with stimuli-responsive systems and summarizing the advantages and challenges of electrospun and electrosprayed protein delivery systems.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Materials Science, Multidisciplinary
Andrew J. Robinson et al.
Summary: Fabrication of anisotropic materials using electrospinning allows for the production of non-woven fibrous meshes with tunable fiber diameters and microarchitectures. Various techniques have been developed to control fiber alignment in electrospun materials to achieve complex microarchitectures and enhance mechanical properties. Future perspectives include developing scalable methods with precise control of microarchitecture.
Review
Materials Science, Biomaterials
Karolina Dziemidowicz et al.
Summary: Electrospinning is a technique for generating polymer-based fibers with diameters ranging from nano- to micron-scale, which has been extensively explored in biomedical applications such as drug delivery systems and tissue engineering. The incorporation of various functional components like small molecule drugs and nanoparticles allows for the creation of materials with complex architectures. However, scaling up production and meeting Good Manufacturing Practice standards are critical considerations when translating electrospinning for clinical use.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Chemistry, Multidisciplinary
Qingmiao Zhang et al.
Summary: In this study, fast-dissolving drug delivery systems were developed using honey and acetylsalicylic acid-embedded PVA nanofibers based on natural DES. The morphological and cellular experiments demonstrated the biocompatibility and drug release efficacy of the materials, suggesting their potential for pharmaceutical applications.
Article
Engineering, Biomedical
Yogendra Pratap Singh et al.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2020)
Review
Chemistry, Physical
Mehmet Berat Taskin et al.
Review
Nanoscience & Nanotechnology
Panna Vass et al.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2020)
Review
Pharmacology & Pharmacy
Erika Maria Tottoli et al.
Review
Engineering, Chemical
Ioannis Partheniadis et al.
Review
Materials Science, Characterization & Testing
Hassan M. Ibrahim et al.
Article
Polymer Science
M. M. Abd El-Hady et al.
Review
Biochemistry & Molecular Biology
Mariela Toriello et al.
Article
Materials Science, Multidisciplinary
Chunhui Luo et al.
Article
Cardiac & Cardiovascular Systems
Umberto Barbero et al.
Review
Chemistry, Multidisciplinary
Soroush Soltani et al.
NEW JOURNAL OF CHEMISTRY
(2020)
Review
Polymer Science
Erfan Rezvani Ghomi et al.
JOURNAL OF APPLIED POLYMER SCIENCE
(2019)
Review
Biochemistry & Molecular Biology
Chenyu Wang et al.
Article
Polymer Science
Ahmad Saudi et al.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2019)
Article
Nanoscience & Nanotechnology
Ranodhi N. Udangawa et al.
ACS APPLIED MATERIALS & INTERFACES
(2019)
Article
Polymer Science
Naomi C. Paxton et al.
EUROPEAN POLYMER JOURNAL
(2019)
Review
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Review
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Review
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(2019)
Review
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Hanna Sofia SalehHudin et al.
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Article
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Iman Soltani et al.
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Parisa Heydari et al.
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Article
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Neslihan Nohut Maslakci et al.
Review
Materials Science, Biomaterials
Minghuan Liu et al.
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Article
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Zhongbiao Shao et al.
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Article
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Zhongbiao Shao et al.
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(2017)
Article
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Zhili Wan et al.
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(2017)
Article
Materials Science, Biomaterials
Zhili Wan et al.
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(2017)
Review
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Linda T. Senbanjo et al.
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Article
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Ana C. Mendes et al.
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Article
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Review
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Review
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Toby D. Brown et al.
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Article
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Article
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(2016)
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Ganary Dabiri et al.
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Article
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E. Kostakova et al.
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(2014)
Article
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Lingyan Kong et al.
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Article
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Haibao Lu et al.
Article
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Kessiena L. Aya et al.
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(2014)
Proceedings Paper
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(2014)
Review
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Article
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Article
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Article
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Article
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Haibao Lu et al.
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Article
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(2010)
Article
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Article
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(2010)
Article
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Article
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Tamer Uyar et al.
Review
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Article
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Article
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(2006)
Article
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Dong Han et al.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2006)
