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Psychedelics in the treatment of eating disorders: Rationale and potential mechanisms

EUROPEAN NEUROPSYCHOPHARMACOLOGY (2023)

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Article Psychology, Clinical

Effect of lysergic acid diethylamide (LSD) on reinforcement learning in humans

Jonathan W. Kanen et al.

Summary: The study aimed to investigate how LSD affects probabilistic reversal learning in healthy individuals. The results showed that LSD increased the reward and punishment learning rates, decreased stimulus stickiness, and induced a state of heightened plasticity.

PSYCHOLOGICAL MEDICINE (2023)

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Review Pharmacology & Pharmacy

MDMA-Assisted Psychotherapy for Treatment of Posttraumatic Stress Disorder: A Systematic Review With Meta-Analysis

Kimberly W. Smith et al.

Summary: This article discusses the use of MDMA-assisted psychotherapy in treating PTSD, showing that it is effective in reducing CAPS scores but also carries risks.

JOURNAL OF CLINICAL PHARMACOLOGY (2022)

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Article Clinical Neurology

Validation of the Psychological Insight Scale: A new scale to assess psychological insight following a psychedelic experience

Joseph M. Peill et al.

Summary: This study developed a new scale, the Psychological Insight Scale (PIS), to measure psychological insight after a psychedelic experience. The scale exhibited high internal consistency at multiple timepoints and was found to significantly mediate the relationship between emotional breakthrough and long-term well-being. This suggests that insight plays a key role in the psychological outcomes following a psychedelic experience.

JOURNAL OF PSYCHOPHARMACOLOGY (2022)

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Article Neurosciences

P450. Pilot Study Evaluation of Psilocybin Therapy for Anorexia Nervosa: Safety, Acceptability, and Preliminary Efficacy

Stephanie Knatz Peck et al.

BIOLOGICAL PSYCHIATRY (2022)

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Editorial Material Clinical Neurology

Toward the helioscope hypothesis of psychedelic therapy

Gregor Hasler

EUROPEAN NEUROPSYCHOPHARMACOLOGY (2022)

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Review Pharmacology & Pharmacy

Ayahuasca, a potentially rapid acting antidepressant: focus on safety and tolerability

Giordano Novak Rossi et al.

Summary: Ayahuasca shows potential as an antidepressant, with relative safety and tolerability demonstrated in clinical trials.

EXPERT OPINION ON DRUG SAFETY (2022)

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Article Clinical Neurology

The Acceptance/Avoidance-Promoting Experiences Questionnaire (APEQ): A theory-based approach to psychedelic drugs' effects on psychological flexibility

Max Wolff et al.

Summary: The study aimed to validate a psychological model of acceptance/avoidance-promoting psychedelic experiences and develop a self-report instrument. Results showed that acceptance and avoidance were relatively independent aspects, but their subaspects were strongly correlated. Motives for therapeutic, escapist, and hedonic use were associated with acceptance and avoidance, and were related to retrospective changes in psychological flexibility.

JOURNAL OF PSYCHOPHARMACOLOGY (2022)

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Review Neurosciences

Genetics and neurobiology of eating disorders

Cynthia M. Bulik et al.

Summary: This review summarizes the progress in genetics, neuroimaging, and animal models of eating disorders and calls for a more unified science in this field.

NATURE NEUROSCIENCE (2022)

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Article Neurosciences

Direct comparison of the acute effects of lysergic acid diethylamide and psilocybin in a double-blind placebo-controlled study in healthy subjects

Friederike Holze et al.

Summary: This study compared the subjective and autonomic effects of LSD and psilocybin, finding that the higher doses of both substances produced similar subjective effects, but psilocybin had weaker effects at a lower dose. Additionally, LSD and psilocybin showed differences in their effects on heart rate and blood pressure.

NEUROPSYCHOPHARMACOLOGY (2022)

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Article Psychiatry

Using a MDMA- and LSD-Group Therapy Model in Clinical Practice in Switzerland and Highlighting the Treatment of Trauma-Related Disorders

Peter Oehen et al.

Summary: The Swiss Federal Act on Narcotics allows for the restricted medical use of scheduled psychotropic drugs in cases of resistance to standard treatment. The authors have developed a psychedelic-assisted group therapy model utilizing MDMA and LSD for patients with chronic complex post-traumatic stress disorder (c-PTSD) and other post-traumatic disorders.

FRONTIERS IN PSYCHIATRY (2022)

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Article Psychology, Clinical

A case series of group-based ketamine-assisted psychotherapy for patients in residential treatment for eating disorders with comorbid depression and anxiety disorders

Reid Robison et al.

Summary: This study assessed the use of group-based ketamine-assisted psychotherapy (G-KAP) in intensive residential treatment for eating disorders. The results showed that G-KAP had positive effects on depression and anxiety symptoms, was well tolerated, and feasible to implement in a residential treatment setting.

JOURNAL OF EATING DISORDERS (2022)

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Review Psychology, Multidisciplinary

Psychedelics and Psychotherapy: Cognitive-Behavioral Approaches as Default

David B. Yaden et al.

Summary: The article discusses the management of psychedelics in European and American clinical research settings and some historical and social influences on this behavior. The authors argue that cognitive-behavioral therapies and other psychotherapeutic paradigms provide the strongest rationale and support for psychedelic-assisted psychotherapy.

FRONTIERS IN PSYCHOLOGY (2022)

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Review Psychiatry

Psychedelic-Assisted Therapy for People with Eating Disorders

Natalie Gukasyan et al.

Summary: Recent studies suggest that psychedelics may have therapeutic effects on eating disorders through various mechanisms. More research is needed to establish the safety and efficacy of PAT in eating disorder treatment, but it has the potential to enhance current interventions.

CURRENT PSYCHIATRY REPORTS (2022)

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Review Psychology, Clinical

The neurobiological reward system and binge eating: A critical systematic review of neuroimaging studies

Nicolas Leenaerts et al.

Summary: This systematic review examines structural and functional changes in the neurobiological reward system in individuals with binge eating disorder (BED) and provides directions for future research. The review finds that BED individuals exhibit lower striatal dopamine release, changes in brain areas' volumes, and lower frontostriatal connectivity at rest. During task performance, BED individuals show heightened brain reward system activity during food anticipation and consumption, as well as increased model-free reinforcement learning and habitual behavior. However, most studies only focus on one group of patients, adopt general reward-related measures, and fail to consider the impact of comorbidities, illness duration, race, and sex.

INTERNATIONAL JOURNAL OF EATING DISORDERS (2022)

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Editorial Material Neurosciences

Serotonergic psychedelic treatment for obesity and eating disorders: potential expectations and caveats for emerging studies

Stephanie L. Borgland et al.

JOURNAL OF PSYCHIATRY & NEUROSCIENCE (2022)

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Review Clinical Neurology

Ketamine Assisted Psychotherapy: A Systematic Narrative Review of the Literature

Sandra J. Drozdz et al.

Summary: Ketamine-assisted psychotherapy (KAP) can significantly reduce pain, anxiety, and depressive symptoms in patients, and can encourage treatment engagement and abstinence. However, further research is needed to understand the relationship between psychotherapy and ketamine and optimize long-term effectiveness.

JOURNAL OF PAIN RESEARCH (2022)

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Review Psychiatry

Psychedelics in the treatment of unipolar and bipolar depression

Oliver G. Bosch et al.

Summary: This narrative review discusses the role of classic and atypical psychedelics in the treatment of unipolar and bipolar depression, highlighting the promising efficacy and safety of psilocybin and the therapeutic value of MDMA and ketamine in psychiatry. Rigorous clinical trials with larger sample sizes will be crucial for determining the future clinical utility of psychedelics.

INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS (2022)

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Article Pharmacology & Pharmacy

Efficacy and Safety of Subcutaneous Esketamine in the Treatment of Suicidality in Major Depressive Disorder and Bipolar Depression

Juliana Surjan et al.

Summary: This study aimed to examine the therapeutic effects of repeated subcutaneous esketamine administration on suicide ideation in depressed patients. The results showed that repeated use of esketamine can significantly reduce suicide ideation, with similar efficacy for different types of depression, and it is well-tolerated and safe.

CLINICAL DRUG INVESTIGATION (2022)

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Article Psychiatry

Percentage of Heavy Drinking Days Following Psilocybin-Assisted Psychotherapy vs Placebo in the Treatment of Adult Patients With Alcohol Use Disorder A Randomized Clinical Trial

Michael P. Bogenschutz et al.

Summary: This study aimed to evaluate the effects of high-dose psilocybin on patients with AUD. The results showed that psilocybin combined with psychotherapy significantly decreased the percentage of heavy drinking days.

JAMA PSYCHIATRY (2022)

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Review Psychology, Clinical

Psychiatric and medical comorbidities of eating disorders: findings from a rapid review of the literature

Ashlea Hambleton et al.

Summary: The mortality rate of eating disorders is significantly higher compared to other psychiatric conditions, and individuals with eating disorders often have comorbid psychiatric or medical conditions. This review provides a comprehensive overview of the psychiatric and medical comorbidities of eating disorders, discussing their impact and associations.

JOURNAL OF EATING DISORDERS (2022)

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Article Psychology, Clinical

The Maudsley Anorexia Nervosa Treatment for Adults (MANTRA): a feasibility case series of an integrated group based approach

Helen Startup et al.

Summary: Individuals with Anorexia Nervosa face social and emotional struggles, making it challenging to manage their disorder. An Integrated Group MANTRA treatment approach, delivering therapy in a group setting, shows feasibility and effectiveness in community services. Participants find value in the relational and experiential aspects of the treatment, benefiting from group support to reduce shame and stigma.

JOURNAL OF EATING DISORDERS (2021)

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Review Psychiatry

Risk factors for eating disorders: an umbrella review of published meta-analyses

Marco Solmi et al.

Summary: This systematic review identified childhood sexual abuse and appearance-related teasing victimization as potentially significant risk factors for eating disorders, although larger prospective cohort studies are needed to confirm these associations.

BRAZILIAN JOURNAL OF PSYCHIATRY (2021)

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Article Pharmacology & Pharmacy

Psilocybin in the treatment of anorexia nervosa: The English transition of a French 1959 case study

Vincent Verroust et al.

Summary: Psilocybin, a psychotropic molecule, was first synthesized in 1958 and has shown potential therapeutic effects for psychiatric disorders, as demonstrated in a case study from 1959 involving a patient with anorexia nervosa. This study provides important insights into the possible therapeutic mechanisms of psilocybin and its efficacy in treating mental health conditions.

ANNALES MEDICO-PSYCHOLOGIQUES (2021)

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Article Psychiatry

A Randomized Controlled Trial of Repeated Ketamine Administration for Chronic Posttraumatic Stress Disorder

Adriana Feder et al.

Summary: This randomized controlled trial demonstrated the efficacy of repeated ketamine infusions in reducing symptom severity in individuals with chronic PTSD, showing superior improvement in the ketamine group compared to the midazolam group. The ketamine group had a higher treatment responder rate and good tolerability, indicating the potential of ketamine as a treatment for chronic PTSD.

AMERICAN JOURNAL OF PSYCHIATRY (2021)

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Article Medicine, Research & Experimental

The potential use of N-methyl-3,4-methylenedioxyamphetamine (MDMA) assisted psychotherapy in the treatment of eating disorders comorbid with PTSD

Timothy D. Brewerton et al.

Summary: MDMA-assisted psychotherapy shows promise for treating individuals with comorbid eating disorders and PTSD, with potential benefits including alleviating fear and enhancing social skills. The unique psychopharmacological effects of MDMA may provide therapeutic value for this challenging population.

MEDICAL HYPOTHESES (2021)

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Article Psychology, Clinical

Posttraumatic stress disorder and eating disorders: maintaining mechanisms and treatment targets

Karen S. Mitchell et al.

Summary: Many individuals with lifetime histories of eating disorders report exposure to interpersonal trauma and posttraumatic stress disorder. Possible mechanisms of the trauma-ED association identified from the literature include self-criticism, shame, depression, anxiety, which may lead to the use of ED behaviors as coping strategies.

EATING DISORDERS (2021)

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Article Clinical Neurology

First study of safety and tolerability of 3,4-methylenedioxymethamphetamine-assisted psychotherapy in patients with alcohol use disorder

Ben Sessa et al.

Summary: The study is the first exploration of the feasibility and efficacy of MDMA therapy in patients with alcohol use disorder. The results show that MDMA treatment is safe and well tolerated in patients with AUD, with improvement in psychosocial functioning and significant reduction in drinking behavior.

JOURNAL OF PSYCHOPHARMACOLOGY (2021)

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Review Nutrition & Dietetics

The Role of the Gut Microbiome, Immunity, and Neuroinflammation in the Pathophysiology of Eating Disorders

Michael J. Butler et al.

Summary: Alterations in the gut microbiome and immune system may play a role in maintaining and exacerbating eating behavior dysregulation in disorders like anorexia and bulimia, and could potentially serve as biomarkers for increased risk of developing these eating disorders. Research focuses on studying gut dysbiosis, peripheral inflammation, and neuroinflammation in each disorder, as well as exploring data from preclinical rodent models to better understand the biological mechanisms underlying eating disorders. This knowledge is crucial for developing novel and effective treatments for these often difficult-to-treat eating disorders.

NUTRIENTS (2021)

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Article Psychiatry

Study Protocol for Psilocybin as a Treatment for Anorexia Nervosa: A Pilot Study

Meg J. Spriggs et al.

Summary: This study aims to assess the feasibility, brain mechanisms, and preliminary outcomes of treating anorexia nervosa with psilocybin-assisted therapy. Feedback obtained through Public Patient Involvement (PPI) and the protocol design will be crucial for shaping future Randomized Control Trials (RCTs).

FRONTIERS IN PSYCHIATRY (2021)

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Article Psychiatry

Case Report: Unexpected Remission From Extreme and Enduring Bulimia Nervosa With Repeated Ketamine Assisted Psychotherapy

Anya Ragnhildstveit et al.

Summary: Repeated ketamine assisted psychotherapy (KAP) has been shown to be an effective treatment alternative for severe and enduring cases of bulimia nervosa, leading to significant symptom improvement and even complete remission in some cases. This highlights the potential for tailored interventions at the individual level and calls for further research and consideration in clinical practice.

FRONTIERS IN PSYCHIATRY (2021)

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Article Psychology, Clinical

Disorder specific rewarding stimuli in anorexia nervosa

Ann-Kathrin Kogel et al.

Summary: The study found that in patients with anorexia nervosa, reward ratings for disorder specific stimuli related to sports, weight loss, and healthy food were higher compared to categories like discipline, thin bodies, and appreciation of others. Patients showed more positive responses to these reward stimuli compared to the comparison group.

INTERNATIONAL JOURNAL OF EATING DISORDERS (2021)

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Article Clinical Neurology

Prediction of MDMA response in healthy humans: a pooled analysis of placebo-controlled studies

Erich Studerus et al.

Summary: The study found that, in addition to MDMA plasma concentration, personality traits and mood state can influence individual's acute physiological and psychological response to MDMA. Both pharmacological and non-pharmacological factors play a role in the response to MDMA.

JOURNAL OF PSYCHOPHARMACOLOGY (2021)

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Article Biochemistry & Molecular Biology

MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study

Jennifer M. Mitchell et al.

Summary: The results demonstrate that MDMA-assisted therapy is safe and effective in treating severe post-traumatic stress disorder. Compared with placebo, MDMA significantly reduces CAPS-5 scores and improves functional impairment.

NATURE MEDICINE (2021)

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Article Medicine, General & Internal

Trial of Psilocybin versus Escitalopram for Depression

Robin Carhart-Harris et al.

Summary: The study compared the efficacy of psilocybin and escitalopram in treating patients with major depressive disorder. While there was no significant difference in antidepressant effects between the two drugs at week 6, secondary outcomes generally favored psilocybin over escitalopram, though these results were not adjusted for multiple comparisons. Larger and longer trials are needed to further compare psilocybin with established antidepressants.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Multidisciplinary Sciences

Harnessing psilocybin: antidepressant-like behavioral and synaptic actions of psilocybin are independent of 5-HT2R activation in mice

Natalie Hesselgrave et al.

Summary: Psilocybin has shown promising rapid and persistent antidepressant effects in mice, possibly through enhancing excitatory synapses in the hippocampus, independent of 5-HT2A receptor activation. Further research is needed to explore the potential combination of psychedelic compounds and 5-HT2AR antagonists for clinical utility in human depression.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Psychology, Multidisciplinary

Classic Psychedelic Use and Mechanisms of Mental Health: Exploring the Mediating Roles of Spirituality and Emotion Processing on Symptoms of Anxiety, Depressed Mood, and Disordered Eating in a Community Sample

Adele Lafrance et al.

Summary: Research has found a relationship between psychedelic use, higher spirituality, better emotion regulation, and lower levels of anxiety, depressed mood, and disordered eating.

JOURNAL OF HUMANISTIC PSYCHOLOGY (2021)

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Article Psychiatry

Effects of Psilocybin-Assisted Therapy on Major Depressive Disorder A Randomized Clinical Trial

Alan K. Davis et al.

Summary: The study showed that psilocybin therapy with psychological support is effective in treating MDD, building on previous findings in patients with cancer and depression, as well as in a nonrandomized study in patients with treatment-resistant depression.

JAMA PSYCHIATRY (2021)

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Article Pharmacology & Pharmacy

Role of the 5-HT2A Receptor in Acute Effects of LSD on Empathy and Circulating Oxytocin

Friederike Holze et al.

Summary: The study found that LSD can enhance empathy with dose-dependent effects on emotional empathy and also increase plasma oxytocin levels, partially independent of the primary action on 5-HT2A receptors. These findings provide important implications for further research investigating the therapeutic effects of LSD in patients with empathy deficits and impairments in social functioning.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Psychiatry

Does Psychedelic Therapy Have a Transdiagnostic Action and Prophylactic Potential?

Rita Kocarova et al.

Summary: Addressing global mental health is a major challenge, and new treatments with prophylactic and transdiagnostic effectiveness would represent a significant advance. Psychedelic therapy increases neuronal and mental plasticity, enhancing the potential for change and therapeutic benefits. The combination of psychedelic-induced plasticity with an adequate therapeutic context has prophylactic and transdiagnostic potential, potentially impacting public health positively.

FRONTIERS IN PSYCHIATRY (2021)

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Article Medicine, General & Internal

A longitudinal case series of IM ketamine for patients with severe and enduring eating disorders and comorbid treatment-resistant depression

Terry Schwartz et al.

Summary: Ketamine treatment shows promise in improving depression in patients with treatment-resistant depression and enduring eating disorders.

CLINICAL CASE REPORTS (2021)

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Review Psychology, Clinical

Metacognitive beliefs across eating disorders and eating behaviours: A systematic review

Sara Palmieri et al.

Summary: Research has shown that individuals with anorexia nervosa tend to have higher levels of metacognitive beliefs, particularly negative beliefs about worry and beliefs about the need to control thoughts. Differences in metacognitive beliefs exist across different eating disorders diagnoses.

CLINICAL PSYCHOLOGY & PSYCHOTHERAPY (2021)

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Article Psychiatry

Positive effects of psychedelics on depression and wellbeing scores in individuals reporting an eating disorder

M. J. Spriggs et al.

Summary: This study found that there were improvements in depressive symptoms and psychological wellbeing after using psychedelic drugs, providing supportive evidence for positive psychological aftereffects of a psychedelic experience.

EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY (2021)

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Article Neurosciences

Distinct acute effects of LSD, MDMA, and d-amphetamine in healthy subjects

Friederike Holze et al.

NEUROPSYCHOPHARMACOLOGY (2020)

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Article Psychiatry

An exploratory study of experiences with conventional eating disorder treatment and ceremonial ayahuasca for the healing of eating disorders

Marika Renelli et al.

EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY (2020)

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Article Medicine, General & Internal

Current approach to eating disorders: a clinical update

Phillipa Hay

INTERNAL MEDICINE JOURNAL (2020)

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Review Behavioral Sciences

Neuropharmacological modulation of the aberrant bodily self through psychedelics

Jasmine T. Ho et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2020)

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Article Multidisciplinary Sciences

Emotions and brain function are altered up to one month after a single high dose of psilocybin

Frederick S. Barrett et al.

SCIENTIFIC REPORTS (2020)

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Review Neurosciences

Rethinking Therapeutic Strategies for Anorexia Nervosa: Insights From Psychedelic Medicine and Animal Models

Claire J. Foldi et al.

FRONTIERS IN NEUROSCIENCE (2020)

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Review Clinical Neurology

Reviewing the Potential of Psychedelics for the Treatment of PTSD

Erwin Krediet et al.

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2020)

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Article Psychiatry

Learning to Let Go: A Cognitive-Behavioral Model of How Psychedelic Therapy Promotes Acceptance

Max Wolff et al.

FRONTIERS IN PSYCHIATRY (2020)

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Article Neurosciences

Me, myself, bye: regional alterations in glutamate and the experience of ego dissolution with psilocybin

N. L. Mason et al.

NEUROPSYCHOPHARMACOLOGY (2020)

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Article Psychiatry

Clinical utility of repeated intravenous ketamine treatment for resistant obsessive-compulsive disorder

Lavanya P. Sharma et al.

ASIAN JOURNAL OF PSYCHIATRY (2020)

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Article Psychiatry

Remission from Chronic Anorexia Nervosa With Ketogenic Diet and Ketamine: Case Report

Barbara Scolnick et al.

FRONTIERS IN PSYCHIATRY (2020)

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Article Psychiatry

Post-Psychedelic Reductions in Experiential Avoidance Are Associated With Decreases in Depression Severity and Suicidal Ideation

Richard J. Zeifman et al.

FRONTIERS IN PSYCHIATRY (2020)

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Review Clinical Neurology

Psychedelic Treatments for Psychiatric Disorders: A Systematic Review and Thematic Synthesis of Patient Experiences in Qualitative Studies

Joost J. Breeksema et al.

CNS DRUGS (2020)

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Article Neurosciences

P300-mediated modulations in self-other processing under psychedelic psilocybin are related to connectedness and changed meaning: A window into the self-other overlap

Lukasz Smigielski et al.

HUMAN BRAIN MAPPING (2020)

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Article Medicine, General & Internal

Psilocybin-assisted group therapy for demoralized older long-term AIDS survivor men: An open-label safety and feasibility pilot study

Brian T. Anderson et al.

ECLINICALMEDICINE (2020)

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Review Psychology, Clinical

Cognitive flexibility in acute anorexia nervosa and after recovery: A systematic review

Stephanie Miles et al.

CLINICAL PSYCHOLOGY REVIEW (2020)

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Article Medicine, Research & Experimental

Psychedelic medicine: The biology underlying the persisting psychedelic effects

K. P. C. Kuypers

MEDICAL HYPOTHESES (2019)

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Article Multidisciplinary Sciences

Oxytocin-dependent reopening of a social reward learning critical period with MDMA

Romain Nardou et al.

NATURE (2019)

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Article Neurosciences

MDMA-assisted psychotherapy for treatment of PTSD: study design and rationale for phase 3 trials based on pooled analysis of six phase 2 randomized controlled trials

Michael C. Mithoefer et al.

PSYCHOPHARMACOLOGY (2019)

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Eating disorders and posttraumatic stress disorder

Cleo Rijkers et al.

CURRENT OPINION IN PSYCHIATRY (2019)

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Article Clinical Neurology

Emotional breakthrough and psychedelics: Validation of the Emotional Breakthrough Inventory

Leor Roseman et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2019)

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REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics

R. L. Carhart-Harris et al.

PHARMACOLOGICAL REVIEWS (2019)

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Article Psychiatry

Olanzapine Versus Placebo in Adult Outpatients With Anorexia Nervosa: A Randomized Clinical Trial

Evelyn Attia et al.

AMERICAN JOURNAL OF PSYCHIATRY (2019)

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Article Psychiatry

Body Image in the Context of Eating Disorders

Sian A. McLean et al.

PSYCHIATRIC CLINICS OF NORTH AMERICA (2019)

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The Neurobiology of Eating Disorders

Guido K. W. Frank et al.

CHILD AND ADOLESCENT PSYCHIATRIC CLINICS OF NORTH AMERICA (2019)

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Review Psychology, Clinical

Meta-analysis on the efficacy of psychological treatments for anorexia nervosa

Elske van den Berg et al.

EUROPEAN EATING DISORDERS REVIEW (2019)

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An Overview of Trauma-Informed Care and Practice for Eating Disorders

Timothy D. Brewerton

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David E. Nichols et al.

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Guido K. W. Frank et al.

JAMA PSYCHIATRY (2018)

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Clinical Interpretations of Patient Experience in a Trial of Psilocybin-Assisted Psychotherapy for Alcohol Use Disorder

Michael P. Bogenschutz et al.

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Quality of Acute Psychedelic Experience Predicts Therapeutic Efficacy of Psilocybin for Treatment-Resistant Depression

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FRONTIERS IN PHARMACOLOGY (2018)

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3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for post-traumatic stress disorder in military veterans, firefighters, and police officers: a randomised, double-blind, dose-response, phase 2 clinical trial

Michael C. Mithoefer et al.

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Disordered eating and obesity: associations between binge-eating disorder, night-eating syndrome, and weight-related comorbidities

Courtney McCuen-Wurst et al.

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Current perspectives on psychedelic therapy: use of serotonergic hallucinogens in clinical interventions

Albert Garcia-Romeu et al.

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Article Psychology, Clinical

Long-term follow-up of psilocybin-facilitated smoking cessation

Matthew W. Johnson et al.

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Article Neurosciences

Two dose investigation of the 5-HT-agonist psilocybin on relative and global cerebral blood flow

Candace R. Lewis et al.

NEUROIMAGE (2017)

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Review Neurosciences

MDMA and PTSD treatment PTSD: From novel pathophysiology to innovative therapeutics

Ben Sessa

NEUROSCIENCE LETTERS (2017)

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Review Nutrition & Dietetics

Are the Gut Bacteria Telling Us to Eat or Not to Eat? Reviewing the Role of Gut Microbiota in the Etiology, Disease Progression and Treatment of Eating Disorders

Yan Y. Lam et al.

NUTRIENTS (2017)

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Acute effects of LSD on amygdala activity during processing of fearful stimuli in healthy subjects

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Review Psychiatry

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CURRENT OPINION IN PSYCHIATRY (2017)

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Review Psychology, Clinical

Psilocybin-Assisted Therapy: A Review of a Novel Treatment for Psychiatric Disorders

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Nourishing the Spirit: Exploratory Research on Ayahuasca Experiences along the Continuum of Recovery from Eating Disorders

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Patients' Accounts of Increased Connectedness and Acceptance After Psilocybin for Treatment-Resistant Depression

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Longitudinal Associations Among Posttraumatic Stress Disorder, Disordered Eating, and Weight Gain in Military Men and Women

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AMERICAN JOURNAL OF EPIDEMIOLOGY (2016)

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Ego-Dissolution and Psychedelics: Validation of the Ego-Dissolution Inventory (EDI)

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FRONTIERS IN HUMAN NEUROSCIENCE (2016)

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LSD-Induced Entropic Brain Activity Predicts Subsequent Personality Change

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HUMAN BRAIN MAPPING (2016)

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Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial

Roland R. Griffiths et al.

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Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial

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JOURNAL OF PSYCHOPHARMACOLOGY (2016)

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LSD Acutely Impairs Fear Recognition and Enhances Emotional Empathy and Sociality

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Review Behavioral Sciences

The neurobiological basis of binge-eating disorder

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NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2016)

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Effects of serotonin 2A/1A receptor stimulation on social exclusion processing

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

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A Virtual Reality Full Body Illusion Improves Body Image Disturbance in Anorexia Nervosa

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PLOS ONE (2016)

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Dimensions of control and their relation to disordered eating behaviours and obsessive-compulsive symptoms

Franzisca V. Froreich et al.

JOURNAL OF EATING DISORDERS (2016)

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Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study

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Acute Effects of Lysergic Acid Diethylamide in Healthy Subjects

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Psilocybin-Induced Decrease in Amygdala Reactivity Correlates with Enhanced Positive Mood in Healthy Volunteers

Rainer Kraehenmann et al.

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Psilocybin-assisted treatment for alcohol dependence: A proof-of-concept study

Michael P. Bogenschutz et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2015)

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Review Behavioral Sciences

A reward-centred model of anorexia nervosa: A focussed narrative review of the neurological and psychophysiological literature

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NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2015)

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The Intestinal Microbiota in Acute Anorexia Nervosa and During Renourishment: Relationship to Depression, Anxiety, and Eating Disorder Psychopathology

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PSYCHOSOMATIC MEDICINE (2015)

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Ketamine as a Potential Treatment for Suicidal Ideation: A Systematic Review of the Literature

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DRUGS IN R&D (2015)

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LSD-assisted psychotherapy for anxiety associated with a life-threatening disease: A qualitative study of acute and sustained subjective effects

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Article Psychology, Clinical

Dysfunctional metacognition and drive for thinness in typical and atypical anorexia nervosa

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Article Clinical Neurology

Safety and Efficacy of Lysergic Acid Diethylamide-Assisted Psychotherapy for Anxiety Associated With Life-threatening Diseases

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Review Behavioral Sciences

The free-energy self: A predictive coding account of self-recognition

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NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2014)

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Editorial Material Medicine, General & Internal

PRACTICE POINTER Serotonin syndrome

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Meta analysis on the efficacy of pharmacotherapy versus placebo on anorexia nervosa

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JOURNAL OF EATING DISORDERS (2014)

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Anorexia nervosa is linked to reduced brain structure in reward and somatosensory regions: a meta-analysis of VBM studies

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BMC PSYCHIATRY (2013)

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Randomized Controlled Crossover Trial of Ketamine in Obsessive-Compulsive Disorder: Proof-of-Concept

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Change mechanisms in psychotherapy: Multiperspective assessment and relation to outcome

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The prevalence and impact of trauma history in eating disorder patients

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Psychological Change Mechanisms in Anorexia Nervosa Treatments: How Much Do We Know?

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MDMA and 5-HT neurotoxicity: the empirical evidence for its adverse effects in humans - no need for translation

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BRITISH JOURNAL OF PHARMACOLOGY (2012)

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MDMA and temperature: A review of the thermal effects of 'Ecstasy' in humans

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Serotonin toxicity involving MDMA (ecstasy) and moclobemide

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Review Neurosciences

Dysregulation of brain reward systems in eating disorders: Neurochemical information from animal models of binge eating, bulimia nervosa, and anorexia nervosa

Nicole M. Avena et al.

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Review Behavioral Sciences

Reward processing in anorexia nervosa

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Early adult sexual assault and disordered eating: The mediating role of posttraumatic stress symptoms

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Review Psychiatry

Mortality Rates in Patients With Anorexia Nervosa and Other Eating Disorders A Meta-analysis of 36 Studies

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ARCHIVES OF GENERAL PSYCHIATRY (2011)

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Reward Abnormalities among Women with Full and Subthreshold Bulimia Nervosa: A Functional Magnetic Resonance Imaging Study

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Article Clinical Neurology

The safety and efficacy of ± 3,4-methylenedioxymethamphetamine-assisted psychotherapy in subjects with chronic, treatment-resistant posttraumatic stress disorder: the first randomized controlled pilot study

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Binge Eating and Weight Control: The Role of Experiential Avoidance

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BEHAVIOR MODIFICATION (2011)

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Altered Striatal Response to Reward in Bulimia Nervosa After Recovery

Angela Wagner et al.

INTERNATIONAL JOURNAL OF EATING DISORDERS (2010)

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Rumination, experiential avoidance, and dysfunctional thinking in eating disorders

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BEHAVIOUR RESEARCH AND THERAPY (2010)

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Traumatic Events, Posttraumatic Stress Symptomatology and Somatoform Symptoms in Eating Disorder Patients

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EUROPEAN EATING DISORDERS REVIEW (2010)

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Review Neurosciences

How do you feel - now? The anterior insula and human awareness

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NATURE REVIEWS NEUROSCIENCE (2009)

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Article Neurosciences

Effects of MDMA on sociability and neural response to social threat and social reward

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Review Clinical Neurology

Human hallucinogen research: guidelines for safety

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JOURNAL OF PSYCHOPHARMACOLOGY (2008)

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Article Psychology, Biological

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PHYSIOLOGY & BEHAVIOR (2008)

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Mediational significance of PTSD in the relationship of sexual trauma and eating disorders

Sarah R. Holzer et al.

CHILD ABUSE & NEGLECT (2008)

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Article Psychology, Clinical

Safety, tolerability, and efficacy of psilocybin in 9 patients with obsessive-compulsive disorder

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JOURNAL OF CLINICAL PSYCHIATRY (2006)

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Article Medicine, Research & Experimental

Citalopram versus fluoxetine for the treatment of patients with bulimia nervosa: A single-blind randomized controlled trial

Paolo Leombruni et al.

ADVANCES IN THERAPY (2006)

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3,4-methylenedioxymethamphetamine (MDMA) modulates cortical and limbic brain activity as measured by [H215O]-PET in healthy humans

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Subcortical and cortical brain activity during the feeling of self-generated emotions

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NATURE NEUROSCIENCE (2000)

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