期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 26, 期 31, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.202300582
关键词
C-H activation; amine; carbonyl derivatives; catalysis; transient directing group
To functionalize C-H bonds of complex molecules and control the regioselectivity, various directing groups have been used. However, the installation and removal of these directing groups may limit the use of C-H activation in synthesis. A transient directing group strategy has emerged, utilizing an amine additive to achieve in situ formation of the directing group. This review presents the latest developments in this field from 2020 to 2023.
In order to directly functionalize C-H bonds of complex molecules and, in particular, to control the regioselectivity of the reaction, a wide range of directing groups has been used. However, these directing groups need to be installed and removed for further applications, which may limit the use of C-H activation in synthesis. Concerning aldehydes and ketones, a transient directing group strategy has recently emerged to overcome this drawback. The addition of an additive, in general an amine, allowed the in situ formation of the real directing group to achieve C-H activation. This review presents the latest developments in the field over the period 2020-2023.
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