Palladium-Catalyzed Enantioselective Hydrofunctionalization of Alkenes: Recent Advances

Palladium-catalyzed asymmetric hydrofunctionalization of alkenes is one of the most powerful and straightforward methods to forge a new C-H bond and a new C-X (X=C, N, O, F, Si etc) bond, which provides an efficient way to obtain valuable enantioenriched molecules from cheap and readily available feedstocks. Catalytic asymmetric hydrofunctionalization of simple alkenes is challenging but still highly sought after. This review will mainly focus on the recent advances in Palladium catalyzed asymmetric hydrofunctionalization of alkenes over the past decade, including hydroamination, hydrooxygenation, hydrofluorination, hydrosilylation, hydroarylation, hydroalkenylation and hydrocarbonylation. Asymmetric hydrofunctionalization of alkenes represents a powerful method to obtain valuable enantioenriched molecules from cheap and readily available materials. In this review, the recent advances in Palladium catalyzed asymmetric hydrofunctionalization of alkenes covering mainly contributions over the past decade are summarized. The remained challenges and opportunities in this field are also discussed.image

Automated summary

Palladium-catalyzed asymmetric hydrofunctionalization of alkenes is a powerful method to obtain valuable enantioenriched molecules from cheap and readily available feedstocks, but it also faces certain challenges and opportunities.