4.7 Article

Design, synthesis and biological evaluation of 4-(4-aminophenoxy) picolinamide derivatives as potential antitumor agents

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

Resistance to MET inhibition in MET-dependent NSCLC and therapeutic activity after switching from type I to type II MET inhibitors

Richard Riedel et al.

Summary: This study describes the resistance mechanisms to MET inhibition in MET-dependent non-small cell lung cancer patients, including MET exon 14 skipping mutation, MET amplification, and MET fusion. Analysis of patient samples revealed on-and off-target resistance mechanisms, such as KRAS mutations and HER2 amplification. Switching between different types of kinase inhibitors can lead to repeated responses in some patients.

EUROPEAN JOURNAL OF CANCER (2023)

Article Chemistry, Medicinal

Design, synthesis, and biological evaluation of 2, 4-dichlorophenoxyacetamide chalcone hybrids as potential c-Met kinase inhibitors

Heena Bhojwani et al.

Summary: c-Met is involved in cellular processes related to cancer development and progression. A series of compounds showed moderate-to-good antiproliferative activities against MCF-7 and A549 cells, with compound 6f exhibiting potential in inhibiting growth and migration of MCF-7 cells.

MEDICINAL CHEMISTRY RESEARCH (2023)

Article Oncology

Cancer statistics, 2023

Rebecca L. Siegel et al.

Summary: The American Cancer Society predicts that there will be 1,958,310 new cancer cases and 609,820 cancer deaths in the United States in 2023. While incidence trends for most cancers are favorable, prostate cancer saw a significant increase of 3% annually from 2014 to 2019. However, the overall cancer death rate continues to decline due to advances in treatment, with a 33% reduction since 1991.

CA-A CANCER JOURNAL FOR CLINICIANS (2023)

Article Medical Laboratory Technology

Roles of MET in human cancer

Xin Yang et al.

Summary: The MET gene plays a significant role in the initiation and development of various human cancers, affecting cell proliferation, migration, and invasion. MET serves as a biomarker for diagnosis and prognosis, and is also a potential therapeutic target. Inhibiting MET expression and function may have clinical benefits in cancer treatment.

CLINICA CHIMICA ACTA (2022)

Article Biochemistry & Molecular Biology

Type II c-Met inhibitors: molecular insight into crucial interactions for effective inhibition

Tahereh Damghani et al.

Summary: This study used molecular dynamics simulations to identify key residues involved in the binding of potent type II c-Met inhibitors, with Phe1223 and Tyr1159 being recognized as the most critical residues. Additionally, hydrogen bond interaction with Met1160 was found to be necessary for effective binding of type II ligands to c-Met.

MOLECULAR DIVERSITY (2022)

Article Biochemistry & Molecular Biology

Synthesis of triazolotriazine derivatives as c-Met inhibitors

Yuting Guo et al.

Summary: The synthesized compound 8 was found to have potent antitumor activity by forming two canonical hydrogen bonds and a pi-pi stacking interaction with the ATP binding site of c-Met kinase domain.

MOLECULAR DIVERSITY (2021)

Article Chemistry, Medicinal

Structure-guided design and development of novel N-phenylpyrimidin-2-amine derivatives as potential c-Met inhibitors

Daowei Huang et al.

Summary: In this study, novel N-phenylpyrimidin-2-amine derivatives were developed and many compounds were found to inhibit c-Met kinase, showing high antiproliferative activities in c-Met sensitive tumor cell lines. Compound 34a showed outstanding inhibitory activity and pharmacokinetic properties, making it a potential candidate for c-Met inhibitors.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

Article Chemistry, Medicinal

Design, synthesis and biological evaluation of novel 4-(pyrrolo[2,3-d]pyrimidine-4-yloxy)benzamide derivatives as potential antitumor agents

Jianqing Zhang et al.

Summary: A series of novel 4-(pyrrolo[2,3-d]pyrimidine-4-yloxy)benzamide derivatives were designed, synthesized, and evaluated for their antitumor activity, with compound 35 showing superior inhibitory activity against the A549, Hela, and MCF-7 cell lines. Further studies were conducted on the binding mode between compound 35 and c-Met kinase through molecular docking.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2021)

Article Chemistry, Medicinal

Discovery of Potent, Selective Triazolothiadiazole-Containing c-Met Inhibitors

Qing Tang et al.

Summary: In this study, a novel series of highly potent and selective triazolothiadiazole c-Met inhibitors were developed, with compound 23 showing excellent kinase selectivity and dose-dependent antitumor efficacy in a SNU-5 gastric cancer xenograft model.

ACS MEDICINAL CHEMISTRY LETTERS (2021)

Review Pharmacology & Pharmacy

MET inhibitors in cancer: pitfalls and challenges

Helena Oliveres et al.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2020)

Review Biochemistry & Molecular Biology

MET targeting: time for a rematch

Jonas P. Koch et al.

ONCOGENE (2020)

Letter Oncology

Crizotinib in ROS1 and MET Deregulated NSCLC-Letter

Marcel Wiesweg et al.

CLINICAL CANCER RESEARCH (2020)

Review Pharmacology & Pharmacy

C-MET inhibitors for advanced non-small cell lung cancer

Giulia Pasquini et al.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2018)

Article Oncology

Cabozantinib for the treatment of kidney cancer

Ahmed Abdelaziz et al.

EXPERT REVIEW OF ANTICANCER THERAPY (2017)

Article Biochemical Research Methods

Development of efficient docking strategies and structure-activity relationship study of the c-Met type II inhibitors

Ming-Jing Li et al.

JOURNAL OF MOLECULAR GRAPHICS & MODELLING (2017)

Review Chemistry, Organic

Fluorination methods in drug discovery

Damian E. Yerien et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2016)

Article Chemistry, Medicinal

Discovery of novel type II c-Met inhibitors based on BMS-777607

Wei Zhang et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2014)

Review Chemistry, Medicinal

Progress in cancer therapy targeting c-Met signaling pathway

Kyung Hee Jung et al.

ARCHIVES OF PHARMACAL RESEARCH (2012)

Article Biochemistry & Molecular Biology

Pharmacophore modeling and virtual screening studies to identify new c-Met inhibitors

Wenting Tai et al.

JOURNAL OF MOLECULAR MODELING (2012)

Article Oncology

An overview of the c-MET signaling pathway

Shawna Leslie Organ et al.

Therapeutic Advances in Medical Oncology (2011)