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Doxorubicin prodrug-based nanomedicines for the treatment of cancer

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2023)

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Article Chemistry, Medicinal

Pleiotropic effects of a mitochondrion-targeted glutathione reductase inhibitor on restraining tumor cells

Renshuai Zhang et al.

Summary: Mitochondria has been identified as a target for tumor therapy. This study developed a mitochondria-targeting anticancer agent, MT-1, which specifically accumulates in mitochondria and binds to GR. MT-1 damages the morphology and function of mitochondria, inhibits mitochondrial respiration and glycolysis, and binds to a new site of GR to inhibit its activity. This provides a potential novel strategy for tumor therapy by targeting novel sites of GR in mitochondria.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2023)

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Article Pharmacology & Pharmacy

Doxorubicin-isoniazid conjugate regulates immune response and tumor microenvironment to enhance cancer therapy

Chan Jin et al.

Summary: Immune checkpoint inhibitors (ICIs) are a promising class of immunotherapy drugs that enhance the immune response in cancer treatment. In this study, a conjugate of doxorubicin (DOX) and isoniazid (INH), a MAOA inhibitor, was synthesized and shown to enhance CD8(+) T cell activity and exhibit synergistic anti-tumor effects. Additionally, DOX-INH inhibited the growth and metastasis of breast cancer by blocking specific signaling pathways. This small molecule conjugate has great potential in cancer therapy.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2023)

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Article Chemistry, Multidisciplinary

Structure-Activity Relationship of pH-Sensitive Doxorubicin-Fatty Acid Prodrug Albumin Nanoparticles

Yinxian Yang et al.

Summary: Albumin has been used as a versatile drug carrier, and researchers have synthesized acid-labile DOX prodrugs using different fatty acids as albumin-binding motifs. These prodrugs assembled albumin nanoparticles with ultrahigh drug loading, and their colloidal stability depended on the saturation of fatty acids, impacting their in vivo pharmacokinetics, tumor accumulation, and antitumor efficacy. The hydrazone bond-bridged prodrugs could release DOX in the acidic tumor environment, resulting in improved antitumor efficacy and safety.

NANO LETTERS (2023)

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Review Chemistry, Multidisciplinary

Tetrazine bioorthogonal chemistry makes nanotechnology a powerful toolbox for biological applications

Renshuai Zhang et al.

Summary: Bioorthogonal chemistry allows manipulation of bioactive molecules in living systems with highly selective and biocompatible reactions. Integration of bioorthogonal chemistry with nanotechnologies broadens the biological applications of nanomaterials, with tetrazine bioorthogonal chemistry playing a crucial role due to its rapid kinetics and high selectivity. This advancement has led to developments in various areas of biomedicine.

NANOSCALE (2023)

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Article Pharmacology & Pharmacy

Doxorubicin-conjugated siRNA lipid nanoparticles for combination cancer therapy

Kamila Butowska et al.

Summary: Evasion of apoptosis is a characteristic of cancer, and overexpression of Bcl-2 is a contributing factor. Therapeutic targeting of Bcl-2 has shown efficacy in the clinic and is being extensively tested in combination with chemotherapy. Therefore, developing co-delivery systems for Bcl-2 targeting agents and chemotherapeutics, such as LNPs, holds promise for combination cancer therapies.

ACTA PHARMACEUTICA SINICA B (2023)

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Article Biotechnology & Applied Microbiology

Nanoalbumin-prodrug conjugates prepared via a thiolation-and-conjugation method improve cancer chemotherapy and immune checkpoint blockade therapy by promoting CD8+ T-cell infiltration

Long Chen et al.

Summary: Protein-drug conjugates are emerging tools for cancer treatment. By using an indirect thiolation-and-conjugation method, nanometric conjugates were prepared, showing enhanced uptake by cancer cells. A nanometric albumin-doxorubicin prodrug conjugate (NanoAlb-proDOX) was successfully prepared and demonstrated superior antitumor activity and synergy with immune checkpoint blockade.

BIOENGINEERING & TRANSLATIONAL MEDICINE (2023)

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Article Materials Science, Biomaterials

Detachable Dual-Targeting Nanoparticles for Improving the Antitumor Effect by Extracellular Matrix Depletion

Songchao Duan et al.

Summary: In the tumor microenvironment, cancer-associated fibroblasts produce extracellular matrix which forms a dense barrier that hinders the penetration of nanodrugs, thus reducing therapeutic efficacy. Recent research has discovered effective strategies involving ECM depletion and the use of small-sized nanoparticles. This study presents a detachable dual-targeting nanoparticle, capable of enhancing penetration by reducing ECM. The nanoparticle is divided into two parts upon reaching the tumor site, responding to overexpressed matrix metalloproteinase-2. This allows for improved tumor cell targeting and the release of therapeutic agents such as metformin and doxorubicin, resulting in enhanced tumor chemotherapy effect.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2023)

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Article Biochemical Research Methods

Design and Evaluation of a Carrier-Free Prodrug-Based Palmitic-DEVD-Doxorubicin Conjugate for Targeted Cancer Therapy

Seong-Bin Yang et al.

Summary: A carrier-free nanomedicine was developed in this study to effectively deliver drugs to tumor tissues through self-assembly. It overcomes the manufacturing complexity, toxicity, and low loading capacity associated with typical polymer-based nanocarriers, exhibiting outstanding drug delivery performance. This carrier-free nanomedicine shows great potential for targeted anticancer therapy, demonstrating significant therapeutic effects for solid tumors.

BIOCONJUGATE CHEMISTRY (2023)

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Article Engineering, Biomedical

A self-cascaded unimolecular prodrug for pH-responsive chemotherapy and tumor-detained photodynamic-immunotherapy of triple-negative breast cancer

Defan Yao et al.

Summary: An engineered self-cascaded prodrug was developed to overcome the immunosuppressive tumor microenvironment in TNBC immunotherapy by releasing chemotherapy and promoting photodynamic therapy, enhancing the effectiveness of TNBC immunotherapy.

BIOMATERIALS (2023)

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Article Biochemistry & Molecular Biology

Intelligent delivery system targeting PD-1/PD-L1 pathway for cancer immunotherapy

Ning Liu et al.

Summary: Drugs targeting the PD-1/PD-L1 pathway have been widely used in cancer immunotherapy, but only a fraction of patients benefit from it. Therefore, developing intelligent delivery systems with controlled release ability and improved tumor targeting capacity is a promising strategy to increase the response rate. By responding to tumor-specific microenvironments or external stimuli, these nanocarriers can release immunomodulators at tumor sites, increasing anti-tumor potency while reducing off-target toxicity.

BIOORGANIC CHEMISTRY (2023)

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Article Chemistry, Medicinal

Substituent effect of benzyl moiety in nitroquinoxaline small molecules upon DNA binding: Cumulative destacking of DNA nucleobases leading to histone eviction

Ritesh Pal et al.

Summary: This study reveals that a quinoxaline-based small molecule can disrupt Watson-Crick hydrogen bonds and induce base-destacking, leading to DNA superstructure formation and condensation. The formation of DNA superstructures is driven by hydrophobic interactions and can result in the eviction of histones from nucleosomes. Furthermore, the study demonstrates that the hydrophobicity of benzyl para-substituents in the quinoxaline derivatives correlates with their anticancer activities.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)

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Article Chemistry, Medicinal

Multiple targeted doxorubicin-lonidamine liposomes modified with p-hydroxybenzoic acid and triphenylphosphonium to synergistically treat glioma

Jiaqi Lu et al.

Summary: In this study, pH-sensitive multi-targeted liposomes were developed for the co-delivery of doxorubicin and lonidamine to brain tumors. These liposomes exhibited excellent pharmacokinetic properties, crossed the blood-brain barrier, and targeted tumor cells. Once inside the cells, the liposomes were positively charged and accumulated in the mitochondria, resulting in the synergistic release of the two drugs and enhanced anti-tumor efficacy. In vitro and in vivo experiments demonstrated that these liposomes significantly inhibited tumor cell proliferation, migration, and invasion, induced apoptosis and necrosis, and interfered with mitochondrial function. They also prolonged the survival of mice with glioma, reduced tumor size, and inhibited tumor infiltration and metastasis.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)

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Article Chemistry, Physical

Molecular recognition-driven supramolecular nanoassembly of a hydrophobic uracil prodrug and hydrophilic cytarabine for precise combination treatment of solid and non-solid tumors

Chang Li et al.

Summary: This study presents a novel molecular co-assembly nanoplatform for efficient co-delivery of hydrophilic and hydrophobic drugs. Through supramolecular co-assembly, a reduction-sensitive prodrug is synthesized and readily co-assembles with another drug, resulting in high drug loading rate and satisfactory therapeutic effects in vivo.

NANOSCALE HORIZONS (2022)

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Article Pharmacology & Pharmacy

GSH-sensitive polymeric prodrug: Synthesis and loading with photosensitizers as nanoscale chemo-photodynamic anti-cancer nanomedicine

Lei Luo et al.

Summary: In this study, a redox-responsive polymeric prodrug was synthesized by RAFT polymerization for precise delivery of combinational therapeutic agents. The prodrug exhibited a chemo-photodynamic therapeutic effect to kill breast cancer cells and showed a remarkable in vivo anticancer efficacy. The findings suggest that the redox-responsive polymeric prodrug has great potential as an anti-cancer agent for combinational therapy.

ACTA PHARMACEUTICA SINICA B (2022)

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Article Engineering, Biomedical

Dual stimuli-responsive dendronized prodrug derived from poly(oligo-(ethylene glycol) methacrylate)-based copolymers for enhanced anti-cancer therapeutic effect

Qiang Luo et al.

Summary: In this study, an enzyme- and pH-responsive polymeric prodrug was developed by combining a dendronized structure with a poly(oligo-(ethylene glycol) methacrylate) backbone. The prodrug exhibited dual stimuli responsiveness and self-assembled into stable nanoparticles, which showed long-term circulation and enhanced cellular uptake. The nanoparticles demonstrated enhanced therapeutic effect and great hemocompatibility and biosafety. This strategy provides insights for the design of drug delivery carriers based on poly(oligo-(ethylene glycol) methacrylate).

ACTA BIOMATERIALIA (2022)

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Article Engineering, Biomedical

pH/ROS dual-responsive supramolecular polypeptide prodrug nanome dicine base d on host-guest recognition for cancer therapy

Yue Ding et al.

Summary: Supramolecular nanomedicine assembly combined with polypeptide prodrug is an effective strategy to minimize drug leakage and trigger drug release in tumor tissue. In this study, a charge-reversal amphiphilic polypeptide and a ROS-sensitive polypeptide prodrug were developed and assembled through host-guest recognition. The loaded drugs prevented premature drug leakage and enhanced stability under physiological conditions. The reversal of charge facilitated efficient cellular internalization and drug delivery in the acidic tumor microenvironment. Upon NIR light irradiation, ROS cleavage rapidly released activated drugs, enabling tumor-specific drug delivery. This intelligent supramolecular polypeptide prodrug represents a promising approach to enhance cancer therapy with reduced side effects.

ACTA BIOMATERIALIA (2022)

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Review Chemistry, Multidisciplinary

Selective N-terminal modification of peptides and proteins: Recent progresses and applications

Hongfei Jiang et al.

Summary: Numerous strategies have been developed and applied in the field of biological chemistry to link desired chemical probes with target peptides and proteins. Site-specific modification of native amino acid residues provides novel biological tools for understanding the role of peptides and proteins. Selective N-terminal modification strategies, which have been extensively studied in the last decade, have the potential for applications in medicine, basic research, and applied materials science.

CHINESE CHEMICAL LETTERS (2022)

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Article Chemistry, Medicinal

pH-redox responsive cascade-targeted liposomes to intelligently deliver doxorubicin prodrugs and lonidamine for glioma

Yi Zhao et al.

Summary: In this study, novel cascadetargeted liposomes (Lip-TPGS) were designed and prepared for synergistic treatment of glioma. These liposomes could intelligently deliver redox-sensitive doxorubicin prodrugs and a chemotherapeutic sensitizer, providing a promising drug delivery system with potential advantages in inhibiting proliferation, promoting apoptosis, inducing mitochondria dysfunction, inhibiting migration and invasion, prolonging survival time, and reducing toxicity.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)

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Article Chemistry, Multidisciplinary

Caspase-3 mediated switch therapy of self-triggered and long-acting prodrugs for metastatic TNBC

Ha Rin Kim et al.

Summary: This article describes a tumoral caspase-3 mediated peptide-doxorubicin conjugates (PDC) switch therapy for targeting metastatic triple-negative breast cancer. The therapy utilizes two different caspase-3 cleavable PDCs to induce apoptosis in tumor cells and target tumor sites, resulting in enhanced tumor-specific apoptosis amplification and potent therapeutic efficacy.

JOURNAL OF CONTROLLED RELEASE (2022)

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Review Chemistry, Multidisciplinary

Triggered azobenzene-based prodrugs and drug delivery systems

Jundong Zhu et al.

Summary: Azobenzene and its derivatives are multifunctional molecules that are sensitive to light, hypoxia, and specific enzymes, making them potentially useful in material science, pharmaceutical science, and biomedicine. This article focuses on their application in triggered prodrugs and drug delivery systems, and discusses relevant issues and potential solutions.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Chemistry, Multidisciplinary

Supramolecular Shear-Thinning Glycopeptide Hydrogels for Injectable Enzyme Prodrug Therapy Applications

Yusuke Sakamoto et al.

Summary: Transplantable catalytic reactors have been developed using amphiphilic glycopeptides that self-assemble into biocatalytic supramolecular hydrogels. These hydrogels can be administered using a syringe and loaded with enzymes to transform prodrugs into anticancer drugs that inhibit tumor cell growth.

LANGMUIR (2022)

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Article Chemistry, Multidisciplinary

Prodrug nanoparticles potentiate tumor chemo-immunometabolic therapy by disturbing oxidative stress

Hongjuan Zhao et al.

Summary: In this study, reactive oxygen species (ROS) responsive prodrug nanoparticles (DHCRJ) were developed for metabolic enhanced chemo-immunotherapy against triple-negative breast cancer (TNBC). DHCRJ reduced oxidative stress and lactate accumulation, reshaped the immunosuppressive tumor microenvironment, and enhanced tumor immunogenicity through the synergistic effect of DOX prodrugs and JQ1. This strategy significantly suppressed tumor growth and metastasis.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Nanoscience & Nanotechnology

Dynamic Effects of Endo-Exogenous Stimulations on Enzyme-Activatable Polymeric Nanosystems with Photo-Sono-Chemo Synergy

Pu Qiu et al.

Summary: This study systematically investigates the interactions between an enzyme-nanosystem model, tumor-overexpressed hyaluronidase (HAase), and doxorubicin-loaded hyaluronic-acid-porphyrin nanoassemblies (DOX@ HPNAs), in order to enhance photo-sono-chemo therapies. The results show that HAase degrades the HPNAs more rapidly in acidic solution, leading to structure disassembly, chain cleavage, and increased singlet oxygen production. The nanosystem can be activated by trimodal stimulations (acidity, ultrasound, and HAase), resulting in controllable release behavior and the highest inhibition rate of malignant tumors. This enzyme-activatable nanosystem exhibits synergistic effects in photodynamic therapy, sonodynamic therapy, and chemotherapy, causing significant necrosis and apoptosis of cancer cells.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Engineering, Environmental

Emerging Prodrug-Engineered nanomedicines for synergistic Chemo-Phototherapy

Xinzhu Shan et al.

Summary: This review discusses the application of prodrug-engineered nanomedicines in synergistic chemo-phototherapy. They offer advantages of synergistic treatment effect and dosage reduction, but also face challenges in design rationale.

CHEMICAL ENGINEERING JOURNAL (2022)

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Review Chemistry, Multidisciplinary

Taxanes prodrug-based nanomedicines for cancer therapy

Linlin Sun et al.

Summary: Malignant tumors pose a great threat to human health, and chemotherapy using taxanes is an important treatment option. However, the hydrophobicity, off-target toxicity, and multidrug resistance of taxanes restrict their therapeutic effects. Prodrug-based nanomedicines (PNS) have shown great potential in cancer therapy due to their advantages such as high drug loading efficiency, low immunogenicity, tumor stimuli-responsive drug release, and combinational therapy. This review summarizes the latest developments in taxanes prodrugs-based nanomedicines (TPNS), including polymer-drug conjugate-based nanoformulations, small molecular prodrug-based self-assembled nanoparticles, and prodrug-encapsulated nanosystems. The future challenges of TPNS for clinical translation are also discussed.

JOURNAL OF CONTROLLED RELEASE (2022)

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Review Biochemistry & Molecular Biology

Tetrazine bioorthogonal chemistry derived in vivo imaging

Gaoxiang Zhao et al.

Summary: Bioorthogonal chemistry represents highly efficient and biocompatible reactions that proceed selectively and rapidly in biological situations. Tetrazine bioorthogonal reactions play an important role in in vivo imaging applications, allowing for the easy tracking of real signals through controlled fluorescence or radiation off-on mechanism.

FRONTIERS IN MOLECULAR BIOSCIENCES (2022)

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Article Pharmacology & Pharmacy

Hyaluronic Acid-Functionalized Mesoporous Silica Nanoparticles Loading Simvastatin for Targeted Therapy of Atherosclerosis

Kechen Song et al.

Summary: In this study, an enzyme-responsive and macrophage-targeting drug delivery system was constructed for precise treatment of atherosclerosis. The results showed that the system had high drug loading efficiency and enzyme-responsive release, as well as robust targeting, anti-inflammatory, and anti-foaming effects, with low cytotoxicity and excellent hemocompatibility.

PHARMACEUTICS (2022)

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Article Engineering, Biomedical

Comparative study of cathepsin B-cleavable linkers for the optimal design of cathepsin B-specific doxorubicin prodrug nanoparticles for targeted cancer therapy

Nayeon Shim et al.

Summary: Carrier-free prodrug nanoparticles have shown potential as a cancer therapy approach, with enhanced tumor targeting and reduced toxicity to normal cells.

BIOMATERIALS (2022)

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Article Food Science & Technology

Applications of natural polysaccharide-based pH-sensitive films in food packaging: Current research and future trends

Nan Li et al.

Summary: With the increasing awareness of food safety and environmental concerns regarding plastic packaging disposal, there is a pressing need for the development of novel food packaging materials. Natural polysaccharides offer great potential as they are biodegradable and possess good film-forming properties. This paper provides an overview of the current research on pH-sensitive films based on natural polysaccharides, and highlights their applications in food packaging, including meat, fruits, and vegetables. Furthermore, the trends and challenges in pH-sensitive films for food packaging are discussed. Overall, natural polysaccharide-based pH-sensitive films show advantages over conventional food packaging films, as they not only protect the packaged food but also provide real-time monitoring of its quality.

INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES (2022)

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Article Chemistry, Multidisciplinary

Enzyme-responsive hybrid prodrug of nitric oxide and hydrogen sulfide for heart failure therapy

Qi Liu et al.

Summary: A hybrid prodrug was synthesized to achieve the combined delivery of nitric oxide and hydrogen sulfide, providing effective treatment for heart failure post-myocardial infarction.

CHEMICAL COMMUNICATIONS (2022)

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Article Chemistry, Multidisciplinary

Triazine-pyridine chemistry for protein labelling on tyrosine

Hongfei Jiang et al.

Summary: In this study, we discovered the new reactivity of the 1,3,5-triazine moiety with a phenol group and developed a biocompatible and catalyst-free triazine-pyridine chemistry (TPC) for tyrosine labeling and proteome profiling under physiological conditions. TPC showed high tyrosine chemoselectivity in biological systems after cysteine blocking, demonstrated potential in tyrosine-guided protein labeling, and exhibited bio-compatibility in live cells.

CHEMICAL COMMUNICATIONS (2022)

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Review Chemistry, Multidisciplinary

Stimulus-responsive self-assembled prodrugs in cancer therapy

Xiao Dong et al.

Summary: This review summarizes the application of self-assembled prodrugs in cancer drug development. Self-assembled prodrugs can improve the physicochemical properties of drugs and achieve controlled release at tumor sites, thus showing potential for clinical applications.

CHEMICAL SCIENCE (2022)

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Article Engineering, Biomedical

Tumor microenvironment-activated therapeutic peptide-conjugated prodrug nanoparticles for enhanced tumor penetration and local T cell activation in the tumor microenvironment

Xianghui Zhu et al.

Summary: Nanomedicine-based chemoimmunotherapy has potential for enhanced tumor penetration and immunotherapeutic effects. A TME-activable prodrug nanoparticle was developed to co-deliver DOX and (D)PPA antagonist, inhibiting regulatory T cells and promoting immune response to prevent tumor recurrence and metastasis.

ACTA BIOMATERIALIA (2021)

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Article Nanoscience & Nanotechnology

Synergistic Cancer Photochemotherapy via Layered Double Hydroxide-Based Trimodal Nanomedicine at Very Low Therapeutic Doses

Jianping Liu et al.

Summary: A novel trifunctional LDH nanosystem was developed for combined photochemotherapy of skin cancer by releasing drugs in an acid-triggered manner and generating heating and reactive oxygen species upon laser irradiation, which nearly eradicated tumor tissues with minimal side effects.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Pathology

Circ-ITCH restrains the expression of MMP-2, MMP-9 and TNF-alpha in diabetic retinopathy by inhibiting miR-22

Lin Zhou et al.

Summary: In diabetic retinopathy, the decreased expression of circ-ITCH in retinal pigment epithelial cells correlates with increased levels of MMP-2, MMP-9, and TNF-alpha, which is reversed by circ-ITCH overexpression. Additionally, the inhibitory effects of circ-ITCH on MMP-2 and MMP-9 are antagonized by miR-22 mimics, indicating a regulatory role of circ-ITCH-inhibited miR-22 activity in DR pathogenesis.

EXPERIMENTAL AND MOLECULAR PATHOLOGY (2021)

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Article Chemistry, Multidisciplinary

Albumin-binding prodrugs via reversible iminoboronate forming nanoparticles for cancer drug delivery

Lingqiao Hao et al.

Summary: Albumin-based nanomedicines are important for cancer drug delivery, with prodrugs functionalized with 2-acetylphenylboronic acid readily binding to proteins and forming nanoparticles. These nanoparticles show enhanced anticancer efficacy compared to clinically used drugs in tumor models, demonstrating a versatile prodrug platform for protein-based drug formulations.

JOURNAL OF CONTROLLED RELEASE (2021)

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Review Oncology

PD-L1 as a biomarker of response to immune-checkpoint inhibitors

Deborah Blythe Doroshow et al.

Summary: PD-L1 expression is currently the best predictor of responsiveness to immune-checkpoint inhibitors, despite challenges in clinical use such as variability in different assays and cut-off points, as well as the lack of prospective comparisons with clinical outcomes. Nevertheless, several immunohistochemical assays have been approved for clinical use, with implications for pathology services and potential impacts on clinical outcomes. Comparison of FDA-approved PD-L1 assays, understanding of the varying implications of PD-L1 expression across different tumour types, and exploration of novel approaches to optimize its clinical utility are important topics for further research and practice.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

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Article Engineering, Biomedical

Photo-responsive prodrug nanoparticles for efficient cytoplasmic delivery and synergistic photodynamic-chemotherapy of metastatic triple-negative breast cancer

Jian Jiao et al.

Summary: In this study, photo-responsive prodrug nanoparticles (AlP/CPT-NPs) were designed for synergistic treatment of metastatic TNBC. Upon light exposure, the generated O-1(2) could promote cytoplasmic delivery of the therapeutic payloads, resulting in potent in vivo phototherapeutic damage through photodynamic-chemotherapy. This approach led to complete tumor ablation with metastasis suppression, showing promise for effective treatment of metastatic TNBC.

ACTA BIOMATERIALIA (2021)

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Article Engineering, Biomedical

Cancer-activated doxorubicin prodrug nanoparticles induce preferential immune response with minimal doxorubicin-related toxicity

Suah Yang et al.

Summary: The construction of cancer-activated DOX prodrug nanoparticles provides a promising approach to enhance anticancer immune responses while minimizing side effects and systemic immunosuppression. These nanoparticles selectively target cancer cells, inducing cytotoxicity and immunogenic cell death, leading to increased response to checkpoint inhibitor immunotherapy.

BIOMATERIALS (2021)

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Review Biotechnology & Applied Microbiology

Nanotechnologies for Reactive Oxygen SpeciesTurn-On Detection

Hongfei Jiang et al.

Summary: This review focuses on evaluating nanotechnologies for ROS detection, especially reaction-based nanomaterials. These materials have high sensitivity, real-time detection capability, and almost infinite contrast, making them suitable for a wide range of biological applications.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

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Article Engineering, Environmental

Doxorubicin/CpG self-assembled nanoparticles prodrug and dendritic cells co-laden hydrogel for cancer chemo-assisted immunotherapy

Afeng Yang et al.

Summary: The study introduced a doxorubicin/CpG self-assembled nanoparticles prodrug and dendritic cells (DC) co-laden hydrogel system for cancer chemo-assisted immunotherapy. The combination effectively induced a strong CTL killing effect, increased effector T cell infiltration, alleviated the immunosuppressive microenvironment, and maximized the immune effect for improving chemo-assisted immunotherapy. The fluorescence imaging tracking provided insight into the in vivo process of immune cells, chemotherapeutic drugs, and immune adjuvants for efficient therapy guidance.

CHEMICAL ENGINEERING JOURNAL (2021)

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Review Medicine, Research & Experimental

A comprehensive review on time-tested anticancer drug doxorubicin

Sruthi Sritharan et al.

Summary: Doxorubicin is a widely used chemotherapeutic drug for cancer treatment, inducing cell death through various mechanisms and aiding in immune clearance of tumor cells, but its applicability is limited by the development of chemoresistance and cardiotoxicity. Various formulations and co-treatments are essential in reducing toxicity and combating resistance. Further research into the molecular mechanisms of chemoresistance development is crucial for improving patient survivability and preventing cancer relapse.

LIFE SCIENCES (2021)

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Article Medicine, Research & Experimental

Prodrug Delivery Using Dual-Targeting Nanoparticles To Treat Breast Cancer Brain Metastases

Xiufeng Ju et al.

Summary: Brain metastases from breast cancer are difficult to surgically remove and have limited drug treatment options due to their growth patterns and the blood-brain barrier. By assembling prodrug-loaded nanoparticles that target both the BBB and metastatic breast cancer, researchers were able to significantly extend the survival time of mice with intracranial metastatic breast cancer, suggesting a potential important direction for drug therapy against brain metastases.

MOLECULAR PHARMACEUTICS (2021)

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Article Engineering, Biomedical

Theranostic Heterodimeric Prodrug with Dual-Channel Fluorescence Turn-On and Dual-Prodrug Activation for Synergistic Cancer Therapy

Maolin Jiang et al.

Summary: In this study, a theranostic heterodimeric prodrug, CyNH-SS-DOX, is developed for synergistic cancer therapy with dual-channel fluorescence monitoring of drug activation, enhancing therapeutic efficacy and minimizing side effects.

ADVANCED HEALTHCARE MATERIALS (2021)

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Review Chemistry, Multidisciplinary

Engineering nanomedicine for glutathione depletion-augmented cancer therapy

Yuxuan Xiong et al.

Summary: The combination of nanomedicine with GSH scavenging agents and therapeutic drugs has attracted significant interest in enhancing cancer treatment outcomes. Despite unsatisfactory results, this approach has shown promising results in a large number of rodent tumor models.

CHEMICAL SOCIETY REVIEWS (2021)

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Article Oncology

Immune checkpoint inhibitors combined with chemotherapy for the treatment of advanced pancreatic cancer patients

Junxun Ma et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2020)

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Article Medicine, General & Internal

Pembrolizumab for Early Triple-Negative Breast Cancer

Peter Schmid et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Horticulture

Integration of Steam with Allyl-isothiocyanate for Soil Disinfestation

Dong Sub Kim et al.

HORTSCIENCE (2020)

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Article Chemistry, Multidisciplinary

Prodrug-Based Versatile Nanomedicine for Enhancing Cancer Immunotherapy by Increasing Immunogenic Cell Death

Shuang Bai et al.

SMALL (2020)

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Article Chemistry, Analytical

Mineralization of pH-Sensitive Doxorubicin Prodrug in ZIF-8 to Enable Targeted Delivery to Solid Tumors

Jiaqi Yan et al.

ANALYTICAL CHEMISTRY (2020)

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Article Chemistry, Multidisciplinary

Tetrazine Carbon Nanotubes for Pretargeted In Vivo Click-to-Release Bioorthogonal Tumour Imaging

He Li et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Article Pharmacology & Pharmacy

A Doxorubicin-Glucuronide Prodrug Released from Nanogels Activated by High-Intensity Focused Ultrasound Liberated β-Glucuronidase

Helena C. Besse et al.

PHARMACEUTICS (2020)

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Article Biochemistry & Molecular Biology

Photo- and pH-Responsive Polycarbonate Block Copolymer Prodrug Nanomicelles for Controlled Release of Doxorubicin

Nagendra Kalva et al.

MACROMOLECULAR BIOSCIENCE (2020)

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Article Chemistry, Multidisciplinary

Carrier-free nanoassembly of doxorubicin prodrug and siRNA for combinationally inducing immunogenic cell death and reversing immunosuppression

Senbiao Chen et al.

NANO TODAY (2020)

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Article Multidisciplinary Sciences

Trisulfide bond-mediated doxorubicin dimeric prodrug nanoassemblies with high drug loading, high self-assembly stability, and high tumor selectivity

Yinxian Yang et al.

SCIENCE ADVANCES (2020)

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Article Chemistry, Multidisciplinary

Tailor-made legumain/pH dual-responsive doxorubicin prodrug-embedded nanoparticles for efficient anticancer drug delivery and in situ monitoring of drug release

Yang Li et al.

NANOSCALE (2020)

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Review Chemistry, Multidisciplinary

Nanoparticle-Mediated Immunogenic Cell Death Enables and Potentiates Cancer Immunotherapy

Xiaopin Duan et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

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Article Materials Science, Biomaterials

Polymer-Doxorubicin Prodrug with Biocompatibility, pH Response, and Main Chain Breakability Prepared by Catalyst-Free Click Reaction

Dian Li et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2019)

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Article Chemistry, Multidisciplinary

Combretastatin A4 Nanodrug-Induced MMP9 Amplification Boosts Tumor-Selective Release of Doxorubicin Prodrug

Jian Jiang et al.

ADVANCED MATERIALS (2019)

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Review Chemistry, Multidisciplinary

Innovative Linker Strategies for Tumor-Targeted Drug Conjugates

Alberto Dal Corso et al.

CHEMISTRY-A EUROPEAN JOURNAL (2019)

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Article Engineering, Biomedical

Synergistic triple-combination therapy with hyaluronic acid-shelled PPy/CPT nanoparticles results in tumor regression and prevents tumor recurrence and metastasis in 4T1 breast cancer

Wei Sun et al.

BIOMATERIALS (2019)

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Review Oncology

Enhancing antitumor response by combining immune checkpoint inhibitors with chemotherapy in solid tumors

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The potentiated checkpoint blockade immunotherapy by ROS-responsive nanocarrier-mediated cascade chemo-photodynamic therapy

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BIOMATERIALS (2019)

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Article Chemistry, Multidisciplinary

Carrier-free nanoparticles of cathepsin B-cleavable peptide-conjugated doxorubicin prodrug for cancer targeting therapy

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JOURNAL OF CONTROLLED RELEASE (2019)

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Review Chemistry, Multidisciplinary

Click and release: bioorthogonal approaches to ''on-demand'' activation of prodrugs

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CHEMICAL SOCIETY REVIEWS (2019)

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Article Materials Science, Biomaterials

A tumor responsive self healing prodrug hydrogel enables synergistic action of doxorubicin and miltefosine for focal combination chemotherapy

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JOURNAL OF MATERIALS CHEMISTRY B (2019)

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Review Biochemistry & Molecular Biology

Prodrug strategies for targeted therapy triggered by reactive oxygen species

Jorge Peiro Cadahia et al.

MEDCHEMCOMM (2019)

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Review Medicine, Research & Experimental

Recent advances and challenges of repurposing nanoparticle-based drug delivery systems to enhance cancer immunotherapy

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THERANOSTICS (2019)

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Article Engineering, Biomedical

pH-sensitive doxorubicin-conjugated prodrug micelles with charge-conversion for cancer therapy

Boxuan Ma et al.

ACTA BIOMATERIALIA (2018)

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Review Cell Biology

Chemotherapeutic Drugs and Mitochondrial Dysfunction: Focus on Doxorubicin, Trastuzumab, and Sunitinib

Stefania Gorini et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)

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Article Materials Science, Biomaterials

A synergistic polyphosphoester-based co-delivery system of the anticancer drug doxorubicin and the tumor suppressor gene p53 for lung cancer therapy

Jie Liu et al.

JOURNAL OF MATERIALS CHEMISTRY B (2018)

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Article Materials Science, Biomaterials

A reactive oxygen species-responsive prodrug micelle with efficient cellular uptake and excellent bioavailability

Long Xu et al.

JOURNAL OF MATERIALS CHEMISTRY B (2018)

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Article Pharmacology & Pharmacy

Harnessing albumin as a carrier for cancer therapies

Ella N. Hoogenboezem et al.

ADVANCED DRUG DELIVERY REVIEWS (2018)

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Article Chemistry, Multidisciplinary

PD-1 Blockade for Improving the Antitumor Efficiency of Polymer-Doxorubicin Nanoprodrug

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SMALL (2018)

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Review Immunology

Combining immune Checkpoint inhibitors with Conventional Cancer Therapy

Yiyi Yan et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Chemistry, Multidisciplinary

Nanoparticle-Mediated Remodeling of the Tumor Microenvironment to Enhance Immunotherapy

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ACS NANO (2018)

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Article Chemistry, Multidisciplinary

Photo- and pH- Dual-Responsive β-Cyclodextrin-Based Supramolecular Prodrug Complex Self-Assemblies for Programmed Drug Delivery

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CHEMISTRY-AN ASIAN JOURNAL (2018)

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Review Biochemistry & Molecular Biology

Immune checkpoint inhibitors: recent progress and potential biomarkers

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EXPERIMENTAL AND MOLECULAR MEDICINE (2018)

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Review Pharmacology & Pharmacy

Stimuli-Responsive Prodrug Chemistries for Drug Delivery

Vincenzo Taresco et al.

ADVANCED THERAPEUTICS (2018)

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Article Engineering, Biomedical

Inducing enhanced immunogenic cell death with nanocarrier-based drug delivery systems for pancreatic cancer therapy

Xiao Zhao et al.

BIOMATERIALS (2016)

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Article Chemistry, Multidisciplinary

Liposomal Texaphyrin Theranostics for Metastatic Liver Cancer

Min Hee Lee et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)

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Article Immunology

TLR4 is essential for dendritic cell activation and anti-tumor T-cell response enhancement by DAMPs released from chemically stressed cancer cells

Hongliang Fang et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2014)

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Review Oncology

An overview of doxorubicin formulations in cancer therapy

Sangeeta Rivankar

JOURNAL OF CANCER RESEARCH AND THERAPEUTICS (2014)

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Review Cell Biology

Cellular mechanisms and physiological consequences of redox-dependent signalling

Kira M. Holmstroem et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)

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Article Chemistry, Multidisciplinary

Click to Release: Instantaneous Doxorubicin Elimination upon Tetrazine Ligation

Ron M. Versteegen et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)

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Article Pharmacology & Pharmacy

Activation of DNA damage response pathways as a consequence of anthracycline-DNA adduct formation

Robert A. Forrest et al.

BIOCHEMICAL PHARMACOLOGY (2012)

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Article Pharmacology & Pharmacy

Cellular Redox Pathways as a Therapeutic Target in the Treatment of Cancer

Alberto J. Montero et al.

DRUGS (2011)

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Article Chemistry, Multidisciplinary

Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery

Ru Cheng et al.

JOURNAL OF CONTROLLED RELEASE (2011)

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Editorial Material Biotechnology & Applied Microbiology

Doxorubicin pathways: pharmacodynamics and adverse effects

Caroline F. Thorn et al.

PHARMACOGENETICS AND GENOMICS (2011)

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Review Oncology

Cardiotoxicity of Anticancer Drugs: The Need for Cardio-Oncology and Cardio-Oncological Prevention

Adriana Albini et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2010)

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Article Cardiac & Cardiovascular Systems

Toll-like receptor-4 deficiency attenuates doxorubicin-induced cardiomyopathy in mice

Alexander Riad et al.

EUROPEAN JOURNAL OF HEART FAILURE (2008)

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Article Biochemistry & Molecular Biology

Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy

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NATURE MEDICINE (2007)

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