SGLT2 breast expression could affect the cardiovascular performance in pre-menopausal women with fatty vs. non fatty breast via over-inflammation and sirtuins' down regulation

Objectives: To evaluate the expression of sodium-glucose transporter 2 (SGLT2), inflammatory cytokines, and sirtuins in breast fat tissue at baseline, and serum cytokines of fatty vs. non-fatty pre-menopausal women at baseline, and at 12 months of follow-up. To correlate SGLT2/cytokines/sirtuins expression to clinical variables, and their changes (& UDelta;) at follow-up, as intima-media wall thickness (IMT), left ventricle mass (LVM), left ventricle ejection fraction (LVEF), and myocardial performance index (MPI), and its normalization. Background: Pre-menopausal women with the lowest breast fat density (fatty breast) vs. higher breast fat density (non-fatty breast) are a high-risk population for cardiovascular diseases and worse prognosis. Methods: We analyzed SGLT2/cytokines/sirtuins of excised fatty breasts of fatty vs. non-fatty pre-menopausal women. We correlated SGLT2/cytokines/sirtuins to & UDelta; IMT, & UDelta; LVM, & UDelta; LVEF, and & UDelta; MPI, and normal cardiac performance (NCP) at 1 year of follow-up. Results: fatty vs. non-fatty breast over-expressed SGLT2/inflammatory cytokines, with lowest values of sirtuins (p<0.05). We found a direct correlation between SGLT2 (R2 0.745), TNF & alpha; (R2 0.262), and & UDelta;MPI (p<0.05), and an inverse correlation between breast density (R2 -0.198), SIRT-3 (R2-0.181), and & UDelta;MPI (p<0.05). Fatty breast (0.761, CI 95% [0.101-0.915]), SGLT2 (0.812, CI 95% [0.674-0.978]) and SIRT-3 (1.945, CI 95% [1.201-3.148]) predicted NCP at 1 year of follow-up. Conclusions: fatty vs. non-fatty breast women over-expressed SGLT2/inflammatory cytokines, and downregulated breast sirtuins. SGLT2/inflammatory cytokines expression and inversely the tissue sirtuin 3 (tSIRT3)

Automated summary

This study evaluated the expression of SGLT2, inflammatory cytokines, and sirtuins in breast fat tissue and serum cytokines of pre-menopausal women. The results showed that women with fatty breasts over-expressed SGLT2 and inflammatory cytokines, while downregulating breast sirtuins. The study also found correlations between the expression of SGLT2/cytokines/sirtuins and clinical variables related to cardiovascular health.