4.6 Article

Clinical features and immune mechanisms directly linked to the altered liver function in patients with rheumatoid arthritis

期刊

EUROPEAN JOURNAL OF INTERNAL MEDICINE
卷 118, 期 -, 页码 49-58

出版社

ELSEVIER
DOI: 10.1016/j.ejim.2023.08.002

关键词

Liver disease risk; Inflammation; NAFLD; Rheumatoid arthritis; ACPAs; Proximity extension assay

向作者/读者索取更多资源

Rheumatoid arthritis patients may experience mild to moderate liver inflammation due to the infiltration of T, B cells, and macrophages, as well as the action of anticitrullinated protein antibodies (ACPAs). This phenomenon is independent of obesity or diabetes and is associated with systemic inflammation and disease activity levels.
Background: The aim of this study was to explore the impact of arthritis on liver function using different approaches in vivo and in vitro.Methods: A cross-sectional study was performed on 330 non-obese/non-T2DM subjects: 180 RA patients, 50 NAFLD non-RA patients, and 100 healthy donors (HDs). A longitudinal study was conducted on 50 RA patients treated with methotrexate for six months. Clinical and laboratory parameters and markers of liver disease were collected. Mechanistic studies were carried out in both the CIA mouse model and hepatocytes treated with anticitrullinated protein antibodies (ACPAs).Results: RA patients have an increased risk of suffering from liver disease independent of obesity or T2DM. This risk was associated with factors such as insulin resistance, autoantibodies, inflammation, and component C3. Methotrexate treatment for six months was associated with liver abnormalities in those newly-diagnosed patients having CV risk factors. ACPAs induced a defective hepatocyte function, promoting IR and inflammation. The induction of arthritis in mice caused the infiltration of immune cells in the liver and increased inflammatory, apoptotic, and fibrotic processes.Conclusion: RA patients may experience mild to moderate liver inflammation due to the infiltration of T, B cells, and macrophages, and the action of ACPAs. This is independent of obesity or diabetes and linked to systemic inflammation, and disease activity levels. The negative effects of methotrexate on liver function could be restricted to the concomitant presence of cardiovascular risk factors.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据