期刊
EUROPEAN JOURNAL OF HAEMATOLOGY
卷 -, 期 -, 页码 -出版社
WILEY
DOI: 10.1111/ejh.14097
关键词
direct oral anticoagulant; inferior vena cava thrombus; vitamin K antagonist; warfarin
类别
This retrospective study evaluated the efficacy and safety of DOACs compared to warfarin in patients with IVC thrombus. The results showed no significant differences in thrombus resolution and bleeding risk between DOACs and warfarin within 6 months. However, the study is limited by a small patient population and availability of repeat imaging.
ObjectiveTo evaluate the efficacy and safety of direct oral anticoagulants (DOACs) compared to warfarin in patients with inferior vena cava (IVC) thrombus.MethodsThis was a single-system, retrospective cohort study of hospitalized adult patients with IVC thrombus treated with a DOAC or warfarin therapy. The primary efficacy endpoint was the thrombus resolution on imaging, and the primary safety endpoint was major bleeding, both assessed within 6 months of hospital discharge. Secondary endpoints included hospitalization for a bleeding-related event, pulmonary embolism, or death within 6 months of hospital discharge.ResultsA total of 33 patients were included in the study. Twenty-three (70%) patients received a DOAC, and 10 (30%) received warfarin. Of the 10 patients with repeat imaging available, complete resolution was noted in two (33%) DOAC patients and no warfarin patients (p = .5). Major bleeding occurred in two (8.7%) DOAC patients and one (10%) warfarin patient (p = .9). No significant differences in secondary endpoints were observed between groups.ConclusionsThere were no differences in efficacy and safety between patients receiving DOACs or warfarin for the treatment of IVC thrombus, although results are limited by the small patient population and number of patients with repeat imaging available.
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