Granulocyte-colony stimulating factor in decompensated liver cirrhosis: a meta-analysis of four randomized controlled trials

Article Gastroenterology & Hepatology

AASLD Practice Guidance: Palliative care and symptom-based management in decompensated cirrhosis

Shari S. Rogal et al.

HEPATOLOGY (2022)

Article Gastroenterology & Hepatology

Multiple cycles of granulocyte colony-stimulating factor in decompensated cirrhosis: a double-blind RCT

Aswath Venkitaraman et al.

Summary: This study aimed to investigate the efficacy of granulocyte colony-stimulating factor (G-CSF) in the treatment of decompensated cirrhosis (DC). The results showed that G-CSF therapy can be safely used and provides some improvements in certain aspects, but the improvement in 12-month survival rate was not statistically significant.

HEPATOLOGY INTERNATIONAL (2022)

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Article Infectious Diseases

The effects of granulocyte-colony stimulating factor on chronic liver disease: a meta-analysis

Pei Shi et al.

Summary: This study evaluated the effects of granulocyte-colony stimulating factor on chronic liver disease. The findings showed that it increased long-term and short-term survival, reduced Child-Turcotte-Pugh score, and had a relative safety profile.

JOURNAL OF INFECTION IN DEVELOPING COUNTRIES (2022)

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Editorial Material Gastroenterology & Hepatology

G-CSF treatment in decompensated liver disease: a double-edged sword?

Cornelius Engelmann et al.

HEPATOLOGY INTERNATIONAL (2022)

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Article Gastroenterology & Hepatology

Multiple Cycles of Granulocyte Colony-Stimulating Factor Increase Survival Times of Patients With Decompensated Cirrhosis in a Randomized Trial

Arka De et al.

Summary: Multiple cycles of G-CSF treatment can increase the survival rate of patients with decompensated cirrhosis, as well as improve outcomes such as reducing complications and improving quality of life.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2021)

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Review Medicine, General & Internal

Therapeutic Effect and Safety of Granulocyte Colony-Stimulating Factor Therapy for Acute-On-Chronic Liver Failure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Xiaoxue Hou et al.

Summary: The study concludes that the current evidence does not support the use of G-CSF for treating ACLF as it does not reduce the risk of death or complications.

FRONTIERS IN MEDICINE (2021)

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Article Gastroenterology & Hepatology

Granulocyte-colony stimulating factor (G-CSF) to treat acute-on- chronic liver failure: A multicenter randomized trial (GRAFT study)

Cornelius Engelmann et al.

Summary: In this multicenter controlled trial, G-CSF did not show significant beneficial effects on ACLF patients compared to standard medical therapy alone. The study was terminated prematurely due to futility after analysis. Therefore, G-CSF should not be recommended as a standard treatment for ACLF.

JOURNAL OF HEPATOLOGY (2021)

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Article Gastroenterology & Hepatology