Early puberty suppression and gender-affirming hormones do not alter final height in transgender adolescents

Article Endocrinology & Metabolism

Just as Tall on Testosterone; a Neutral to Positive Effect on Adult Height of GnRHa and Testosterone in Trans Boys

Lieve Anne Willemsen et al.

Summary: This study investigates the impact of puberty suppression and gender-affirming hormone treatment on growth and adult height in transgender boys. The results show that during puberty suppression, growth slows down and bone maturation decelerates, while during gender-affirming hormone treatment, growth accelerates. Despite having similar adult height standard deviation scores compared to baseline, puberty suppression and gender-affirming hormone treatment do not negatively impact adult height in transgender boys and may even result in slightly taller adult height.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2023)

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Article Endocrinology & Metabolism

Transgender Girls Grow Tall: Adult Height Is Unaffected by GnRH Analogue and Estradiol Treatment

Lidewij Sophia Boogers et al.

Summary: This study investigates the effects of GnRHa and GAHT on growth and the efficacy of growth-reductive treatment. The results show that GnRHa decelerates growth velocity, while GAHT accelerates it. Adult height after regular-dose treatment is slightly lower than predicted at the start of GnRHa, but not significantly different from target height.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2022)

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Review Endocrinology & Metabolism

Challenges in the care of transgender and gender-diverse youth: an endocrinologist's view

Stephen M. Rosenthal

Summary: An increasing number of transgender and gender-diverse (TGD) youth are seeking medical services to align their physical sex characteristics with their gender identity. This review highlights advances in understanding TGD youth, challenges in providing gender-affirming care, and research priorities.

NATURE REVIEWS ENDOCRINOLOGY (2021)

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Article Psychiatry