EEG microstate co-specificity in schizophrenia and obsessive-compulsive disorder

The past 20 years of research on EEG microstates has yielded the hypothesis that the imbalance pattern in the temporal dynamics of microstates C (increased) and D (decreased) is specific to schizophrenia. A similar microstate imbalance has been recently found in obsessive-compulsive disorder (OCD). The aim of the present high-density EEG study was to examine whether this pathological microstate pattern is co-specific to schizophrenia and OCD. We compared microstate temporal dynamics using Bayesian analyses, transition probabilities analyses and the Topographic Electrophysiological State Source-Imaging method for source reconstruction in 24 OCD patients and 28 schizophrenia patients, respectively, free of comorbid psychotic and OCD symptoms, and 27 healthy controls. OCD and schizophrenia patients exhibited the same increased contribution of microstate C, decreased duration and contribution of microstate D and greater D & RARR; C transition probabilities, compared with controls. A Bayes factor of 4.424 for the contribution of microstate C, 4.600 and 3.824, respectively, for the duration and contribution of microstate D demonstrated that there was no difference in microstate patterns between the two disorders. Source reconstruction further showed undistinguishable dysregulations between the Salience Network (SN), associated with microstate C, and the Executive Control Network (ECN), associated with microstate D, and between the ECN and cognitive cortico-striato-thalamo-cortical (CSTC) loop in the two disorders. The ECN/CSTC loop dysconnectivity was slightly worsened in schizophrenia. Our findings provide substantial evidence for a common aetiological pathway in schizophrenia and OCD, i.e. microstate co-specificity, and same anomalies in salience and external attention processing, leading to co-expression of symptoms.

Automated summary

The research on EEG microstates in the past 20 years has suggested that the imbalance in the temporal dynamics of microstates C and D is specific to schizophrenia, but a similar microstate imbalance has also been found in obsessive-compulsive disorder (OCD). This study aimed to determine if this microstate pattern is specific to both schizophrenia and OCD. The results showed that both OCD and schizophrenia patients exhibited the same microstate imbalance, with an increased contribution of microstate C, decreased duration and contribution of microstate D, and higher transition probabilities from D to C compared to healthy controls. The source reconstruction further revealed similar dysfunctions in the Salience Network (SN), Executive Control Network (ECN), and cognitive cortico-striato-thalamo-cortical (CSTC) loop in both disorders. The findings provide substantial evidence for a common pathway and anomalies in salience and external attention processing in schizophrenia and OCD.