期刊
EUROPACE
卷 25, 期 9, 页码 -出版社
OXFORD UNIV PRESS
DOI: 10.1093/europace/euad276
关键词
Atrial fibrillation; Atrial cardiomyopathy; Atypical atrial flutter; Fibrosis; Atrial remodelling
Pre-existing atrial cardiomyopathy is associated with the occurrence of atypical atrial flutter following catheter ablation of atrial fibrillation.
Aims Recurrence of arrhythmia after catheter ablation of atrial fibrillation (AF) in the form of atypical atrial flutter (AFL) is common among a significant number of patients and often requires redo ablation with limited success rates. Identifying patients at high risk of AFL after AF ablation could aid in patient selection and personalized ablation approach. The study aims to assess the relationship between pre-existing atrial cardiomyopathy and the occurrence of AFL following AF ablation.Methods and results We analysed a cohort of 1007 consecutive AF patients who underwent catheter ablation and were included in a prospective registry. Patients who did not have baseline cardiac magnetic resonance imaging and late gadolinium enhancement (LGE-CMR) or did not experience any recurrences were excluded. A total of 166 patients were included gathering 56 patients who underwent re-ablation due to AFL recurrences and 110 patients who underwent re-ablation due to AF recurrences (P = 0.11). A multiparametric assessment of atrial cardiomyopathy was based on basal LGE-CMR, including left atrial (LA) volume, LA sphericity, and global and segmental LA fibrosis using semiautomated post-processing software. Out of the initial cohort of 1007 patients, AFL and AF occurred in 56 and 110 patients, respectively. An age higher than 65 [odds ratio (OR) = 5.6, 95% confidence interval (CI): 2.2-14.4], the number of previous ablations (OR = 3.0, 95% CI: 1.2-7.8), and the management of ablation lines in the index procedure (OR = 2.5, 95% CI: 1.0-6.3) were independently associated with AFL occurrence. Furthermore, several characteristics assessed by LGE-CMR were identified as independent predictors of AFL recurrence after the index ablation for AF, such as enhanced LA sphericity (OR = 1.3, 95% CI: 1.1-1.6), LA global fibrosis (OR = 1.03, 95% CI: 1.01-1.07), and increased fibrosis in the lateral wall (OR = 1.03, 95% CI: 1.01-1.04).Conclusion Advanced atrial cardiomyopathy assessed by LGE-CMR, such as increased LA sphericity, global LA fibrosis, and fibrosis in the lateral wall, is independently associated with arrhythmia recurrence in the form of AFL following AF ablation. Graphical Abstract Advanced atrial cardiomyopathy assessed by LGE-CMR as a predictor of atypical atrial flutter occurrence following atrial fibrillation ablation. Two aspects of atrial cardiomyopathy, specifically increased LA sphericity and LA global fibrosis, are independent predictors of atypical atrial flutter onset compared to atrial fibrillation recurrence following catheter ablation. aOR, adjusted odds ratio; CI, confidence interval; LA, left atrium; LGE-CMR, late gadolinium enhancement cardiac magnetic resonance.
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