期刊
CHEMICAL COMMUNICATIONS
卷 51, 期 28, 页码 6226-6229出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc00677e
关键词
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资金
- National Institute of Health [AI080671]
- Fulbright Commission
- Scripps Research Institute [29038]
Dyngo-4a (TM) has been found to be an endocytic inhibitor of BoNT/A neurotoxicity through dynamin inhibition. Herein, we demonstrate this molecule to have a previously unrecognized dual activity against BoNT/A, dynamin-protease inhibition. To establish the importance of this dual activity, detailed kinetic analysis of Dyngo-4a's inhibition of BoNT/A metalloprotease as well as cellular and animal toxicity studies have been described. The research presented is the first polypharmacological approach to counteract BoNT/A intoxication.
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