期刊
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
卷 102, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.etap.2023.104252
关键词
Androgen; Estrogen; Glyphosate; Herbicide; Reproductive disorders; Sex hormones
Glyphosate-based herbicides, containing glyphosate as the active component, may pose potential risks to human health by affecting the endocrine system and reproductive system, leading to changes in sex hormone levels and pathological changes. Prenatal exposure may have transgenerational effects on offspring.
Glyphosate-based herbicides (GBHs) containing glyphosate as the active component are extensively used worldwide. Concerns have arisen about their potential risk to human, as glyphosate has been detected in human body fluids. Current controversies surround the endocrine-disrupting properties and transgenerational inheritance of diseases and germline epimutations resulting from exposure to GBHs and glyphosate. This review discusses evidence from in vitro, in vivo, and clinical studies on their impact on sex hormone regulation and reproductive system. Evidence suggests that they act as endocrine-disrupting chemicals, which altering sex hormone levels. Mechanistically, they interfere with hormone signaling pathways by disrupting proteins involved in hormone transport and metabolism. Pathological changes have been observed in male and female reproductive systems, potentially leading to reproductive toxicity. Prenatal exposure may lead to transgenerational inheritance of pathologies and sperm epimutations. However, due to the complexity of glyphosate formulations containing adjuvants identifying higher risk components in environmental exposure becomes challenging.
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