期刊
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
卷 102, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.etap.2023.104233
关键词
Phthalates; Polycystic ovary; Polycystic ovary syndrome; Phthalate metabolite mixture
Phthalate exposures are associated with increased prevalence of polycystic ovary (PCO) and polycystic ovary syndrome (PCOS).
Phthalates are widespread endocrine disrupting chemicals that adversely affect female reproductive health. We aimed to investigate the individual and joint associations of phthalate exposures measured by repeated urinary metabolites with polycystic ovary (PCO) and polycystic ovary syndrome (PCOS) (96 PCO cases, 96 PCOS cases and 370 controls). In single-pollutant analyses, mono-isobutyl phthalate (MiBP), monobenzyl phthalate (MBzP) and the sum of di(2-ethylhexyl) phthalate ( n-ary sumation DEHP) were associated with increased prevalence of PCO. Mono(2-ethylhexyl) phthalate (MEHP), MBzP and n-ary sumation DEHP were associated with elevated prevalence of PCOS. In multiple-pollutant analyses, one-quartile increase of weighted quantile sum index in phthalate metabolite mixtures was associated with increased prevalence of PCO and PCOS, and MBzP was the most major contributor. Our findings suggest a potential role for phthalate exposures, both individually and in mixtures, in the devel-opment of PCO and PCOS.
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