4.5 Article

Photolysis Products of Fluorinated Pharmaceuticals: A Combined Fluorine Nuclear Magnetic Resonance Spectroscopy and Mass Spectrometry Approach

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Analytical

Fluorous Liquids for Magnetic Resonance-Based Thermometry with Enhanced Responsiveness and Environmental Degradation

Jiaqian Li et al.

Summary: Accurate temperature measurement is crucial for evaluating disease pathology and medical interventions. Traditional methods have limitations, and the use of fluorocarbon liquids as temperature sensors shows promise but also raises concerns. This research presents a new organofluorine liquid, DD-1, with improved responsiveness and degradation characteristics, making it a leading candidate for thermometry applications.

ANALYTICAL CHEMISTRY (2023)

Article Engineering, Environmental

Identifying Unknown Fluorine-Containing Compounds in Environmental Samples Using 19F NMR and Spectral Database Matching

Scott Andrew R. Mabury et al.

Summary: The ubiquity of PFAS in the environment is a concern. Current analytical methods may not account for all fluorinated compounds. F-19 NMR can help identify these compounds without limitations of other methods. This study presents the current state of F-19 NMR for PFAS analysis and provides a database for other researchers.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2023)

Article Engineering, Environmental

Wavelength-Dependent UV-LED Photolysis of Fluorinated Pesticides and Pharmaceuticals

Akash P. Bhat et al.

Summary: The wavelength dependence of photoproduct formation and quantum yields was evaluated for fluorinated pesticides and pharmaceuticals using UV-LEDs. Quantum yields were higher for UV-C wavelengths, and did not correlate with molar absorptivity. Different major products were observed at different wavelengths, and aliphatic-CF2/CF3 products were stable under all wavelengths. The results provide guidance for selecting efficient UV-LED wavelengths and designing fluorinated compounds.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2023)

Article Chemistry, Analytical

Noise-Reduced Quantitative Fluorine NMR Spectroscopy Reveals the Presence of Additional Per- and Polyfluorinated Alkyl Substances in Environmental and Biological Samples When Compared with Routine Mass Spectrometry Methods

Jeremy R. Gauthier et al.

Summary: Per- and polyfluorinated alkyl substances (PFAS) are commonly found in the environment. Analysis of PFAS using mass spectrometry often underestimates the total fluorine concentration. This study utilized F-19 NMR technique to accurately detect and quantify PFAS compounds in environmental and biological samples, revealing the presence of PFAS that were missed by routine mass spectrometric methods.

ANALYTICAL CHEMISTRY (2022)

Article Engineering, Environmental

Finding Fluorine: Photoproduct Formation during the Photolysis of Fluorinated Pesticides

Akash P. Bhat et al.

Summary: This study evaluated the formation of fluorinated products in the photolysis of pesticides with different fluorine motifs. The results showed that the formation of fluoride varied among different pesticides and under different treatment processes. The structure of fluorine motifs also influenced the generation of products.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2022)

Article Engineering, Environmental

Tracking Fluorine during Aqueous Photolysis and Advanced UV Treatment of Fluorinated Phenols and Pharmaceuticals Using a Combined 19F-NMR, Chromatography, and Mass Spectrometry Approach

Akash P. Bhat et al.

Summary: Fluorine incorporation into organic molecules has increased due to desirable changes in the molecular physiochemical properties. Photolysis of fluorinated compounds can lead to the formation of new fluorinated byproducts. Monitoring of product formation during photolysis of various fluorinated motifs is important due to the potential persistence and toxicity of these byproducts. 19F-NMR is a useful method to detect and quantify fluorine-containing species.

ACS ENVIRONMENTAL AU (2022)

Article Environmental Sciences

Phototransformation study of the antidepressant paroxetine in surface waters

Tjasa Gornik et al.

Summary: This study investigated the photochemistry of the antidepressant paroxetine (PXT) in surface waters, revealing that PXT reacts with HO center dot radicals approaching a diffusion-controlled kinetics, while direct photolysis, together with reactions with HO center dot and CO3 center dot- radicals, are the main photodegradation pathways for PXT. Additionally, it was found that reaction with CO3 center dot- is particularly important for low amounts of dissolved organic matter (DOM), high pH, and high inorganic carbon, characteristics typical of surface waters in Slovenia.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

Review Chemistry, Analytical

Insufficient evidence for the existence of natural trifluoroacetic acid

Shira Joudan et al.

Summary: Research findings suggest that the presence of TFA in the deep ocean and the incomplete global budget are not enough evidence to prove the natural occurrence of TFA, and the concept of natural TFA should be abandoned.

ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS (2021)

Review Engineering, Environmental

Destruction of Per- and Polyfluoroalkyl Substances (PFAS) with Advanced Reduction Processes (ARPs): A Critical Review

Junkui Cui et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2020)

Article Infectious Diseases

Voriconazole topical cream formulation: evidence for stability and antifungal activity

Camille Bouchand et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2020)

Review Chemistry, Analytical

The high persistence of PFAS is sufficient for their management as a chemical class

Ian T. Cousins et al.

ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS (2020)

Article Chemistry, Medicinal

Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design

Nicholas A. Meanwell

JOURNAL OF MEDICINAL CHEMISTRY (2018)

Article Engineering, Environmental

p-Nitroanisole/Pyridine and p-Nitroacetophenone/Pyridine Actinometers Revisited: Quantum Yield in Comparison to Ferrioxalate

Juliana R. Laszakovits et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS (2017)

Article Engineering, Environmental

A Never-Ending Story of Per- and Polyfluoroalkyl Substances (PFASs)?

Zhanyun Wang et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2017)

Article Chemistry, Physical

Application of 19F quantitative NMR to pharmaceutical analysis

Allison O. Mattes et al.

CONCEPTS IN MAGNETIC RESONANCE PART A (2016)

Article Chemistry, Multidisciplinary

Catalytic activation of a single C-F bond in trifluoromethyl arenes

Hester Dang et al.

CHEMICAL SCIENCE (2016)

Article Engineering, Environmental

Aquatic photolysis of florfenicol and thiamphenicol under direct UV irradiation, UV/H2O2 and UV/Fe(II) processes

Ning Liu et al.

CHEMICAL ENGINEERING JOURNAL (2015)

Review Chemistry, Multidisciplinary

Natural and engineered biosynthesis of fluorinated natural products

Mark C. Walker et al.

CHEMICAL SOCIETY REVIEWS (2014)

Article Chemistry, Medicinal

Targeted Fluorination of a Nonsteroidal Anti-inflammatory Drug to Prolong Metabolic Half-Life

Maxwell J. Shaughnessy et al.

CHEMMEDCHEM (2014)

Article Engineering, Environmental

Advanced Reduction Processes: A New Class of Treatment Processes

Bhanu Prakash Vellanki et al.

ENVIRONMENTAL ENGINEERING SCIENCE (2013)

Article Engineering, Environmental

Direct photochemistry of three fluoroquinolone antibacterials: Norfloxacin, ofloxacin, and enrofloxacin

Kristine H. Wammer et al.

WATER RESEARCH (2013)

Article Engineering, Environmental

Influence of pH on the Formation of Sulfate and Hydroxyl Radicals in the UV/Peroxymonosulfate System

Ying-Hong Guan et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2011)

Review Multidisciplinary Sciences

Fluorine in pharmaceuticals:: Looking beyond intuition

Klaus Mueller et al.

SCIENCE (2007)

Review Environmental Sciences

Photodegradation of pharmaceuticals in the aquatic environment: A review

AL Boreen et al.

AQUATIC SCIENCES (2003)

Review Pharmacology & Pharmacy

Metabolism of fluorine-containing drugs

BK Park et al.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY (2001)

Article Engineering, Environmental

Biodegradability of trifluoroacetic acid

BR Kim et al.

ENVIRONMENTAL ENGINEERING SCIENCE (2000)