4.7 Article

The neddylation inhibitor MLN4924 inhibits proliferation and triggers apoptosis of oral cancer cells but not for normal cells

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Ginger-Derived 3HDT Exerts Antiproliferative Effects on Breast Cancer Cells by Apoptosis and DNA Damage

Chung-Yi Chen et al.

Summary: This study found that 3HDT has an antiproliferative effect on triple-negative breast cancer cells, while having less impact on normal cells. Through various tests, it was found that 3HDT mainly acts on TNBC cells through oxidative stress and causes DNA damage. Therefore, 3HDT is an effective drug with selective antiproliferative and therapeutic effects on TNBC cells.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Article Oncology

High concentration of γ-H2AX correlates with a marker of apoptotic suppression and PI3K/Akt pathway upregulation in glioblastoma multiforme

Christine Tiarma Ully Banjarnahor et al.

Summary: This study investigated the concentrations of gamma-H2AX and cleaved caspase-3 in patients with GBM, as well as their correlations with PI3K and Akt. The results showed a moderate positive correlation between gamma-H2AX and PI3K, a moderate positive correlation between gamma-H2AX and Akt, and a strong negative correlation between gamma-H2AX and cleaved caspase-3. Therefore, gamma-H2AX may affect GBM cell apoptosis via the PI3K/Akt pathway.

ONCOLOGY LETTERS (2023)

Review Biochemistry & Molecular Biology

The interplay of autophagy and oxidative stress in the pathogenesis and therapy of retinal degenerative diseases

Kun-Che Chang et al.

Summary: Oxidative stress caused by intracellular reactive oxygen species (ROS) production is closely associated with the pathogenesis of ocular diseases. Autophagy, a self-clearance pathway, plays an antioxidant role by regulating cellular ROS levels. However, excessive autophagy may lead to cell death. This review summarizes the mechanisms of interaction between ROS and autophagy and their roles in several ocular diseases.

CELL AND BIOSCIENCE (2022)

Article Medicine, Research & Experimental

Telomerase inhibition on acute myeloid leukemia stem cell induced apoptosis with both intrinsic and extrinsic pathways

Ali Rafat et al.

Summary: The study revealed that Telomerase Inhibition (TI) induced apoptosis through intrinsic, extrinsic, and p53 pathways and increased the expression of DNMT3a and TET2 epigenetic markers.

LIFE SCIENCES (2022)

Article Multidisciplinary Sciences

Neddylation inhibition induces glutamine uptake and metabolism by targeting CRL3SPOP E3 ligase in cancer cells

Qiyin Zhou et al.

Summary: This study reveals that neddylation inhibition increases glutamine metabolism by stabilizing glutamine transporter ASCT2, suggesting that targeting ASCT2 improves the anti-cancer effect of neddylation inhibitors.

NATURE COMMUNICATIONS (2022)

Article Biochemistry & Molecular Biology

Brown Algae-Derived Fucoidan Exerts Oxidative Stress-Dependent Antiproliferation on Oral Cancer Cells

Jun-Ping Shiau et al.

Summary: This study provides a detailed understanding of the preferential antiproliferation effects and mechanisms of fucoidan in oral cancer cells. Fucoidan showed higher antiproliferation in oral cancer cells compared to non-malignant oral cells. The antiproliferative effects of fucoidan in oral cancer cells were attributed to oxidative stress and DNA damage induction.

ANTIOXIDANTS (2022)

Article Biology

The Antileukemic and Anti-Prostatic Effect of Aeroplysinin-1 Is Mediated through ROS-Induced Apoptosis via NOX Activation and Inhibition of HIF-1a Activity

Shou-Ping Shih et al.

Summary: Aeroplysinin-1 exhibits cytotoxicity against leukemia and prostate cancer cells through multiple pathways.

LIFE-BASEL (2022)

Article Biochemistry & Molecular Biology

Strontium Peroxide-Loaded Composite Scaffolds Capable of Generating Oxygen and Modulating Behaviors of Osteoblasts and Osteoclasts

Sheng-Ju Lin et al.

Summary: A strontium peroxide (SrO2)-loaded composite scaffold has been developed as a multifunctional bioactive bone graft for bone tissue engineering. The scaffold can release strontium ions in a sustained manner, stimulating the proliferation of osteoblasts and suppressing the formation of osteoclasts. It can also generate hydrogen peroxide and oxygen molecules, increasing local oxygen tension for osteogenesis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Hematology

Pevonedistat plus azacitidine vs azacitidine alone in higher-risk MDS/chronic myelomonocytic leukemia or low-blast-percentage AML

Lionel Ades et al.

Summary: The study compared the efficacy of pevonedistat+azacitidine to azacitidine monotherapy in patients with newly diagnosed higher-risk myelodysplastic syndromes and found that in certain patient populations, the new treatment may yield better clinical outcomes, while continued therapy could potentially improve survival.

BLOOD ADVANCES (2022)

Article Biochemistry & Molecular Biology

Antioral Cancer Effects by the Nitrated [6,6,6]Tricycles Compound (SK1) In Vitro

Yan-Ning Chen et al.

Summary: SK1 exhibits stronger antiproliferation effects, primarily through oxidative stress, in oral cancer cells compared to normal cells. The oxidative stress-associated responses, including ROS burst, MMP, GSH depletion, apoptosis, and DNA damage, are more significant in oral cancer cells than in normal cells.

ANTIOXIDANTS (2022)

Review Biotechnology & Applied Microbiology

Potential application of γ-H2AX as a biodosimetry tool for radiation triage

Venkateswarlu Raavi et al.

Summary: This review focuses on the recent developments of the γ-H2AX assay in radiation triage and biodosimetry, highlighting its importance in identifying exposed individuals in radiological emergencies and analyzing large samples efficiently.

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH (2021)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Medicine, Research & Experimental

Asia-inclusive global development of pevonedistat: Clinical pharmacology and translational research enabling a phase 3 multiregional clinical trial

Xiaofei Zhou et al.

Summary: The study evaluated the similarities in epidemiology, treatment, molecular alterations, and drug metabolism between Western and East Asian populations to support the design of an Asia-inclusive Phase 3 trial. These findings suggested that a sample size of around 30 East Asian patients out of approximately 450 randomized patients would be needed to demonstrate consistency in efficacy relative to the global population, highlighting the importance of considering regional differences in clinical trial design.

CTS-CLINICAL AND TRANSLATIONAL SCIENCE (2021)

Review Cell Biology

Advances in Cancer Treatment by Targeting the Neddylation Pathway

Wenbin Gai et al.

Summary: NEDD8 is a key protein involved in the progression of tumors, with its inhibitor MLN4924 showing promise in treating cancer. Inhibiting the neddylation pathway can effectively halt the development of tumors.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Biochemistry & Molecular Biology

Cell-Penetrating Delivery of Nitric Oxide by Biocompatible Dinitrosyl Iron Complex and Its Dermato-Physiological Implications

Yu-Chieh Chen et al.

Summary: The study investigated the cellular uptake, intracellular release, and regulatory effects of a compound DNIC-2 on epidermal cells. The results showed that DNIC-2 can be taken up by human fibroblast cells, transformed into protein-bound forms, and release NO intracellularly, leading to enhanced cellular proliferation, accelerated wound healing, and increased collagen deposition. The biocompatible DNIC-2 holds potential to be a novel active ingredient for skincare products based on in vitro and in vivo biocompatibility evaluation.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Medicine, Research & Experimental

MLN4924 inhibits cell proliferation by targeting the activated neddylation pathway in endometrial carcinoma

Huanrong Liu et al.

Summary: The neddylation pathway, highly activated in endometrial cancer, is identified as an important player in the disease. The specific inhibitor MLN4924 shows potential as a therapeutic drug for endometrial carcinoma by suppressing cell proliferation through various mechanisms.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH (2021)

Review Nanoscience & Nanotechnology

8-Hydroxy-2′-deoxyguanosine (8-OHdG) as a biomarker of oxidative DNA damage induced by occupational exposure to nanomaterials: a systematic review

Soqrat Omari Shekaftik et al.

Summary: This study reviewed research on oxidative DNA damage caused by occupational exposure to nanomaterials using the biomarker 8-OHdG. It found a significant relationship between job title, amount of produced nanomaterials, and the presence of 8-OHdG. Levels of 8-OHdG can be measured in urine, blood, and inhalation samples, and may serve as an important biomarker for assessing oxidative damage in workers exposed to nanomaterials.

NANOTOXICOLOGY (2021)

Article Biochemistry & Molecular Biology

Dehydroxyhispolon Methyl Ether, A Hispolon Derivative, Inhibits WNT/β-Catenin Signaling to Elicit Human Colorectal Carcinoma Cell Apoptosis

Hueng-Chuen Fan et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Biochemistry & Molecular Biology

Disruption of protein neddylation with MLN4924 attenuates paclitaxel-induced apoptosis and microtubule polymerization in ovarian cancer cells

Xiaoling Hong et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

Review Dentistry, Oral Surgery & Medicine

Oral cancer databases: A comprehensive review

Gargi S. Sarode et al.

JOURNAL OF ORAL PATHOLOGY & MEDICINE (2018)

Article Chemistry, Medicinal

Isoaaptamine Induces T-47D Cells Apoptosis and Autophagy via Oxidative Stress

Chih-Fung Wu et al.

MARINE DRUGS (2018)

Article Biochemistry & Molecular Biology

Sinularin Selectively Kills Breast Cancer Cells Showing G2/M Arrest, Apoptosis, and Oxidative DNA Damage

Hurng-Wern Huang et al.

MOLECULES (2018)

Review Cell Biology

ROS signalling in the biology of cancer

Jennifer N. Moloney et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2018)

Article Oncology

Dual Effects of Resveratrol on Cell Death and Proliferation of Colon Cancer Cells

Alvaro San Hipolito-Luengo et al.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2017)

Article Physiology

Withaferin A Induces Oxidative Stress-Mediated Apoptosis and DNA Damagein Oral Cancer Cells

Hsueh-Wei Chang et al.

FRONTIERS IN PHYSIOLOGY (2017)

Article Multidisciplinary Sciences

Neddylation inhibitor MLN4924 suppresses growth and migration of human gastric cancer cells

Huiyin Lan et al.

SCIENTIFIC REPORTS (2016)

Article Cell Biology

The novel protective role of P27 in MLN4924-treated gastric cancer cells

Q. Zhang et al.

CELL DEATH & DISEASE (2015)

Article Oncology

Overactivated Neddylation Pathway as a Therapeutic Target in Lung Cancer

Lihui Li et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2014)

Review Oncology

Targeting neddylation in cancer therapy

Kristal Duncan et al.

FUTURE ONCOLOGY (2012)

Review Oncology

NEDD8 Pathways in Cancer, Sine Quibus Non

Ian R. Watson et al.

CANCER CELL (2011)

Article Biochemistry & Molecular Biology

Superoxide Flashes EARLY MITOCHONDRIAL SIGNALS FOR OXIDATIVE STRESS-INDUCED APOPTOSIS

Qi Ma et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Oncology

Targeting NEDD8-Activated Cullin-RING Ligases for the Treatment of Cancer

Teresa A. Soucy et al.

CLINICAL CANCER RESEARCH (2009)

Article Multidisciplinary Sciences

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

Teresa A. Soucy et al.

NATURE (2009)

Review Biotechnology & Applied Microbiology

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

Dunyaporn Trachootham et al.

NATURE REVIEWS DRUG DISCOVERY (2009)

Article Cell Biology

Control of cell proliferation via elevated NEDD8 conjugation in oral squamous cell carcinoma

Kongthawat Chairatvit et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2007)

Review Biochemistry & Molecular Biology

The role of iron in cell cycle progression and the proliferation of neoplastic cells

NTV Le et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2002)