CircCRIM1/microRNA-141-3p/thioredoxin-binding protein axis mediates neuronal apoptosis after cerebral ischemia-reperfusion

Article Immunology

CircCRIM1 mediates proliferation, migration, and invasion of trophoblast cell through regulating miR-942-5p/IL1RAP axis

Fen Yu et al.

Summary: The study found that circCRIM1 inhibited the proliferation, migration, and invasion of trophoblast cells by sponging miR-942-5p and up-regulating IL1RAP, providing a possible new mechanism for preeclampsia.

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2023)

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Article Oncology

Circular RNA hsa_circ_0002938 (circCRIM1) promotes the progression of esophageal squamous cell carcinoma by upregulating transcription factor 12

Xiao-Peng Li et al.

Summary: This study identifies a novel onco-circRNA, circCRIM1, which is highly expressed in ESCC tissues and positively correlated with clinical parameters. Functional experiments show that circCRIM1 promotes the progression of ESCC by sponging miR-342-3p to regulate TCF12 and promote EMT.

NEOPLASMA (2023)

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Article Biochemistry & Molecular Biology

Silencing of circCDC14A prevents cerebral ischemia-reperfusion injury via miR-23a-3p/CXCL12 axis

Huiyi Huo et al.

Summary: circCDC14A plays an important role in ischemic stroke by regulating the miR-23a-3p/CXCL12 axis, making it a potential therapeutic target for CI/R injury.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2022)

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Article Neurosciences

Circular RNA AXL increases neuron injury and inflammation through targeting microRNA-328 mediated BACE1 in Alzheimer's disease

Yuanlong Li et al.

Summary: This study explores the role of circ-AXL in regulating neuron injury and inflammation in cellular AD models. It shows that circ-AXL overexpression increases apoptosis and inflammation, while circ-AXL knockdown has opposite effects. Additionally, circ-AXL negatively regulates miR-328 and positively modulates BACE1, and miR-328 negatively regulates BACE1. The findings suggest that circ-AXL may serve as a potential treatment target via miR-328-mediated BACE1 in AD.

NEUROSCIENCE LETTERS (2022)

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Article Cell Biology

circ-Pank1 promotes dopaminergic neuron neurodegeneration through modulating miR-7a-5p/α-syn pathway in Parkinson's disease

Qing Liu et al.

Summary: This study investigates the regulatory role of circular RNA circ-Pank1 in Parkinson's disease. The findings reveal that circ-Pank1 is highly expressed in Parkinson's disease models and enhances locomotor dysfunction through the miR-7a-5p/alpha-syn signaling axis.

CELL DEATH & DISEASE (2022)

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Article Biotechnology & Applied Microbiology

CircRNA CTNNB1 (circCTNNB1) ameliorates cerebral ischemia/reperfusion injury by sponging miR-96-5p to up-regulate scavenger receptor class B type 1 (SRB1) expression

Chun Chen et al.

Summary: Emerging studies have shown that circRNA catenin beta 1 (circCTNNB1) plays a critical role in cancer. However, its expression and function in cerebral ischemia/reperfusion injury (IRI) have not been studied. This study found that circCTNNB1 can alleviate cell apoptosis, oxidative stress, and the inflammatory response induced by cerebral IRI. It interacts with SRB1 and miR-96-5p, indicating that circCTNNB1 and SRB1 may serve as biomarkers and therapeutic targets for cerebral IRI.

BIOENGINEERED (2022)

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Article Cell Biology

CircCRIM1 Ameliorates Endothelial Cell Angiogenesis in Aging through the miR-455-3p/Twist1/VEGFR2 Signaling Axis

Lei Zhao et al.

Summary: This study identified that circCRIM1 expression was downregulated in aging, impairing angiogenesis through the miR-455-3p/Twist1/VEGFR2 axis. The findings suggest that overexpression of circCRIM1 may be an effective therapeutic strategy for promoting ischemic lower limb blood flow recovery.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

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Article Medicine, Research & Experimental

CircCRIM1 promotes nasopharyngeal carcinoma progression via the miR-34c-5p/FOSL1 axis

Weifeng He et al.

Summary: This study found that circCRIM1 is upregulated in NPC cells and silencing circCRIM1 can significantly inhibit the malignant behavior of NPC cells. miR-34c-5p was found to have a binding relationship with circCRIM1, and FOSL1 was identified as a downstream target of miR-34c-5p.

EUROPEAN JOURNAL OF MEDICAL RESEARCH (2022)

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Article Medicine, Research & Experimental

Downregulation of circular RNA HECTD1 induces neuroprotection against ischemic stroke through the microRNA-133b/TRAF3 pathway

Quande Dai et al.

Summary: In this study, it was found that circRNA HECTD1 plays a crucial role in cerebral ischemia/reperfusion injury by regulating the expression of miR-133b and TRAF3, affecting neuronal cell death and brain infarction volume.

LIFE SCIENCES (2021)

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Article Physiology

MiRNA-190 exerts neuroprotective effects against ischemic stroke through Rho/Rho-kinase pathway

Chuan Jiang et al.

Summary: miR-190 plays a protective role against brain I/R damage by modulating Rho/Rho-kinase signaling.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2021)

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Article Endocrinology & Metabolism

CircCRIM1 promotes ovarian cancer progression by working as ceRNAs of CRIM1 and targeting miR-383-5p/ZEB2 axis

Yuping Du et al.

Summary: Ovarian cancer is the leading cause of death in patients with gynecologic cancer, and circular RNAs (circRNAs) play important roles in cancer progression. CircCRIM1, derived from CRIM1, is highly expressed in ovarian cancer and promotes cancer progression by binding with miR-145-5p as a competing endogenous RNA (ceRNA) of CRIM1, and also by binding with miR-383-5p to regulate ZEB2 expression in ovarian cancer.

REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY (2021)

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Article Cell & Tissue Engineering

Circular RNA TTC3 regulates cerebral ischemia-reperfusion injury and neural stem cells by miR-372-3p/TLR4 axis in cerebral infarction

Bo Yang et al.

Summary: The study revealed that circTTC3 plays a role in regulating CIR injury and NSCs, with its depletion shown to reduce cerebral infarction and promote NSC proliferation. CircTTC3 was found to sponge miR-372-3p and regulate TLR4 expression, suggesting potential targets for stroke treatment.

STEM CELL RESEARCH & THERAPY (2021)

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Review Medicine, Research & Experimental

Anti-cerebral ischemia reperfusion injury of polysaccharides: A review of the mechanisms

Qianghua Yuan et al.

Summary: Cerebral ischemia-reperfusion injury can lead to serious brain diseases and polysaccharides may be a potential treatment. Research shows that polysaccharides can improve neural damage through various mechanisms such as anti-oxidation and anti-inflammation.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Review Oncology

ChrXq27.3 miRNA cluster functions in cancer development

Kosuke Yoshida et al.

Summary: The chrXq27.3 miRNA cluster is crucial in cancer progression, with miRNAs like miR-506-3p showing tumor-suppressive functions that could serve as prognostic factors in various cancers.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Article Cell Biology

Protective effect of dimethyl itaconate against fibroblast-myofibroblast differentiation during pulmonary fibrosis by inhibiting TXNIP

Yong-Yue Han et al.

Summary: The study suggests that activation of Nrf2 can inhibit TXNIP-mediated FMD, thereby protecting against PF. In both mouse models and in vitro experiments, Nrf2 reduced FMD and the increase of ROS by decreasing TXNIP expression.

JOURNAL OF CELLULAR PHYSIOLOGY (2021)

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Article Biochemistry & Molecular Biology

The circular RNA circCRIM1 inhibits osteosarcoma progression through sponging miR-513

Pengfei Wu et al.

Summary: The study showed that circCRIM1 expression was downregulated in osteosarcoma tissues and cell lines, correlated with lymph node metastasis, advanced disease stage, and low survival rates. Mechanistically, circCRIM1 functions as a ceRNA of miR-513 to inhibit proliferation, migration, and invasion of OS cells, suggesting its potential as a therapeutic target in OS treatment.

MAMMALIAN GENOME (2021)

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Article Immunology

A20 Establishes Negative Feedback With TRAF6/NF-κB and Attenuates Early Brain Injury After Experimenta Subarachnoid Hemorrhage

Hong-Ji Deng et al.

Summary: The study showed that A20 can attenuate early brain injury after SAH by suppressing the NF-kappa B pathway and reducing inflammatory responses, thereby exerting neuroprotective effects.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Biotechnology & Applied Microbiology

By targeting apoptosis facilitator BCL2L13, microRNA miR-484 alleviates cerebral ischemia/reperfusion injury-induced neuronal apoptosis in mice

Xindong Liu et al.

Summary: This study investigated the role of miR-484 in regulating neuronal apoptosis induced by cerebral ischemia/reperfusion injury in mice. Upregulation of miR-484 was found to increase neuronal viability and inhibit apoptosis by targeting BCL2L13. These findings suggest that miR-484 alleviates cerebral ischemia/reperfusion injury-induced neuronal apoptosis by targeting the apoptosis facilitator BCL2L13.

BIOENGINEERED (2021)

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Review Biochemistry & Molecular Biology

The Potential Role of MicroRNA-124 in Cerebral Ischemia Injury

Xiaolu Liu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Biochemistry & Molecular Biology

Circular RNA CRIM1 functions as a ceRNA to promote nasopharyngeal carcinoma metastasis and docetaxel chemoresistance through upregulating FOXQ1

Xiaohong Hong et al.

MOLECULAR CANCER (2020)

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Article Pharmacology & Pharmacy

Isorhapontigenin alleviates cerebral ischemia/reperfusion injuries in rats and modulated the PI3K/Akt signaling pathway

Xin Sun et al.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2020)

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Article Biochemistry & Molecular Biology

Silencing of TXNIP Alleviated Oxidative Stress Injury by Regulating MAPK-Nrf2 Axis in Ischemic Stroke

Yu Tian et al.

NEUROCHEMICAL RESEARCH (2020)

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Article Medicine, Research & Experimental

Protection against acute cerebral ischemia/reperfusion injury by QiShenYiQi via neuroinflammatory network mobilization

Yule Wang et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Neurosciences

MicroRNA-193b-3p alleviates focal cerebral ischemia and reperfusion-induced injury in rats by inhibiting 5-lipoxygenase expression

Zhihao Chen et al.

EXPERIMENTAL NEUROLOGY (2020)

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Article Multidisciplinary Sciences

Circ-camk4 involved in cerebral ischemia/reperfusion induced neuronal injury

Zhao-huan Zhang et al.

SCIENTIFIC REPORTS (2020)

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Article Neurosciences

Downregulation of Microrna-421 Relieves Cerebral Ischemia/Reperfusion Injuries: Involvement of Anti-apoptotic and Antioxidant Activities

Yuehong Yue et al.

NEUROMOLECULAR MEDICINE (2020)

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Review Pharmacology & Pharmacy

Pathophysiology of Ischemic Stroke: Role of Oxidative Stress

Sofia Orellana-Urzua et al.

CURRENT PHARMACEUTICAL DESIGN (2020)

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Review Biotechnology & Applied Microbiology

Long Noncoding RNA/Circular RNA-miRNA-mRNA Axes in Ischemia-Reperfusion Injury

Chengwu Gong et al.

BIOMED RESEARCH INTERNATIONAL (2020)

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Article Medicine, Research & Experimental

Overexpression of circRNA circUCK2 Attenuates Cell Apoptosis in Cerebral Ischemia-Reperfusion Injury via miR-125b-5p/GDF11 Signaling

Wanghao Chen et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

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Article Biochemistry & Molecular Biology

The possible roles of necroptosis during cerebral ischemia and ischemia/reperfusion injury

Suchan Liao et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2020)

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Article Cell Biology

Circular RNA circCCDC9 alleviates ischaemic stroke ischaemia/reperfusion injury via the Notch pathway

Liquan Wu et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Article Neurosciences

Circular RNA TLK1 Aggravates Neuronal Injury and Neurological Deficits after Ischemic Stroke via miR-335-3p/TIPARP

Fangfang Wu et al.

JOURNAL OF NEUROSCIENCE (2019)

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Review Genetics & Heredity

The biogenesis, biology and characterization of circular RNAs

Lasse S. Kristensen et al.

NATURE REVIEWS GENETICS (2019)

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Article Medicine, Research & Experimental

Inhibition of microRNA-141-3p Reduces Hypoxia-Induced Apoptosis in H9c2 Rat Cardiomyocytes by Activating the RP105-Dependent PI3K/AKT Signaling Pathway

Qiaoji Qin et al.

MEDICAL SCIENCE MONITOR (2019)

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Review Cell Biology

An overview of microRNAs: Biology, functions, therapeutics, and analysis methods

Kioomars Saliminejad et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Article Biochemistry & Molecular Biology

Downregulation of circ_008018 protects against cerebral ischemia-reperfusion injury by targeting miR-99a

Xuelian Yang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

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Review Neurosciences

Thioredoxin-Interacting Protein (TXNIP) in Cerebrovascular and Neurodegenerative Diseases: Regulation and Implication

Sanaz Nasoohi et al.

MOLECULAR NEUROBIOLOGY (2018)

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Article Neurosciences

Role of PPAR-β/δ/miR-17/TXNIP pathway in neuronal apoptosis after neonatal hypoxic-ischemic injury in rats

Marcin Gamdzyk et al.

NEUROPHARMACOLOGY (2018)

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Review Clinical Neurology

Pathogenic mechanisms following ischemic stroke

Seyed Esmaeil Khoshnam et al.

NEUROLOGICAL SCIENCES (2017)

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Article Clinical Neurology

Circular RNA Expression Profiles Alter Significantly in Mouse Brain After Transient Focal Ischemia

Suresh L. Mehta et al.

STROKE (2017)

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Article Biochemistry & Molecular Biology

Circular RNA expression alterations are involved in OGD/R-induced neuron injury

Shao-Peng Lin et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

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Article Biochemistry & Molecular Biology

MicroRNA-25 Negatively Regulates Cerebral Ischemia/Reperfusion Injury-Induced Cell Apoptosis Through Fas/FasL Pathway

Jun-feng Zhang et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2016)

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Article Biochemistry & Molecular Biology

Ruscogenin Attenuates Cerebral Ischemia-Induced Blood-Brain Barrier Dysfunction by Suppressing TXNIP/NLRP3 Inflammasome Activation and the MAPK Pathway

Guosheng Cao et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

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Review Physiology

MICRORNAS IN DEVELOPMENT AND DISEASE

Danish Sayed et al.

PHYSIOLOGICAL REVIEWS (2011)

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Article Endocrinology & Metabolism

Early release of HMGB-1 from neurons after the onset of brain ischemia

Jianhua Qiu et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2008)

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CircCRIM1/microRNA-141-3p/thioredoxin-binding protein axis mediates neuronal apoptosis after cerebral ischemia-reperfusion

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