期刊
ENVIRONMENTAL SCIENCE & TECHNOLOGY
卷 -, 期 -, 页码 -出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.est.3c02388
关键词
chronic metal exposure; drinking water; gut microflora; intestinal inflammation; health risks
This study found that long-term exposure to arsenic, lead, and cadmium in drinking water, at concentrations equivalent to the China provisional guideline values, can lead to a decrease in weight gain in male mice. Additionally, this exposure can cause a reduction in protective bacteria (Akkermansia) and an increase in chronic intestinal inflammation in male mice.
Few studies have investigated the long-term effect of exposure to arsenic (As), lead (Pb), and cadmium (Cd) via drinking water at the provisional guideline values on gut microflora. In this study, male and female mice were exposed to water As, Pb, or Cd at 10, 10, or 5 mu g L-1 for 6 months. At the end of the exposure, the net weight gain of male mice exposed to As and Pb (9.91 +/- 1.35 and 11.2 +/- 1.50 g) was significantly (p < 0.05) lower compared to unexposed control mice (14.1 +/- 3.24 g), while this was not observed for female mice. Relative abundance of Akkermansia, a protective gut bacterium against intestinal inflammation, was reduced from 29.7% to 3.20%, 4.83%, and 17.0% after As, Pb, and Cd exposure in male mice, which likely caused chronic intestinal inflammation, as suggested by 2.81- to 9.60-fold higher mRNA levels of pro-inflammatory factors in ileal enterocytes of male mice. These results indicate that long-term exposure to drinking water As, Pb, and Cd at concentrations equivalent to the China provisional guideline values can cause loss of protective bacteria and lead to chronic intestinal inflammation, thereby affecting body weight gain in male mice.
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