期刊
CHEMICAL COMMUNICATIONS
卷 51, 期 58, 页码 11587-11590出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc04376j
关键词
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资金
- National Natural Science Foundation of China [21371145]
- City University of Hong Kong [9610303]
A nanohybrid is assembled by ratiometrically co-loading Pt(IV) prodrugs and photosensitizers into layered double hydroxide nanoparticles. The nanohybrid shows synergistic cell-killing effects and is significantly active against the proliferation of cisplatin-resistant human cancer cells with nanomolar IC50 values. Profound mechanistic investigations confirm its action mode of combined chemo-and photodynamic therapy.
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