☆ 4.7 Review

A comprehensive review on environmental pollutants and osteoporosis: Insights into molecular pathways

ENVIRONMENTAL RESEARCH (2023)

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Review Environmental Sciences

An overview of the occurrence, fate, and human risks of the bisphenol-A present in plastic materials, components, and products

John N. Hahladakis et al.

Summary: The investigation of human exposure to bisphenol-A (BPA) over the lifecycle of BPA-based plastic materials, components, and products is necessary. Current regulations and safety limits may underestimate the potential health implications of BPA exposure. Controversies regarding dose-response curves, sources and pathways of exposure, and the quality of toxicological studies hinder the regulation of BPA-based plastic materials. Further research and collaboration among stakeholders are needed to explore the long-term impacts of BPA and introduce restrictions to BPA-based products.

INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT (2023)

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Review Biochemistry & Molecular Biology

Lipid Peroxidation and Iron Metabolism: Two Corner Stones in the Homeostasis Control of Ferroptosis

Luc Rochette et al.

Summary: Regulated cell death (RCD), including ferroptosis, plays a significant role in development, tissue homeostasis, and disease occurrence. Ferroptosis is a type of regulated necrosis dependent on reactive oxygen species (ROS) and lipid peroxidation. Iron accumulation and lipid peroxidation are central events leading to ferroptosis, and organelles such as mitochondria and lysosomes are involved in regulating iron metabolism and redox imbalance. This review provides an overview of lipid peroxidation and key components involved in the ferroptotic cascade.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Article Agriculture, Multidisciplinary

Nano-Selenium Antagonized Cadmium-Induced Liver Fibrosis in Chicken

Xiao-Han Sun et al.

Summary: This study determined the mechanism of nano-Se antagonism in Cd-induced hepatocyte pyroptosis by targeting the APJAMPK-PGC1 alpha pathway. The results showed that Cd activated the NLRP3 inflammasome and caused hepatocyte pyroptosis. Furthermore, Cd also increased hepatic fibrosis. However, the co-treatment of nano-Se and Cd significantly reduced the degree of fibrosis.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2023)

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Article Biochemistry & Molecular Biology

Toxic effect of heavy metals on ovarian deformities, apoptotic changes, oxidative stress, and steroid hormones in rainbow trout

Rayees Ahmad Bhat et al.

Summary: This study aimed to assess the severity of pollution impact on rainbow trout ovaries in two different hatcheries. The results revealed that fish from Panzath hatchery exhibited various deformities and irregularly shaped oocytes, while fish from Verinag hatchery showed normal ovarian structure. Fish from Panzath hatchery also exhibited DNA damage, cellular apoptosis, and oxidative damage, while fish from Verinag hatchery did not. In conclusion, pollution has a direct impact on fish growth and reproduction in aquaculture practices.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2023)

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Article Water Resources

Hexavalent chromium contamination in groundwater and its implication to human health: a Monte Carlo model approach in Indonesia

Ratna Dwi Puji Astuti et al.

Summary: Through investigating 18 shallow groundwater samples near Pangkajene river, it was found that the concentration of hexavalent chromium (Cr(VI)) exceeded the public health goals for drinking water. However, there was no non-carcinogenic risk from groundwater exposure and the Pangkep community had a low tendency of developing cancer, with adults being more vulnerable than children.

SUSTAINABLE WATER RESOURCES MANAGEMENT (2023)

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Article Engineering, Environmental

PM2.5 Increases Systemic Inflammatory Cells and Associated Disease Risks by Inducing NRF2-Dependent Myeloid-Biased Hematopoiesis in Adult Male Mice

Yuanyuan Wang et al.

Summary: Pulmonary exposure to PM2.5 induces stress hematopoiesis dependent on NRF2 in the lungs and bone marrow, resulting in related health outcomes. The detailed alterations in systemic hematopoiesis and the underlying mechanisms under PM2.5 exposure are still unclear. NRF2 is essential for regulating hematopoiesis under steady-state or stress conditions, but upon PM2.5 exposure, it is involved in stress myelopoiesis and enhanced PM2.5 toxicity, leading to systemic inflammation.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2023)

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Article Oncology

Occupational exposure to nickel and hexavalent chromium and the risk of lung cancer in a pooled analysis of case-control studies (SYNERGY)

Thomas Behrens et al.

Summary: Limited evidence exists regarding the exposure-effect relationship between lung-cancer risk and hexavalent chromium (Cr(VI)) or nickel. This study found that occupational exposure to Cr(VI) and nickel was associated with lung-cancer risks, particularly in men. In men, the highest quartile of cumulative exposure to CR(VI) and nickel were both significantly associated with increased odds ratios for lung cancer.

INTERNATIONAL JOURNAL OF CANCER (2023)

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Article Endocrinology & Metabolism

A Critical Role of the Bone Marrow Envelope in Human Bone Remodeling

Thomas Levin Andersen et al.

Summary: Proper bone remodeling relies not only on the actions of osteoclasts and osteoblasts, but also on the delivery of osteoblast lineage cells to the remodeling site. A CD271-positive/PDGF beta-R-positive cell layer surrounding the bone marrow provides osteoblastogenic potential on all bone surfaces, including both quiescent and remodeling sites. This cell layer, known as the canopy, plays a critical role in initiating bone remodeling by activating early markers of osteoblastogenesis and supporting cell delivery to the bone surface.

JOURNAL OF BONE AND MINERAL RESEARCH (2023)

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Review Biochemistry & Molecular Biology

Neurotoxicity and the Global Worst Pollutants: Astroglial Involvement in Arsenic, Lead, and Mercury Intoxication

Gabriela de Paula Arrifano et al.

Summary: Environmental pollution is a global threat that poses a strong risk to human health. Certain pollutants have the ability to cross the blood-brain barrier and affect the central nervous system, potentially causing neurological disorders. Arsenic, lead, and mercury are commonly prioritized pollutants by regulatory agencies. Astrocytes, as the first line of defense in the central nervous system, play a crucial role in combating xenobiotics and maintaining brain functions. This review discusses the current understanding of astroglial involvement in neurotoxicity induced by these pollutants, focusing on their toxicokinetic characteristics and the impact on various astrocytic mechanisms.

NEUROCHEMICAL RESEARCH (2023)

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Article Environmental Sciences

Syringol, a wildfire residual methoxyphenol causes cytotoxicity and teratogenicity in zebrafish model

P. Snega Priya et al.

Summary: This study evaluates the cytotoxic and teratogenic effects of methoxy phenols (MPs) generated by wildfire lignin on human embryonic kidney (HEK-293) cells and zebrafish embryos. The results indicate that MPs, particularly syringol, have toxic effects on both cells and embryos, including cell death, developmental abnormalities, and increased oxidative stress response. Therefore, syringol has the potential to pose serious health hazards in various living systems.

SCIENCE OF THE TOTAL ENVIRONMENT (2023)

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Review Environmental Sciences

Epidemiological evidence for the effect of environmental heavy metal exposure on the immune system in children

Keyang Zheng et al.

Summary: Heavy metals pose a serious public health problem due to their wide presence in daily life and contamination of the environment. Children are more vulnerable to the adverse effects of heavy metal exposure on immune function compared to adults. This review summarizes epidemiological studies on the impact of heavy metal exposure on childhood immune function, focusing on the effects of six heavy metals on different components of the immune system. The review finds that heavy metal exposure, particularly to lead, cadmium, arsenic, and mercury, impairs immune responses in children and increases the risk of immune-related diseases.

SCIENCE OF THE TOTAL ENVIRONMENT (2023)

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Article Environmental Sciences

Comparative pharyngeal cartilage developmental toxicity of bisphenol A, bisphenol S and bisphenol AF to zebrafish (Danio rerio) larvae: A combination of morphometry and global transcriptome analyses

Wenlong Huang et al.

Summary: Exposure to BPA has been found to affect cartilage development in teleost fishes, but it is unclear whether its two analogues, BPS and BPAF, have similar effects. In this study, zebrafish were used as an in-vivo larval model to compare the developmental toxicity of BPA, BPS, and BPAF on pharyngeal arch-derived cartilage. It was found that BPA and BPAF lengthen and broaden cartilage angles, while BPS shortens and narrows them. The transcriptome analysis revealed different signaling pathways associated with the toxicity of each analogue. The study suggests that caution should be exercised when using BPS and BPAF, as they may not be safer than BPA in terms of their impact on fish cartilage development.

SCIENCE OF THE TOTAL ENVIRONMENT (2023)

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Article Environmental Sciences

Relationship of multiple metals mixture and osteoporosis in older Chinese women: An aging and longevity study

Xiuming Feng et al.

Summary: Osteoporosis is a major health problem in older women, and this study aimed to investigate the individual and combined association between multiple metal mixture and osteoporosis risk in older Chinese women. The results showed that metal mixture exposure was associated with osteoporosis risk in older Chinese women.

ENVIRONMENTAL POLLUTION (2023)

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Article Environmental Sciences

Complex polycyclic aromatic compound mixtures in PM2.5 in a Chinese megacity: Spatio-temporal variations, toxicity, and source apportionment

Yuan Zeng et al.

Summary: This study investigated the spatial-temporal variations of polycyclic aromatic compounds (PACs) in fine particulate matter (PM2.5) and their toxicity. The results found that high molecular weight polycyclic aromatic hydrocarbons (MW302 PAHs) played a significant role in reactive oxygen species (ROS) generation, and industrial sources were identified as important contributors to PM2.5 toxicity in the studied city.

ENVIRONMENT INTERNATIONAL (2023)

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Article Environmental Sciences

Contributions of non-tailpipe emissions to near-road PM2.5 and PM10: A chemical mass balance study

L. -W. Antony Chen et al.

Summary: As the importance of non-tailpipe particles (NTP) increases in urban traffic, it is necessary to evaluate their contributions to ambient particulate matter (PM) using representative source profiles. A Brake and Tire Wear Study conducted in Los Angeles examined PM samples and source contributions from brake and tire wear, exhaust emissions, and road dust. The study found that resuspended dust was dominant in both PM2.5 and PM10, and brake and tire wear contributed significantly to PM2.5 and PM10, especially on I-5.

ENVIRONMENTAL POLLUTION (2023)

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Article Environmental Sciences

Delineating the protective action of cordycepin against cadmium induced oxidative stress and gut inflammation through downregulation of NF-KB pathway

P. Snega Priya et al.

Summary: This study investigated the protective effects of cordycepin against gut inflammation induced by Cadmium (Cd) exposure. The results showed that cordycepin significantly reduced Cd-induced embryotoxicity and oxidative stress. It also normalized the levels of liver-related biomarkers affected by Cd exposure and downregulated the expression of inflammatory genes.

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2023)

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Review Biochemistry & Molecular Biology

Endocrine Disruptor-Induced Bone Damage Due to Hormone Dysregulation: A Review

Nneamaka Iwobi et al.

Summary: Hormones play a vital role in bone development, growth, and maintenance. Recent discoveries in endocrinology have advanced the fields of bone biology and toxicology by uncovering the effects of endocrine-disrupting chemicals (EDCs) on hormone pathways and bone morphological changes. Understanding how EDCs interfere with bone formation contributes to a comprehensive toxicological profile of chemicals.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Article

The menace and mitigation of air pollution in the built environment: A review

C.C. Nnaji et al.

Nigerian Journal of Technology (2023)

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Review Medicine, Research & Experimental

Oxidative stress: A common pathological state in a high-risk population for osteoporosis

Chi Zhang et al.

Summary: Osteoporosis is a major concern and high-risk populations need regular bone mineral density testing and appropriate preventive treatment. Oxidative stress, including the direct effect of reactive oxygen species and the reduction of antioxidant enzyme activity, plays a significant role in the development of osteoporosis. Understanding the impact of oxidative stress on osteoporosis can greatly optimize therapeutic schedules.

BIOMEDICINE & PHARMACOTHERAPY (2023)

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Review Environmental Sciences

Impacts and mechanisms of PM2.5 on bone

Yuqing Tian et al.

Summary: Osteoporosis is a metabolic bone disease characterized by decreased bone mass and deterioration of bone microstructure, leading to increased bone fragility and fracture risk. PM2.5, fine particles in the atmosphere, can carry toxic substances and negatively affect extrapulmonary organs, including bones. This review presents evidence linking PM2.5 exposure to abnormal bone turnover and osteoporosis, discussing mechanisms such as inflammatory response, oxidative damage, estrogen receptor competition, endocrine disruption, and impaired synthesis of vitamin D.

REVIEWS ON ENVIRONMENTAL HEALTH (2023)

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Article Public, Environmental & Occupational Health

Associations between exposure to cadmium, lead, mercury and mixtures and women's infertility and long-term amenorrhea

Maria Mcclam et al.

Summary: The study found that blood concentrations of lead and heavy metal mixtures were significantly higher in women who had experienced infertility compared to pregnant women, while cadmium and mercury concentrations were comparable. Multiple logistic regression analyses showed a significant and dose-dependent positive association between blood lead concentrations and women's historical infertility, a negative association between cadmium and women's long-term amenorrhea, and no associations between mercury and heavy metal mixture and women's infertility or long-term amenorrhea.

ARCHIVES OF PUBLIC HEALTH (2023)

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Article Biochemistry & Molecular Biology

Linarin Protects against Cadmium-Induced Osteoporosis Via Reducing Oxidative Stress and Inflammation and Altering RANK/RANKL/OPG Pathway

Yating Yang et al.

Summary: This study found that linarin can effectively prevent bone deformities in mice exposed to cadmium, and reduce oxidative stress and inflammation by modulating the RANK/RANKL/OPG pathway.

BIOLOGICAL TRACE ELEMENT RESEARCH (2022)

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Article Food Science & Technology

Bisphenol A induces pyroptotic cell death via ROS/NLRP3/Caspase-1 pathway in osteocytes MLO-Y4

Yun Zhang et al.

Summary: BPA induces pyroptotic death of osteocytes via the ROS/NLRP3/Caspase-1 pathway, increasing apoptosis and up-regulating protein expressions related to inflammation and cell damage. The oxidative stress and mitochondrial dysfunction caused by BPA are reversed by ROS scavengers and mitochondrial antioxidants, highlighting potential therapeutic targets for BPA-induced bone cell damage.

FOOD AND CHEMICAL TOXICOLOGY (2022)

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Article Environmental Sciences

Associations between Long-Term Air Pollution Exposure and Risk of Osteoporosis-Related Fracture in a Nationwide Cohort Study in South Korea

Seulkee Heo et al.

Summary: Long-term exposure to sulfur dioxide (SO2) is associated with an increased risk of osteoporotic fractures in Korean adults, while particulate matter (PM10), carbon monoxide (CO), nitrogen dioxide (NO2), and ozone (O-3) show no associations with osteoporotic fractures.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2022)

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Article Chemistry, Multidisciplinary

Diterbutyl phthalate attenuates osteoarthritis in ACLT mice via suppressing ERK/c-fos/NFATc1 pathway, and subsequently inhibiting subchondral osteoclast fusion

Chao Fang et al.

Summary: This study demonstrated that diterbutyl phthalate (DP) from Panax notoginseng inhibits abnormal osteoclastogenesis in subchondral bone, thereby preventing progression of osteoarthritis in a mouse model. DP treatment reduced articular cartilage degeneration and neurogenesis, leading to alleviation of OA pain.

ACTA PHARMACOLOGICA SINICA (2022)

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Article Environmental Sciences

Elevated levels of per- and polyfluoroalkyl substances (PFAS) in freshwater benthic macroinvertebrates from the Hudson River Watershed

Richard A. Brase et al.

Summary: This study investigated the PFAS contamination in two streams in the Hudson River Watershed using benthic macroinvertebrates (BMIs) as indicator organisms. The results showed that although PFAS concentrations in surface water and sediment were not excessively high, elevated levels were still measured in most BMI taxa. This suggests that the extent of PFAS contamination in a local system may be severely underestimated if only surface water and sediment are used for monitoring. Moreover, these findings have relevance for human exposure assessment considering BMIs are the primary food source of many fish.

CHEMOSPHERE (2022)

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Article Endocrinology & Metabolism

Association between exposure to fine particulate matter and osteoporosis: a population-based cohort study

G. Adami et al.

Summary: Long-term exposure to air pollution is associated with higher risk of osteoporosis, especially at the femoral neck site.

OSTEOPOROSIS INTERNATIONAL (2022)

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Review Engineering, Environmental

The potential osteoporosis due to exposure to particulate matter in ambient air: Mechanisms and preventive methods

Javad Torkashvand et al.

Summary: This review examines the relationship between particulate matter (PM) and osteoporosis. The results indicate a significant association between PM10 and osteoporosis, but the relationship with PM2.5 remains unclear. Additionally, particle matter indirectly contributes to osteoporosis through reduced UV-B exposure and vitamin D absorption. Furthermore, it can lead to other diseases by affecting bone health and increasing the risk of falling in the elderly.

JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION (2022)

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Review Genetics & Heredity

An Overlooked Bone Metabolic Disorder: Cigarette Smoking-Induced Osteoporosis

Weidong Weng et al.

Summary: Cigarette smoking leads to bone loss, and there are currently no effective interventions. This review summarizes the mechanisms by which smoking affects bone metabolism, providing new ideas and targets for preventing smoking-induced osteoporosis.

GENES (2022)

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Review Immunology

The Role Of BMPs in the Regulation of Osteoclasts Resorption and Bone Remodeling: From Experimental Models to Clinical Applications

Tatjana Bordukalo-Niksic et al.

Summary: Bone remodeling in the adult skeleton involves a continuous process of old and damaged bone removal by osteoclasts and subsequent new bone formation by osteoblasts. BMPs play a crucial role in maintaining healthy bone, affecting both bone formation and resorption, and may be involved in pathological processes related to inflammatory disorders affecting bones and joints.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Multidisciplinary Sciences

Impact of heavy metals on the environment and human health: Novel therapeutic insights to counter the toxicity

Saikat Mitra et al.

Summary: Heavy metals are toxic pollutants that can accumulate in the human body through bioaccumulation. Recent studies have explored treatment options for heavy metal removal, including nanotechnology-based methods, which offer advantages such as a broad linear range, low detection limits, and high sensitivity.

JOURNAL OF KING SAUD UNIVERSITY SCIENCE (2022)

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Article Meteorology & Atmospheric Sciences

The underappreciated role of anthropogenic sources in atmospheric soluble iron flux to the Southern Ocean

Mingxu Liu et al.

Summary: This study reveals that the contribution of anthropogenic soluble iron to the Southern Ocean has been underestimated. It predicts a substantial decrease in anthropogenic soluble iron deposition by the year 2100, which will play a major role in the atmospheric soluble iron inputs to the Southern Ocean.

NPJ CLIMATE AND ATMOSPHERIC SCIENCE (2022)

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Article Endocrinology & Metabolism

Long-term exposure to air pollution might decrease bone mineral density T-score and increase the prevalence of osteoporosis in Hubei province: evidence from China Osteoporosis Prevalence Study

Faxue Zhang et al.

Summary: Long-term exposure to air pollution is associated with decreased bone mineral density and increased risk of osteoporosis. The effects of air pollution vary among different populations.

OSTEOPOROSIS INTERNATIONAL (2022)

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Article Neurosciences

Effect of cadmium administration on the antioxidant system and neuronal death in the hippocampus of rats

Samuel Trevino et al.

Summary: Cadmium exposure affects the function of the central nervous system, especially the hippocampus, leading to neurodegeneration. This is a result of the oxidative stress response caused by cadmium. The study confirms that cadmium administration increases the concentration of cadmium in plasma and the hippocampus, and exacerbates the oxidative stress response. These findings are important in understanding the harmful effects of cadmium exposure on the nervous system and its impact on health and the environment.

SYNAPSE (2022)

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Article Environmental Sciences

Long-term BPA exposure leads to bone malformation and abnormal expression of MAPK/Wnt/FoxO signaling pathway genes in zebrafish offspring

Zhu Zhu et al.

Summary: This study demonstrates that long-term parental exposure to BPA severely affects cartilage development and bone mineralization in fish offspring, with the involvement of the MAPK/Wnt/FoxO signaling pathways.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2022)

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Article Engineering, Environmental

Bisphenol A inhibits osteogenic activity and causes bone resorption via the activation of retinoic acid-related orphan receptor α

Wisurumuni Arachchilage Hasitha Maduranga Karunarathne et al.

Summary: This study reveals that BPA inhibits osteoblast differentiation and bone formation by activating ROR alpha, potentially causing bone-resorptive diseases such as osteoporosis.

JOURNAL OF HAZARDOUS MATERIALS (2022)

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Review Pharmacology & Pharmacy

Advances in pathogenesis and therapeutic strategies for osteoporosis

Shasha Song et al.

Summary: Osteoporosis, the most common bone disorder globally, is characterized by low bone mineral density and increased fracture risk. The pathogenesis of osteoporosis involves various factors, including the gut microbiome, autophagy, iron balance, and cellular senescence. Promising drugs targeting these mechanisms, such as probiotics, alpha-ketoglutarate, senolytics, and hydrogen sulfide, have been identified for osteoporosis treatment.

PHARMACOLOGY & THERAPEUTICS (2022)

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Review Environmental Sciences

Phthalates and bone mineral density: a systematic review

Nina Z. Heilmann et al.

Summary: Studies among postmenopausal women suggest an association between urinary phthalate metabolite concentration and decreased BMD. However, studies of childhood BMD are inconclusive due to limited data and study limitations. Further research is needed to investigate the association between phthalate exposure and human BMD.

ENVIRONMENTAL HEALTH (2022)

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Article Biochemistry & Molecular Biology

Human Health Implication of Major and Trace Elements Present in Commercial Crustaceans of a Traditional Seafood Marketing Region, Egypt

Ghada F. El-Said et al.

Summary: The study focused on the distribution of major and trace elements in different tissues of crustaceans from a traditional seafood market region in Egypt. It also examined the physical and biological statuses of the crustaceans, as well as their potential impact on human health.

BIOLOGICAL TRACE ELEMENT RESEARCH (2021)

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Review Endocrinology & Metabolism

Non-endemic skeletal fluorosis: Causes and associated secondary hyperparathyroidism (case report and literature review)

Fiona J. Cook et al.

Summary: This case report highlights a male patient who experienced chronic musculoskeletal pain and developed skeletal fluorosis due to inhaling difluoroethane found in computer cleaner. Symptoms improved with calcium and vitamin D supplementation, and investigations into unusual causes of non-endemic SF revealed common sources such as high consumption of black tea, use of fluoride-containing toothpaste, and inhalation of fluorine-containing vapors.

BONE (2021)

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Review Environmental Sciences

PFAS Exposure Pathways for Humans and Wildlife: A Synthesis of Current Knowledge and Key Gaps in Understanding

Amila O. De Silva et al.

Summary: The understanding of human and wildlife exposures to PFAS has mainly focused on a few traditional substances, but there is a need for assessment of a wider range of new PFAS. Diet is a major pathway of human exposure to some PFAS, but there is significant variability across populations and compounds. Total fluorine data and information on unidentified organofluorine are essential, and water has been identified as a major exposure source in contaminated communities. As water sources are remediated, other sources of exposure such as dust, personal care products, and indoor environments may become more significant.

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY (2021)

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Article Environmental Sciences

Associations of multiple metals with bone mineral density: A population-based study in US adults

Mu-Hong Wei et al.

Summary: This study examined the associations of multiple metals exposure with bone mineral density (BMD) and found that lead (Pb), manganese (Mn), and selenium (Se) were the main contributors driving the overall effects on BMD. Co-exposure to cadmium (Cd), lead (Pb), mercury (Hg), manganese (Mn), copper (Cu), selenium (Se), and zinc (Zn) above their 50th percentiles was associated with reduced BMD.

CHEMOSPHERE (2021)

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Article Environmental Sciences

Cadmium exposure induces osteoporosis through cellular senescence, associated with activation of NF-kappa B pathway and mitochondrial dysfunction

Huigen Luo et al.

Summary: Cd exposure induces bone cell senescence, impairs osteogenic differentiation, increases adipogenesis, and causes defects such as mitochondrial dysfunction and DNA damage in bone marrow mesenchymal cells. Chronic Cd exposure in rats resulted in increased adipocytes and decreased mineralization tissues in bone marrow, hindering bone repair and regeneration. Pre-treatment with melatonin partially prevented Cd-induced senescence-associated defects, and selectively inhibiting NF-kappa B may alleviate Cd-induced cell senescence phenotypes.

ENVIRONMENTAL POLLUTION (2021)

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Article Immunology

Immunomodulation by heavy metals as a contributing factor to inflammatory diseases and autoimmune reactions: Cadmium as an example

Aleksandra Popov Aleksandrov et al.

Summary: Cadmium poses a unique hazard due to its long biological half-life in humans, leading to organ accumulation and potential immune system involvement in tissue toxicity. Current knowledge suggests a link between cadmium exposure and inflammatory/autoimmune disease manifestations, with cellular and molecular immune mechanisms potentially influencing disease susceptibility or progression.

IMMUNOLOGY LETTERS (2021)

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Review Chemistry, Medicinal

Effects of Caffeic Acid and Its Derivatives on Bone: A Systematic Review

Sophia Ogechi Ekeuku et al.

Summary: Caffeic acid, a metabolite of hydroxycinnamate and phenylpropanoid, acts as an antioxidant to reduce osteoclastogenesis and bone resorption. However, in some cases, it may have no effect on bone resorption or even impair bone mechanical properties in normal rats.

DRUG DESIGN DEVELOPMENT AND THERAPY (2021)

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Review Environmental Sciences

Environmental Substances Associated with Osteoporosis-A Scoping Review

Hanna Elonheimo et al.

Summary: There is evidence indicating a potential link between environmental substances such as heavy metals and industrial chemicals, and osteoporosis. However, more epidemiological research is needed to further understand the relationship between health effects and exposure to these chemicals. The results of studies are inconsistent, and there is a lack of comprehensive epidemiological studies on chemical exposure.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

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Review Chemistry, Multidisciplinary

The Double Face of Metals: The Intriguing Case of Chromium

Giuseppe Genchi et al.

Summary: Chromium is a common element in the Earth's crust, which exists in different oxidation states including Cr(III) and Cr(VI). While Cr(III) is beneficial for human health, Cr(VI) is a human carcinogen. Research on both forms of chromium is important for understanding their impact on human health.

APPLIED SCIENCES-BASEL (2021)

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Review Endocrinology & Metabolism

Direct and Indirect Effect of Honey as a Functional Food Against Metabolic Syndrome and Its Skeletal Complications

Elvy Suhana Mohd Ramli et al.

Summary: This review focuses on the effects of honey on bone metabolism and components of MetS. Polyphenols in honey can alleviate MetS by preventing oxidative damage and inflammation, reduce blood glucose levels, improve lipid metabolism, and prevent bone loss. Honey supplementation could be integrated into the management of MetS and MetS-induced bone loss as a preventive and adjunct therapeutic agent.

DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY (2021)

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Article Endocrinology & Metabolism

Endocrine disrupting chemicals and bone

Serap Turan

Summary: Endocrine-disrupting chemicals (EDCs) can adversely affect bone by altering bone modelling and remodelling through various mechanisms, from basic molecular research to clinical implications.

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM (2021)

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Review Endocrinology & Metabolism

Flavonoids in Bone Erosive Diseases: Perspectives in Osteoporosis Treatment

Daniele Bellavia et al.

Summary: This article provides comprehensive information on flavonoids with potential anti-resorptive and pro-osteogenic effects, highlighting their molecular mechanisms, often epigenetic, and emphasizing their potential pharmacological use in the prevention and treatment of osteoporosis.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2021)

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Review Endocrinology & Metabolism

The endocrine disruptor cadmium: a new player in the pathophysiology of metabolic diseases

V. M. Bimonte et al.

Summary: Cadmium is a highly toxic heavy metal found in soil, environment, contaminated water, and food. It is used in various industrial activities and cigarettes, and has been linked to diseases such as obesity, diabetes, atherosclerosis, and hypertension.

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION (2021)

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Article Endocrinology & Metabolism

Effects of fluoride intake on cortical and trabecular bone microstructure at early adulthood using multi-row detector computed tomography (MDCT)

Punam K. Saha et al.

Summary: This study aimed to investigate the effects of period-specific and cumulative fluoride intake on bone microstructural outcomes in early adulthood. The results showed that there were no significant associations between fluoride intake and bone microstructural outcomes at age 19, indicating weak or absent effects of fluoride intake on bone structures during early adulthood.

BONE (2021)

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Article Environmental Sciences

Chromium Contamination from Tanning Industries and Phytoremediation Potential of Native Plants: A Study of Savar Tannery Industrial Estate in Dhaka, Bangladesh

Shaikh Md. Mahady Hasan et al.

Summary: This study assessed Cr contamination caused by tannery wastewater in the Dhaleshwari River and identified Xanthium strumarium L. as a preferable native species for phytoremediation of Cr.

BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY (2021)

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Review Environmental Sciences

Molecular mechanism of heavy metals (Lead, Chromium, Arsenic, Mercury, Nickel and Cadmium) - induced hepatotoxicity - A review

Kaviyarasi Renu et al.

Summary: Exposure to heavy metals beyond permissible limits poses a serious threat to human health, causing hepatotoxicity, cellular damage, and inflammatory responses.

CHEMOSPHERE (2021)

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Review Endocrinology & Metabolism

The Relationship Between Bone and Reproductive Hormones Beyond Estrogens and Androgens

Edouard G. Mills et al.

Summary: Reproductive hormones play a key role in the growth and maintenance of mammalian skeleton, impacting bone density and risk of fractures. Recent research on traditional reproductive hormones as well as new reproductive neuro peptides and hormones has enhanced our understanding of the interaction between bone and the reproductive system.

ENDOCRINE REVIEWS (2021)

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Article Environmental Sciences

Fluoride in Drinking Water, Diet, and Urine in Relation to Bone Mineral Density and Fracture Incidence in Postmenopausal Women

Emilie Helte et al.

Summary: This study examined the associations between fluoride exposure in postmenopausal women consuming drinking water with fluoride concentration <= 1 mg/L and bone mineral density (BMD) and fracture incidence. The results showed that fluoride exposure was positively associated with hip fractures, but less pronounced for other fractures. It suggests that high consumption of drinking water with fluoride concentration of 1 mg/L may increase both BMD and skeletal fragility in older women.

ENVIRONMENTAL HEALTH PERSPECTIVES (2021)

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Review Endocrinology & Metabolism

Obesogens: How They Are Identified and Molecular Mechanisms Underlying Their Action

Nicole Mohajer et al.

Summary: The rising rates of obesity and related metabolic diseases are demanding increasing attention on chemical screening efforts and worldwide preventative strategies. Obesogens, a subset of endocrine disrupting chemicals (EDCs), can affect the metabolic system through multiple pathways. Their impact on systems such as the gut microbiome and brown adipose tissue needs to be carefully studied.

FRONTIERS IN ENDOCRINOLOGY (2021)

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Article Endocrinology & Metabolism

Bone Lining Cells Could Be Sources of Bone Marrow Adipocytes

Ji Yeon Lee et al.

Summary: Lineage-tracing studies have shown that parathyroid hormone and anti-sclerostin antibody can convert bone lining cells into active osteoblasts, while these cells may also differentiate into bone marrow adipocytes. Rosiglitazone can stimulate this differentiation process, but Scl-Ab administration may suppress it, contributing to anabolic effects.

FRONTIERS IN ENDOCRINOLOGY (2021)

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Article Endocrinology & Metabolism

Urinary Phthalate Biomarkers and Bone Mineral Density in Postmenopausal Women

Katherine W. Reeves et al.

Summary: The study found that certain phthalate biomarkers were associated with greater percentage decreases in total hip and femoral neck bone mineral density (BMD), suggesting that phthalate exposure may have clinically significant effects on BMD and potentially increase fracture risk.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2021)

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Article Environmental Sciences

Chromium contamination and effect on environmental health and its remediation: A sustainable approaches

Shiv Prasad et al.

Summary: Chromium is a critical trace element for human health, but contamination, particularly in the form of hexavalent chromium [Cr(VI)], has increased in terrestrial and aquatic ecosystems due to anthropogenic activities. Excessive exposure to chromium can lead to toxic health effects in humans and animals, while pollution negatively affects plant metabolic activities, reducing crop quality. Monitoring and implementing remediation technologies is essential to balance the environment and nature.

JOURNAL OF ENVIRONMENTAL MANAGEMENT (2021)

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Article Environmental Sciences

Cadmium toxicity: A role in bone cell function and teeth development

Yonggang Ma et al.

Summary: Cadmium is a widespread environmental contaminant that causes severe bone metabolism disease and dental issues. It affects bone cell and teeth development, leading to oxidative stress and DNA damage, ultimately resulting in cell apoptosis.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

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Review Biochemistry & Molecular Biology

The Effects of Calcium, Magnesium, Phosphorus, Fluoride, and Lead on Bone Tissue

Zaneta Ciosek et al.

Summary: Bones are metabolically active organs that play a crucial role in skeletal growth and remodeling, fracture healing, and maintaining mineral balance. This study examines the impact of macroelements, microelements, and heavy metals on bone tissue, discussing their concentrations and influences on bone metabolism and properties.

BIOMOLECULES (2021)

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Review Endocrinology & Metabolism

PFAS and Potential Adverse Effects on Bone and Adipose Tissue Through Interactions With PPARγ

Andrea B. Kirk et al.

Summary: PFAS are a widespread class of synthetic chemicals with complex effects on biological systems, potentially leading to various adverse outcomes. Enhanced regulatory oversight and risk assessment of PFAS are needed to protect public and environmental health.

ENDOCRINOLOGY (2021)

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Review Environmental Sciences

Epigenetic changes by per- and polyfluoroalkyl substances (PFAS)

Sujin Kim et al.

Summary: Studies have shown that per- and polyfluoroalkyl substances (PFAS) can cause epigenetic modifications, including DNA methylation, histone modification, and microRNA expression. Different types of research have revealed the potential harm of PFAS to human health, and further studies are needed to understand the specific effects of PFAS.

ENVIRONMENTAL POLLUTION (2021)

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Review Endocrinology & Metabolism

The diverse origin of bone-forming osteoblasts

Toshihide Mizoguchi et al.

Summary: Osteoblasts are the only cells capable of forming bones in vertebrates, with their main function being the production of mineralized matrix. Disruption of their regulation can lead to various bone diseases, highlighting the importance of understanding the origin of these cells for the development of novel therapeutic approaches. Recent advances in technology have provided new insights into the diverse sources of osteoblasts involved in bone formation under different conditions.

JOURNAL OF BONE AND MINERAL RESEARCH (2021)

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Article Medicine, Legal

Occupational exposure to hexavalent chromium. Part I. Hazard assessment of non-cancer health effects

Ellen V. S. Hessel et al.

Summary: Occupational exposure to hexavalent chromium (Cr(VI)) compounds can lead to irreversible adverse health effects such as perforation of the nasal septum, chronic lung diseases, skin ulcers, and allergic contact dermatitis. The possibility of Cr(VI) causing irreversible diseases related to immune system disturbances, fertility issues, or adverse prenatal development in humans remains unclear.

REGULATORY TOXICOLOGY AND PHARMACOLOGY (2021)

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Article Food Science & Technology

Risk assessment of per- and polyfluoroalkyl substances (PFAS) in food: Symposium proceedings

K. L. Vorst et al.

Summary: PFAS are synthetic chemicals with a history of use in various products, and high levels of exposure may have adverse health effects. Research gaps exist in understanding human exposure to PFAS from food and food packaging. Key discussions at the symposium focused on analytical methods, exposure routes, and potential health effects of PFAS.

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2021)

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Review Health Care Sciences & Services

Particulate Air Pollution and Osteoporosis: A Systematic Review

Kok-Lun Pang et al.

Summary: Air pollution can lead to inflammation and oxidative stress, increasing the risk of chronic diseases in humans. Research suggests that the severity and progression of osteoporosis may be directly impacted by pollutants like particulate matter. However, current studies show inconsistent associations between PM exposure and osteoporosis risk or fractures.

RISK MANAGEMENT AND HEALTHCARE POLICY (2021)

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Article Urology & Nephrology

Aluminum Intoxication in Chronic Kidney Disease

Rodrigo Bueno de Oliveira et al.

JORNAL BRASILEIRO DE NEFROLOGIA (2021)

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Review Biochemistry & Molecular Biology

Long-Term Accumulation of Metals in the Skeleton as Related to Osteoporotic Derangements

Geir Bjorklund et al.

CURRENT MEDICINAL CHEMISTRY (2020)

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Article Biochemistry & Molecular Biology

Long-Term Exposure to Low-Dose Lead Induced Deterioration in Bone Microstructure of Male Mice

Zhijie Sheng et al.

BIOLOGICAL TRACE ELEMENT RESEARCH (2020)

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Article Biochemistry & Molecular Biology

A Comparative Analysis of Fluoride-Contaminated Groundwater and Sodium Fluoride-Induced Reproductive Toxicity and Its Reversibility in Male Rats

Basavalingappa Chaithra et al.

BIOLOGICAL TRACE ELEMENT RESEARCH (2020)

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Review Public, Environmental & Occupational Health

Environmental and Health Impacts of Air Pollution: A Review

Ioannis Manisalidis et al.

FRONTIERS IN PUBLIC HEALTH (2020)

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Article Multidisciplinary Sciences

An association between air pollution and daily most frequently visits of eighteen outpatient diseases in an industrial city

Tang-Tat Chau et al.

SCIENTIFIC REPORTS (2020)

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Article Toxicology

E-vapor aerosols do not compromise bone integrity relative to cigarette smoke after 6-month inhalation in an ApoE-/- mouse model

Marie K. Reumann et al.

ARCHIVES OF TOXICOLOGY (2020)

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Review Immunology

Mercury-induced autoimmunity: Drifting from micro to macro concerns on autoimmune disorders

Geir Bjorklund et al.

CLINICAL IMMUNOLOGY (2020)

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Article Engineering, Environmental

Chronic cadmium exposure and cardiovascular disease in adults

Emmanuel Obeng-Gyasi

JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING (2020)

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Review Environmental Sciences

The Effects of Cadmium Toxicity

Giuseppe Genchi et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2020)

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Review Endocrinology & Metabolism

Exposure to heavy metals and the risk of osteopenia or osteoporosis: a systematic review and meta-analysis

C. Jalili et al.

OSTEOPOROSIS INTERNATIONAL (2020)

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Article Environmental Sciences

Associations between essential metals exposure and metabolic syndrome (MetS): Exploring the mediating role of systemic in flammation in a general Chinese population

Jixuan Ma et al.

ENVIRONMENT INTERNATIONAL (2020)

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Article Environmental Sciences

Serum concentrations of perfluoroalkyl substances and their association with osteoporosis in a population in Jeddah, Saudi Arabia

Abeer A. Banjabi et al.

ENVIRONMENTAL RESEARCH (2020)

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Review Environmental Sciences

Molecular and cellular mechanisms linking air pollution and bone damage

Diddier Prada et al.

ENVIRONMENTAL RESEARCH (2020)

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Review Endocrinology & Metabolism

Are Oxidative Stress and Inflammation Mediators of Bone Loss Due to Estrogen Deficiency? A Review of Current Evidence

Nur-Vaizura Mohamad et al.

ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS (2020)

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Article Rheumatology

Cobalt hip prosthesis intoxication mimicking an autoimmune disease

Alessandro Biglia et al.

JOINT BONE SPINE (2020)

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Article Public, Environmental & Occupational Health

Respiratory Health and Inflammatory Markers-Exposure to Cobalt in the Swedish Hard Metal Industry

Lena Andersson et al.

JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE (2020)

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Article Environmental Sciences

Exposure to multiple heavy metals associate with aberrant immune homeostasis and inflammatory activation in preschool children

Yu Zhang et al.

CHEMOSPHERE (2020)

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Article Multidisciplinary Sciences

Dermal and inhalable cobalt exposure-Uptake of cobalt for workers at Swedish hard metal plants

Fredrik Wahlqvist et al.

PLOS ONE (2020)

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Article Environmental Sciences

Association between low-to-moderate fluoride exposure and bone mineral density in Chinese adults: Non-negligible role of RUNX2 promoter methylation

Minghui Gao et al.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2020)

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Article Food Science & Technology

Lactobacillus plantarum LP33 attenuates Pb-induced hepatic injury in rats by reducing oxidative stress and inflammation and promoting Pb excretion

Ting Hu et al.

FOOD AND CHEMICAL TOXICOLOGY (2020)

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Article Chemistry, Multidisciplinary

Heavy Metals Impact: Adverse Impact of Heavy Metals on Bone Cells and Bone Metabolism Dependently and Independently through Anemia (Adv. Sci. 19/2020)

Shuping Zhang et al.

Advanced Science (2020)

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Review Environmental Sciences

Mercury in the terrestrial environment: a review

Barbara Gworek et al.

ENVIRONMENTAL SCIENCES EUROPE (2020)

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Article Pharmacology & Pharmacy

Potential effects of noxious chemical-containing fine particulate matter on oral health through reactive oxygen species-mediated oxidative stress: Promising clues

Thi Thuy Tien Vo et al.

BIOCHEMICAL PHARMACOLOGY (2020)

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Article Toxicology

Hepatotoxic evaluation of Di-n-butyl phthalate in Wistar rats upon sub-chronic exposure: A multigenerational assessment

M. J. Radha et al.

TOXICOLOGY REPORTS (2020)

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Review Environmental Sciences

Effects of Cadmium, Lead, and Mercury on the Structure and Function of Reproductive Organs

Peter Massanyi et al.

TOXICS (2020)

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Article Environmental Sciences

Low-dose cadmium exposure acts on rat mesenchymal stem cells via RANKL/OPG and downregulate osteogenic differentiation genes

Ying-Jian Lv et al.

ENVIRONMENTAL POLLUTION (2019)

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Review Endocrinology & Metabolism

Endocrine Disrupting Chemicals: Effects on Endocrine Glands

Rosa Lauretta et al.

FRONTIERS IN ENDOCRINOLOGY (2019)

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Review Oncology

The Effect of Hexavalent Chromium on the Incidence and Mortality of Human Cancers: A Meta-Analysis Based on Published Epidemiological Cohort Studies

Yujiao Deng et al.

FRONTIERS IN ONCOLOGY (2019)

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Article Biochemistry & Molecular Biology

Cigarette Smoke Induces the Risk of Metabolic Bone Diseases: Transforming Growth Factor Beta Signaling Impairment via Dysfunctional Primary Cilia Affects Migration, Proliferation, and Differentiation of Human Mesenchymal Stem Cells

Romina H. Aspera-Werz et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Biochemistry & Molecular Biology

Heavy metal toxicity: An update of chelating therapeutic strategies

Jong-Joo Kim et al.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2019)

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Review Chemistry, Physical

A review on heavy metal pollution, toxicity and remedial measures: Current trends and future perspectives

Kilaru Harsha Vardhan et al.

JOURNAL OF MOLECULAR LIQUIDS (2019)

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Article Pharmacology & Pharmacy

A comparison of particulate hexavalent chromium cytotoxicity and genotoxicity in human and leatherback sea turtle lung cells from a one environmental health perspective

Rachel M. Speer et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2019)

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Review Environmental Sciences

Toxicity of cadmium in musculoskeletal diseases

D. Reyes-Hinojosa et al.

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2019)

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Review Biochemistry & Molecular Biology

Osteoporosis in Rheumatic Diseases

Giovanni Adami et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Pediatrics

Aluminum Effects in Infants and Children

Mark R. Corkins et al.

PEDIATRICS (2019)

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Article Chemistry, Physical

Analysis of Cellular Activity and Induction of Inflammation in Response to Short-Term Exposure to Cobalt and Chromium Ions in Mature Human Osteoblasts

Anika Jonitz-Heincke et al.

MATERIALS (2019)

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Article Environmental Sciences

Renal toxicity of heavy metals (cadmium and mercury) and their amelioration with ascorbic acid in rabbits

Shaukat Ali et al.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2019)

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Article Environmental Sciences

Enhanced removal of hexavalent chromium by engineered biochar composite fabricated from phosphogypsum and distillers grains

Guoqi Lian et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2019)

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Review Engineering, Environmental

Concentration of fluoride in groundwater of India: A systematic review, meta-analysis and risk assessment

Shakir Ali et al.

GROUNDWATER FOR SUSTAINABLE DEVELOPMENT (2019)

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Article Medicine, General & Internal

Mercury Is Taken Up Selectively by Cells Involved in Joint, Bone, and Connective Tissue Disorders

Roger Pamphlett et al.

FRONTIERS IN MEDICINE (2019)

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Review Hematology

Iron toxicity - Its effect on the bone marrow

Alessandro Isidori et al.

BLOOD REVIEWS (2018)

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Article Environmental Sciences

A comprehensive study including monitoring, assessment of health effects and development of a remediation method for chromium pollution

Masafumi Yoshinaga et al.

CHEMOSPHERE (2018)

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Review Environmental Sciences

Role of 24-epibrassinolide (EBL) in mediating heavy metal and pesticide induced oxidative stress in plants: A review

Babar Shahzad et al.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2018)

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Review Medicine, Research & Experimental

Toxic effects of fluoride on organisms

Huan Zuo et al.

LIFE SCIENCES (2018)

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Review Medicine, Research & Experimental

Bisphenol A exposure disturbs the bone metabolism: An evolving interest towards an old culprit

Zar Chi Thent et al.

LIFE SCIENCES (2018)

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Review Biotechnology & Applied Microbiology

Chromium(VI) Toxicity in Legume Plants: Modulation Effects of Rhizobial Symbiosis

Uliana Ya. Stambulska et al.

BIOMED RESEARCH INTERNATIONAL (2018)

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Article Cell Biology

Nicotine and Cotinine Inhibit Catalase and Glutathione Reductase Activity Contributing to the Impaired Osteogenesis of SCP-1 Cells Exposed to Cigarette Smoke

Romina H. Aspera-Werz et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)

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Review Public, Environmental & Occupational Health

The Effect of Tobacco Smoking on Musculoskeletal Health: A Systematic Review

Ahmad M. AL-Bashaireh et al.

JOURNAL OF ENVIRONMENTAL AND PUBLIC HEALTH (2018)

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Review Toxicology

A Review of Metal Exposure and Its Effects on Bone Health

Juliana Rodriguez et al.

JOURNAL OF TOXICOLOGY (2018)

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Article Biochemistry & Molecular Biology

Effects of aluminum trichloride on the cartilage stimulatory growth factors in rats

Fan Zhang et al.

BIOMETALS (2017)

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Article Environmental Sciences

Heavy metals accumulation affects bone microarchitecture in osteoporotic patients

Manuel Scimeca et al.

ENVIRONMENTAL TOXICOLOGY (2017)

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Article Environmental Sciences

Sodium fluoride induces hypertension and cardiac complications through generation of reactive oxygen species and activation of nuclear factor kappa beta

Ademola Adetokunbo Oyagbemi et al.

ENVIRONMENTAL TOXICOLOGY (2017)

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Article Oncology

Low doses of Co nanoparticles induce death and regulate osteogenic differentiation in MG-63 cells

Qinglin Han et al.

MOLECULAR MEDICINE REPORTS (2017)

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Article Plant Sciences

Allelic Variation of NtNramp5 Associated with Cultivar Variation in Cadmium Accumulation in Tobacco

Zhong Tang et al.

PLANT AND CELL PHYSIOLOGY (2017)

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Review Pharmacology & Pharmacy

Cobalt toxicity in humans-A review of the potential sources and systemic health effects

Laura Leyssens et al.

TOXICOLOGY (2017)

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Article

Inflammatory responses and inflammation-associated diseases in organs

Linlin Chen et al.

Oncotarget (2017)

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Review Pharmacology & Pharmacy

Clinical Impact and Cellular Mechanisms of Iron Overload-Associated Bone Loss

Viktoria Jeney

FRONTIERS IN PHARMACOLOGY (2017)

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Article Environmental Sciences

Association of air particulate pollution with bone loss over time and bone fracture risk: analysis of data from two independent studies

Diddier Prada et al.

LANCET PLANETARY HEALTH (2017)

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Review Rheumatology

An overview and management of osteoporosis

Tumay Sozen et al.

EUROPEAN JOURNAL OF RHEUMATOLOGY (2017)

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Article Environmental Sciences

Association of Perfluoroalkyl Substances, Bone Mineral Density, and Osteoporosis in the US Population in NHANES 2009-2010

Naila Khalil et al.

ENVIRONMENTAL HEALTH PERSPECTIVES (2016)

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Article Environmental Sciences

Associations between bone mineral density and urinary phthalate metabolites among post-menopausal women: a cross-sectional study of NHANES data 2005-2010

Stephanie A. DeFlorio-Barker et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH (2016)

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Article Biochemistry & Molecular Biology

Iron overload enhances human mesenchymal stromal cell growth and hampers matrix calcification

Adriana Borriello et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2016)

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Article Biochemistry & Molecular Biology

The Antagonistic Effect of Selenium on Lead-Induced Inflammatory Factors and Heat Shock Protein mRNA Level in Chicken Cartilage Tissue

Shufang Zheng et al.

BIOLOGICAL TRACE ELEMENT RESEARCH (2016)

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Review Endocrinology & Metabolism

Inflammation, fracture and bone repair

Florence Loi et al.

BONE (2016)

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Review Endocrinology & Metabolism

Bone Disease in Thalassemia: A Molecular and Clinical Overview

Phillip Wong et al.

ENDOCRINE REVIEWS (2016)

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Article Endocrinology & Metabolism

Deletion of FGFR3 in Osteoclast Lineage Cells Results in Increased Bone Mass in Mice by Inhibiting Osteoclastic Bone Resorption

Nan Su et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2016)

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Article Nutrition & Dietetics

Involvement of reactive oxygen species derived from mitochondria in neuronal injury elicited by methylmercury

Yasuhiro Ishihara et al.

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION (2016)

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Article Medicine, General & Internal

Environmental Exposure to Arsenic, Lead, and Cadmium in People Living near Janghang Copper Smelter in Korea

Yong-Dae Kim et al.

JOURNAL OF KOREAN MEDICAL SCIENCE (2016)

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Review Endocrinology & Metabolism

Osteocytic signalling pathways as therapeutic targets for bone fragility

Lilian I. Plotkin et al.

NATURE REVIEWS ENDOCRINOLOGY (2016)

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Article Plant Sciences

The Mechanism of the Osteoprotective Action of a Polyphenol-Rich Aronia melanocarpa Extract during Chronic Exposure to Cadmium is Mediated by the Oxidative Defense System

Malgorzata M. Brzoska et al.

PLANTA MEDICA (2016)

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Article Multidisciplinary Sciences

Does oral exposure to cadmium and lead mediate susceptibility to colitis? The dark-and-bright sides of heavy metals in gut ecology

Jerome Breton et al.

SCIENTIFIC REPORTS (2016)

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Article Water Resources

Human Health Risk Assessment of Chromium in Drinking Water: A Case Study of Sukinda Chromite Mine, Odisha, India

Aliya Naz et al.

EXPOSURE AND HEALTH (2016)

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Review Immunology

Selected aspects of the action of cobalt ions in the human body

Katarzyna Czarnek et al.

CENTRAL EUROPEAN JOURNAL OF IMMUNOLOGY (2015)

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Article Environmental Sciences

Alpha-lipoic acid protects against methylmercury-induced neurotoxic effects via inhibition of oxidative stress in rat cerebral cortex

Tian-yao Yang et al.

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2015)

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Article Engineering, Biomedical

Biological responses of preosteoblasts to particulate and ion forms of Co-Cr alloy

Shuye Yang et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2015)

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Article Biochemistry & Molecular Biology

Effects of thirty elements on bone metabolism

Michael Dermience et al.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2015)

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Article Medicine, General & Internal

Exposure to Air pollution Increases the Risk of Osteoporosis A Nationwide Longitudinal Study

Kuang-Hsi Chang et al.

MEDICINE (2015)

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Article Endocrinology & Metabolism

Living near a freeway is associated with lower bone mineral density among Mexican Americans

Z. Chen et al.

OSTEOPOROSIS INTERNATIONAL (2015)

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Review Nutrition & Dietetics

Chronic Iron Deficiency as an Emerging Risk Factor for Osteoporosis: A Hypothesis

Laura Toxqui et al.

NUTRIENTS (2015)

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Review Biotechnology & Applied Microbiology

Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells

Rinaldo Florencio-Silva et al.

BIOMED RESEARCH INTERNATIONAL (2015)

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Article Endocrinology & Metabolism

An Overview of the Metabolic Functions of Osteocalcin

Jianwen Wei et al.

CURRENT OSTEOPOROSIS REPORTS (2015)

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Review Endocrinology & Metabolism

The effects of phthala

Patrick R. Hannon et al.

FRONTIERS IN ENDOCRINOLOGY (2015)

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Article Biochemistry & Molecular Biology

Fluorosis Induces Endoplasmic Reticulum Stress and Apoptosis in Osteoblasts In Vivo

Lu Liu et al.

BIOLOGICAL TRACE ELEMENT RESEARCH (2015)

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Article Endocrinology & Metabolism

Therapeutic Effect of Deferoxamine on Iron Overload-Induced Inhibition of Osteogenesis in a Zebrafish Model

Bin Chen et al.

CALCIFIED TISSUE INTERNATIONAL (2014)

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Article Environmental Sciences

Fluoride decreased osteoclastic bone resorption through the inhibition of NFATc1 gene expression

Junrui Pei et al.

ENVIRONMENTAL TOXICOLOGY (2014)

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Article Environmental Sciences

Cellular mechanisms of cadmium-induced toxicity: a review

Anju Rani et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH (2014)

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Article Endocrinology & Metabolism

Urinary Phthalate Metabolites and the Risk of Low Bone Mineral Density and Osteoporosis in Older Women

Kyoung-bok Min et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2014)

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Article Endocrinology & Metabolism

Negative Association Between Serum Perfluorooctane Sulfate Concentration and Bone Mineral Density in US Premenopausal Women: NHANES, 2005-2008

Lian-Yu Lin et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2014)

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Article Geriatrics & Gerontology

Associations Between Bone Mineral Density, Grip Strength, and Lead Body Burden in Older Men

Naila Khalil et al.

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2014)

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Article Multidisciplinary Sciences

Holding Thermal Receipt Paper and Eating Food after Using Hand Sanitizer Results in High Serum Bioactive and Urine Total Levels of Bisphenol A (BPA)

Annette M. Hormann et al.

PLOS ONE (2014)

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Editorial Material Multidisciplinary Sciences

Particulate Matter Matters

Francesca Dominici et al.

SCIENCE (2014)

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Review Sport Sciences

Bone Quality: The Determinants of Bone Strength and Fragility

Helder Fonseca et al.

SPORTS MEDICINE (2014)

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Article Cell & Tissue Engineering

LPS-Stimulated Inflammatory Environment Inhibits BMP-2-Induced Osteoblastic Differentiation Through Crosstalk Between TLR4/MyD88/NF-κB and BMP/Smad Signaling

Ru-Lin Huang et al.

STEM CELLS AND DEVELOPMENT (2014)

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Review Pharmacology & Pharmacy

Assessment of the mode of action for hexavalent chromium-induced lung cancer following inhalation exposures

Deborah M. Proctor et al.

TOXICOLOGY (2014)

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Article Dentistry, Oral Surgery & Medicine

FOCUS ON FLUORIDES: UPDATE ON THE USE OF FLUORIDE FOR THE PREVENTION OF DENTAL CARIES

Clifton M. Carey

JOURNAL OF EVIDENCE-BASED DENTAL PRACTICE (2014)

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Article Marine & Freshwater Biology

Gene transcription reflects poor health status of resident European eel chronically exposed to environmental pollutants

G. E. Maes et al.

AQUATIC TOXICOLOGY (2013)

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Review Immunology

Immunological Reaction in TNF-α-Mediated Osteoclast Formation and Bone Resorption In Vitro and In Vivo

Hideki Kitaura et al.

CLINICAL & DEVELOPMENTAL IMMUNOLOGY (2013)

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Article Environmental Sciences

Heavy Metal Lead Exposure, Osteoporotic-like Phenotype in an Animal Model, and Depression of Wnt Signaling

Eric E. Beier et al.

ENVIRONMENTAL HEALTH PERSPECTIVES (2013)

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Review Biochemistry & Molecular Biology

Bioavailability of Heavy Metals in Soil: Impact on Microbial Biodegradation of Organic Compounds and Possible Improvement Strategies

Ademola O. Olaniran et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)

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Article Geriatrics & Gerontology

Basic Biology of Skeletal Aging: Role of Stress Response Pathways

Maria Almeida et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2013)

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Article Medicine, Research & Experimental

Bisphenol A reduces differentiation and stimulates apoptosis of osteoclasts and osteoblasts

Jin Kyung Hwang et al.

LIFE SCIENCES (2013)

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Review Biochemistry & Molecular Biology

Metals, oxidative stress and neurodegeneration: A focus on iron, manganese and mercury

Marcelo Farina et al.

NEUROCHEMISTRY INTERNATIONAL (2013)

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Article Endocrinology & Metabolism

Secondhand smoke exposure and osteoporosis in never-smoking postmenopausal women: the Fourth Korea National Health and Nutrition Examination Survey

K. H. Kim et al.

OSTEOPOROSIS INTERNATIONAL (2013)

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Article Pharmacology & Pharmacy

Protective effect of zinc supplementation against cadmium-induced oxidative stress and the RANK/RANKL/OPG system imbalance in the bone tissue of rats

Malgorzata M. Brzoska et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2013)

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Review Endocrinology & Metabolism

Bone Mineral Density and Osteoporosis after Preterm Birth: The Role of Early Life Factors and Nutrition

Claire L. Wood et al.

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (2013)

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Article Endocrinology & Metabolism

Osteoporosis in the European Union: medical management, epidemiology and economic burden

E. Hernlund et al.

ARCHIVES OF OSTEOPOROSIS (2013)

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Article Biochemistry & Molecular Biology

Aluminum Induces Osteoblast Apoptosis Through the Oxidative Stress-Mediated JNK Signaling Pathway

Xinwei Li et al.

BIOLOGICAL TRACE ELEMENT RESEARCH (2012)

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Review Chemistry, Multidisciplinary

Fluoride in Drinking Water and Defluoridation of Water

Sneha Jagtap et al.

CHEMICAL REVIEWS (2012)

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Article Engineering, Environmental

Coal Fly Ash as a Source of Iron in Atmospheric Dust

Haihan Chen et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2012)

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Article Endocrinology & Metabolism

High prevalence of vitamin D deficiency among healthy Saudi Arabian men: relationship to bone mineral density, parathyroid hormone, bone turnover markers, and lifestyle factors

M. -S. M. Ardawi et al.

OSTEOPOROSIS INTERNATIONAL (2012)

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Review Endocrinology & Metabolism

Iron homeostasis in osteoporosis and its clinical implications

G. F. Li et al.

OSTEOPOROSIS INTERNATIONAL (2012)

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Article Toxicology

Cadmium impact and osteoporosis: mechanism of action

Eman R. Youness et al.

TOXICOLOGY MECHANISMS AND METHODS (2012)

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Article Biochemistry & Molecular Biology

Sodium fluoride induces apoptosis and alters bcl-2 family protein expression in MC3T3-E1 osteoblastic cells

Shiyong Yang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)

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Article Multidisciplinary Sciences

Emission inventories of primary particles and pollutant gases for China

Cao GuoLiang et al.

CHINESE SCIENCE BULLETIN (2011)

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Article Engineering, Environmental

Modeling and evaluation of chromium remediation from water using low cost bio-char, a green adsorbent

Dinesh Mohan et al.

JOURNAL OF HAZARDOUS MATERIALS (2011)

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Review Food Science & Technology

Assessing exposure to phthalates - The human biomonitoring approach

Matthias Wittassek et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2011)

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Article Endocrinology & Metabolism

Association between passive smoking in adulthood and phalangeal bone mineral density: results from the KRAM study-the Danish Health Examination Survey 2007-2008

T. Holmberg et al.

OSTEOPOROSIS INTERNATIONAL (2011)

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Review Biochemistry & Molecular Biology

Heavy metal hyperaccumulating plants: How and why do they do it? And what makes them so interesting?

Nicoletta Rascio et al.

PLANT SCIENCE (2011)

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Review Pharmacology & Pharmacy

Advances in metal-induced oxidative stress and human disease

Klaudia Jomova et al.

TOXICOLOGY (2011)

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Article Toxicology

Fluoride induces apoptosis and alters collagen I expression in rat osteoblasts

Xiaoyan Yan et al.

TOXICOLOGY LETTERS (2011)

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Article Environmental Sciences

Indoor Air Pollution from Unprocessed Solid Fuels in Developing Countries

C. Kaplan

REVIEWS ON ENVIRONMENTAL HEALTH (2011)

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Article Public, Environmental & Occupational Health

Human biomonitoring on heavy metals in Ath: methodological aspects

Javiera Rebolledo et al.

ARCHIVES OF PUBLIC HEALTH (2011)

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Review Endocrinology & Metabolism

From Estrogen-Centric to Aging and Oxidative Stress: A Revised Perspective of the Pathogenesis of Osteoporosis

Stavros C. Manolagas

ENDOCRINE REVIEWS (2010)

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Editorial Material Environmental Sciences

Exposure on Tap Drinking Water as an Overlooked Source of Lead

Rebecca Renner

ENVIRONMENTAL HEALTH PERSPECTIVES (2010)

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Article Pharmacology & Pharmacy

3,6-Dihydroxyflavone induces apoptosis in leukemia HL-60 cell via reactive oxygen species-mediated p38 MAPK/JNK pathway

Hui Chang et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2010)

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Article Immunology

Effects of tobacco smoke on immunity, inflammation and autoimmunity

Yoav Arnson et al.

JOURNAL OF AUTOIMMUNITY (2010)

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Article Endocrinology & Metabolism

Outdoor air pollution, bone density and self-reported forearm fracture: the Oslo Health Study

K. Alver et al.

OSTEOPOROSIS INTERNATIONAL (2010)

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Article Environmental Sciences

Lead in housing paints: An exposure source still not taken seriously for children lead poisoning in China

G. Z. Lin et al.

ENVIRONMENTAL RESEARCH (2009)

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Article Environmental Sciences

Cadmium-induced bone effect is not mediated via low serum 1,25-dihydroxy vitamin D

Annette Engstrom et al.

ENVIRONMENTAL RESEARCH (2009)

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Review Public, Environmental & Occupational Health

Perfluorinated compounds - Exposure assessment for the general population in western countries

Hermann Fromme et al.

INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH (2009)

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Article Biochemistry & Molecular Biology

Increased Lipid Oxidation Causes Oxidative Stress, Increased Peroxisome Proliferator-activated Receptor-γ Expression, and Diminished Pro-osteogenic Wnt Signaling in the Skeleton

Maria Almeida et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

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Article Biochemistry & Molecular Biology

The Orphan Nuclear Receptor Estrogen Receptor-related Receptor γ Negatively Regulates BMP2-induced Osteoblast Differentiation and Bone Formation

Byung-Chul Jeong et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

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Review Pharmacology & Pharmacy

Cadmium osteotoxicity in experimental animals: Mechanisms and relationship to human exposures

Maryka H. Bhattacharyya

TOXICOLOGY AND APPLIED PHARMACOLOGY (2009)

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Article Biology

The Developmental Basis of Skeletal Cell Differentiation and the Molecular Basis of Major Skeletal Defects

Harry C. Blair et al.

BIOLOGICAL REVIEWS (2008)

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Review Endocrinology & Metabolism

Osteoimmunology: Interactions of the bone and immune system

Joseph Lorenzo et al.

ENDOCRINE REVIEWS (2008)

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Article Pediatrics

Baby care products: Possible sources of infant phthalate exposure

Sheela Sathyanarayana et al.

PEDIATRICS (2008)

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Review Nutrition & Dietetics

Importance of vitamin D, calcium and exercise to bone health with specific reference to children and adolescents

S. A. Lanham-New et al.

NUTRITION BULLETIN (2007)

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Article Pharmacology & Pharmacy

New and evolving concepts in the neurotoxicology of lead

L. D. White et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2007)

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Article Environmental Sciences

Biomonitoring of the adverse effects induced by the chronic exposure to lead and cadmium on kidney function:: Usefulness of alpha-glutathione S-transferase

Guillaume Garcon et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2007)

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Article Environmental Sciences

Cadmium induces apoptosis in the human osteoblast-like cell line Saos-2

K. G. Coonse et al.

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES (2007)

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Review Environmental Sciences

Human health risk assessment for aluminium, aluminium oxide, and aluminium hydroxide

Daniel Krewski et al.

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS (2007)

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Review Public, Environmental & Occupational Health

Cadmium-induced cancers in animals and in humans

James Huff et al.

INTERNATIONAL JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH (2007)

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Review Chemistry, Multidisciplinary

What is responsible for the initiating chemistry of iron-mediated lipid peroxidation: An update

Zhiyong Cheng et al.

CHEMICAL REVIEWS (2007)

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Article Engineering, Environmental

Fluoride in drinking water and its removal

Meenakshi et al.

JOURNAL OF HAZARDOUS MATERIALS (2006)

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Article Engineering, Biomedical

Effect of cobalt and chromium ions on human MG-63 osteoblasts in vitro: Morphology, cytotoxicity, and oxidative stress

C Fleury et al.

BIOMATERIALS (2006)

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Article Environmental Sciences

Cadmium-induced effects on bone in a population-based study of women

Agneta Akesson et al.

ENVIRONMENTAL HEALTH PERSPECTIVES (2006)

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Review Medicine, General & Internal

High prevalence of vitamin D inadequacy and implications for health

MF Holick

MAYO CLINIC PROCEEDINGS (2006)

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Article Endocrinology & Metabolism

Osteoporosis: A still increasing prevalence

JY Reginster et al.

BONE (2006)

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Article Substance Abuse

Health consequences of smoking 1-4 cigarettes per day

K Bjartveit et al.

TOBACCO CONTROL (2005)

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Article Engineering, Chemical

Airborne particulate matter and human health: A review

CI Davidson et al.

AEROSOL SCIENCE AND TECHNOLOGY (2005)

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Article Engineering, Chemical

Removal of chromium(VI) from dilute aqueous solutions by activated carbon developed from Terminalia arjuna nuts activated with zinc chloride

K Mohanty et al.

CHEMICAL ENGINEERING SCIENCE (2005)

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Review Medicine, General & Internal

The roles of bone mineral density, bone turnover, and other properties in reducing fracture risk during antiresorptive therapy

S Epstein

MAYO CLINIC PROCEEDINGS (2005)

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Article Engineering, Environmental

Determination of 14 polycyclic aromatic hydrocarbons in mainstream smoke from domestic cigarettes

YS Ding et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2005)

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Review Biochemistry & Molecular Biology

Metals, toxicity and oxidative stress

M Valko et al.

CURRENT MEDICINAL CHEMISTRY (2005)

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Article Pharmacology & Pharmacy

Disorders in bone metabolism of female rats chronically exposed to cadmium

MM Brzoska et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2005)

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Article Pharmacology & Pharmacy

Bone metabolism and oxidative stress in postmenopausal rats with iron overload

H Isomura et al.

TOXICOLOGY (2004)

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Article Biochemistry & Molecular Biology

Oxidative stress inhibits osteoblastic differentiation of bone cells by ERK and NF-κB

XC Bai et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)

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Review Environmental Sciences

Sources and remediation for mercury contamination in aquatic systems - a literature review

QR Wang et al.

ENVIRONMENTAL POLLUTION (2004)

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Article Toxicology

Nuclear factor κB activity determines the sensitivity of kidney epithelial cells to apoptosis:: Implications for mercury-induced renal failure

FJ Dieguez-Acuña et al.

TOXICOLOGICAL SCIENCES (2004)

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Review Biotechnology & Applied Microbiology

Cadmium carcinogenesis

Michael P. Waalkes

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2003)

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Review Multidisciplinary Sciences

Osteoclast differentiation and activation

WJ Boyle et al.

NATURE (2003)

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Article Medicine, Research & Experimental

Mechanisms of TNF-α- and RANKL-mediated osteoclastogenesis and bone resorption in psoriatic arthritis

CT Ritchlin et al.

JOURNAL OF CLINICAL INVESTIGATION (2003)

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Letter Medicine, General & Internal

Mercury in infants given vaccines containing thiomersal

G Westphal et al.

LANCET (2003)

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Article Medicine, General & Internal

Blood lead levels and mortality

M Lustberg et al.

ARCHIVES OF INTERNAL MEDICINE (2002)

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Article Environmental Sciences

Brain uptake, retention, and efflux of aluminum and manganese

RA Yokel

ENVIRONMENTAL HEALTH PERSPECTIVES (2002)

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Review Biochemistry & Molecular Biology

Molecular bases of cellular iron toxicity

JW Eaton et al.

FREE RADICAL BIOLOGY AND MEDICINE (2002)

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Article Public, Environmental & Occupational Health

Aluminum as a toxicant

A Becaria et al.

TOXICOLOGY AND INDUSTRIAL HEALTH (2002)

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Review Biochemistry & Molecular Biology

Chemistry and biology of eukaryotic iron metabolism

P Aisen et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2001)

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Article Medicine, General & Internal

Indoor air pollution from biomass combustion and acute respiratory infections in Kenya: an exposure-response study

M Ezzati et al.

LANCET (2001)

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Article Endocrinology & Metabolism

Effect of long-term exposure to fluoride in drinking water on risks of bone fractures

YM Li et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2001)

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Review Medicine, Legal

Safety evaluation of dietary aluminum

MG Soni et al.

REGULATORY TOXICOLOGY AND PHARMACOLOGY (2001)

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Article Endocrinology & Metabolism

Low-level cadmium exposure and osteoporosis

T Alfvén et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2000)

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Article Genetics & Heredity

Fosl1 is a transcriptional target of c-Fos during osteoclast differentiation

K Matsuo et al.

NATURE GENETICS (2000)

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Article Endocrinology & Metabolism

The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption

LC Hofbauer et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2000)

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