☆ 4.8 Article

Associations between perfluoroalkyl substances and the severity of non-alcoholic fatty liver disease

ENVIRONMENT INTERNATIONAL (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Food Science & Technology

Systemic toxicity induced by topical application of perfluoroheptanoic acid (PFHpA), perfluorohexanoic acid (PFHxA), and perfluoropentanoic acid (PFPeA) in a murine model

Lisa M. Weatherly et al.

Summary: This study conducted a dermal exposure experiment on mice and found that alternative PFAS caused pathological changes in liver and skin tissues, as well as changes in gene expression related to fatty acid metabolism, necrosis, and inflammation. These findings support the liver damage caused by PFAS and raise questions about the suitability of these alternative PFAS as substitutes for legacy PFAS.

FOOD AND CHEMICAL TOXICOLOGY (2023)

添加到收藏夹

Article Environmental Sciences

PPARa/ACOX1 as a novel target for hepatic lipid metabolism disorders induced by per- and polyfluoroalkyl substances: An integrated approach

Wang Yang et al.

Summary: This study aimed to explore the link between PFAS exposure and NAFLD and investigate the molecular mechanisms involved. Cross-sectional analyses using NHANES data showed a significant association between PFAS exposure and hepatic steatosis/NAFLD. Further in vivo and in vitro experiments confirmed that ACOX1-mediated oxidative stress contributed to mitochondrial compromise and lipid accumulation in PFOA/PFOS-exposed mouse hepatocytes. Additionally, the study found that hepatic ACOX1 exhibited a response to short-term exposures of long-chain PFAS in human hepatocyte spheroids.

ENVIRONMENT INTERNATIONAL (2023)

添加到收藏夹

Article Endocrinology & Metabolism

Exposure to low-dose perfluorooctanoic acid promotes hepatic steatosis and disrupts the hepatic transcriptome in mice

Brecht Attema et al.

Summary: The study found that long-term low-dose exposure to PFOA and GenX disrupts hepatic lipid metabolism in mice, particularly having adverse effects on the liver. The effects of PFOA and GenX differ in pathways, with PFOA being regulated by multiple nuclear receptors and GenX being entirely mediated by PPARa.

MOLECULAR METABOLISM (2022)

添加到收藏夹

Article Environmental Sciences

Interlaboratory Comparison Investigations (ICIs) and External Quality Assurance Schemes (EQUASs) for human biomonitoring of perfluoroalkyl substances (PFASs) in serum as part of the quality assurance programme under HBM4EU

Stefanie Nuebler et al.

Summary: Perfluoroalkyl substances (PFASs) are of high concern due to their persistent and accumulative behavior as well as their adverse health effects. Human biomonitoring (HBM) based on PFAS determination in serum samples is a suitable strategy for assessing population exposure and risk. The paper presents the evaluation process and results of quality assurance and quality control (QA/QC) measures for PFAS analysis in serum, showing the successful establishment of a network of laboratories with high analytical comparability in 12 European countries.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

添加到收藏夹

Article Environmental Sciences

Environmental exposure to perfluoroalkyl substances in early pregnancy, maternal glucose homeostasis and the risk of gestational diabetes: A prospective cohort study

Guoqi Yu et al.

Summary: Exposure to PFAS during pregnancy may impact glucose homeostasis and increase the risk of GDM, particularly in women with normal prepregnant BMI. Some PFAS, such as PFHpA and PFOS, were found to be significantly associated with GDM incidence and glucose levels during pregnancy.

ENVIRONMENT INTERNATIONAL (2021)

添加到收藏夹

Article Environmental Sciences

Exposure of the French population to bisphenols, phthalates, parabens, glycol ethers, brominated flame retardants, and perfluorinated compounds in 2014-2016: Results from the Esteban study

Clemence Fillol et al.

Summary: The Esteban study in France provides data on the biological exposure of the general population to contaminants. Results show wide exposure to pollutants in 2014-2016, with determinants identified. This study will help inform stakeholders and future policies aimed at reducing harmful substance exposure.

ENVIRONMENT INTERNATIONAL (2021)

添加到收藏夹

Article Medicine, General & Internal

Prospective Study of Outcomes in Adults with Nonalcoholic Fatty Liver Disease

Arun J. Sanyal et al.

Summary: In this study involving patients with nonalcoholic fatty liver disease, advanced fibrosis stages F3 and F4 were associated with increased risks of liver-related complications and death over a median of 4 years of follow-up. Advanced fibrosis was also related to an increased incidence of liver decompensation events.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

添加到收藏夹

Article Engineering, Environmental

Chronic exposure to PFO4DA and PFO5DoDA, two perfluoroalkyl ether carboxylic acids (PFECAs), suppresses hepatic stress signals and disturbs glucose and lipid metabolism in male mice

Jiamiao Chen et al.

Summary: Perfluoroalkyl ether carboxylic acids (PFECAs), including substances like PFO4DA and PFO5DoDA, have been found in polluted regions in both surface water and volunteer blood samples. The study showed that PFO5DoDA had a longer serum half-life and stronger hepatic bioaccumulation compared to PFO4DA, contributing to its stronger hepatotoxicity. Chronic exposure to these compounds led to weight gain, disrupted stress signals, and disturbed glucose and lipid metabolism in the liver.

JOURNAL OF HAZARDOUS MATERIALS (2021)

添加到收藏夹

Article Environmental Sciences

Serum concentrations of per-/polyfluoroalkyl substances and risk of type 2 diabetes: A case-control study

Yishuang Duan et al.

Summary: The study found that exposure to certain PFASs may increase the risk of type 2 diabetes mellitus (T2DM), while most PFASs are inversely associated with T2DM risk. Different PFASs may have non-monotonic dose-response effects on T2DM at varying exposure levels. Further research is needed to clarify the mechanisms of action of different PFASs on T2DM at different exposure levels.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

添加到收藏夹

Article Environmental Sciences

Perfluoroalkyl substances and severity of nonalcoholic fatty liver in Children: An untargeted metabolomics approach

Ran Jin et al.

ENVIRONMENT INTERNATIONAL (2020)

添加到收藏夹

Article Gastroenterology & Hepatology

Prenatal Exposure to Perfluoroalkyl Substances Associated With Increased Susceptibility to Liver Injury in Children

Nikos Stratakis et al.

HEPATOLOGY (2020)

添加到收藏夹

Article Public, Environmental & Occupational Health

Association between exposure to per- and polyfluoroalkyl substances and blood glucose in pregnant women

Juxiao Li et al.

INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH (2020)

添加到收藏夹

Article Environmental Sciences

Persistent organic pollutants and gestational diabetes: A multi-center prospective cohort study of healthy US women

Mohammad L. Rahman et al.

ENVIRONMENT INTERNATIONAL (2019)

添加到收藏夹

Article Environmental Sciences

Liver function biomarkers disorder is associated with exposure to perfluoroalkyl acids in adults: Isomers of C8 Health Project in China

Min Nian et al.

ENVIRONMENTAL RESEARCH (2019)

添加到收藏夹

Article Gastroenterology & Hepatology

New sequential combinations of non-invasive fibrosis tests provide an accurate diagnosis of advanced fibrosis in NAFLD

Jerome Boursier et al.

JOURNAL OF HEPATOLOGY (2019)

添加到收藏夹

Article Environmental Sciences

Environmental perfluoroalkyl acid exposures are associated with liver disease characterized by apoptosis and altered serum adipocytokines

John Bassler et al.

ENVIRONMENTAL POLLUTION (2019)

添加到收藏夹

Article Environmental Sciences

A mortality study on male subjects exposed to polyfluoroalkyl acids with high internal dose of perfluorooctanoic acid

Paolo Girardi et al.

ENVIRONMENTAL RESEARCH (2019)

添加到收藏夹

Review Immunology

Epidemiology of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis: Implications for Liver Transplantation

Zobair M. Younossi et al.

TRANSPLANTATION (2019)

添加到收藏夹

Article Environmental Sciences

Polybrominated diphenyl ethers and perfluorinated alkyl substances in blood serum of New Zealand adults, 2011-2013

J. Coakley et al.

CHEMOSPHERE (2018)

添加到收藏夹

Article Environmental Sciences

Perfluoroalkyl substances in adolescents in northern Norway: Lifestyle and dietary predictors. The Tromso study, Fit Futures 1

Maria Averina et al.

ENVIRONMENT INTERNATIONAL (2018)

添加到收藏夹

Article Environmental Sciences

Changes in markers of liver function in relation to changes in perfluoroalkyl substances - A longitudinal study

Samira Salihovic et al.

ENVIRONMENT INTERNATIONAL (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Mechanisms of NAFLD development and therapeutic strategies

Scott L. Friedman et al.

NATURE MEDICINE (2018)

添加到收藏夹

Article Toxicology

Serum concentrations of perfluorinated compounds among children living in Sicily (Italy)

Caterina Ledda et al.

TOXICOLOGY LETTERS (2018)

添加到收藏夹

Article Public, Environmental & Occupational Health

ADONA and perfluoroalkylated substances in plasma samples of German blood donors living in South Germany

Hermann Fromme et al.

INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH (2017)

添加到收藏夹

Article Gastroenterology & Hepatology

EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease

Giulio Marchesini et al.

JOURNAL OF HEPATOLOGY (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Effects of Perfluorooctanoic Acid on Metabolic Profiles in Brain and Liver of Mouse Revealed by a High-throughput Targeted Metabolomics Approach

Nanyang Yu et al.

SCIENTIFIC REPORTS (2016)

添加到收藏夹

Article Environmental Sciences

Persistent organic pollutants and non-alcoholic fatty liver disease in morbidly obese patients: a cohort study

Panu Rantakokko et al.

ENVIRONMENTAL HEALTH (2015)

添加到收藏夹

Article Environmental Sciences

Levels of perfluoroalkyl substances and risk of coronary heart disease: Findings from a population-based longitudinal study

Kristina Mattsson et al.

ENVIRONMENTAL RESEARCH (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

Perfluorooctanoic acid exposure induces endoplasmic reticulum stress in the liver and its effects are ameliorated by 4-phenylbutyrate

Shengmin Yan et al.

FREE RADICAL BIOLOGY AND MEDICINE (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Perinatal Exposure to Perfluorooctane Sulfonate Affects Glucose Metabolism in Adult Offspring

Hin T. Wan et al.

PLOS ONE (2014)

添加到收藏夹

Article Environmental Sciences

Accumulation of perfluoroalkyl substances in human tissues

Francisca Perez et al.

ENVIRONMENT INTERNATIONAL (2013)

添加到收藏夹

Article Gastroenterology & Hepatology

Investigation of the Associations Between Low-Dose Serum Perfluorinated Chemicals and Liver Enzymes in US Adults

Chien-Yu Lin et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2010)

添加到收藏夹

Article Environmental Sciences

Altered Fatty Acid Homeostasis and Related Toxicologic Sequelae in Rats Exposed to Dietary Potassium Perfluorooctanesulfonate (PFOS)

Ivan Curran et al.

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES (2008)

添加到收藏夹

Article Toxicology

Perfluorooctanoic acid-induced hepatic toxicity following 21-day oral exposure in mice

Hee-Young Son et al.

ARCHIVES OF TOXICOLOGY (2008)

添加到收藏夹

Article Gastroenterology & Hepatology

Design and validation of a histological scoring system for nonalcoholic fatty liver disease

DE Kleiner et al.

HEPATOLOGY (2005)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.