Estimating Mutual Information for Spike Trains: A Bird Song Example

Zebra finches are a model animal used in the study of audition. They are adept at recognizing zebra finch songs, and the neural pathway involved in song recognition is well studied. Here, this example is used to illustrate the estimation of mutual information between stimuli and responses using a Kozachenko-Leonenko estimator. The challenge in calculating mutual information for spike trains is that there are no obvious coordinates for the data. The Kozachenko-Leonenko estimator does not require coordinates; it relies only on the distance between data points. In the case of bird songs, estimating the mutual information demonstrates that the information content of spiking does not diminish as the song progresses.

Automated summary

Zebra finches are used to study audition and the neural pathway for song recognition. This study illustrates the estimation of mutual information between stimuli and responses using the Kozachenko-Leonenko estimator. The findings show that the information content of spiking does not decrease as the song progresses.