Spns2/S1P: it takes two to tango with inflammation and metabolic rewiring during sepsis

Sepsis is the result of a dysregulated host response to an infection and causes high morbidity and mortality at the intensive care units worldwide. Despite intensive research, the current management of sepsis is supportive rather than curative. Therefore, new therapeutic interventions for sepsis and septic shock patients are urgently needed. In this issue of EMBO Reports, Fang et al have used rat sepsis models to show that macrophage-expressed SPNS2, a major transporter of S1P, is a crucial mediator of metabolic reprogramming of macrophages during sepsis which regulates inflammation via the lactate-ROS axis.

Automated summary

Sepsis is a life-threatening response to infection, causing high morbidity and mortality in intensive care units worldwide. Current management of sepsis is supportive, and there is an urgent need for new therapeutic interventions. This study shows that the transporter SPNS2 plays a crucial role in metabolic reprogramming of macrophages during sepsis, regulating inflammation through the lactate-ROS axis.