期刊
EMBO JOURNAL
卷 42, 期 17, 页码 -出版社
WILEY
DOI: 10.15252/embj.2022111515
关键词
Alzheimer's disease; blood-cerebrospinal fluid barrier; gut microbiota; short-chain fatty acids; vagus nerve
Accumulating evidence suggests that gut microbiota dysbiosis is associated with increased blood-brain barrier (BBB) permeability and contributes to Alzheimer's disease (AD) pathogenesis. However, the influence of gut microbiota on the blood-cerebrospinal fluid (CSF) barrier has not been studied. This study found that mice lacking gut microbiota show increased blood-CSF barrier permeability associated with disorganized tight junctions (TJs), which can be rescued by recolonization with gut microbiota or supplementation with short-chain fatty acids (SCFAs).
Accumulating evidence indicates that gut microbiota dysbiosis is associated with increased blood-brain barrier (BBB) permeability and contributes to Alzheimer's disease (AD) pathogenesis. In contrast, the influence of gut microbiota on the blood-cerebrospinal fluid (CSF) barrier has not yet been studied. Here, we report that mice lacking gut microbiota display increased blood-CSF barrier permeability associated with disorganized tight junctions (TJs), which can be rescued by recolonization with gut microbiota or supplementation with short-chain fatty acids (SCFAs). Our data reveal that gut microbiota is important not only for the establishment but also for the maintenance of a tight barrier. Also, we report that the vagus nerve plays an important role in this process and that SCFAs can independently tighten the barrier. Administration of SCFAs in App(NL-G-F) mice improved the subcellular localization of TJs at the blood-CSF barrier, reduced the & beta;-amyloid (A & beta;) burden, and affected microglial phenotype. Altogether, our results suggest that modulating the microbiota and administering SCFAs might have therapeutic potential in AD via blood-CSF barrier tightening and maintaining microglial activity and A & beta; clearance.
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