Electrochemical determination of sulfaguanidine using COOH-MWCNT coated GC electrode

The electrochemical behavior of sulfaguanidine was investigated in PBS buffer aqueous solutions. Cyclic voltammograms have shown that (1) the Sg provided a well-defined irreversible oxidation peak (2) the signal-to-background current ratio is 3 times higher at COOH-MWCNT coated GCE than that of bare GCE and (3) the modifying GCE surface by COOH-MWCNT led to a significant improvement (2.7 folds) of the electrochemical response. It has been shown that Sg oxidizes according to a diffusion-controlled mechanism. A linear calibration curve was obtained for the oxidation of Sg at 10-70 & mu;M. The COOH-MWCNT coated GCE has also been successfully used for the determination of Sg in real samples.

Automated summary

The electrochemical behavior of sulfaguanidine was studied in PBS buffer solutions. Cyclic voltammograms revealed that (1) Sg displayed a defined irreversible oxidation peak; (2) the signal-to-background current ratio was three times higher on COOH-MWCNT coated GCE than bare GCE; (3) modifying GCE with COOH-MWCNT significantly improved the electrochemical response (2.7-fold increase). The oxidation of Sg was found to follow a diffusion-controlled mechanism. A linear calibration curve was obtained for the oxidation of Sg in the concentration range of 10-70 μM. The COOH-MWCNT coated GCE was successfully used for the determination of Sg in real samples.