Analyzing the impact and mechanism of bisphenol A on testicular lipid metabolism in Gobiocypris rarus through integrated lipidomics and transcriptomics

Article Biochemistry & Molecular Biology

Fetal Exposure to Endocrine Disrupting-Bisphenol A (BPA) Alters Testicular Fatty Acid Metabolism in the Adult Offspring: Relevance to Sperm Maturation and Quality

Saikanth Varma et al.

Summary: Daily exposure to bisphenols can affect reproductive functions due to their pseudo-estrogenic and/or anti-androgenic effects. Whether prenatal exposure to bisphenols alters testicular fatty acid metabolism in adult offspring is unknown.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Article Multidisciplinary Sciences

Different types of bisphenols alter ovarian steroidogenesis: Special attention to BPA

Hamed Shoorei et al.

Summary: Endocrine disruptors such as BPA can severely affect the functionality of the female reproductive system by altering hormone production and genes involved in ovarian steroidogenesis. Exposure to bisphenol compounds can disrupt the normal function of the HPG axis, leading to abnormal production of LH and FSH. These compounds also negatively affect the release of hormones such as E2, P4, and T, and alter the transcription of genes involved in ovarian steroidogenesis.

HELIYON (2023)

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Article Environmental Sciences

G protein-coupled estrogen receptor activation by bisphenol-A disrupts lipid metabolism and induces ferroptosis in the liver

Wanqiu He et al.

Summary: This study found that exposure to bisphenol A (BPA) disrupts lipid metabolism and induces inflammation in the liver. Furthermore, BPA significantly affects the expression of G-protein-coupled estrogen receptor (GPER) in the liver. Inhibition of GPER can considerably improve BPA-induced lipid metabolism disorder, inflammatory response, and ferroptosis, highlighting the crucial role of GPER in BPA-induced liver abnormalities.

ENVIRONMENTAL POLLUTION (2023)

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Article Chemistry, Multidisciplinary

Sperm quality and oxidative stress in chub Squalius orientalis and Padanian barbel Barbus plebejus (Teleostei: Cyprinidae) after in vitro exposure to low doses of bisphenol A

Filiz Kutluyer et al.

Summary: Bisphenol A (BPA) has adverse effects on fish sperm quality, decreasing enzyme activity and increasing lipid peroxidation, leading to reduced sperm motility.

DRUG AND CHEMICAL TOXICOLOGY (2022)

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Article Reproductive Biology

In vivo and in vitro short-term bisphenol A exposures disrupt testicular energy metabolism and negatively impact spermatogenesis in zebrafish

Hemily Batista-Silva et al.

Summary: The study investigated the effects of Bisphenol A (BPA) on testicular energy metabolism and morphology in zebrafish through in vitro and short-term in vivo experiments. Results showed that BPA exposure decreased lactate and glycogen content, altered enzyme activity, induced apoptosis in testicular cells, and affected spermatogenesis in male zebrafish. Overall, short-term BPA exposure was found to impact energy metabolism and spermatogenesis in zebrafish.

REPRODUCTIVE TOXICOLOGY (2022)

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Article Biochemistry & Molecular Biology

Bisphenol A (BPA) Leading to Obesity and Cardiovascular Complications: A Compilation of Current In Vivo Study

Ruth Naomi et al.

Summary: This review paper explores the impact of BPA on obesity and potential cardiovascular complications. By analyzing relevant studies, it is found that BPA exposure may lead to obesity and potentially affect lipid profile and genes associated with lipolysis in in vivo trials.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Reproductive Biology

Transgenerational effects of bisphenol A on zebrafish reproductive tissues and sperm motility

Mst. Habiba Mostari et al.

Summary: This study demonstrates the transgenerational adverse effects of bisphenol A (BPA) on zebrafish reproduction. Even low doses of BPA can cause negative effects on gonadal activity, fertility, survival rate, and malformation in the offspring. Furthermore, these adverse effects can be transmitted to subsequent generations.

REPRODUCTIVE TOXICOLOGY (2022)

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Article Marine & Freshwater Biology

Long-term exposure of zebrafish to bisphenol F: Adverse effects on parental reproduction and offspring neurodevelopment

Jie Gu et al.

Summary: This study investigated the effects of life-cycle exposure to environmental concentrations of BPF on zebrafish reproduction and offspring development. The results showed that BPF exposure increased oxidative stress levels, induced gonadal apoptosis, and reduced zebrafish spawning. Additionally, through maternal transfer, BPF significantly affected the development of the offspring, resulting in decreased hatching rate, spontaneous movements, heart rate, body length, and locomotor behavior. Gene expression related to oxidative stress, apoptosis, and neurodevelopment was also altered in the offspring.

AQUATIC TOXICOLOGY (2022)

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Article Veterinary Sciences

Impact of bisphenol-A on the spliceosome and meiosis of sperm in the testis of adolescent mice

Yongjie Wang et al.

Summary: This study investigated the effects of BPA exposure at various doses on testis development in male mice offspring. The results showed that long-term exposure to low doses of BPA inhibits spermatogonial meiosis and impairs reproductive function in male offspring.

BMC VETERINARY RESEARCH (2022)

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Article Food Science & Technology

Bisphenol a exposure decreases learning ability through the suppression of mitochondrial oxidative phosphorylation in the hippocampus of male mice

Zhuo Zhang et al.

Summary: This study investigates the neurotoxic effects of BPA exposure in male mouse hippocampus. The results show that BPA disrupts cell arrangement, reduces learning abilities and testosterone/estradiol ratio, inhibits gene expressions related to mitochondrial oxidative phosphorylation, alters ATP synthesis in hippocampal mitochondria, and impairs energy supply in the brain.

FOOD AND CHEMICAL TOXICOLOGY (2022)

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Review Environmental Sciences

Bisphenol A in Africa: A review of environmental and biological levels

Oluwakemi A. Rotimi et al.

Summary: BPA, a synthetic environmental toxicant found in various products, has been shown to disrupt hormone pathways and physiological processes. A study was conducted to assess the bioaccumulation of BPA across Africa, highlighting the need for regulatory measures to minimize its environmental and toxicological impact.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

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Article Marine & Freshwater Biology

Bisphenol A regulates apolipoprotein A1 expression through estrogen receptors and DNA methlylation and leads to cholesterol disorder in rare minnow testis

Yingying Zhang et al.

Summary: This study reveals the mechanism by which BPA interferes with spermatogenesis through altering the expression of ApoA1, affecting HDL cholesterol levels and reverse cholesterol transport, ultimately leading to sex hormone disorder and sperm head membrane damage.

AQUATIC TOXICOLOGY (2021)

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Article Environmental Sciences

Bisphenol A induces hepatic triglyceride level in adult male rare minnow Gobiocypris rarus

Kaihang Mi et al.

Summary: The study showed that BPA exposure significantly increased hepatic lipid deposition in male rare minnow, with an increase in triglyceride level and a decrease in diglyceride level. The expression of lipid metabolism related genes indicated that BPA up-regulates TG synthesis related genes expression and down-regulates TG degradation genes expression, disrupting TG transport related genes as well. Overall, the study enriches the understanding of how environmental endocrine disruptors like BPA affect lipid accumulation in fish.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

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Article Marine & Freshwater Biology

Chronic exposure to Bisphenol A resulted in alterations of reproductive functions via immune defense, oxidative damage and disruption DNA/ histone methylation in male rare minnow Gobiocypris rarus

Long Zhu et al.

Summary: Chronic exposure to BPA in fish can impair male reproductive capacity, leading to decreased fertilization ability and motility of sperm. BPA induces oxidative stress, inflammatory response, and DNA/histone methylation, affecting the normal function of the reproductive system.

AQUATIC TOXICOLOGY (2021)

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Review Biochemistry & Molecular Biology

Sperm Lipid Markers of Male Fertility in Mammals

Shuwen Shan et al.

Summary: Sperm plasma membrane lipids play a crucial role in maintaining the function and integrity of mammalian spermatozoa. Different types of lipids are involved in key steps of fertilization in a coordinated manner, with balanced lipid metabolism being essential for physiological cellular processes, especially for sperm motility, capacitation, acrosome reaction, and fusion. Studies suggest that male reproductive function is influenced by the homeostasis of sperm lipids.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Cell Biology

Tanycytic TSPO inhibition induces lipophagy to regulate lipid metabolism and improve energy balance

Seolsong Kim et al.

AUTOPHAGY (2020)

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Review Environmental Sciences

A review on sources and health impacts of bisphenol A

Anna Abraham et al.

REVIEWS ON ENVIRONMENTAL HEALTH (2020)

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Review Biochemistry & Molecular Biology

Integration of lipidomics and metabolomics for in-depth understanding of cellular mechanism and disease progression

Raoxu Wang et al.

JOURNAL OF GENETICS AND GENOMICS (2020)

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Review Engineering, Environmental

Hazards of bisphenol A (BPA) exposure: A systematic review of plant toxicology studies

Changyun Xiao et al.

JOURNAL OF HAZARDOUS MATERIALS (2020)

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Article Engineering, Environmental

Toxicity comparison of nano-sized and micron-sized microplastics to Goldfish Carassius auratus Larvae

Hui Yang et al.

JOURNAL OF HAZARDOUS MATERIALS (2020)

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Article Pharmacology & Pharmacy

Distinct phospholipid and sphingolipid species are linked to altered HDL function in apolipoprotein A-I deficiency

Emile Zakiev et al.

JOURNAL OF CLINICAL LIPIDOLOGY (2019)

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Article Environmental Sciences

Toxic effects of bisphenol A on goldfish gonad development and the possible pathway of BPA disturbance in female and male fish reproduction

Qing Wang et al.

CHEMOSPHERE (2019)

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Article Environmental Sciences

Male exposure to bisphenol a impairs spermatogenesis and triggers histone hyperacetylation in zebrafish testes

S. Gonzalez-Rojo et al.

ENVIRONMENTAL POLLUTION (2019)

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Article Entomology

Effect of physiological factors on the flight ability of Calliptamus italicus L

Kai-Li Cao et al.

PHYSIOLOGICAL ENTOMOLOGY (2019)

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Article Environmental Sciences

Adult exposure to bisphenol A in rare minnow Gobiocypris rarus reduces sperm quality with disruption of testicular aquaporins

Yingying Zhang et al.

CHEMOSPHERE (2018)

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Review Food Science & Technology

Obesity and Male Infertility: Role of Fatty Acids in the Modulation of Sperm Energetic Metabolism

Alessandra Ferramosca et al.

EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY (2018)

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Article Environmental Sciences

Effects of diethylene glycol dibenzoate and Bisphenol A on the lipid metabolism of Danio rerio

Stefania Santangeli et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2018)

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Article Agriculture, Dairy & Animal Science

Spermatozoa quality and sperm lipid composition in intensively cultured and wild burbot (Lota iota)

Miroslav Blecha et al.

ANIMAL REPRODUCTION SCIENCE (2018)

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Article Environmental Sciences

A Study on Environmental Bisphenol A Pollution in Plastics Industry Areas

Zhenkun Lin et al.

WATER AIR AND SOIL POLLUTION (2017)

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Article Public, Environmental & Occupational Health

Urinary bisphenol A and obesity in adults: results from the Canadian Health Measures Survey

Minh T. Do et al.

HEALTH PROMOTION AND CHRONIC DISEASE PREVENTION IN CANADA-RESEARCH POLICY AND PRACTICE (2017)

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Article Public, Environmental & Occupational Health

Bisphenol A exposure may increase the risk of development of atopic disorders in children

I-Jen Wang et al.

INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH (2016)

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Article Multidisciplinary Sciences

Conditional steroidogenic cell-targeted deletion of TSPO unveils a crucial role in viability and hormone-dependent steroid formation

Jinjiang Fan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

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Review Multidisciplinary Sciences

Lipid landscapes and pipelines in membrane homeostasis

Joost C. M. Holthuis et al.

NATURE (2014)

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Article Andrology

Lipid concentrations and semen quality: the LIFE study

E. F. Schisterman et al.

ANDROLOGY (2014)

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Article Endocrinology & Metabolism

Characterization of four nr5a genes and gene expression profiling for testicular steroidogenesis-related genes and their regulatory factors in response to bisphenol A in rare minnow Gobiocypris rarus

Yingying Zhang et al.

GENERAL AND COMPARATIVE ENDOCRINOLOGY (2013)

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Review Biochemistry & Molecular Biology

Lipidomics as a Principal Tool for Advancing Biomedical Research

Sin Man Lam et al.

JOURNAL OF GENETICS AND GENOMICS (2013)

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Article Marine & Freshwater Biology

Effects of 17α-ethinylestradiol and bisphenol A on steroidogenic messenger ribonucleic acid levels in the rare minnow gonads

Shaozhen Liu et al.

AQUATIC TOXICOLOGY (2012)

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Article Environmental Sciences

Adverse effects of bisphenol A on reproductive physiology in male goldfish at environmentally relevant concentrations

Azadeh Hatef et al.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2012)

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Article Environmental Sciences

Bisphenol A (BPA) in China: A review of sources, environmental levels, and potential human health impacts

Y. Q. Huang et al.

ENVIRONMENT INTERNATIONAL (2012)

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Article Biochemistry & Molecular Biology

Apolipoprotein A-I Modulates Processes Associated with Diet-Induced Nonalcoholic Fatty Liver Disease in Mice

Eleni A. Karavia et al.

MOLECULAR MEDICINE (2012)

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Review Biochemistry & Molecular Biology

Generation and Biological Activities of Oxidized Phospholipids

Valery N. Bochkov et al.

ANTIOXIDANTS & REDOX SIGNALING (2010)

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Article Fisheries

In vitro effects of Bisphenol A on sperm motility characteristics in Perca fluviatilis L. (Percidae; Teleostei)

A. Hatef et al.

JOURNAL OF APPLIED ICHTHYOLOGY (2010)

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Article Biochemical Research Methods

Dispersive liquid-liquid microextraction combined with high-performance liquid chromatography-UV detection as a very simple, rapid and sensitive method for the determination of bisphenol A in water samples

Mohammad Rezaee et al.

JOURNAL OF CHROMATOGRAPHY A (2009)

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Article Biochemistry & Molecular Biology

Haptoglobin inhibits phospholipid transfer protein activity in hyperlipidemic human plasma

Ryan J. Henderson et al.

LIPIDS IN HEALTH AND DISEASE (2009)

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Review Cell Biology

Membranes:: a meeting point for lipids, proteins and therapies

Pablo V. Escriba et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2008)

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Review Cell Biology

Lipid signalling in disease

Matthias P. Wymann et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)

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Article Fisheries

Seasonal variation of sperm quality and the relationship between spermatocrit and sperm concentration in yamu Brycon amazonicus

Pablo E. Cruz-Casallas et al.

NORTH AMERICAN JOURNAL OF AQUACULTURE (2007)

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Article Biochemistry & Molecular Biology

Overexpression of APOC1 in obob mice leads to hepatic steatosis and severe hepatic insulin resistance

M Muurling et al.

JOURNAL OF LIPID RESEARCH (2004)

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Article Environmental Sciences

Effects of bisphenol A on the reproduction of Japanese medaka (Oryzias latipes)

IJ Kang et al.

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY (2002)

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Article Engineering, Environmental

Reproductive effects of long-term exposure to bisphenol a in the fathead minnow (Pimephales promelas)

P Sohoni et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2001)

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Analyzing the impact and mechanism of bisphenol A on testicular lipid metabolism in Gobiocypris rarus through integrated lipidomics and transcriptomics

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