Single-component organic semiconducting polymer nanoparticles for near-infrared afterglow imaging

Editorial Material Engineering, Biomedical

Seeing cancer via sonoafterglow

Wenhui Zeng et al.

Summary: Ultrasound can induce afterglow luminescence from nanoparticles, which can be used for image-guided treatment and monitoring of tumors in mice.

NATURE BIOMEDICAL ENGINEERING (2023)

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Review Chemistry, Multidisciplinary

Biomarker-Responsive Nanosystems for Chronic Disease Theranostics

Qinrui Fu et al.

Summary: Chronic diseases claim millions of lives every year, and it is important to develop advanced drugs for better treatment. Nanotheranostics, which integrate diagnosis and treatment into a single nanosystem, have shown great potential. However, their applications in nanomedicine are still in the early stages.

ADVANCED FUNCTIONAL MATERIALS (2023)

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Review Chemistry, Multidisciplinary

Designing Next Generation of Persistent Luminescence: Recent Advances in Uniform Persistent Luminescence Nanoparticles

Kai Huang et al.

Summary: This review summarizes the evolution and optimization strategies of uniform persistent luminescent nanoparticles (PLNPs), as well as their prospects in applications such as bioimaging and X-ray detection. Milestones of uniform PLNPs prepared by different synthesis methods are summarized, and the key optical properties are analyzed. Strategies to enhance each optical property are discussed. Future challenges and the development prospects of next-generation PLNPs with novel applications are highlighted.

ADVANCED MATERIALS (2022)

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Article Chemistry, Multidisciplinary

Activatable Persistent Luminescence from Porphyrin Derivatives and Supramolecular Probes with Imaging-Modality Transformable Characteristics for Improved Biological Applications**

Xingchen Duan et al.

Summary: The study demonstrated the use of porphyrin derivatives for near-infrared persistent luminescence in biological applications, offering potential for tumor targeting and drug screening. The construction of a supramolecular probe with beta-sheet structure enhanced the imaging capabilities for advanced image-guided cancer surgery. The peroxynitrite-activated persistent luminescence of the probe also showed promise for rapid and precise screening of immunogenic cell death drugs.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

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Article Chemistry, Multidisciplinary

Light/Force-Sensitive 0D Lead-Free Perovskites: From Highly Efficient Blue Afterglow to White Phosphorescence with Near-Unity Quantum Efficiency

Shangwei Feng et al.

Summary: New types of zero-dimensional perovskites with blue room-temperature phosphorescence were obtained and found to be highly sensitive to external light and force stimuli. The quantum yield of blue phosphorescence was enhanced and high-efficiency white phosphorescence was achieved by introducing Sb3+. This work overcomes the challenges of low quantum yield and short lifetime of blue phosphorescence, providing a feasible method for achieving high-efficiency white phosphorescence.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

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Article Chemistry, Multidisciplinary

Amplification of Activated Near-Infrared Afterglow Luminescence by Introducing Twisted Molecular Geometry for Understanding Neutrophil-Involved Diseases

Chao Chen et al.

Summary: A dual-responsive nanoprobe has been developed in this study for real-time monitoring of neutrophil-involved diseases, providing sensitive and accurate information on the mechanism and progression of these diseases.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

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Article Chemistry, Multidisciplinary

Surfactant-Stripped Semiconducting Polymer Micelles for Tumor Theranostics and Deep Tissue Imaging in the NIR-II Window

Yuanmeng Ding et al.

Summary: The study introduces a semiconducting polymer with strong absorption in the second near infrared (NIR-II) window, leading to the development of surfactant-stripped semiconductor polymeric micelles (SSS-micelles) with water solubility and high photothermal conversion efficiency for deep tissue imaging and tumor theranostics.

SMALL (2022)

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Review Chemistry, Multidisciplinary

Chemical Design of Activatable Photoacoustic Probes for Precise Biomedical Applications

Yongchao Liu et al.

Summary: Photoacoustic imaging technology combines the advantages of optical and acoustic imaging, offering high imaging depth and resolution for molecular imaging. Activatable molecular PA probes show promise for real-time molecular visualization and precise biomedical diagnosis. These probes can alter their PA intensities upon reacting with specific targets or biological events, providing new possibilities for biomedical applications.

CHEMICAL REVIEWS (2022)

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Article Chemistry, Multidisciplinary

An Activatable Near-Infrared Afterglow Theranostic Prodrug with Self-Sustainable Magnification Effect of Immunogenic Cell Death

Zhiyuan Gao et al.

Summary: In this study, an activatable near-infrared (NIR) afterglow theranostic prodrug was developed to release a cancer drug and monitor tumor transformation through triggering immunogenic cell death (ICD) process. The prodrug induced ICD through photodynamic therapy (PDT) and amplified the ICD process, leading to anti-tumor immune response.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

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Article Chemistry, Multidisciplinary

A Ratiometric Photoacoustic Probe with a Reversible Response to Hydrogen Sulfide and Hydroxyl Radicals for Dynamic Imaging of Liver Inflammation

Luyan Wu et al.

Summary: In this study, a reversible ratiometric photoacoustic imaging nanoprobe was developed for real-time imaging of the redox cycle. The nanoprobe displayed different photoacoustic ratios upon oxidation and reduction reactions, allowing for the study of redox imbalance-related diseases.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

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Review Pharmacology & Pharmacy

The in vivo fate of polymeric micelles

Yifan Cai et al.

Summary: This review provides a systemic analysis of the in vivo and subcellular fate of polymeric micelles (PMs), discussing their circulation stability, biodistribution, internalization, and degradation in cells. The findings contribute to the understanding of the mechanisms of PMs and facilitate their clinical translation.

ADVANCED DRUG DELIVERY REVIEWS (2022)

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Review Chemistry, Multidisciplinary

Minimally invasive nanomedicine: nanotechnology in photo-/ultrasound-/radiation-/magnetism-mediated therapy and imaging

Jiang Ouyang et al.

Summary: Traditional treatments like chemotherapy and surgery often have severe side effects and cause pain. The emergence of nanomedicines and minimally invasive therapies has brought hope to patients with malignant diseases. Minimally invasive nanomedicines combine the advantages of nanomedicines and minimally invasive therapies, effectively targeting pathological cells and minimizing side effects. This review provides a comprehensive overview of the research status and challenges of minimally invasive nanomedicines and their applications in various fields.

CHEMICAL SOCIETY REVIEWS (2022)

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Article Materials Science, Multidisciplinary

Bright NIR-II Fluorescent Small-Molecule Nanoparticles with Reduced Intermolecular Interaction for Targeted In Vivo Inflammation Imaging

Shangyu Chen et al.

Summary: Bright NIR-II fluorescent small-molecule NPs were successfully prepared in the study, showing superior fluorescence performance in vitro. The TQFPN was successfully applied for targeted in vivo inflammation imaging, providing high-resolution imaging for mouse models.

ACS APPLIED POLYMER MATERIALS (2021)

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Review Chemistry, Multidisciplinary

Organic Semiconducting Macromolecular Dyes for NIR-II Photoacoustic Imaging and Photothermal Therapy

Chao Yin et al.

Summary: Organic semiconducting macromolecular dyes (OSMDs) are emerging as alternative candidates for NIR-II photoacoustic imaging (PAI) and photothermal therapy (PTT) due to their reliable biocompatibility, durable photostability, and ideal photothermal conversion capability. Their applications in the NIR-II optical window include tumor imaging, stem cell tracking, vasculature imaging, and tumor ablation.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Near-Infrared-Light Remote-Controlled Activation of Cancer Immunotherapy Using Photothermal Conjugated Polymer Nanoparticles

Xuancheng Fu et al.

Summary: Remote control of cancer immunotherapy process using a conjugated polymer nanoparticles-mediated optogenetic system has been proposed. By triggering gene transcription of IFN-gamma cytokine under near-infrared laser irradiation, this system can elicit immune response against cancer cells. The synergetic optogenetic system provides a promising approach for cancer immunotherapy with minimized side effects and enhanced efficacy.

ADVANCED MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Singlet Oxygen Afterglow Therapy with NIR-II Fluorescent Molecules

Jianhua Zou et al.

Summary: The synthesized ABDPTPA is an efficient heavy-atom-free photosensitizer that can improve the lifespan of O-1(2) under dark and hypoxic conditions. Its high O-1(2) quantum yield and ability to promote O-1(2) awakening make it suitable for phototherapy to enhance tumor regression.

ADVANCED MATERIALS (2021)

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Review Chemistry, Multidisciplinary

NIR-II Organic Nanotheranostics for Precision Oncotherapy

Hanming Dai et al.

Summary: Precision oncotherapy can effectively remove tumors without harming normal tissues.NIR-II organic nanotheranostics show good biocompatibility and safety, holding great potential for clinical tumor treatment.

SMALL (2021)

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Review Chemistry, Multidisciplinary

Recent progress in photosensitizers for overcoming the challenges of photodynamic therapy: from molecular design to application

Xueze Zhao et al.

Summary: This review summarizes recent progress in developing photosensitizers (PSs) for photodynamic therapy, including enhanced tolerance, improved selectivity, and deep tissue applicability. PSs are classified based on molecular design and application, with strategies for designing and future perspectives briefly outlined.

CHEMICAL SOCIETY REVIEWS (2021)

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Article Chemistry, Multidisciplinary